Apoptose
Os inibidores da apoptose são compostos que previnem ou retardam o processo de morte celular programada, conhecido como apoptose. Esses inibidores são vitais no estudo dos mecanismos de sobrevivência celular e são usados para investigar doenças onde a apoptose é desregulada, como câncer, distúrbios neurodegenerativos e doenças autoimunes. Ao modular a apoptose, esses inibidores podem ajudar no desenvolvimento de terapias destinadas a controlar a morte celular. Na CymitQuimica, oferecemos uma ampla seleção de inibidores da apoptose de alta qualidade para apoiar sua pesquisa em biologia celular, oncologia e áreas relacionadas.
Subcategorias de "Apoptose"
- ASK(6 produtos)
- BCL(11 produtos)
- Caspase(125 produtos)
- FOXO1(3 produtos)
- IAP(66 produtos)
- Mdm2(12 produtos)
- PD-1/PD-L1(125 produtos)
- PDK(9 produtos)
- PERK(25 produtos)
- Serina/treonina quinase(15 produtos)
- Survivina(13 produtos)
- TNF(92 produtos)
- c-RET(51 produtos)
- p53(62 produtos)
Exibir 6 mais subcategorias
Foram encontrados 5598 produtos de "Apoptose"
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SZUH280
CAS:<p>SZUH280 is a potent, selective PROTAC (proteolysis targeting chimera) HDAC8 (histone deacetylase 8) degrader, demonstrating a DC50 of 0.58 μM in A549 cells.</p>Fórmula:C36H34N8O8Cor e Forma:SolidPeso molecular:706.7F1324 TFA
<p>F1324 TFA is a potent, high affinity peptidic inhibitor of B cell lymphoma 6 (BCL6), with an IC50 of 1 nM.</p>Fórmula:C85H122N21F3O22SPureza:98%Cor e Forma:SolidPeso molecular:1879.06Finotonlimab
<p>Finotonlimab (SCT-I10A), a humanized IgG PD-1 monoclonal antibody, shows potential in the research of solid tumors or lymphomas [1].</p>Cor e Forma:Odour LiquidHellebrin
CAS:<p>Cytotoxic and antiproliferative effects of Hellebrin on breast and lung cancer cells.</p>Fórmula:C36H52O15Cor e Forma:SolidPeso molecular:724.79Vorsetuzumab
CAS:<p>Vorsetuzumab (Anti-Human CD70 Recombinant Antibody) is a monoclonal antibody targeting the CD70 antibody.</p>Pureza:SDS-PAGE:95% SEC-HPLC:99.29%Cor e Forma:LiquidPeso molecular:146.1 kDaTasisulam sodium
CAS:<p>Tasisulam triggers apoptosis, halts mitosis, and normalizes blood vessels to combat cancer.</p>Fórmula:C11H5BrCl2NNaO3S2Cor e Forma:SolidPeso molecular:437.09Ranevetmab
CAS:<p>Ranevetmab (NV-01), a caninized anti-NGF mAb, relieves pain in DJD research.</p>Cor e Forma:LiquidFLT3-IN-21
<p>FLT3-IN-21 (compound LC-3), a potent FLT3 inhibitor with an IC50 value of 8.4 nM, induces apoptosis and arrests the cell cycle in the G1 phase.</p>Fórmula:C20H22FN5O2Cor e Forma:SolidPeso molecular:383.42BM-1197
CAS:<p>BM-1197, a highly potent and specific dual inhibitor of Bcl-2 and Bcl-xL, effectively targets these proteins with IC50 values of 3.5 nM and 5.2 nM for Bcl-2 and</p>Fórmula:C53H59ClF4N6O7S4Cor e Forma:SolidPeso molecular:1131.77ReACp53
<p>ReACp53 inhibits amyloid formation, restores p53 in cancer cells and HGSOC-derived organoids.</p>Fórmula:C108H206N52O24Pureza:98%Cor e Forma:SolidPeso molecular:2617.13DTUN
<p>DTUN: lipophilic radical initiator, starts STY-BODIPY liposome co-autoxidization at 0.2 mM, useful in FENIX assays.</p>Cor e Forma:SolidPROTAC Bcl-xL degrader-1
<p>PROTAC Bcl-xL degrader-1 targets Bcl-xL & IAP E3 ligases, degrades Bcl-xL, toxic to human platelets & MyLa 1929 (IC50: 62 nM, 8.5 μM).</p>Fórmula:C76H96ClF3N10O11S3Cor e Forma:SolidPeso molecular:1514.28VB-85247
<p>VB-85247 is a STING agonist that, by activating the STING pathway, induces the upregulation of inflammatory cytokines IFNα/β, TNFα, IL6, and CXCL10, as well as the maturation and activation of dendritic cells. It can lead to the regression of tumors within the bladder and is applicable in bladder cancer research.</p>Cor e Forma:Odour SolidAntitumor agent-61
CAS:<p>Antitumor agent-61, a potent Irinotecan derivative, exhibits IC50s of 0.92-3.23 μM in 6 cancer cells, inducing apoptosis via mitochondrial pathways.</p>Fórmula:C54H63FN5O10PCor e Forma:SolidPeso molecular:992.08GSPT1 degrader-1
<p>GSPT1 Degrader-1 (Compound 9q) effectively facilitates the degradation of G1 to S phase transition 1 (GSPT1) through the ubiquitin-proteasome system and induces</p>Fórmula:C28H33ClN4O5Pureza:98%Cor e Forma:SolidPeso molecular:541.04KC01
CAS:<p>KC01 selectively inhibits ABHD16A (IC50: 0.2-0.5 μM), much more potent than KC02 (>10 μM); human ABHD16A IC50: 90±20 nM.</p>Fórmula:C22H39NO3Pureza:98%Cor e Forma:SolidPeso molecular:365.558Ac-IEPD-AFC
CAS:<p>Ac-IEPD-AFC (IEPD) is a fluorescent substrate for granzyme B and can be used to measure granzyme B activity.</p>Fórmula:C32H38F3N5O11Pureza:99.16%Cor e Forma:SolidPeso molecular:725.67Maceneolignan A
CAS:<p>Maceneolignan A, a natural product isolated from the aril of Myristica fragrans (Myristicaceae), inhibits β-hexosaminidase release in RBL-2H3 cells, exhibiting</p>Fórmula:C21H24O5Cor e Forma:SolidPeso molecular:356.41KB03-SLF
CAS:<p>KB03-SLF is a protease with the capability to target specific proteins and regulate intracellular protein levels by inducing protein degradation. This mechanism renders KB03-SLF potentially valuable in the suppression of related diseases.</p>Fórmula:C50H63ClF3N5O12Cor e Forma:SolidPeso molecular:1018.51MDM2/4-p53-IN-3
<p>MDM2/4-p53-IN-3 inhibits MDM2/4-p53 PPIs (IC50: 18.5nM MDM2, 14.8nM MDM4), used in cancer research.</p>Fórmula:C25H24Cl2FN3O3Cor e Forma:SolidPeso molecular:504.38MEK/PI3K-IN-1
CAS:<p>MEK/PI3K-IN-1 (6r) is a dual MEK/PI3K inhibitor; IC50: 124 nM (MEK1), 130 nM (PI3Kα), 236 nM (PI3Kδ). It reduces pAKT, pERK1/2, and hinders tumor growth.</p>Fórmula:C36H37F5IN9O6Cor e Forma:SolidPeso molecular:913.63Taltirelin acetate
CAS:<p>Taltirelin acetate (TA-0910 acetate) is a superagonist at thyrotropin-releasing hormone receptor (TRH-R)(IC50 of 910 nM and EC50 of 36 nM for stimulating an</p>Fórmula:C19H27N7O7Pureza:99.21%Cor e Forma:SolidPeso molecular:465.46Rozanolixizumab
CAS:<p>Rozanolixizumab (RYSTIGGO) is a humanized IgG4 monoclonal antibody that targets FcRn in newborns for autoimmune research.</p>Pureza:SDS-PAGE:97.2%;SEC-HPLC:95.9%Cor e Forma:LiquidPeso molecular:145.19 kDaStreptonigrin
CAS:<p>Streptonigrin, from Streptomyces flocculus, has anti-tumor and anti-bacterial properties, inhibiting PAD1-4.</p>Fórmula:C25H22N4O8Pureza:98%Cor e Forma:SolidPeso molecular:506.46(E/Z)-10-Hydroxy-2-decenoic acid
CAS:<p>(E/Z)-10-Hydroxy-2-decenoic acid is a useful organic compound for research related to life sciences.</p>Fórmula:C10H18O3Cor e Forma:SolidPeso molecular:186.251Ceftiofur hydrochloride
CAS:<p>Ceftiofur hydrochloride (U-67279A) is a stable, broad-spectrum 3rd-gen cephalosporin with antibacterial properties.</p>Fórmula:C19H17N5O7S3·HClPureza:99.51%Cor e Forma:Off-White SolidPeso molecular:560.02Albicanol
CAS:<p>Albicanol is a biochemical.</p>Fórmula:C15H26OCor e Forma:SolidPeso molecular:222.372SC-2001
CAS:<p>SC-2001 inhibits MCL-1 and STAT3, enhances SHP-1, induces apoptosis in breast cancer, and counters STAT3-driven sorafenib resistance in liver cancer.</p>Fórmula:C18H14BrN3OPureza:98%Cor e Forma:SolidPeso molecular:368.23TAT-BH4 (Bcl-xL) (TFA)
<p>"TAT-BH4 (Bcl-xL) TFA, primarily localized at the mitochondria, inhibits apoptotic cell death.</p>Fórmula:C159H268N58O45·xC2HF3O2Pureza:98%Cor e Forma:SolidPeso molecular:3712.19 (free acid)Haemanthamine hydrochloride
<p>Haemanthamine hydrochloride, an alkaloid from Amaryllidaceae, has anticancer, antioxidant, antiviral, antimalarial, and anticonvulsant properties.</p>Fórmula:C17H20ClNO4Cor e Forma:SolidPeso molecular:337.8YJ1206
CAS:<p>YJ1206 is a highly potent and selective CDK12/13 PROTAC degrader oral, DNA damage and cell-cycle arrest,and inhibits the proliferation of prostate cancer cells.</p>Fórmula:C49H52FN11O5Pureza:97.14%Cor e Forma:SolidPeso molecular:894.01N-Acetylpsychosine
CAS:<p>N-Acetylpsychosine, also known as α-galactosylated C2-ceramide (d18:1/2:0), exhibits immunostimulatory properties.</p>Fórmula:C26H49NO8Cor e Forma:SolidPeso molecular:503.67MG-C-30
CAS:<p>MG-C-30 is an orally active CD27 agonist with an EC50 of 0.84 μM. It activates co-stimulatory signaling in NK cells and T cells, thereby enhancing the immune response. In the EG7-OVA mouse model, MG-C-30 demonstrates antitumor activity.</p>Fórmula:C24H26N4O3SCor e Forma:SolidPeso molecular:450.55Silicon naphthalocyanine dichloride
CAS:<p>Silicon naphthalocyanine dichloride is a photosensitizer with potential anti-tumor activity. This compound is employed in photodynamic therapy to inhibit cancer by effectively absorbing specific wavelengths of light, thereby generating oxygen radicals that aid in the destruction of cancer cells. The biocompatibility of Silicon naphthalocyanine dichloride demonstrates promising prospects for medical applications.</p>Fórmula:C48H24Cl2N8SiCor e Forma:SolidPeso molecular:811.75Peginterferon β-1a
CAS:<p>Peginterferon beta-1a: first pegylated interferon for cancer, RMS research; induces tumor cell apoptosis.</p>Cor e Forma:SolidBcl-2-IN-22
<p>Bcl-2-IN-22 (compound 1), a gold (I) NHC complex, exhibits anticancer activity. It induces cell death (apoptosis) via the mitochondrial pathway with an IC50 value of 0.014 μM. Additionally, Bcl-2-IN-22 targets members of the BCL-2 family, promoting apoptosis and sensitization in multidrug-resistant leukemia cells overexpressing BCL-2.</p>Cor e Forma:Odour SolidSodium propionate
CAS:<p>Sodium propionate (Propionic acid sodium salt) has potential anti-inflammatory and anti-apoptotic activities, inhibiting certain signaling pathways.</p>Fórmula:C3H5NaO2Cor e Forma:SoildPeso molecular:96.06Isorhamnetin 3-glucuronide
<p>Isorhamnetin 3-glucuronide is a useful organic compound for research related to life sciences and the catalog number is T124938.</p>Fórmula:C22H20O13Cor e Forma:SolidPeso molecular:492.389C-Reactive Protein (CRP) (174-185)
CAS:<p>CRP protein and its fragment (174-185, RS-83277) boost human monocyte and macrophage cancer-killing effects in vitro.</p>Fórmula:C62H93N13O16Pureza:98%Cor e Forma:SolidPeso molecular:1276.48Thiocolchicine
CAS:<p>Thiocolchicine inhibits tubulin polymerization (IC50: 2.5 µM, Ki: 0.7 µM), induces apoptosis, and serves as an ADC cytotoxin.</p>Fórmula:C22H25NO5SPureza:98.19%Cor e Forma:SolidPeso molecular:415.5Poly(I:C):Kanamycin (1:1) sodium
<p>Poly(I:C):Kanamycin (1:1) sodium is a complex.Poly(I:C) is a TLR3 and RIG-I/MDA5 agonist.Kanamycin is an antimicrobial,Gram-negative and positive bacteria.</p>Pureza:99%Cor e Forma:SolidNFh-NMe-2
<p>NFh-NMe-2 is a photosensitizer that interacts with nitroreductase (nitroreductase) to generate singlet oxygen in tumor cells, exhibiting cytotoxicity in cancer cells and inducing apoptosis (apoptosis). In mouse models, NFh-NMe-2 demonstrates antitumor activity.</p>Fórmula:C32H33IN2OCor e Forma:SolidPeso molecular:588.522MDM2 ligand 4
<p>MDM2ligand 4 is a ligand of MDM2 and can be used in the synthesis of the PROTAC degrader [KT-253].</p>Fórmula:C31H33Cl2FN2O4Cor e Forma:SolidPeso molecular:587.509DCZ3301
CAS:<p>DCZ3301 is a novel aryl-guanidino inhibitor.</p>Fórmula:C20H16ClF3N6O2Pureza:99.89%Cor e Forma:SolidPeso molecular:464.83RD-23
CAS:<p>RD-23 is an orally active and selective RET PROTAC degrader. It facilitates the ubiquitination and degradation of the RETG810C mutant with a DC50 value of 11.7 nM. Additionally, RD-23 inhibits the activation of downstream Shc signaling and induces apoptosis (Apoptosis). It is useful for studying RET-related cancers.</p>Fórmula:C52H56N12O4Cor e Forma:SolidPeso molecular:913.079EGFR-IN-143
<p>EGFR-IN-143 (Compound 5f) is a potent EGFR inhibitor with an IC50 value of 0.15 μM. It induces apoptosis by arresting the cell cycle at the G2/M phase and exhibits antitumor activity.</p>Fórmula:C20H21ClN6O3Cor e Forma:SolidPeso molecular:428.872Mitochondria modulator-2
<p>Mitochondria modulator-2 (Compound Ir1) induces depolarization of the mitochondrial membrane potential, generates reactive oxygen species (ROS), inhibits the migration of A549 cells, causes cell cycle arrest at the G2/M phase, and triggers apoptosis in A549 cells.</p>Fórmula:C63H50F12IrN6OP3Cor e Forma:SolidPeso molecular:1420.23Antioxidant agent-20
<p>Antioxidant agent-20 (Compound 3d) exhibits potent anti-inflammatory and antioxidant activities. It reduces reactive oxygen species (ROS) and apoptosis in a dose-dependent manner. Antioxidant agent-20 demonstrates photoprotective effects on UVB-exposed human skin keratinocytes (HaCaT) (IC50=5.13 µM) by activating Nrf2/HO-1 signaling and inhibiting the NF-κB pathway.</p>Fórmula:C18H24O4Cor e Forma:SolidPeso molecular:304.381FeTPPS
CAS:<p>FeTPPS, a decomposition catalyst for 5,10,15,20-tetrakis(4-sulfonatophenyl) porphyrin iron(III) chloride peroxynitrite, neuroprotective.</p>Fórmula:C44H28ClFeN4O12S4Cor e Forma:SolidPeso molecular:1024.27TRK-IN-30
<p>TRK-IN-30 (Compound C11) is an inhibitor of tropomyosin receptor kinases (TRK), effectively inhibiting TRKA, TRKB, TRKC, and the resistant mutant TRKAG595R, with IC50 values of 1.8, 0.98, 3.8, and 54 nM, respectively. It also suppresses the activation of downstream PI3K/AKT and MEK/ERK signaling pathways. TRK-IN-30 hinders colony formation and cell migration of Km-12, induces cell cycle arrest at the G0/G1 phase, and triggers apoptosis in Km-12 cells.</p>Fórmula:C24H21N5O3Cor e Forma:SolidPeso molecular:427.455D-Trimannuronic acid
CAS:<p>D-Trimannuronic acid from seaweed induces TNF-α in mouse macrophages; useful in pain, dementia studies.</p>Fórmula:C18H26O19Cor e Forma:SolidPeso molecular:546.387TRF2-IN-1
<p>TRF2-IN-1 (compound F2) is a potent inhibitor of telomere repeat-binding factor 2 (TRF2). It exhibits antiproliferative activity and induces apoptosis. TRF2-IN-1 binds directly to the TRF2TRFH domain, selectively inhibiting TRF2 protein expression and telomere localization. Additionally, TRF2-IN-1 possesses anticancer properties and shows potential for osteosarcoma research.</p>Fórmula:C18H17BrO4Cor e Forma:SolidPeso molecular:377.229Necroptosis-IN-3
CAS:<p>Necroptosis-IN-3 (Cyclohexanecarboxamide, N-(2-thienylmethyl)-) (Compound 69) is a Necroptosis inhibitor that inhibits TNF-α induced necroptosis.</p>Fórmula:C12H17NOSPureza:99.85%Cor e Forma:SoildPeso molecular:223.33TrxR-IN-7
<p>TrxR-IN-7 (14f) is a potent inhibitor of thioredoxin reductase (TrxR), with an IC50 value of 3.5 µM. It exhibits antiproliferative activity and can induce apoptosis and the production of reactive oxygen species (ROS).</p>Fórmula:C22H21NO3Cor e Forma:SolidPeso molecular:347.407LD4172
CAS:<p>LD4172 is a PROTAC degrader capable of degrading RIP kinase (RIPK1) with a DC50 in the nanomolar range. When used in combination with TNF-α, LD4172 can induce apoptosis in B16F10 cells. In mouse models, it demonstrates antitumor activity. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligase VHL)</p>Fórmula:C61H75F3N10O7SCor e Forma:SolidPeso molecular:1149.37IRAK4-IN-27
<p>IRAK4-IN-27 (Compound 22) is a potent and selective IRAK4 inhibitor, demonstrating an IC50 of 8.7 nM.</p>Fórmula:C23H22N6O3Pureza:98%Cor e Forma:SolidPeso molecular:430.46Sterigmatocystine
CAS:<p>Sterigmatocystine, a G1 phase and DNA synthesis inhibitor, curbs p21 and is a mycotoxin precursor from Aspergillus versicolor.</p>Fórmula:C18H12O6Pureza:98%Cor e Forma:Pale-Yellow Crystals Pale Yellow SolidPeso molecular:324.28TS-IN-5
<p>TS-IN-5 (Compound 15) is an inhibitor of thymidylate synthase (TS). It induces apoptosis by modulating the proteins Bax, BCL-2, PI3K, and STAT1. TS-IN-5 exhibits antitumor activity against liver cancer, breast cancer, and colon cancer.</p>Fórmula:C16H17N5OSCor e Forma:SolidPeso molecular:327.404F1324 acetate
<p>F1324 acetate is an efficient, high-affinity b-cell lymphoma inhibitor with IC50 of 1 nM.</p>Fórmula:C85H125N21O22SPureza:98%Cor e Forma:SolidPeso molecular:1825.09Episilvestrol
CAS:<p>Episilvestrol is a derivative of silvestrol with eIF4A-targeted antitumor properties, found in Aglaia silvestris fruits and twigs.</p>Fórmula:C34H38O13Pureza:98%Cor e Forma:SolidPeso molecular:654.66mTOR inhibitor-27
<p>mTORinhibitor-27 (Compound 7e) is an inhibitor of mammalian target of rapamycin (mTOR) with an IC50 value of 5.47 μM. It can induce apoptosis in tumor cells and arrest the cell cycle in the S phase, thereby inhibiting cancer cell growth. mTORinhibitor-27 presents potential for research in cancer, including skin cancer.</p>Cor e Forma:Odour SolidDeoxynyboquinone
CAS:<p>Deoxynyboquinone is a potent inducer of cancer cell death with IC(50) values between 16 and 210 nM.</p>Fórmula:C15H12N2O4Pureza:98%Cor e Forma:SolidPeso molecular:284.27Diazepinomicin
CAS:<p>Diazepinomicin, from Micromonospora, blocks EGF-Ras-ERK pathway and induces apoptosis; an anti-tumor agent for K-Ras mutants.</p>Fórmula:C28H34N2O4Pureza:98%Cor e Forma:SolidPeso molecular:462.58Anticancer agent 273
<p>Anticanceragent 273 (Compound 9q) is an effective anticancer compound identified from matrine. It inhibits cancer cell proliferation, with an IC50 of 4.48 μM against HeLa cells. Anticanceragent 273 exerts its anticancer effects by modulating PI3K/AKT expression and activating activating transcription factor 4 (ATF4), which induces endoplasmic reticulum stress and triggers apoptosis. It holds potential for cancer research, including cervical cancer.</p>Cor e Forma:Odour SolidHDAC-IN-84
<p>HDAC-IN-84 (compound 4a) is a potent HDAC inhibitor with IC50 values of 0.0045, 0.015, 0.013, 0.038, 5.8, and 26 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC11, respectively. It effectively inhibits the proliferation of leukemia cells without causing toxicity.</p>Fórmula:C17H21N3O5SCor e Forma:SolidPeso molecular:379.431CDK4/6/HDAC-IN-1
<p>CDK4/6/HDAC-IN-1 (Compound N14) is a dual-target inhibitor of CDK4/6 and HDAC, with IC50 values of 7.23 nM for CDK4, 13.20 nM for CDK6, 55.66 nM for HDAC1, and 48.38 nM for HDAC6. It induces apoptosis and G0/G1 phase arrest through the HDAC-p21-CDK signaling pathway and can inhibit hepatocellular carcinoma.</p>Fórmula:C35H39N9O5Cor e Forma:SolidPeso molecular:665.742PROTAC RIPK degrader-2
CAS:<p>PROTAC RIPK degrader-2 is a nonpeptidic PROTAC ,and potently targets serine-threonine kinase RIPK2 and has highly selective for RIPK2 degradation.</p>Fórmula:C52H65N7O11S3Pureza:98%Cor e Forma:SolidPeso molecular:1060.31Psalmotoxin 1
CAS:<p>Psalmotoxin 1 is a potent and selective acid-sensing ion channel 1a (ASIC1a) blocker.</p>Fórmula:C200H312N62O57S6Pureza:98%Cor e Forma:SolidPeso molecular:4689.41SP3N hydrochloride
<p>SP3N hydrochloride is a specific degrader of the prolyl isomerase (FKBP12). Its alkylamine moiety is metabolized into an active aldehyde (SP3CHO), which recruits the SCFFBXO22 ligase for the degradation of FKBP12. SP3N hydrochloride is applicable in cancer research.</p>Cor e Forma:Odour SolidSuramin
CAS:<p>Suramin is an RdRp and PTPase inhibitor with anti-parasitic, anti-tumor, and anti-angiogenic activities, inhibiting sirtuins and DNA topoisomerase II.</p>Fórmula:C51H40N6O23S6Pureza:99.80%Cor e Forma:SolidPeso molecular:1297.28TTQ-SA
<p>TTQ-SA is a near-infrared spiraling aggregation-induced emitter capable of converting near-infrared light (NIR) into thermal energy, resulting in thermal damage and death of tumor cells. In cancer cells MF-7, TTQ-SA shows cell uptake and targeting capabilities. TTQ-SA binds with DNAzyme to inhibit the expression of the survivin gene, enhancing the sensitivity of tumor cells to photothermal therapy.</p>Fórmula:C78H53N7SCor e Forma:SolidPeso molecular:1120.37VEGFR-2-IN-61
<p>VEGFR-2-IN-61 (Compound 7b) is an inhibitor of VEGFR-2 with an IC50 of 2.83 µM. It effectively inhibits the proliferation of various cancer cells, including MCF-7 cells, with an IC50 of 2.12 µM. Additionally, VEGFR-2-IN-61 suppresses cell migration and induces oxidative stress and apoptosis in MCF-7 cells.</p>Fórmula:C27H25N5OCor e Forma:SolidPeso molecular:435.52CQ627
<p>CQ627 is a molecular glue that targets the degradation of RIOK2. It effectively recruits the E3 ubiquitin ligase RNF126, inducing the proteasomal degradation of RIOK2 via the ubiquitin-proteasome system (UPS) in MOLT4 leukemia cell lines, with a DC50 value of 410 nM. Additionally, CQ627 induces apoptosis in a dose-dependent manner in these cells, blocking the cell cycle at the G2/M phase, and exhibits antiproliferative activity across various cancer cell lines. It also demonstrates in vivo anticancer activity in MOLT4 xenograft mouse models.</p>Fórmula:C36H27F4N7O4Cor e Forma:SolidPeso molecular:697.638AMPK-IN-6
<p>AMPK-IN-6 (compound 13a) is a potent AMPK inhibitor with an IC50 value of 0.093 µM. It induces apoptosis and suppresses autophagy. Additionally, AMPK-IN-6 exhibits antiproliferative activity and holds potential for research into pulmonary arterial hypertension.</p>Fórmula:C18H20FN5OCor e Forma:SolidPeso molecular:341.383PZ703b
CAS:<p>PZ703b is a novel BCL-XL PROTAC degrader with enhanced BCL-2 inhibition.</p>Fórmula:C80H102ClF3N10O11S4Cor e Forma:SolidPeso molecular:1600.44Shepherdin (79-87)
CAS:<p>Shepherdin 79-87: Amino acid fragment 79-87 of Hsp90/Survivin antagonist with anticancer properties.</p>Fórmula:C41H64N12O12SPureza:98%Cor e Forma:SolidPeso molecular:949.09JAK-IN-40
<p>JAK-IN-40 (Compound 46) is an inhibitor of JAK, effectively targeting JAK1, JAK2, and JAK3 with IC50 values of 0.022, 0.759, and 1.601 μM, respectively. It reduces the phosphorylation of STAT3 and inhibits the proliferation of cancer cells Ba/F3 and JAK1-TEL Ba/F3 with GI50 values of 0.614 μM and 0.193 μM. JAK-IN-40 arrests cell cycle progression at the G2/M phase in H1975 and H2087 cells, leading to apoptosis. Additionally, JAK-IN-40 exhibits a synergistic anti-tumor effect when used in combination with Osimertinib.</p>Fórmula:C26H32N8O3SCor e Forma:SolidPeso molecular:536.65Z-VEID-FMK
CAS:<p>Z-VEID-FMK is a selective caspase-6 peptide inhibitor that irreversibly covalently binds to the enzyme, thereby inhibiting apoptosis and DNA breakage.</p>Fórmula:C31H45FN4O10Pureza:98%Cor e Forma:SolidPeso molecular:652.71Dual Galectin-3/EGFR-IN-1
<p>Dual Galectin-3/EGFR-IN-1 (Compound 29) is a dual inhibitor targeting Galectin-3 and EGFR, with dissociation constants (KD) of 52.29 μM and 3.31 μM, respectively. It inhibits TGF-β-induced hepatic stellate cell (HSC) activation, induces apoptosis in LX-2 cells, and shows antifibrotic activity in the liver.</p>Fórmula:C32H41N7O10Cor e Forma:SolidPeso molecular:683.709EMB-02
<p>EMB-02 is a bispecific antibody targeting both PD-1 and LAG-3. It inhibits the downregulation of T cell activation and proliferation mediated by PD-1 and LAG-3, showing potent anti-cancer properties.</p>Cor e Forma:Odour Liquidp38-α MAPK-IN-8
<p>p38-α MAPK-IN-8 (Compound 13) is a lipophilic cationic derivative. It exhibits cytotoxicity toward various tumor cells, inducing cell cycle arrest and apoptosis, as well as increasing reactive oxygen species (ROS) production and causing mitochondrial membrane potential depolarization. Its antitumor activity may be related to the p38α MAPK pathway, making it a potential candidate for cancer research.</p>Fórmula:C49H62BrO4PCor e Forma:SolidPeso molecular:825.892PARP1-IN-27
<p>PARP1-IN-27 (Compound 9B) serves as an inhibitor of both PARP1 and PARP2, exhibiting IC 50 values of 2.53 nM and 6.45 nM, respectively, in SUM149PT cells. This compound effectively suppresses the proliferation of BRCA-mutated cancer cell lines such as SUM149PT, HCC1937, and Capan-1, with respective IC 50 values of 0.62, 1.91, and 4.26 μM. Additionally, PARP1-IN-27 exacerbates DNA double-strand breaks, enhances ROS production, causes G2/M phase cell cycle arrest, and triggers apoptosis in SUM149PT cells.</p>Fórmula:C17H12FNO4Cor e Forma:SolidPeso molecular:313.28WR-S-462
<p>WR-S-462 is a STAT3 inhibitor. It effectively blocks the phosphorylation and biological functions of STAT3 in vitro. The IC50 of WR-S-462 for inhibiting MDA-MB-231 cells is 0.03 μM, and it exhibits a strong binding affinity for STAT3 protein with a Kd of 58 nM. WR-S-462 prevents the nuclear translocation of p-STAT3 and selectively inhibits the expression of p-STAT3Tyr705 in MDA-MB-231 cells, as well as the expression of downstream target genes regulated by STAT3, such as Cyclin D1, Bcl-2, and Bcl-xl. This compound inhibits the growth and metastasis of triple-negative breast cancer (TNBC).</p>Fórmula:C24H22N4O4SCor e Forma:SolidPeso molecular:462.52TopoII/tubulin-IN-1
<p>TopoII/tubulin-IN-1 (Compound 1B8) is an inhibitor of TopoII/tubulin. It effectively suppresses the proliferation of tumor cells and reduces ROS levels, while inducing apoptosis and cell cycle arrest, without showing significant cytotoxicity to normal cells. TopoII/tubulin-IN-1 exhibits antitumor activity.</p>Fórmula:C21H18ClN5O3Cor e Forma:SolidPeso molecular:423.85APG-1387
CAS:<p>APG-1387 inhibits IAPs, degrades cIAP1/2, XIAP, boosts chemosensitivity, and induces apoptosis in NPC.</p>Fórmula:C60H72N10O10S2Cor e Forma:SolidPeso molecular:1157.41Anticancer agent 267
<p>Anticanceragent 267 (Compound 5q) serves as an activator of RIPK3 and MLKL. It effectively inhibits the proliferation of several cancer cell lines, with IC50 values of 9.79, 10.77, and 5.94 μM for MDA-MB-231, MDA-MB-486, and MCF-7, respectively. The compound induces cell cycle arrest at the subG1 phase and triggers necroptosis in MDA-MB-231 cells. Additionally, Anticanceragent 267 demonstrates antitumor activity in mouse xenograft models.</p>Fórmula:C13H11N5O4SCor e Forma:SolidPeso molecular:333.32ERK1/2 inhibitor 13
<p>ERK1/2 inhibitor 13 (Compound 21y) is an orally bioavailable ERK inhibitor that targets ERK1 and ERK2, with IC50 values of 91.71 nM and 97.87 nM, respectively. It effectively suppresses the proliferation of cancer cell lines MCF-7, 4T1, MDA-MB-468, and HCC1970 with IC50 values of 0.67 μM, 2.76 μM, 2.15 μM, and 1.68 μM, respectively. Additionally, it inhibits cancer cell migration, induces apoptosis and autophagy in MCF-7 cells, and demonstrates anti-tumor and anti-metastatic effects in a 4T1 xenograft mouse model.</p>Fórmula:C36H29BrF6N4OCor e Forma:SolidPeso molecular:727.54PEAQX tetrasodium hydrate
<p>PEAQX tetrasodium hydrate: potent/selective oral NMDA antagonist, IC50 270 nM (1A/2A), 29600 nM (1A/2B).</p>Fórmula:C17H15BrN3Na4O6PPureza:99%Cor e Forma:SolidPeso molecular:560.15IDOi-Pt(IV) prodrug-1
<p>IDOi-Pt(IV) prodrug-1 (Compound 10) is an IDOi-Pt(IV) prodrug that suppresses IDO expression. It induces apoptosis, reduces mitochondrial membrane potential, and inhibits tumor cell migration and invasion. Additionally, IDOi-Pt(IV) prodrug-1 triggers reactive oxygen species-mediated endoplasmic reticulum stress and the secretion of damage-associated molecular patterns (DAMPs), leading to immunogenic cell death (ICD). Compared to cisplatin, IDOi-Pt(IV) prodrug-1 exhibits relatively high efficiency and low toxicity in its antitumor activity.</p>Fórmula:C21H26Cl3N3O6PtSCor e Forma:SolidPeso molecular:749.96PD-1-IN-20
<p>PD-1-IN-20 is the less active enantiomer of PD-1-IN-1.</p>Fórmula:C12H20N6O7Pureza:98%Cor e Forma:SolidPeso molecular:360.32iNOs-IN-5
<p>iNOs-IN-5 (Compound BN-4) is an inhibitor of iNOS with an IC50 value of 0.1707 μM, effectively reducing NO expression in RAW264.7 cells stimulated by LPS (HT-D1056). It further diminishes the expression of ROS and lactate dehydrogenase induced by hypoxic injury, displaying anti-necrotic and anti-apoptotic properties. In an SD rat model, iNOs-IN-5 exhibits neuroprotective effects against cerebral ischemia and is capable of crossing the blood-brain barrier.</p>Cor e Forma:Odour SolidYTHDF2-IN-1
<p>YTHDF2-IN-1 (Compound CK-75) is an inhibitor of YT521-B homology domain family 2 (YTHDF2) with a dissociation constant (Kd) of 26.2 μM, and it effectively blocks the interaction between YTHDF2 and m6A RNA. It suppresses colony formation in JAR cells and exhibits antiproliferative activity in various cancer cell lines, with an IC50 in the micromolar range. Additionally, YTHDF2-IN-1 induces apoptosis in K562 cells and causes cell cycle arrest at the G0/G1 phase.</p>Fórmula:C21H14N2O4Cor e Forma:SolidPeso molecular:358.35Cardanol (C15:1)
CAS:<p>Cardanol (C15:1), found in cashew nut shell liquid, induces mitochondria-associated apoptosis in human melanoma cells.</p>Fórmula:C21H34OPureza:98.48% - 99.77%Cor e Forma:SolidPeso molecular:302.49H-20
CAS:<p>H-20 is a PD-1 agonist that reduces the required dosage of morphine for analgesia. It can be used in studies related to chronic pain.</p>Fórmula:C44H64N10O15Cor e Forma:SolidPeso molecular:973.037Thevetiaflavone
CAS:<p>Thevetiaflavone, a natural flavonoid from W. indica, blocks LDH leakage, boosting cell survival.</p>Fórmula:C16H12O5Pureza:98%Cor e Forma:SolidPeso molecular:284.26hCAIX-IN-23
<p>hCAIX-IN-23 (Compound 27) is a human carbonic anhydrase (hCA) inhibitor with Ki values of 10.4 nM for hCA IX and 8.5 nM for hCA XII. It not only inhibits hCA activity but also releases NO, exerting dual anti-tumor effects. By reducing the expression of hCA IX and iron regulatory proteins, hCAIX-IN-23 regulates mitochondrial caspase activity and the ferroptosis pathway, thereby inducing apoptosis. This compound is utilized in research focused on renal cancer.</p>Cor e Forma:Odour SolidKRASG12C IN-16
<p>KRASG12C IN-16 (Compound SK-17) is a selective, covalent, and orally active KRASG12C inhibitor. It can induce apoptosis and effectively prevent the activation of the MAPK and PI3K/mTOR signaling pathways. Additionally, KRASG12C IN-16 exhibits antitumor activity against pancreatic cancer.</p>Fórmula:C28H35ClN8O2Cor e Forma:SolidPeso molecular:551.08IPH10
<p>IPH10 is an anticancer agent with strong antitumor effects in vivo and exhibits no liver or kidney toxicity. It significantly increases the reactive oxygen species (ROS) levels in tumor cells, decreases mitochondrial membrane potential, and induces apoptosis (apoptosis) in these cells.</p>Fórmula:C32H33NO4Cor e Forma:SolidPeso molecular:495.61BRD4 Inhibitor-38
<p>BRD4 Inhibitor-38 (Compound 25) is an orally active BRD4 inhibitor, exhibiting IC50 values of 3.64 μM for BRD4 BD1 and 0.12 μM for BRD4 BD2. It also demonstrates anti-inflammatory properties, with an IC50 value of 1.98 μM for nitric oxide (NO) production.</p>Fórmula:C19H18N2O4Cor e Forma:SolidPeso molecular:338.357Caspase-3 activator 3
<p>Caspase-3 activator 3 (compound 2h) effectively induces apoptosis in HL-60 and K562 cells by substantially activating caspase-3, demonstrating antileukemic</p>Pureza:98%Cor e Forma:Odour Solid
