Angiogénese

Os inibidores da angiogênese são compostos que interferem na formação de novos vasos sanguíneos, um processo crítico no crescimento e metástase do câncer. Ao inibir a angiogênese, esses compostos podem restringir o suprimento de sangue para os tumores, retardando ou interrompendo seu crescimento. Os inibidores da angiogênese são essenciais na pesquisa do câncer e no desenvolvimento terapêutico, fornecendo insights sobre os mecanismos de progressão tumoral e oferecendo potenciais tratamentos para o câncer e outras doenças relacionadas à angiogênese. Na CymitQuimica, oferecemos uma ampla gama de inibidores da angiogênese de alta qualidade para apoiar sua pesquisa em oncologia e biologia vascular.

Subcategorias de "Angiogénese"

Exibir 6 mais subcategorias

Foram encontrados 2040 produtos de "Angiogénese"

Pureza (%)

100

produtos por página.

+ Info
MAX-40279 hemifumarate
CAS:
- 2388506-43-0
MAX-40279 hemifumarate inhibits FLT3 and FGFR kinases, showing promise for AML treatment.
Fórmula:C₄₈H₅₀F₂N₁₂O₆S₂
Cor e Forma:Solid
Peso molecular:993.12
Ref: TM-T63916
+ Info
BCR-ABL-IN-2
CAS:
- 897369-18-5
BCR-ABL-IN-2 is a BCR-ABL1 tyrosine kinase inhibitor (IC50s: 57 nM, 773 nM for ABL1 native and ABL1 T315I).
Fórmula:C₂₄H₂₅Cl₂N₅O₃
Pureza:98%
Cor e Forma:Solid
Peso molecular:502.39
Ref: TM-T10489
+ Info
BLK-IN-2
CAS:
- 2694871-86-6
BLK-IN-2为一种高效、选择性且不可逆的B-淋巴酪氨酸激酶(BLK)抑制剂，具有5.9 nM的IC50值。该化合物亦能抑制BTK，其IC50值为202.0 nM。BLK-IN-2在多种淋巴瘤细胞中展现出显著的抗增殖作用。
Fórmula:C₃₉H₄₁N₉O₃
Cor e Forma:Solid
Peso molecular:683.8
Ref: TM-T73366
+ Info
TM-233
CAS:
- 1103745-28-3
TM-233 is an inhibitor of both JAK/STAT and proteasome activities that acts by inducing cell death in myeloma cells.
Fórmula:C₂₅H₂₀O₄
Pureza:98%
Cor e Forma:Solid
Peso molecular:384.42
Ref: TM-T24890
+ Info
EGFR-IN-56
CAS:
- 2477726-83-1
EGFR-IN-56 (13a) inhibits EGFR, EGFRT790M (IC50: 541.7nM), EGFRT790M/L858R (IC50: 132.1nM), blocks G2/M phase, and triggers apoptosis.
Fórmula:C₂₃H₂₂N₄O₃S
Cor e Forma:Solid
Peso molecular:434.51
Ref: TM-T62458
+ Info
JAK3-IN-12
CAS:
- 1430095-86-5
JAK3-IN-12 (compound 15k) is a potent inhibitor of JAK3 (IC50: 9.5 nM) and can be used in the study of rheumatoid arthritis.
Fórmula:C₁₉H₁₉N₅O₄S
Cor e Forma:Solid
Peso molecular:413.45
Ref: TM-T62114
+ Info
Ilorasertib hydrochloride
CAS:
- 1847485-91-9
Ilorasertib hydrochloride (ABT-348 hydrochloride) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A (IC50s:
Fórmula:C₂₅H₂₂ClFN₆O₂S
Pureza:98.45%
Cor e Forma:Solid
Peso molecular:525
Ref: TM-T11638
+ Info
HSP90-IN-13
CAS:
- 2446055-29-2
HSP90-IN-13 (5k): potent HSP90 inhibitor, IC50 25.07 nM, targets EGFR/VEGFR-2/Topo-2, blocks MCF-7 G2/M cycle, induces apoptosis.
Fórmula:C₂₆H₂₁N₅O₃S
Cor e Forma:Solid
Peso molecular:483.54
Ref: TM-T63205
+ Info
M1002
CAS:
- 823830-85-9
M1002, a HIF-2 agonist, boosts HIF-2alpha/ARNT activation and alters HIF-281alpha PAS-B, working with PHD inhibitors.
Fórmula:C₁₅H₈F₆N₂O₂S
Pureza:99.95%
Cor e Forma:Solid
Peso molecular:394.29
Ref: TM-T61822
+ Info
Tyk2-IN-5
CAS:
- 1797432-62-2
Tyk2-IN-5 is a selective and orally active inhibitor of Tyk2 JH2 (Ki: 0.086 nM for Tyk2 JH2; IC50: 25 nM for IFNα).
Fórmula:C₂₁H₁₉FN₈O₂
Pureza:98%
Cor e Forma:Solid
Peso molecular:434.43
Ref: TM-T13234
+ Info
JBJ-04-125-02
CAS:
- 2060610-53-7
JBJ-04-125-02: Oral EGFR inhibitor, targets EGFRL858R/T790M with 0.26 nM IC50, halts cancer growth, anti-tumor.
Fórmula:C₂₉H₂₆FN₅O₃S
Pureza:98%
Cor e Forma:Solid
Peso molecular:543.61
Ref: TM-T11714
+ Info
VEGFR-2-IN-19
CAS:
- 2456315-41-4
VEGFR-2-IN-19 (15b) effectively inhibits VEGFR2, induces apoptosis, and increases oxidative stress, showing potential as an anticancer drug.
Fórmula:C₂₁H₁₉N₃O₂
Cor e Forma:Solid
Peso molecular:345.39
Ref: TM-T61137
+ Info
BPTQ
CAS:
- 1802665-43-5
BPTQ: DNA intercalator, halts cancer cell growth by blocking S/G2/M phases.
Fórmula:C₁₇H₁₆N₄S
Pureza:98%
Cor e Forma:Solid
Peso molecular:308.4
Ref: TM-T23817
+ Info
FAK-IN-8
CAS:
- 1374959-91-7
FAK-IN-8 (compound 5h), a FAK inhibitor with an IC50 of 5.32 μM, exhibits potent anti-proliferative activity, making it suitable for use in cancer research [1].
Fórmula:C₁₅H₉Cl₂N₃O₂S
Cor e Forma:Solid
Peso molecular:366.22
Ref: TM-T61410
+ Info
ULK1-IN-2
CAS:
- 2497409-01-3
ULK1-IN-2, a potent anticancer agent, inhibits ULK1, induces apoptosis, blocks autophagy, and shows high cytotoxicity with an IC50 of 1.94 μM in A549 cells.
Fórmula:C₁₉H₁₆BrFN₄O₆
Pureza:99.25% - 99.25%
Cor e Forma:Solid
Peso molecular:495.26
Ref: TM-T63343
+ Info
R916562
CAS:
- 1037798-41-6
R916562 is an orally active and selective Axl/VEGF-R2 inhibitor with IC50s of 136 nM and 24 nM, respectively. R916562 has anti-angiogenesis and anti-metastasis.
Fórmula:C₂₆H₃₀ClN₉S
Pureza:98%
Cor e Forma:Solid
Peso molecular:536.09
Ref: TM-T12650
+ Info
AZM475271
CAS:
- 476159-98-5
AZM475271 is a potent and selective inhibitor of Src kinase(IC50 : 5 nM)
Fórmula:C₂₃H₂₇ClN₄O₃
Pureza:99.78%
Cor e Forma:Solid
Peso molecular:442.94
Ref: TM-T14487
+ Info
(R)-Afatinib
CAS:
- 439081-17-1
(R)-Afatinib: oral ErbB inhibitor (EGFR/HER2), IC50 ≤14 nM. For ESCC, NSCLC, gastric cancer research.
Fórmula:C₂₄H₂₅ClFN₅O₃
Cor e Forma:Solid
Peso molecular:485.94
Ref: TM-T72912
+ Info
MAX-40279 hemiadipate
CAS:
- 2388506-44-1
MAX-40279 hemiadipate: Potent FLT3/FGFR inhibitor; potential in AML treatment. (Patent WO2021180032A1)
Fórmula:C₅₀H₅₆F₂N₁₂O₆S₂
Cor e Forma:Solid
Peso molecular:1023.19
Ref: TM-T64129
+ Info
TX-1123
CAS:
- 157397-06-3
TX-1123: PTK/COX inhibitor, Src/eEF2-K/PKA/EGFR-K/PKC targeted, IC50 of 1.16μM(COX2), 15.7μM(COX1), low mitochondrial toxicity.
Fórmula:C₂₀H₂₄O₃
Cor e Forma:Solid
Peso molecular:312.4
Ref: TM-T70431