Apoptose
Os inibidores da apoptose são compostos que previnem ou retardam o processo de morte celular programada, conhecido como apoptose. Esses inibidores são vitais no estudo dos mecanismos de sobrevivência celular e são usados para investigar doenças onde a apoptose é desregulada, como câncer, distúrbios neurodegenerativos e doenças autoimunes. Ao modular a apoptose, esses inibidores podem ajudar no desenvolvimento de terapias destinadas a controlar a morte celular. Na CymitQuimica, oferecemos uma ampla seleção de inibidores da apoptose de alta qualidade para apoiar sua pesquisa em biologia celular, oncologia e áreas relacionadas.
Subcategorias de "Apoptose"
- ASK(9 produtos)
- BCL(1 produtos)
- Caspase(154 produtos)
- FOXO1(2 produtos)
- IAP(67 produtos)
- Mdm2(12 produtos)
- PD-1/PD-L1(134 produtos)
- PDK(9 produtos)
- PERK(23 produtos)
- Serina/treonina quinase(17 produtos)
- Survivina(14 produtos)
- TNF(93 produtos)
- c-RET(61 produtos)
- p53(63 produtos)
Exibir 6 mais subcategorias
Foram encontrados 6190 produtos de "Apoptose"
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Mas7
CAS:Amphiphilic peptide Mas7, a structural analogue of mastoparan is a known activator of heterotrimeric Gi-proteins and its downstream effectors.Fórmula:C67H124N18O15Pureza:98%Cor e Forma:SolidPeso molecular:1421.81Human PD-L1 inhibitor V
CAS:Human PD-L1 Inhibitor V is a peptide that binds to the human PD-1 protein with an affinity characterized by a dissociation constant (Kd) of 3.32 μM, effectivelyFórmula:C65H104N20O18SPureza:98%Cor e Forma:SolidPeso molecular:1485.71YL-5092
CAS:YL-5092, YTHDC1 inhibitor (IC50=7.4 nM), induces G0/G1 arrest and apoptosis, used for acute myeloid leukemia (AML).Fórmula:C22H14F3N3O2SCor e Forma:SolidPeso molecular:441.43YT117R
YT117R is a PROTAC that targets degradation of FKBP12 and BRD4.Fórmula:C50H52ClN9O7SCor e Forma:SolidPeso molecular:958.52Ac-AAVALLPAVLLALLAP-DEVD-CHO
CAS:Ac-AAVALLPAVLLALLAP-DEVD-CHO (DEVD-CHO-CPP 32) serves as a potent and reversible inhibitor of caspase-3 [1].Fórmula:C94H158N20O27Pureza:98%Cor e Forma:SolidPeso molecular:2000.38AFMK
CAS:AFMK (Formyl-N-acetyl-5-methoxykynurenamine) is an active metabolite of Melatonin with antioxidant and free radical scavenging activity.Fórmula:C13H16N2O4Pureza:98.34% - 99.81%Cor e Forma:SolidPeso molecular:264.281,2-Naphthoquinone
CAS:1,2-Naphthoquinone inhibits urease, induces apoptosis in PBMC cells, inhibitory activity against hiCE, hCE1, hAChE, and hBChE.Fórmula:C10H6O2Pureza:98.01%Cor e Forma:Golden Yellow Needles Color On Standing (Ntp 1992)Peso molecular:158.15MEDI-7352
MEDI-7352 is a human bispecific antibody targeting NGF/bNGF and TNF. It can be utilized in research focused on osteoarthritis (OA) pain.Cor e Forma:Odour LiquidAc-AAVALLPAVLLALLAP-YVAD-CHO
CAS:Ac-AAVALLPAVLLALLAP-YVAD-CHO is a cell-permeable inhibitor of caspase-1 exhibiting antitumor activity [1].Fórmula:C97H160N20O24Pureza:98%Cor e Forma:SolidPeso molecular:1990.43Enlonstobart
CAS:Enlonstobart is a humanized IgG4-κ monoclonal antibody targeting PDCD1, functioning as both an immunostimulant and antineoplastic agent [1].Cor e Forma:LiquidTelitacicept
CAS:Telitacicept (RC18), a fully human TACI-Fc fusion protein, acts as a dual inhibitor of B lymphocyte stimulator (BLyS) and APRIL (a proliferation-inducing ligandCor e Forma:LiquidRozibafusp alfa
CAS:Rozibafusp alfa is an IgG2-κ antibody that targets ICOSLG, combined with a TNFSF13B fusion protein [1].Cor e Forma:LiquidIparomlimab
CAS:Iparomlimab: anti-PD-1 IgG4κ antibody, targets PSB103 γ4/κ-chains, forms dimers, used in cancer research.Cor e Forma:LiquidRanevetmab
CAS:Ranevetmab (NV-01), a caninized anti-NGF mAb, relieves pain in DJD research.Cor e Forma:LiquidAtorolimumab
CAS:Atorolimumab (P3x22914G4), a monoclonal antibody, is employed in immunotherapies that target the programmed death-1 (PD-1) receptor [1].Cor e Forma:LiquidCofetuzumab
CAS:Cofetuzumab (PF-06523435) is a antibody targeting protein tyrosine kinase 7 (PTK7), which can be used to synthesize ADC compounds like cofetuzumab pelidotin.Pureza:>95%Cor e Forma:LiquidPeso molecular:146.7 kDaAnti-Mouse TNF α Antibody (TN3-19.12)
Anti-Mouse TNF alpha Antibody is a rat-derived IgG inhibitor targeting mouse TNF alpha.Pureza:95%Cor e Forma:Odour LiquidPeso molecular:150 kDaOnfekafusp alfa
CAS:Onfekafusp alfa (L19TNF), a trimeric fusion of L19 scFv and human TNF, targets malignant glioma.Cor e Forma:LiquidLorigerlimab
CAS:Lorigerlimab (MGD019) is a bispecific IgG4 DART that blocks PD-1/CTLA-4, enhancing T-cells for mCRPC research.Cor e Forma:LiquidAnti-Mouse PD-L1/B7-H1 (LALA-PG) Antibody (10F.9G2)
Anti-Mouse PD-L1/B7-H1 (LALA-PG) Antibody (10F.9G2) is an IgG2a, κ antibody inhibitor derived from mice, specifically targeting and inhibiting mouse PD-L1/B7-H1.Cor e Forma:Odour LiquidAnti-Mouse PD-1 Antibody (RMP1-14)
Anti-Mouse PD-1 Antibody (RMP1-14) is an IgG2a antibody inhibitor against mouse PD-1 and can block PD-1/PD-L1 signaling. High-Quality, Low-Cost!Pureza:14.68mg/ml - >95%Cor e Forma:LiquidPeso molecular:147.57 kDaδ-secretase inhibitor 11
CAS:δ-secretase inhibitor 11 is an inhibitor of δ-secretase and can be used as a lead compound for translational development of AD treatment.Fórmula:C10H12N4O2Pureza:99.84%Cor e Forma:SolidPeso molecular:220.23Lipustobart
CAS:Lipustobart is an IgG4-kappa humanized monoclonal antibody targeting PDCD1 (programmed cell death 1, PD1, PD-1, CD279), with immunostimulant and antineoplasticPureza:98%Cor e Forma:LiquidTulinercept
CAS:Tulinercept (OPRX-106), a monoclonal antibody, may be utilized in a range of biochemical research applications [1].Cor e Forma:LiquidZigakibart
CAS:Zigakibart (BION-1301) is a humanized monoclonal antibody targeting TNFSF13 with anti-inflammatory activity for the study of immunoglobulin A nephropathy (IgAN)Pureza:95.8% (SDS-PAGE); 99.8% (SEC-HPLC) - 95.8% (SDS-PAGE); 99.8% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:145.03 kDaBMS-986156
BMS-986156 is a fully humanized IgG1 agonist monoclonal antibody that targets the glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR). It binds to GITR and enhances the activation of T effector cells while deactivating T regulatory cells. BMS-986156 is applicable for research in advanced solid tumors.Giloralimab
CAS:Giloralimab (ABBV-927) is a antibody targeting CD40 with anticancer activity for the study of triple-negative breast cancer and non-small cell lung cancer.Pureza:95.6% (SDS-PAGE); 95.1% (SEC-HPLC) - 95.6% (SDS-PAGE); 95.1% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:146.34 kDaBesufetamig
CAS:Besufetamig is a bispecific antibody targeting programmed cell death protein 1 (PD-1) and the CD3ε chain. It modulates immune cell activity, exerting both immunosuppressive and antitumor effects. Besufetamig holds promise for cancer research.Cor e Forma:LiquidMoflerafusp alfa
CAS:Moflerafusp alfa is a fusion protein that targets the human signal-regulatory protein alpha (SIRPα) variant V2 D1 domain and human programmed death-ligand 1 (PD-L1). It shows potential for research in various cancer treatments.Cor e Forma:LiquidVolrustomig
CAS:Volrustomig is a bi-engineered fragment crystallizable (Fc) domain, a monovalent bispecific IgG1 monoclonal antibody targeting the key immune checkpoint receptors PD-1 and CTLA-4. It boosts T-cell activation and antitumor immunity, making it a promising immunotherapy for various cancers. Molecular weight: 146.77 kDa.Cor e Forma:LiquidTebentafusp
CAS:Tebentafusp (IMCgp100) is a protein that targets gp100 with potential anti-tumor activity.Pureza:97.2% (SDS-PAGE); 100% (SEC-HPLC) - 97.2% (SDS-PAGE); 100% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:76.14 kDaGarivulimab
CAS:Garivulimab (BGB-A333), a humanized IgG1 monoclonal antibody, binds to PD-L1, blocking PD-1 interaction and exhibiting antitumor activity.Cor e Forma:LiquidLiensinine Perchlorate
CAS:Liensinine is the active constituent of plumula nelambinis with anti-hypertension.
Fórmula:C37H43ClN2O10Pureza:99.80%Cor e Forma:SolidPeso molecular:711.2Flavopiridol
CAS:Flavopiridol (Alvocidib) blocks CDK1/2/4/6 by competing with ATP (IC50 ~40 nM); 7.5x selectivity over CDK7; also inhibits EGFR, PKA. In Phase 1/2 trials.Fórmula:C21H20ClNO5Pureza:97.74% - 99.99%Cor e Forma:SolidPeso molecular:401.84Dynorphin A
CAS:Dynorphin A is a endogenous opioid peptide and a κ-opioid receptor (KOR) agonist,a neurotransmitter and regulator in the central and peripheral nervous systemsFórmula:C99H155N31O23Pureza:95.93%Cor e Forma:SolidPeso molecular:2147.48Kdo2-Lipid A ammonium
CAS:Kdo2-Lipid A ammonium (KLA) is a selective and potent TLR4 agonist, a lipopolysaccharide.Kdo2-Lipid A ammonium induces the release of TNF and PGE2.Fórmula:C110H214N6O39P2Pureza:98%Cor e Forma:SolidPeso molecular:2306.84Pantoprazole Sodium Hydrate
CAS:Pantoprazole Sodium Hydrate (BY1023 (sodium hydrate)) is a proton pump inhibitor drug, used for short-term treatment of erosion and ulceration of the esophagusFórmula:C16H14F2N3NaO4SH2OPureza:98.32%Cor e Forma:SolidPeso molecular:432.37Daporinad hydrochloride
CAS:Daporinad hydrochloride (FK 866 hydrochloride) is a NAMPT inhibitor with antitumor and antiangiogenic activity that induces apoptosis in tumor cells.Fórmula:C24H30ClN3O2Pureza:98.99%Cor e Forma:SolidPeso molecular:427.97MG-277
MG-277 is a molecular glue compound transformed from PROTAC degradation agent, MG-277 potently inhibits tumor cell growth in a p53-independent manner.Fórmula:C41H42Cl2FN5O5Pureza:98%Cor e Forma:SolidPeso molecular:774.71TRAP-1
TRAP-1 (XJZ-06-462) is a p53 transcription activator that effectively activates mutant p53 and triggers the transcription of p53 target genes. In the p53Y220C pancreatic cell line, TRAP-1 rapidly upregulates p21 and other p53 target genes. TRAP-1 also inhibits cell proliferation, exhibiting IC50 values of 3.94 μM and 0.531 μM in BxPC-3 and A549 cell lines, respectively. Additionally, TRAP-1 modulates autophagy in lung cancer cells and provides protection against oxidative stress and apoptosis.Fórmula:C57H66ClF3N11O3PSCor e Forma:SolidPeso molecular:1108.69EJMC-1
CAS:EJMC-1 is an inhibitor of TNF-α with an IC50 value of 42 μM and can be used in studies about auto-inflammatory diseases.Fórmula:C17H11ClN2O4SPureza:98.38%Cor e Forma:SolidPeso molecular:374.8BIM-46174 HCl
BIM-46174 HCl is a G-protein inhibitor with anticancer activity that induces cysteine 3-dependent apoptosis.
Fórmula:C22H31ClN4OSPureza:99.77% - 99.77%Cor e Forma:SolidPeso molecular:435.03AKN-028
CAS:AKN-028 is an orally active and potent FLT3 tyrosine kinase inhibitor ( IC 50 = 6 nM). AKN-028 causes dose-dependent inhibition of FLT3 autophosphorylation.
Fórmula:C17H14N6Pureza:99.88%Cor e Forma:SolidPeso molecular:302.33PCC0208017
CAS:PCC0208017 is an inhibitor of MARK3 and MARK4 with IC50s of 1.8 and 2.01 nM. PCC0208017 disrupts microtubule dynamics and displays potent antitumor activity.
Fórmula:C19H20F3N7Pureza:99.48%Cor e Forma:SolidPeso molecular:403.4BM 957
CAS:BM 957 is an effective Bcl-2 and Bcl-xL inhibitor (Kis: 1.2 and <1 nM; IC50s: 5.4 and 6.0 nM).Fórmula:C52H56ClF3N6O7S3Pureza:98%Cor e Forma:SolidPeso molecular:1065.68SPOP-IN-6lc
CAS:SPOP-IN-6lc is a SPOP inhibitor with oncogenic effects in renal cancer cells.SPOP-IN-6lc can be used to study apoptosis.
Fórmula:C26H31N7O2SPureza:99.19%Cor e Forma:SolidPeso molecular:505.64Glutathione arsenoxide hydrochloride
Glutathione arsenoxide hydrochloride: anti-cancer, inhibits tumour metabolism, targets ANT, promotes apoptosis, marks cell proteins.Fórmula:C18H26AsClN4O9SPureza:99.74%Cor e Forma:SoildPeso molecular:584.86PERK-IN-4
CAS:PERK-IN-4 is a potent and selective PERK inhibitor with an IC50 value of 0.3 nM.PERK-IN-4 can be used in the study of cancer and neurological disorders.Fórmula:C24H19F4N5OPureza:99.44% - 99.49%Cor e Forma:SolidPeso molecular:469.43PI3Kδ-IN-16
CAS:PI3Kδ-IN-16 is a selective and potent PI3Kδ inhibitor with anticancer and antiproliferative activity, induces cell cycle arrest and apoptosis.Fórmula:C22H26N6O2Pureza:99.68%Cor e Forma:SoildPeso molecular:406.48SDU-071
CAS:SDU-071 is a BRD4-p53 inhibitor, suppressing MDA-MB-231 cell proliferation, inducing cell cycle arrest and apoptosis.Fórmula:C28H25N3O2Pureza:99.54%Cor e Forma:SolidPeso molecular:435.52KHKI-01215
KHKI-01215 is a NUAK2 inhibitor with anticancer activity, inhibiting the proliferation of SW480 cancer cells and inducing apoptosis.Fórmula:C24H26F3IN6OPureza:98.19%Cor e Forma:SolidPeso molecular:598.4Sandacanol
CAS:Sandacanol (Sandranol) is an olfactory receptor (OR10H1) agonist.Sandacanol induces cell cycle arrest and partial apoptosis in bladder cancer cells.Fórmula:C14H24OPureza:99.59%Cor e Forma:SolidPeso molecular:208.34SFI003
CAS:SFI003 is a novel SRSF3 inhibitor that exerts anticancer activity against colorectal cancer by modulating the SRSF3 / DHCR24 / ROS axis and driving apoptosis inFórmula:C19H17N5OSPureza:99.44%Cor e Forma:SoildPeso molecular:363.44Ref: TM-T72068
1mg75,00€5mg164,00€1mL*10mM (DMSO)172,00€10mg255,00€25mg495,00€50mg712,00€100mg973,00€200mg1.341,00€TV 3279
CAS:TV 3279 is a ChE-MAI inhibitor with neuroprotection via anti-apoptotic protein induction and blocks pro-apoptotic enzymes in cells.
Fórmula:C16H20N2O2Pureza:97%Cor e Forma:SoildPeso molecular:272.34CWI1-2 HCL
CAS:CWI1-2 HCL: Potent IGF2BP2 inhibitor, induces apoptosis/differentiation, targets leukemia therapy.Fórmula:C22H18Cl4N6O3Pureza:98.09%Cor e Forma:SolidPeso molecular:556.23Ref: TM-T67930L
1mg49,00€5mg92,00€1mL*10mM (DMSO)116,00€10mg145,00€25mg281,00€50mg409,00€100mg580,00€200mg798,00€BK60106
BK60106 is a selective and direct inhibitor of the transmembrane protein CD99, which causes cell death in Ewing Sarcoma cells.Fórmula:C15H15FN6O3Pureza:99.30% - >99.99%Cor e Forma:SolidPeso molecular:346.32Antimycin A2c
Anticancer Agent 141 (Compound AE), an antimycin alkaloid, exhibits inhibitory potential against HPV-infected cervical cancer.Fórmula:C28H40N2O9Pureza:98%Cor e Forma:SolidPeso molecular:548.63Anticancer agent 133
Compound Rh2 (Anticancer agent 133) is a cytotoxic and antimetastatic agent that induces cell cycle arrest, apoptosis, and autophagy.Fórmula:C24H19Cl3N5ORhPureza:98%Cor e Forma:SolidPeso molecular:602.71fac-[Re(CO)3(L6)(H2O)][NO3]
Compound 6, fac-[Re(CO)3(L6)(H2O)][NO3], a rhenium(I) tricarbonyl aqua complex, serves as an anticancer agent by disrupting mitochondrial function.Fórmula:C24H14N5O7ReSPureza:98%Cor e Forma:SolidPeso molecular:702.67Pyridinium bisretinoid A2E TFA
CAS:Pyridinium bisretinoid A2E (A2E) TFA, a fluorophore derived from retinal pigment epithelium (RPE) lipofuscin, initiates blue-light-induced apoptosis, mediatesFórmula:C44H58F3NO3Pureza:98%Cor e Forma:SolidPeso molecular:705.93Antitumor agent-112
Antitumor agent-112 (compound 3a) is a potent antitumor agent that induces apoptosis and exhibits cytotoxic activity on A549 cells, with an IC50 value of 91.35Fórmula:C18H17ClN4O2SPureza:98%Cor e Forma:SolidPeso molecular:388.87Cholicamideβ
Cholicamideβ (compound 6), a self-assembling small molecule cancer vaccine adjuvant, forms low cytotoxicity virus-like particles and upon binding to peptideFórmula:C55H94N2O6Pureza:98%Cor e Forma:SolidPeso molecular:879.34TAT-GluN2BCTM
CAS:TAT-GluN2BCTM is a membrane-permeable peptide that selectively targets active DAPK1 (Death-associated protein kinase 1) for lysosomal degradation, therebyFórmula:C224H374N86O54Pureza:98%Cor e Forma:SolidPeso molecular:5135.91Antitumor photosensitizer-4
Antitumor Photosensitizer-4 (compound 10b), a conjugate of dasatinib and imatinib, serves as a potent tyrosine kinase inhibitor (TKI) targeting ABCG2.Fórmula:C65H77ClN12O11SPureza:98%Cor e Forma:SolidPeso molecular:1269.9Anticancer agent 132
Compound Rh1 (Anticancer agent 132) acts as an inducer of apoptosis and autophagy, exhibiting both antitumor and antimetastatic activities.Fórmula:C24H16Cl3F3N5ORhPureza:98%Cor e Forma:SolidPeso molecular:656.68Antitumor agent-103
Antitumor Agent-103 (compound 24l) induces apoptosis and possesses antiproliferative and anti-colony formation properties.Fórmula:C36H36N8O9S2Pureza:98%Cor e Forma:SolidPeso molecular:788.85Anticancer agent 153
Anticancer Agent 153 (Compound 3) promotes apoptosis through the generation of Reactive Oxygen Species (ROS) and elevates the loss of Mitochondrial MembraneFórmula:C16H11Cl2N3O3Pureza:98%Cor e Forma:SolidPeso molecular:364.184-hydroperoxy cyclophosphamide
CAS:4-hydroperoxy cyclophosphamide (4-OOH-CY) induces hepatotoxicity. It increases ghrelin levels and enhances inflammatory factors and oxidative markers.Fórmula:C7H15Cl2N2O4PPureza:98%Cor e Forma:SolidPeso molecular:293.09Thrombospondin-1 (1016-1023) (human, bovine, mouse)
CAS:Thrombospondin-1 (1016-1023) (human, bovine, mouse) is part of Thrombospondin-1 (TSP-1), a peptide with CD47 agonism.Fórmula:C56H81N13O10SPureza:99.23%Cor e Forma:SolidPeso molecular:1128.39Ref: TM-T75720
1mg49,00€5mg105,00€10mg172,00€1mL*10mM (DMSO)200,00€25mg268,00€50mg416,00€100mg600,00€Se-Aspirin
CAS:Se-Aspirin (Se-NSAID-8) has anticancer activity and gastroprotective effects, inhibits activation of proinflammatory and pro-survival NF-ĸB pathways, and inhibits the expression of anti-apoptotic targets downstream of NF-ĸB (e.g., Bcl-xL, Mcl-1, and survivin).Se-Aspirin induces Cell cycle arrest and activation of apoptosis accelerates ulcer healing and can be used to study pancreatic and colorectal cancer.Fórmula:C12H12N2O3SePureza:98.07%Cor e Forma:SolidPeso molecular:311.2Dynorphin A TFA
Dynorphin A TFA: endogenous peptide, potent KOR agonist, affects CNS, involved in neuron death research.Fórmula:C101H156F3N31O25Peso molecular:2261.5tetrathiomolybdate
CAS:Tetrathiomolybdate (TM) promotes the dimerization of the metal-binding domain (WLN4) of the cellular copper efflux protein ATP7B through its characteristicFórmula:MoS4Cor e Forma:SolidPeso molecular:224.2ARI-1
ARI-1 is a receptor tyrosine kinase-like orphan receptor 1 (ROR1) inhibitor that binds to ROR1's extracellular Frizzled domain, effectively inhibiting aberrantCor e Forma:Odour SolidAluminum phthalocyanine disulfonate disodium
CAS:AlPcS2 disodium: a photosensitizer for cancer therapies, isomeric mix, and used as a dye, reagent, and luminescent agent.Fórmula:C32H14AlClN8Na2O6S2Cor e Forma:SolidPeso molecular:779.05Sec61-IN-4
Sec61-IN-4 (Compound 16b) is a potent Sec61 inhibitor with an IC50 value of 0.04 nM in U87-MG cells [1].Cor e Forma:Odour SolidTNF-α-IN-11
TNF-α-IN-11 (Compound 10) is a TNF-α inhibitor exhibiting a dissociation constant (K D) of 12.06 μM.Fórmula:C24H26N2O5Cor e Forma:SolidPeso molecular:422.47(E)-Ajoene
CAS:(E)-Ajoene, found in A. sativum, fights bacteria (MICs: 10-500 μg/ml), fungi (MICs: 15-50 μg/ml), cancer cells, and protects neurons in ischemia.Fórmula:C9H14OS3Cor e Forma:SolidPeso molecular:234.39Diethyl phthalate
CAS:Diethyl phthalate disrupts endocrine and induces apoptosis in PC12 cells; common in plastics, personal care items.Fórmula:C12H14O4Pureza:99.68% - 99.8%Cor e Forma:SolidPeso molecular:222.24RET-IN-29
RET-IN-29 (Compound 8W) is a selective RET kinase inhibitor. It demonstrates inhibitory effects on BaF3 cells with the CCDC6-RETV804M mutation, with an IC50 of 0.715 μM. RET-IN-29 shows potential for research in non-small cell lung cancer (NSCLC).Fórmula:C22H22N6OCor e Forma:SolidPeso molecular:386.45LL-K9-3
CAS:LL-K9-3, a selective hydrophobic tagging technology (HyT)-based degrader, specifically targets the CDK9-cyclin T1 complex, displaying DC50 values of 589 nM forFórmula:C31H49N5O6S3Cor e Forma:SolidPeso molecular:683.94BODIPY FL thalidomide
CAS:BODIPY FL thalidomide is a fluorescent probe that binds human cereblon protein with high affinity, exhibiting a dissociation constant (Kd) of 3.6 nM [1].Fórmula:C37H43BF2N6O7Cor e Forma:SolidPeso molecular:732.58fac-[Re(CO)3(L3)(H2O)][NO3]
Fac-[Re(CO)3(L3)(H2O)][NO3] (Compound 3), a rhenium(I) tricarbonyl aqua complex, acts as an anticancer agent through the induction of mitochondrial dysfunction.Fórmula:C25H17N6O8ReCor e Forma:SolidPeso molecular:715.64Thalidomide-Piperazine 5-fluoride hydrochloride
CAS:Thalidomide-Piperazine 5-fluoride hydrochloride, a derivative of the cereblon (CRBN) inhibitor Thalidomide, serves as a ligand for E3 ubiquitin ligase (Ligands for E3 Ligase), facilitating the synthesis of PROTACs [1].Fórmula:C17H18ClFN4O4Cor e Forma:SolidPeso molecular:396.8Gal-ARV-771
Gal-ARV-771 is a PROTAC prodrug, modified with galactose, based on ARV-771. It is activated in senescent cancer cells that express SA-β-Gal, thereby releasing ARV-771. Through the ubiquitin-proteasome pathway, Gal-ARV-771 induces selective degradation of the BRD4 protein in senescent cells and promotes apoptosis (apoptosis) of these cancer cells.Fórmula:C71H84ClN9O19S2Peso molecular:1465.50134Euphjatrophane M
Euphjatrophane M (Compound 6) is a FOXO1 inhibitor that reduces NF-κBp65 phosphorylation and exhibits anti-inflammatory properties. It can inhibit the production of nitric oxide and also suppress the mRNA expression of IL-6, IL-1β, and TNFα in LPS-induced RAW 264.7 macrophages.Fórmula:C20H28O4Cor e Forma:SolidPeso molecular:332.43Anticancer agent 205
Anticanceragent 205 (compound 9) is an effective anticancer agent that binds to the G4-mtDNA target, inhibiting the replication, transcription, and translation of mtDNA (mitochondrial genome). It induces mitochondrial dysfunction, increases ROS production, and triggers DNA damage and cellular senescence. Anticanceragent 205 also promotes apoptosis and causes cell cycle arrest at the G0/G1 phase, showing potential for research in colorectal cancer.Fórmula:C52H60I2N4Peso molecular:994.29074LWY713
LWY713 is a PROTAC-based FLT3 degrader (DC50=0.64 nM) that selectively induces FLT3 degradation through a cereblon and proteasome-dependent mechanism. It inhibits cell proliferation and causes G0/G1 phase arrest and apoptosis (apoptosis) in MV4-11 cells. In MV4-11 xenograft models, LWY713 demonstrates significant in vivo antitumor activity. The E3 ligase ligand and linker consist of Lenalidomide-Glycolic acid, while the target protein ligand's active control is NaproxenGilteritinib.Fórmula:C43H54N10O8Peso molecular:838.41261AKT-IN-24
AKT-IN-24 (Compound M17) is an allosteric inhibitor of AKT exhibiting antitumor activity. In combination with Trametinib, it targets the AKT/mTOR and MEK/ERK signaling pathways while inhibiting epithelial-mesenchymal transition, resulting in a synergistic suppression effect on TNBC. This combination promotes apoptosis and inhibits cell proliferation and migration.Fórmula:C32H28N2O10Cor e Forma:SolidPeso molecular:600.572NLRP3-IN-60
NLRP3-IN-60 (Compound 39) is an orally bioavailable inhibitor of NLRP3. It effectively suppresses pyroptosis in THP-1 cells with an IC50 of 13 nM and inhibits IL-1β release in human whole blood, exhibiting an IC50 of 225 nM.
Fórmula:C23H24F2N4O4SCor e Forma:SolidPeso molecular:490.523TRK-IN-30
TRK-IN-30 (Compound C11) is an inhibitor of tropomyosin receptor kinases (TRK), effectively inhibiting TRKA, TRKB, TRKC, and the resistant mutant TRKAG595R, with IC50 values of 1.8, 0.98, 3.8, and 54 nM, respectively. It also suppresses the activation of downstream PI3K/AKT and MEK/ERK signaling pathways. TRK-IN-30 hinders colony formation and cell migration of Km-12, induces cell cycle arrest at the G0/G1 phase, and triggers apoptosis in Km-12 cells.Fórmula:C24H21N5O3Cor e Forma:SolidPeso molecular:427.455TRF2-IN-1
TRF2-IN-1 (compound F2) is a potent inhibitor of telomere repeat-binding factor 2 (TRF2). It exhibits antiproliferative activity and induces apoptosis. TRF2-IN-1 binds directly to the TRF2TRFH domain, selectively inhibiting TRF2 protein expression and telomere localization. Additionally, TRF2-IN-1 possesses anticancer properties and shows potential for osteosarcoma research.Fórmula:C18H17BrO4Cor e Forma:SolidPeso molecular:377.229LD4172
CAS:LD4172 is a PROTAC degrader capable of degrading RIP kinase (RIPK1) with a DC50 in the nanomolar range. When used in combination with TNF-α, LD4172 can induce apoptosis in B16F10 cells. In mouse models, it demonstrates antitumor activity. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligase VHL)Fórmula:C61H75F3N10O7SCor e Forma:SolidPeso molecular:1149.37Pipermethystine
Pipermethystine is a useful organic compound for research related to life sciences and the catalog number is T124340.Fórmula:C16H17NO4Cor e Forma:SolidPeso molecular:287.315Tubulin-IN-53
Tubulin-IN-53 is a potent inhibitor of microtubulin (Tubulin) with an IC50 of 6.06 μM. By targeting the colchicine binding site on tubulin, Tubulin-IN-53 hinders tubulin polymerization, disrupting the microtubule network. It induces cell cycle arrest at the G2/M phase and apoptosis (apoptosis) in MCF-7 cells, while inhibiting cell migration. This compound also leads to a reduction in mitochondrial membrane potential and an increase in reactive oxygen species (ROS) accumulation. Additionally, Tubulin-IN-53 disrupts angiogenesis in human umbilical vein endothelial cells and is applicable in research on cancers such as breast and lung cancer.Cor e Forma:Odour SolidTizanidine
CAS:Tizanidine, an α2-adrenergic receptor agonist, suppresses the release of neurotransmitters from central nervous system (CNS) noradrenergic neurons.Fórmula:C9H8ClN5SPureza:99.11%Cor e Forma:White SolidPeso molecular:253.71NEP162
CAS:NEP162 is a BRD4 PROTAC degrader with DC50 values of 1.2 μM in SW480 cells and 1.6 μM in U2OS cells. NEP162 exhibits antiproliferative activity, effectively inhibiting tumor growth and inducing apoptosis. It is applicable in research on cancers such as osteosarcoma, colorectal cancer, and non-small cell lung cancer.Fórmula:C50H56ClN11O3SCor e Forma:SolidPeso molecular:926.57Bcl-2-IN-23
Bcl-2-IN-23 (compound 5) is a selective inhibitor targeting Bcl-2. It demonstrates an IC50 range of 25.7-33.7 μM in HTB-140, HeLa, and SW620 cells. Acting through non-covalent competitive binding to the Bcl-2 protein, Bcl-2-IN-23 significantly reduces Bcl-2 expression, inducing late-stage apoptosis and necroptosis in cancer cells. By disrupting the Bcl-2-mediated mitochondrial apoptotic inhibition pathway, it increases cancer cell susceptibility to apoptosis and reduces the release of the inflammatory factor IL-6. Bcl-2-IN-23 is applicable in anti-apoptosis research for malignant tumors such as melanoma, cervical cancer, and colorectal cancer.Cor e Forma:Odour SolidMB-314
MB-314 is a humanized IgG1 monoclonal antibody (mAb) targeting Lewis Y. This compound enhances antibody-dependent cell-mediated cytotoxicity (ADCC) activity and increases the release of IFN-γ, TNF-α, MCP-1, and IL-6. MB-314 is applicable in cancer research.Cor e Forma:Odour LiquidAnticancer agent 39
CAS:Compound B12, a JOA derivative, collapses MMP to induce apoptosis, inhibits cloning/migration, and has an IC50 of 0.39 μM against HGC-27 cells.Fórmula:C50H65N5O10Cor e Forma:SolidPeso molecular:896.08
