Angiogénese
Os inibidores da angiogênese são compostos que interferem na formação de novos vasos sanguíneos, um processo crítico no crescimento e metástase do câncer. Ao inibir a angiogênese, esses compostos podem restringir o suprimento de sangue para os tumores, retardando ou interrompendo seu crescimento. Os inibidores da angiogênese são essenciais na pesquisa do câncer e no desenvolvimento terapêutico, fornecendo insights sobre os mecanismos de progressão tumoral e oferecendo potenciais tratamentos para o câncer e outras doenças relacionadas à angiogênese. Na CymitQuimica, oferecemos uma ampla gama de inibidores da angiogênese de alta qualidade para apoiar sua pesquisa em oncologia e biologia vascular.
Subcategorias de "Angiogénese"
- BTK(165 produtos)
- Bcr-Abl(117 produtos)
- EGFR(561 produtos)
- FAK(72 produtos)
- FLT(89 produtos)
- Receptor do Factor de Crescimento Fibroblasto (FGFR)(177 produtos)
- JAK(243 produtos)
- PDGFR(127 produtos)
- RAAS(86 produtos)
- Src(82 produtos)
- Syk(37 produtos)
- Trombina(51 produtos)
- VDA(2 produtos)
- VEGFR(239 produtos)
Exibir 6 mais subcategorias
Foram encontrados 2254 produtos de "Angiogénese"
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PTD10
CAS:PTD10, a highly potent PROTAC BTK degrader, exhibits a DC50 of 0.5 nM and a KD of 2.28 nM.Fórmula:C49H51N11O8Pureza:99.12%Cor e Forma:SolidPeso molecular:922MHES0488A
MHES0488A is a selective humanized antibody targeting HER2, with a KD value of 0.8 nM. It constitutes the antibody portion of DHES0815A. Upon cellular internalization, MHES0488A is transported to lysosomes, releasing PBD-monoamide into the nucleus, where it alkylates DNA, inducing DNA damage and apoptosis. It shows potential for research in cancers such as HER2-positive breast cancer and gastric cancer.Cor e Forma:Odour LiquidPD-149163 hydrochloride
PD-149163 hydrochloride is a neurokinin B agonist with antipsychotic activity, used for research on neurological diseases.Fórmula:C42H72ClN9O6Cor e Forma:SolidPeso molecular:834.53BTK degrader-1
CAS:BTK degrader-1 (compound 1), a bifunctional degrader of Bruton's tyrosine kinase (BTK), demonstrates the capability to be conjugated with CD79b and exhibits anti-tumor effects [1].Fórmula:C52H54F2N8O6Cor e Forma:SolidPeso molecular:925.03SNIPER(ABL)-058
CAS:SNIPER(ABL)-058, a compound that links Imatinib (ABL inhibitor) with a derivative of LCL161 (IAP ligand) through a linker, effectively decreases BCR-ABL proteinFórmula:C62H75N11O9SPureza:98%Cor e Forma:SolidPeso molecular:1150.39EGFR-IN-22
CAS:EGFR-IN-22: potent for EGFR (IC50: 4.91 nM) & L858R/T790M/C797S mutation (IC50: 0.54 nM).Fórmula:C38H47BrFN10O2PCor e Forma:SolidPeso molecular:805.72SJ988497
CAS:SJ988497: PROTAC JAK2 degrader, inhibits CRLF2r cell growth, degrades GSPT1, combines Ruxolitinib, linker, Pomalidomide; researched for ALL.Fórmula:C36H36N10O5Cor e Forma:SolidPeso molecular:688.74Multi-kinase-IN-5
Multi-kinase-IN-5 (compound 15c) is a multi-kinase inhibitory agent that shows significant inhibition against a range of protein kinases including RET, KIT,Fórmula:C19H15N5O2SCor e Forma:SolidPeso molecular:377.42PROTAC BCR-ABL Degrader-1
PROTAC BCR-ABL Degrader-1 (compound PROTAC 1), featuring a 2-oxoethyl linker, promotes Bcr-Abl degradation through the ubiquitin-proteasome pathway andFórmula:C43H40N10O6Pureza:98%Cor e Forma:SolidPeso molecular:792.84K882
K882 (Compound 4e) is an Src inhibitor with a KD of 0.315 μM. It induces apoptosis and inhibits XIAP and Survivin. Additionally, K882 blocks the activation of the PI3K/Akt/mTOR, Jak1/Stat3, and Ras/MAPK signaling pathways. K882 exhibits antitumor activity against non-small cell lung cancer.Fórmula:C18H16N2O2Cor e Forma:SolidPeso molecular:292.33PKM2/PDK1-IN-1
PKM2/PDK1-IN-1, a shikonin derivative, dual inhibitor of PKM2/PDK1, halts NSCLC growth, triggers apoptosis, and boosts ROS affecting cell death pathways.Fórmula:C36H43NO7S3Cor e Forma:SolidPeso molecular:697.92AG-825
CAS:AG-825（Tyrphostin C15） is a selective and competitive ErbB2 inhibitor that inhibits tyrosine phosphorylation with an IC50 value of 0.35 μM.AG-825 (TyrphostinFórmula:C19H15N3O3S2Pureza:99.52%Cor e Forma:Yellow SolidPeso molecular:397.47Ref: TM-T14138
1mg34,00€5mg66,00€10mg105,00€25mg222,00€50mg371,00€100mg597,00€500mg1.234,00€1mL*10mM (DMSO)73,00€Modotuximab
CAS:Modotuximab (DS 1024) is a humanized antibody targeting EGFR with antitumor activity that accelerates the internalization and degradation of EGFR.Pureza:95.5% (SDS-PAGE); 99.3% (SEC-HPLC) - 95.5% (SDS-PAGE); 99.3% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:146.45 kDaSNIPER(ABL)-049
SNIPER(ABL)-049, a compound that conjugates Imatinib (ABL inhibitor) with Bestatin (IAP ligand) through a linker, effectively reduces BCR-ABL protein levels,Fórmula:C52H66N10O8Pureza:98%Cor e Forma:SolidPeso molecular:959.14BCPyr
CAS:BCPyr is a new candidate BTK degrader ( DC 50 = 800 nM).Fórmula:C58H65F2N11O8Cor e Forma:SolidPeso molecular:1082.224(R)-3-Hydroxy Midostaurin
CAS:(R)-3-Hydroxy Midostaurin: potent kinase inhibitor, major midostaurin metabolite via CYP3A4, potential AML treatment.Fórmula:C35H30N4O5Pureza:98%Cor e Forma:SolidPeso molecular:586.648INCB-000928
CAS:Zilurgisertib (INCB-000928) is a selective and potent ALK 2 inhibitor for the study of cancer and MF anemia.
Fórmula:C30H38N4O3Pureza:98.93%Cor e Forma:SolidPeso molecular:502.65WDR5 ligand 2
CAS:WDR5ligand 2 is a ligand for WDR5 and can be utilized in the synthesis of PROTAC WDR5degrader 1.Fórmula:C29H31F3N4O4Cor e Forma:SolidPeso molecular:556.576EGFR/CDK2-IN-2
EGFR/CDK2-IN-2 (compound 6a) serves as a dual inhibitor targeting both EGFR and CDK-2, exhibiting IC50 values of 19.6 nM and 87.9 nM, respectively.Fórmula:C49H32N12O2S2Pureza:98%Cor e Forma:SolidPeso molecular:884.99Glaziovine
CAS:Glaziovine is an agent of anti-ulcerogenic natural alkaloid.Fórmula:C18H19NO3Pureza:98%Cor e Forma:SolidPeso molecular:297.35
