(-)-Huperzine A

CAS: 102518-79-6

Ref. TR-H826000

Product Information

• Name: (-)-Huperzine A
• Synonyms: 5,9-Methanocycloocta[b]pyridin-2(1H)-one, 5-amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-, (5R,9R,11E)-, 5,9-Methanocycloocta[b]pyridin-2(1H)-one, 5-amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-, [5R-(5α,9β,11E)]-, Selagine (6CI,8CI), (5R,9R,11E)-5-Amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-5,9-methanocycloocta[b]pyridin-2(1H)-one, (-)-Selagine, Hup A, Huperzine, Hupzine A
• Brand: TRC

Description

Applications Reversible alkaloid inhibitor of AChE which crosses the blood-brain barrier. A potential therapeutic agent for Alzheimer’s disease. It reduces cell death induced by glutamate in primary cultures derived from forebrain, hippocampus, cortex and cerebellum of embryonic rat brain.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wang, Y.-E., et al.: Acta Pharmacol. Sin., 7, 110 (1986), Ved, H.S., et al.: Neuroreport, 8, 963 (1997)

Chemical properties

• Molecular weight: 242.32
• Formula: C₁₅H₁₈N₂O
• Color/Form: Neat
• InChI: InChI=1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)/b11-3+/t10-,15+/m0/s1
• InChI key: InChIKey=ZRJBHWIHUMBLCN-YQEJDHNASA-N
• SMILES: C/C=C1\[C@H]2C=C(C)C[C@]1(N)c1ccc(=O)[nH]c1C2