Angiogénese
Os inibidores da angiogênese são compostos que interferem na formação de novos vasos sanguíneos, um processo crítico no crescimento e metástase do câncer. Ao inibir a angiogênese, esses compostos podem restringir o suprimento de sangue para os tumores, retardando ou interrompendo seu crescimento. Os inibidores da angiogênese são essenciais na pesquisa do câncer e no desenvolvimento terapêutico, fornecendo insights sobre os mecanismos de progressão tumoral e oferecendo potenciais tratamentos para o câncer e outras doenças relacionadas à angiogênese. Na CymitQuimica, oferecemos uma ampla gama de inibidores da angiogênese de alta qualidade para apoiar sua pesquisa em oncologia e biologia vascular.
Subcategorias de "Angiogénese"
- BTK(147 produtos)
- Bcr-Abl(103 produtos)
- EGFR(572 produtos)
- FAK(71 produtos)
- FLT(91 produtos)
- Receptor do Factor de Crescimento Fibroblasto (FGFR)(169 produtos)
- JAK(246 produtos)
- PDGFR(126 produtos)
- RAAS(88 produtos)
- Src(80 produtos)
- Syk(37 produtos)
- Trombina(47 produtos)
- VDA(2 produtos)
- VEGFR(267 produtos)
Exibir 6 mais subcategorias
Foram encontrados 1483 produtos de "Angiogénese"
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Tyrphostin AG 112
CAS:Produto Controlado<p>Applications Tyrphostin AG 112 is an EGFR inhibitor.<br></p>Fórmula:C13H8N4OCor e Forma:NeatPeso molecular:236.23E3330
CAS:<p>E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.</p>Fórmula:C21H30O6Pureza:99.52%Cor e Forma:SolidPeso molecular:378.46Bucillamine
CAS:<p>Bucillamine (DE019) protects against Ischemia/reperfusion injury in high-risk organ transplants and inhibits the production of VEGF.</p>Fórmula:C7H13NO3S2Pureza:99.47%Cor e Forma:SolidPeso molecular:223.31BIBX 1382 Dihydrochloride
CAS:<p>BIBX 1382 Dihydrochloride blocks Lassa/Ebola entry, aids in studying virus-host interactions, and hints at kinase targets for therapy.</p>Fórmula:C18H21Cl3FN7Cor e Forma:SolidPeso molecular:460.76FLT3-IN-15
CAS:<p>FLT3-IN-15 is an orally active and potent FLT3 inhibitor, capable of acting on FLT3 (IC50: 0.87 nM) and FLT3/D835Y (IC50: 0.32 nM).</p>Fórmula:C22H23ClFN5O2Cor e Forma:SolidPeso molecular:443.91BCR-ABL1-IN-1
CAS:<p>BCR-ABL1-IN-1: potent, orally active ABL kinase inhibitor with high specificity, promising for CNS research.</p>Fórmula:C18H12F3N3O2Cor e Forma:SolidPeso molecular:359.3pan-HER-IN-1
CAS:<p>Compound C5: Irreversible, oral pan-HER inhibitor with low IC50s for EGFR/HERs; induces apoptosis and has antitumor effects.</p>Fórmula:C19H14BrN5OCor e Forma:SolidPeso molecular:408.25EGFR/HER2/CDK9-IN-1
CAS:<p>EGFR/HER2/CDK9-IN-1 is a potent inhibitor (IC50: EGFR 90.17 nM, HER2 131.39 nM, CDK9 67.04 nM) with notable anti-tumor activity.</p>Fórmula:C23H21N3O3S2Cor e Forma:SolidPeso molecular:451.56MAX-40279
CAS:<p>MAX-40279 is a potent, dual FLT3 kinase and FGFR kinase inhibitor. MAX-40279 has potential for acute myeloid leukemia (AML) studies.</p>Fórmula:C22H23FN6OSCor e Forma:SolidPeso molecular:438.52EGFR/HER2/TS-IN-1
CAS:<p>EGFR/HER2/TS-IN-1 inhibits EGFR (0.203 μM), HER2 (0.088 μM), TS (0.168 μM), and induces apoptosis in MCF7 cells.</p>Fórmula:C24H15N5O4S2Cor e Forma:SolidPeso molecular:501.54LDC0496
CAS:<p>LDC0496: Potent EGFR/Her2 exon 20 inhibitor; selective for wild-type EGFR, kinase-specific.</p>Fórmula:C32H35N5O3Cor e Forma:SolidPeso molecular:537.65TX-1918
CAS:<p>TX-1918, a tyrphostin, blocks eEF-2K to hinder HepG2, HCT116 cell growth.</p>Fórmula:C14H12O3Cor e Forma:SolidPeso molecular:228.24AFG210
CAS:AFG210 is a novel first-generation “type II” FLT3 inhibitor.Fórmula:C19H14F3N3O2Cor e Forma:SolidPeso molecular:373.33VEGFR-2-IN-23
CAS:<p>VEGFR-2-IN-23 (11b) is a potent VEGFR-2 inhibitor with an IC50 of 0.34 nM, exhibits antitumor effects, and causes G1 cell cycle arrest.</p>Fórmula:C22H15N5O2Cor e Forma:SolidPeso molecular:381.39Esuberaprost Sodium
CAS:<p>Famitinib (SHR1020), an oral drug, inhibits c-kit, VEGFR-2, and PDGFRβ (IC50: 2.3/4.7/6.6 nM) and triggers apoptosis in gastric cancer.</p>Fórmula:C23H27FN4O2Cor e Forma:SolidPeso molecular:410.48OD36 hydrochloride
CAS:<p>OD36 hydrochloride (OD-36 hydrochloride) is a potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 hydrochloride is a macrocyclic inhibitor that binds efficiently</p>Fórmula:C16H16Cl2N4O2Pureza:99.85%Cor e Forma:SolidPeso molecular:367.23Lck-IN-1
CAS:<p>Lck-IN-1 is a potent inhibitor of lymphocyte protein tyrosine kinase (Lck) [1].</p>Fórmula:C14H15N5Cor e Forma:SolidPeso molecular:253.3TK4b
CAS:<p>TK4b, a JAK inhibitor, targets leukemia/lymphoid diseases, with IC50s: 18.42 nM (JAK3) & 19.40 nM (JAK2).</p>Fórmula:C21H22N2O2Cor e Forma:SolidPeso molecular:334.41AGL 2043
CAS:<p>AGL 2043 is a potent, reversible, ATP-competitive inhibitor of type III receptor tyrosine kinases.</p>Fórmula:C15H12N4SCor e Forma:SolidPeso molecular:280.35VEGFR-2-IN-21
CAS:<p>VEGFR-2-IN-21 is a potent inhibitor of VEGFR-2 (IC50: 0.10 μM) and exhibits anticancer effects.</p>Fórmula:C28H24ClN7O3SCor e Forma:SolidPeso molecular:574.05α7 nAchR-JAK2-STAT3 agonist 1
CAS:<p>α7 nAchR-JAK2-STAT3 agonist 1 is a potent inhibitor of the α7 nAchR-JAK2-STAT3 pathway that acts on nitric oxide (NO) (IC50: 0.32 μM).</p>Fórmula:C25H30O6Cor e Forma:SolidPeso molecular:426.5AAE871
CAS:<p>AAE871 is a type I FLT3 inhibitor.</p>Fórmula:C24H34N8O2SCor e Forma:SolidPeso molecular:498.64Tyrphostin AG 112
CAS:Tyrphostin AG 112 is an inhibitor of EGFR phosphorylation.Fórmula:C13H8N4OPureza:99.14%Cor e Forma:SolidPeso molecular:236.23BCR-ABL-IN-5
CAS:BCR-ABL-IN-5: Bcr-Abl kinase inhibitor, IC50: Bcr-AblWT 0.014 μM, Bcr-AblT315I 0.45 μM; anti-leukemia cell growth.Fórmula:C25H21Cl2N5O2Cor e Forma:SolidPeso molecular:494.37Luxeptinib
CAS:<p>Luxeptinib (CG-806) is an oral, non-covalent pan-FLT3/BTK inhibitor for acute myeloid leukemia.</p>Fórmula:C25H17F4N5O2Cor e Forma:SolidPeso molecular:495.43TYK2-IN-12
CAS:<p>TYK2-IN-12: selective oral TYK2 inhibitor (Ki: 0.51 nM), blocks IL-12-induced IFNγ; IC50: human 2.7 µM, mouse 7.0 µM, used for psoriasis research.</p>Fórmula:C24H20F2N4O2Cor e Forma:SolidPeso molecular:434.44GDC-4379
CAS:<p>GDC-4379 is a JAK1 inhibitor that can be used to study asthma.</p>Fórmula:C21H18ClF2N7O3Cor e Forma:SolidPeso molecular:489.86PHA-680626
CAS:<p>PHA-680626 is a PLK inhibitor, effective on resistant leukemia cells, with IC50: Plk1 (0.53 μM), Plk2 (0.07 μM), Plk3 (1.61 μM).</p>Fórmula:C23H26N6O2SCor e Forma:SolidPeso molecular:450.56ON 146040
CAS:ON 146040 is an effective inhibitor of PI3K isoforms with IC50s of 14 and 20 nM for PI3Kα and PI3Kδ, respectively.Fórmula:C24H23N7O3SPureza:97.39%Cor e Forma:SolidPeso molecular:489.55EGFR-IN-63
CAS:<p>EGFR- IN-63 is an EGFR inhibitor with an IC50 value of 0.096 μM. EGFR- IN-63 exhibited anticancer effects on MCF-7 cells (IC50: 2.49 μM).</p>Fórmula:C20H12BrN5SCor e Forma:SolidPeso molecular:434.31AFG206
CAS:AFG206 is the novel first-generation type II" FLT3 inhibitor."Fórmula:C20H19N3O2Cor e Forma:SolidPeso molecular:333.38BTK-IN-22
CAS:<p>BTK-IN-22 is a selective BTK inhibitor with IC50 of 0.9 nM; also targets BLX, BMX (IC50s: 1.4, 1.2 nM); better selectivity than Ibrutinib.</p>Fórmula:C26H26N6O2Cor e Forma:SolidPeso molecular:454.52VEGFR-2-IN-22
CAS:<p>VEGFR-2-IN-22 blocks VEGFR-2/beta-tubulin, IC50=19.82 nM, induces apoptosis.</p>Fórmula:C26H24ClFN4O6Cor e Forma:SolidPeso molecular:542.94CAY10583
CAS:CAY10583 is a selective BLT2 agonist that increases TGF-β1 and bFGF, promotes keratinocyte migration, accelerates wound healing in diabetic mice.Fórmula:C25H25NO3Pureza:98%Cor e Forma:SolidPeso molecular:387.47Glufanide disodium
CAS:<p>Glufanide disodium is an immunomodulator.</p>Fórmula:C16H17N3O5Na2Cor e Forma:SolidPeso molecular:377.3pan-HER-IN-2
CAS:<p>pan-HER-IN-2 (Compound C6) is an orally active, reversible, broad-spectrum HER inhibitor that acts on EGFR (IC50: 0.72 nM), HER4 (IC50: 2.0 nM), EGFRT790M (IC50</p>Fórmula:C19H15BrClN5OCor e Forma:SolidPeso molecular:444.71EGFR/C797S-IN-1
CAS:<p>EGFR/C797S-IN-1: Potent EGFR-C797S inhibitor, IC50 of 0.128 µM, dose-dependent p-EGFR suppression, anti-tumor properties.</p>Fórmula:C28H30N4O3Cor e Forma:SolidPeso molecular:470.56JBJ-04-125-02
CAS:<p>JBJ-04-125-02: Oral EGFR inhibitor, targets EGFRL858R/T790M with 0.26 nM IC50, halts cancer growth, anti-tumor.</p>Fórmula:C29H26FN5O3SPureza:98%Cor e Forma:SolidPeso molecular:543.61VI 16832
CAS:VI 16832 is a broad-spectrum Type I kinase inhibitor used to quantify relative kinase abundance and study signaling across SILAC-encoded cancer cell lines.Fórmula:C22H25N5O2Pureza:98%Cor e Forma:SolidPeso molecular:391.47PDGFRα/FLT3-ITD-IN-3
CAS:<p>PDGFRα/FLT3-ITD-IN-3 (Compound 18d) is a potent inhibitor of PDGFRα (IC50: 0.153 μM), FLT3 (IC50: 0.004 μM) and PDGFRα/FLT3-ITD-IN-3 has the potential to be</p>Fórmula:C26H39N9Cor e Forma:SolidPeso molecular:477.65SYK/JAK-IN-1
CAS:<p>SYK/JAK-IN-1 is a dual SYK/JAK inhibitor with IC50 values of less than 5 nM for both SYK and JAK2.</p>Fórmula:C24H26N8O3Cor e Forma:SolidPeso molecular:474.52FGFR-IN-7
CAS:<p>FGFR-IN-7: Oral FGFR modulator, crosses blood-brain barrier, neuroprotective, phospholipidosis-resistant, useful for neurodegeneration study.</p>Fórmula:C16H21ClF2N4O2Cor e Forma:SolidPeso molecular:374.81VEGFR-2-IN-6
CAS:<p>VEGFR-2-IN-6 (WO 02/059110, example 64) is a potent inhibitor of VEGFR2, a crucial receptor involved in the regulation of angiogenesis [1].</p>Fórmula:C20H21N7O2SPureza:99.01%Cor e Forma:SolidPeso molecular:423.49CHMFL-ABL-053
CAS:<p>CHMFL-ABL-053: potent, selective BCR-ABL/SRC/p38 inhibitor (IC50: 70/90/62 nM). Orally available, potential CML drug.</p>Fórmula:C28H26F3N7O2Cor e Forma:SolidPeso molecular:549.55EMI56
CAS:<p>EMI56, a derivative of EMI1, exhibits enhanced potency against mutant EGFR compared to EMI1. Additionally, EMI56 effectively inhibits EGFR triple mutants[1].</p>Fórmula:C21H20N2O3Cor e Forma:SolidPeso molecular:348.4EGFR/HER2-IN-9
CAS:<p>EGFR/HER2-IN-9, a compound inhibiting both EGFR and HER2, demonstrates potency with IC50 values of 3.2 nM for EGFR, 14 nM for HER2, and 8.3 nM against the EGFR</p>Fórmula:C25H25ClFN5O4Cor e Forma:SolidPeso molecular:513.95ZK-261991
CAS:<p>ZK-261991 is an orally active inhibitor of VEGFR tyrosine kinase(IC50 of 5 nM, VEGFR2).</p>Fórmula:C24H25N7O2Pureza:98%Cor e Forma:SolidPeso molecular:443.5Ebselen oxide
CAS:<p>Ebselen oxide (EB-2) is a HER2 inhibitor with antibacterial and antifungal activity and has shown cytoprotective effects against HN2 in vitro.</p>Fórmula:C13H9NO2SePureza:98%Cor e Forma:SolidPeso molecular:290.18WDR5-IN-4
CAS:WIN site inhibitor 1 is a WIN site of chromatin-associated WD repeat-containing protein 5 (WDR5) inhibitor (Kd: 0.1 nM), with anti-cancer activity.Fórmula:C25H22Cl2FN5OPureza:98%Cor e Forma:SolidPeso molecular:498.38SMU-B
CAS:<p>SMU-B is a well-tolerated c-Met/ALK dual inhibitor.</p>Fórmula:C26H25Cl2FN4O2Pureza:98%Cor e Forma:SolidPeso molecular:515.41
