Apoptose
Os inibidores da apoptose são compostos que previnem ou retardam o processo de morte celular programada, conhecido como apoptose. Esses inibidores são vitais no estudo dos mecanismos de sobrevivência celular e são usados para investigar doenças onde a apoptose é desregulada, como câncer, distúrbios neurodegenerativos e doenças autoimunes. Ao modular a apoptose, esses inibidores podem ajudar no desenvolvimento de terapias destinadas a controlar a morte celular. Na CymitQuimica, oferecemos uma ampla seleção de inibidores da apoptose de alta qualidade para apoiar sua pesquisa em biologia celular, oncologia e áreas relacionadas.
Subcategorias de "Apoptose"
- ASK(9 produtos)
- BCL(1 produtos)
- Caspase(154 produtos)
- FOXO1(2 produtos)
- IAP(67 produtos)
- Mdm2(12 produtos)
- PD-1/PD-L1(134 produtos)
- PDK(9 produtos)
- PERK(23 produtos)
- Serina/treonina quinase(17 produtos)
- Survivina(14 produtos)
- TNF(93 produtos)
- c-RET(61 produtos)
- p53(63 produtos)
Exibir 6 mais subcategorias
Foram encontrados 6222 produtos de "Apoptose"
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Emavusertib Phosphate
CAS:Emavusertib Phosphate (also known as CA-4948) is a potent inhibitor of IRAK4 and FLT3, exhibiting antitumor activity. In ABC DLBCL and AML cell lines, it demonstrates significant cellular efficacy. Furthermore, CA-4948 shows moderate to high selectivity across a panel of 329 kinases and possesses favorable ADME and PK profiles, including good oral bioavailability in mice, rats, and dogs. It achieves over 90% tumor growth inhibition in relevant tumor models and correlates excellently with in vivo PD modulation.Fórmula:C24H28N7O9PPeso molecular:589.49Triphenyl phosphate
CAS:Triphenyl phosphate is an flame retardant and endocrine disruptor that activates MAO-A/ROS/NF-κB pathways, disrupting placental tryptophan metabolism.Fórmula:C18H15O4PPureza:99.94%Peso molecular:326.288NSC 15830 hydrochloride
CAS:NSC 15830 (S-(1,2-Dichlorovinyl)-L-cysteine) hydrochloride is a nephrotoxic compound that serves as a metabolite of trichloroethylene. This compound is capable of inhibiting TNF-α stimulated by pathogens.Fórmula:C5H8Cl3NO2SPeso molecular:252.55Delmitide
CAS:Delmitide, a TNF-alpha production inhibitor, is used potentially for the treatment of Crohn's disease and ulcerative colitis.Fórmula:C59H105N17O11Pureza:98%Cor e Forma:SolidPeso molecular:1228.57AZT triphosphate TEA
AZT triphosphate TFA, a Zidovudine metabolite, inhibits HIV & HBV replication and triggers mitochondrial apoptosis.Cor e Forma:SolidMofarotene
CAS:Mofarotene (Ro-40-8757) is a small molecule compound that shows considerable antitumor activity in many cancer cell lines and can be used for the treatment ofFórmula:C29H39NO2Pureza:99.96%Cor e Forma:SolidPeso molecular:433.63Mcl-1 inhibitor 12
CAS:Mcl-1 Inhibitor 12 (Example 10), with a K i of 0.22 nM, functions as an MCL-1 inhibitor. It is utilized in cancer research [1].Fórmula:C47H45ClFN7O6Cor e Forma:SolidPeso molecular:858.35Amino-PEG6-Thalidomide
Amino-PEG6-Thalidomide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules.Fórmula:C27H39N3O10Pureza:98%Cor e Forma:SolidPeso molecular:565.61Ono 3403
CAS:Ono 3403, a synthetic serine protease inhibitor, blocks TNF-alpha, NO production, and has antitumor properties.Fórmula:C26H31N3O8SPureza:98%Cor e Forma:SolidPeso molecular:545.6Aviculin
CAS:Aviculin, a lignan glycoside, exhibits anticancer properties by inducing apoptosis in breast cancer cells with an IC50 of 75.47 μM.Fórmula:C26H34O10Cor e Forma:SolidPeso molecular:506.54Glutathione arsenoxide hydrochloride
Glutathione arsenoxide hydrochloride: anti-cancer, inhibits tumour metabolism, targets ANT, promotes apoptosis, marks cell proteins.Fórmula:C18H26AsClN4O9SPureza:99.74%Cor e Forma:SoildPeso molecular:584.86Fludarabine triphosphate trisodium
Fludarabine triphosphate (F-ara-ATP) trisodium inhibits DNA synthesis; IC50 2.3 μM, Ki 6.1 μM, blocks DNA primase, prompts apoptosis.Fórmula:C10H12FN5Na3O13P3Cor e Forma:SolidPeso molecular:591.12Tasisulam sodium
CAS:Tasisulam triggers apoptosis, halts mitosis, and normalizes blood vessels to combat cancer.Fórmula:C11H5BrCl2NNaO3S2Cor e Forma:SolidPeso molecular:437.09Thalidomide-Piperazine-PEG2-NH2
CAS:Thalidomide-Piperazine-PEG2-NH2 is a synthetic E3 ligase ligand-linker for PROTAC, combining cereblon ligand with a PEG2 linker.Fórmula:C23H31N5O6Cor e Forma:SolidPeso molecular:473.53Bcl-2-IN-2
CAS:Bcl-2-IN-2 is a highly potent and selective inhibitor targeting Bcl-2 and Bcl-xL.Fórmula:C48H57N7O7SCor e Forma:SolidPeso molecular:876.09BM-1197
CAS:BM-1197, a highly potent and specific dual inhibitor of Bcl-2 and Bcl-xL, effectively targets these proteins with IC50 values of 3.5 nM and 5.2 nM for Bcl-2 andFórmula:C53H59ClF4N6O7S4Cor e Forma:SolidPeso molecular:1131.77ReACp53
ReACp53 inhibits amyloid formation, restores p53 in cancer cells and HGSOC-derived organoids.Fórmula:C108H206N52O24Pureza:98%Cor e Forma:SolidPeso molecular:2617.13FC-116
CAS:FC-116 is a potent Tubulin inhibitor with antitumour activity and inhibits tumour growth in mice.FC-116 induces apoptosis and promotes protein degradation.Fórmula:C21H20FNO4Pureza:98.18%Cor e Forma:SoildPeso molecular:369.39Ref: TM-T77519
1mg52,00€5mg111,00€1mL*10mM (DMSO)127,00€10mg177,00€25mg313,00€50mg447,00€100mg587,00€200mg800,00€Thrombospondin-1 (1016-1023) (human, bovine, mouse)
CAS:Thrombospondin-1 (1016-1023) (human, bovine, mouse) is part of Thrombospondin-1 (TSP-1), a peptide with CD47 agonism.Fórmula:C56H81N13O10SPureza:99.23%Cor e Forma:SolidPeso molecular:1128.39Ref: TM-T75720
1mg49,00€5mg105,00€10mg172,00€1mL*10mM (DMSO)200,00€25mg268,00€50mg416,00€100mg600,00€Chalcones A-N-5
CAS:Chalcones A-N-5, a non-cytotoxic trihydroxy chalcone, aids cell growth & neuroprotection, inhibits ferroptosis, and targets AD research.Fórmula:C21H20N4O4Cor e Forma:SolidPeso molecular:392.41Sanggenon G
CAS:Sanggenon G inhibits XIAP by binding its BIR3 domain; affinity is 34.26 μM, boosting caspase activation.Fórmula:C40H38O11Cor e Forma:SolidPeso molecular:694.72AZD5582 dihydrochloride
CAS:Dimeric Smac mimetic inhibits XIAP, cIAP1/2 (IC50: 15/15/21 nM); binds BIR3 domain; degrades cIAPs; induces apoptosis in cancer cells; shrinks tumors in mice.Fórmula:C58H80Cl2N8O8Cor e Forma:SolidPeso molecular:1088.23Antitumor agent-41
Antitumor Agent-41 (Compound N-12) exhibits potent antitumor properties, demonstrating significant antimigration and anti-invasion activities.Fórmula:C64H109IN2O21Cor e Forma:SolidPeso molecular:1369.462-aminobenzo[d]thiazol-6-ol
CAS:2-aminobenzo[d]thiazol-6-ol: antimicrobial, antioxidant, anticancer; may trigger cancer cell apoptosis.Fórmula:C7H6N2OSPureza:98.92%Cor e Forma:SolidPeso molecular:166.2LSD1-IN-26
LSD1-IN-26 (12u) is a potent LSD1 inhibitor (IC50=25.3 nM), also inhibits MAO-A/B, induces apoptosis in MGC-803, for gastric cancer research.Fórmula:C27H25Cl2F2N3OCor e Forma:SolidPeso molecular:516.41EGFR/BRAFV600E-IN-3
EGFR/BRAFV600E-IN-3 is an inhibitor targeting EGFR, BRAFV600E, and EGFRT790M with IC50 values of 57 nM, 68 nM, and 9.70 nM, respectively.Fórmula:C25H18N4O3Pureza:98%Cor e Forma:SolidPeso molecular:422.44MitoEbselen-2 chloride
CAS:MitoEbselen-2 mitigates radiation, cuts lipid hydroperoxides, blocks cell death, and boosts survival in irradiated mice.Fórmula:C35H30ClN2O2PSeCor e Forma:SolidPeso molecular:656.01DS-5272
CAS:DS-5272 is a potent and orally active inhibitor of p53-MDM2 interaction.Fórmula:C34H38Cl2F2N6O2SCor e Forma:SolidPeso molecular:703.67BM-1074
CAS:BM-1074 is a potent and highly efficacious inhibitor of Bcl-2/Bcl-xL with Ki value of < 1nM [1].Fórmula:C50H57ClN8O7S3Cor e Forma:SolidPeso molecular:1013.69Pralnacasan
CAS:Pralnacasan blocks IL-18, IL-1β, IFN-γ. It’s a potent oral enzyme inhibitor with use in arthritis therapy (Ki: 1.4 nM).Fórmula:C26H29N5O7Pureza:98%Cor e Forma:SolidPeso molecular:523.54SM-164 Hydrochloride
SM-164 Hydrochloride: Smac mimetic, cell-permeable, binds XIAP BIR2 and BIR3, IC50 of 1.39 nM, potent XIAP antagonist.Fórmula:C62H85ClN14O6Cor e Forma:SolidPeso molecular:1157.8827-O-(tert-Butyldimethylsilyl)withaferin A
CAS:Compound 9a, a withanolide, induces apoptosis and has anti-cancer properties.Fórmula:C34H52O6SiCor e Forma:SolidPeso molecular:584.86Thalidomide-O-C10-NH2
CAS:Thalidomide-O-C10-NH2: synthetic cereblon-based E3 ligase ligand-linker for PROTACs.Fórmula:C23H31N3O5Cor e Forma:SolidPeso molecular:429.517Antitumor agent-116
Antitumor Agent-116 (Compound 6C) is an anti-tumor agent that exhibits anti-proliferative properties and induces apoptosis.Fórmula:C31H23BrN4O4SPureza:98%Cor e Forma:SolidPeso molecular:627.51Thalidomide-O-C2-acid
CAS:Thalidomide-O-C2-acid: E3 ligase ligand-linker for PROTAC, with cereblon-derived Thalidomide component.Fórmula:C16H14N2O7Cor e Forma:SolidPeso molecular:346.2916Zapalog
CAS:Zapalog: photocleavable dimerizer controlling instant protein interactions.Fórmula:C58H73N7O15Pureza:98%Cor e Forma:SolidPeso molecular:1108.24PROTAC MNK1 degrader-1
ROTACMNK1degrader-1 is a selective MNK1 PROTAC degrader with a DC50 of 11.92 nM and a Dmax greater than 96% in MV4-11 cells. It significantly reduces p-eIF4E levels with an IC50 of 22.07 nM, induces apoptosis, and causes cell cycle arrest at the G1 phase. This compound exhibits potent antitumor activity, demonstrating strong anti-leukemic effects in MV4-11 xenograft mouse models with acceptable drug safety.Fórmula:C35H38N6O6SCor e Forma:SolidPeso molecular:670.78Antiproliferative agent-23
Antiproliferative agent-23: destabilizes microtubules, induces apoptosis in cancer cells via mitochondrial path, and triggers ER stress.Fórmula:C23H28Cl3N3O6PtCor e Forma:SolidPeso molecular:743.93Ganoderic acid T1
Ganoderic acid T1, a derivative of Ganoderic acid T, triggers cancer cell apoptosis by boosting ROS and activating caspases.Fórmula:C34H50O7Cor e Forma:SolidPeso molecular:570.76Antibiotic DC 81
CAS:DC 81: Streptomyces-derived antitumor antibiotic, potent nucleic acid synthesis inhibitor, binds DNA sequences, forms covalent adducts.Fórmula:C13H14N2O3Cor e Forma:SolidPeso molecular:246.262,4-D sodium salt
CAS:Sodium 2,4-dichlorophenoxyacetate: selective herbicide, controls broadleaf weeds by disrupting growth and protein/DNA synthesis.Fórmula:C8H5Cl2NaO3Cor e Forma:SolidPeso molecular:243.02Anagrelide hydrochloride monohydrate
CAS:Anagrelide HCl monohydrate is a platelet-reducing imidazoquinazoline for ET and PV research.Fórmula:C10H10Cl3N3O2Cor e Forma:SolidPeso molecular:310.56Ganglioside GD3 disodium salt
CAS:Ganglioside GD3 disodium salt is a melanoma-associated antigen often targeted in immune therapy for melanomas.Fórmula:C70H123N3Na2O29Cor e Forma:SolidPeso molecular:1516.71R1-ICR-5
CAS:R1-ICR-5 is a selective PROTAC degrader targeting serine/threonine-protein kinase 1 (RIPK1). Mediated by VHL, R1-ICR-5 promotes the degradation of RIPK1, disrupting the TNFR1 and TLR3/4 signaling hubs, enhancing NF-κB, MAPK, and IFN signal output, and facilitating RIPK3 activation and necroptosis induction. R1-ICR-5 holds potential for research in cancer and inflammatory diseases.Fórmula:C54H70N8O7S2Cor e Forma:SolidPeso molecular:1007.31Anticancer agent 104
Anticancer agent 104 has anticancer activity, and induces cancer cell apoptosis [1] .Fórmula:C34H47F3N2O2S2Cor e Forma:SolidPeso molecular:636.87TAS-117
CAS:TAS-117, a PKB/Akt inhibitor, is used potentially for the treatment of solid tumors.Fórmula:C26H24N4O2Cor e Forma:SolidPeso molecular:424.49Thalidomide-O-C4-COOH
CAS:Thalidomide-O-C4-COOH is a synthetic E3 ligase linker derived from Thalidomide for PROTAC tech.Fórmula:C18H18N2O7Cor e Forma:SolidPeso molecular:374.3447Tripchlorolide
Tripchlorolide is a useful organic compound for research related to life sciences and the catalog number is T126047.Fórmula:C20H25ClO6Cor e Forma:SolidPeso molecular:396.86Bromoiodoacetamide
CAS:Bromoiodoacetamide (I-HAcAm): cytotoxic, induces ROS & apoptosis in HepG-2 cells.Fórmula:C2H3BrINOCor e Forma:SolidPeso molecular:263.86eIF4A3-IN-7
CAS:eIF4A3-IN-7: Potent eIF4A3 inhibitor, potential cancer/dysproliferation research (WO2019161345A1, Compound 8).Fórmula:C26H25NO7Cor e Forma:SolidPeso molecular:463.486tetrathiomolybdate
CAS:Tetrathiomolybdate (TM) promotes the dimerization of the metal-binding domain (WLN4) of the cellular copper efflux protein ATP7B through its characteristicFórmula:MoS4Cor e Forma:SolidPeso molecular:224.2Toremifene citrate
CAS:Toremifene citrate is a selective estrogen receptor modulator (SERM). It is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on the mammary and uterine tissue.Fórmula:C32H36ClNO8Pureza:99.83% - >99.99%Cor e Forma:White Or Almost White PowderPeso molecular:598.08Cytostatin
CAS:Cytostatin: Natural antitumor, inhibits cell adhesion, blocks B16 melanoma, induces apoptosis, selectively targets PP2A (IC50 = 29 nM).Fórmula:C21H33O7PCor e Forma:SolidPeso molecular:428.462AKN-028
CAS:AKN-028 is an orally active and potent FLT3 tyrosine kinase inhibitor ( IC 50 = 6 nM). AKN-028 causes dose-dependent inhibition of FLT3 autophosphorylation.
Fórmula:C17H14N6Pureza:99.88%Cor e Forma:SolidPeso molecular:302.33TRAP-1
TRAP-1 (XJZ-06-462) is a p53 transcription activator that effectively activates mutant p53 and triggers the transcription of p53 target genes. In the p53Y220C pancreatic cell line, TRAP-1 rapidly upregulates p21 and other p53 target genes. TRAP-1 also inhibits cell proliferation, exhibiting IC50 values of 3.94 μM and 0.531 μM in BxPC-3 and A549 cell lines, respectively. Additionally, TRAP-1 modulates autophagy in lung cancer cells and provides protection against oxidative stress and apoptosis.Fórmula:C57H66ClF3N11O3PSCor e Forma:SolidPeso molecular:1108.69Beclin1-Bcl-2 interaction inhibitor 1
Beclin1-Bcl-2 Interaction Inhibitor 1 effectively disrupts the binding of Beclin 1 to Bcl-2, and is utilized in cancer and neurodegeneration research [1].Cor e Forma:Odour SolidhMcl-1-IN-1
hMcl-1-IN-1 (Compound 9) is an hMcl-1 inhibitor based on a His224 arylsulfonyl fluoride, displaying an IC50 value of 5.8 nM.Fórmula:C69H113FN20O19SCor e Forma:SolidPeso molecular:1577.82SCR7
CAS:SCR7, a specific DNA Ligase IV inhibitor, blocks nonhomologous end-joining (NHEJ).Fórmula:C18H14N4OSPureza:98%Cor e Forma:SolidPeso molecular:334.4XM-U-14
XM-U-14 is a selective PROTAC USP7 degrader that induces the degradation of USP7 in the RS4;11 cell line with a DC50 of 0.74 nM. This compound elevates the levels of p53 and p21, and significantly inhibits the growth of acute lymphoblastic leukemia (ALL) cells, with IC50 values of 0.5 nM in RS4;11 cells and 8.3 nM in Reh cells. Moreover, XM-U-14 induces apoptosis and cell cycle arrest, and effectively inhibits tumor growth.Cor e Forma:Odour SolidXIAP BIR2/BIR2-3 inhibitor-1
CAS:XIAP BIR2/BIR2-3 inhibitor-1 (compound 3) serves as a potent dual inhibitor targeting BIR2 and BIR2-3 domains, with IC50 values of 1.9 nM and 0.8 nM, respectively. This compound is utilized in cancer research studies [1].Fórmula:C72H96N16O14Cor e Forma:SolidPeso molecular:1409.63Azurin p28 peptide
CAS:Azurin p28 peptide, a tumor-penetrating antitumor agent, stabilizes p53 by reducing its proteasomal degradation via the formation of a p28:p53 complex.
Fórmula:C122H197N31O47S2Cor e Forma:SolidPeso molecular:2914.18Pantoprazole Sodium Hydrate
CAS:Pantoprazole Sodium Hydrate (BY1023 (sodium hydrate)) is a proton pump inhibitor drug, used for short-term treatment of erosion and ulceration of the esophagusFórmula:C16H14F2N3NaO4SH2OPureza:98.32%Cor e Forma:SolidPeso molecular:432.37BMSpep-57
CAS:BMSpep-57: Macrocyclic peptide, inhibits PD-1/PD-L1, IC50=7.68 nM, binds PD-L1 (Kd=19 nM/MST, 19.88 nM/SPR), boosts T cell IL-2 in PBMCs.Fórmula:C89H126N24O19SCor e Forma:SolidPeso molecular:1868.2CDC20-IN-2
CDC20-IN-2 (14c) is an inhibitor of Cdc20 with a KD of 7.65 μM, inducing G2/M phase arrest, promoting DNA damage accumulation, and stabilizing key substrates such as Cyclin B1 and Bim. This leads to enhanced apoptosis, as well as inhibition of tumor cell proliferation and migration.Cor e Forma:Odour SolidFOXO4-DRI
CAS:FOXO4-DRI: a peptide blocking FOXO4/p53 interaction; induces senescent cells' apoptosis.Fórmula:C228H388N86O64Cor e Forma:SolidPeso molecular:5358.06A947
CAS:A947 is a potent and selective SMARCA2 PROTAC that induces the degradation of SMARCA2, with significant antitumor activity in SMARCA4-mutant NSCLC cells.Fórmula:C61H76N12O7SPureza:98.84%Cor e Forma:SolidPeso molecular:1121.4p-MPPF
CAS:p-MPPF is a 5-HT antagonist that can be used to study neurological diseases.Fórmula:C25H27FN4O2Pureza:99.92%Cor e Forma:SolidPeso molecular:434.51CIGB-300
CAS:CIGB-300 (P15-Tat) is an anti-casein kinase 2 (CK2) peptide that exhibits anticancer properties by disrupting the phosphorylation activity of protein kinase CK2. The compound induces apoptosis in various tumor cell lines, making it valuable for research in cancer therapy.Fórmula:C127H215N53O30S3Cor e Forma:SolidPeso molecular:3060.6VEGFR/PARP-IN-1
VEGFR/PARP-IN-1 (Compound 14b) is a dual inhibitor of VEGFR and PARP with IC50 values of 191 nM and 60.9 nM, respectively.Fórmula:C29H27N9OPureza:98%Cor e Forma:SolidPeso molecular:517.58Cannflavin A
CAS:Cannflavin A, isolated from Cannabis sativa L., exhibits anti-cancer, neuroprotective, and anti-inflammatory activities by inhibiting Aβ1-42 aggregation andFórmula:C26H28O6Cor e Forma:SolidPeso molecular:436.5GLP-2(rat)
CAS:intestinal epithelium-specific growth factorFórmula:C166H256N44O56SPureza:98%Cor e Forma:SolidPeso molecular:3796.17Indinavir
CAS:Indinavir is an HIV protease inhibitor,HAART. inhibits the activation of MMP-2 in endothelial cells and exhibits affinity for α7-nAchR and SARS-CoV-2 Mpro.Fórmula:C36H47N5O4Cor e Forma:SolidPeso molecular:613.79GPX4-IN-5
CAS:GPX4-IN-5 is a GPX4 inhibitor with antitumor activity.GPX4-IN-5 induces iron death and may be used for the treatment of triple negative breast cancer.Fórmula:C18H17ClFNO5Pureza:99.58%Cor e Forma:SoildPeso molecular:381.78Ref: TM-T77755
1mg48,00€5mg92,00€1mL*10mM (DMSO)102,00€10mg147,00€25mg243,00€50mg353,00€100mg527,00€200mg750,00€FKBP12 PROTAC dTAG-7
CAS:dTAG-7 selectively degrades BRD4 and FKBP12F36V by linking BET bromodomains to E3 ligase CRBN; it's a heterobifunctional degrader.Fórmula:C63H79N5O19Pureza:98%Cor e Forma:SolidPeso molecular:1210.32BT44
CAS:BT44, a potent second-gen GDNF mimetic, is a lead for treating neurodegeneration.Fórmula:C28H27F4N3O4SPureza:99.87%Cor e Forma:SoildPeso molecular:577.59Ref: TM-T67733
1mg74,00€5mg160,00€1mL*10mM (DMSO)188,00€10mg235,00€25mg424,00€50mg635,00€100mg924,00€RIPK1-IN-30
RIPK1-IN-30 (compound 24) is a potent RIPK1 inhibitor with an IC50 of 2.01 μM. It demonstrates a protective effect in the HT-29 cell model of TSZ-induced necroptosis, with an EC50 of 6.77 μM.Fórmula:C27H25FN2O4Cor e Forma:SolidPeso molecular:460.17984Cot inhibitor-1 hydrochloride
Cot inhibitor-1 hydrochloride blocks TPL-2 kinase (IC50=28nM) and TNF-α synthesis (IC50=5.7nM) in human blood.Fórmula:C27H28Cl3FN8Pureza:98.37%Cor e Forma:SoildPeso molecular:589.92Ref: TM-T10865L
1mg118,00€5mg227,00€1mL*10mM (DMSO)268,00€10mg359,00€25mg598,00€50mg852,00€100mg1.153,00€CALP1
CAS:Cell-permeable CaM agonist; activates phosphodiesterase, binds to Ca2+ channels, inhibits cytotoxicity (IC50=52μM), protects cells, reduces inflammation.Fórmula:C40H75N9O10Pureza:98%Cor e Forma:SolidPeso molecular:842.09PBE-AMF
PBE-AMF is a prodrug that activates H2O2 and exhibits anticancer activity. It impedes tumor proliferation by inhibiting DNA synthesis, reducing ATP levels, inducing cell death (apoptosis), and blocking the cell cycle. PBE-AMF effectively and selectively inhibits the proliferation of MDA-MB-231 cells (IC50=6.4 μM) while sparing non-cancerous MCF-10A cells.Cor e Forma:Odour SolidKdo2-Lipid A ammonium
CAS:Kdo2-Lipid A ammonium (KLA) is a selective and potent TLR4 agonist, a lipopolysaccharide.Kdo2-Lipid A ammonium induces the release of TNF and PGE2.Fórmula:C110H214N6O39P2Pureza:98%Cor e Forma:SolidPeso molecular:2306.84Flavopiridol
CAS:Flavopiridol (Alvocidib) blocks CDK1/2/4/6 by competing with ATP (IC50 ~40 nM); 7.5x selectivity over CDK7; also inhibits EGFR, PKA. In Phase 1/2 trials.Fórmula:C21H20ClNO5Pureza:97.74% - 99.99%Cor e Forma:SolidPeso molecular:401.84UM4118
CAS:UM4118 (N-quinolin-8-ylpyridine-2-carboxamide) is a copper ion carrier used in the study of acute myeloid leukemia.Fórmula:C15H11N3OPureza:99.76%Cor e Forma:SolidPeso molecular:249.27UNC10245380
UNC10245380 is a CIB1 inhibitor with an IC50 of 8 μM. It also inhibits the phosphorylation of AKT and ERK while upregulating the expression of TRAIL-R1/D5. UNC10245380 specifically kills cancer cells that are dependent on CIB1, demonstrating its potential value in the development of CIB1 probes and cancer research.Cor e Forma:Odour SolidVinepidine sulfate
CAS:Vinepidine (LY-119863) sulfate, a derivative of vincristine, exhibits antitumor activity .Fórmula:C46H58N4O13SCor e Forma:SolidPeso molecular:907.04Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2
CAS:Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthetic conjugate compound that combines a Thalidomide-based cereblon ligand and a linker, which is commonly
Fórmula:C25H34N4O9Pureza:98%Cor e Forma:SolidPeso molecular:534.566A011
A011, a potent and selective ataxia-telangiectasia mutated (ATM) inhibitor, exhibits an IC50 of 1.0 nM and triggers apoptosis as well as G2/M phase cell cycleFórmula:C27H28N6OPureza:98%Cor e Forma:SolidPeso molecular:452.55F1324
F1324: potent BCL6 inhibitor, IC50=1nM, binding t1/2=441s, strongly inhibits BCL6 PPI.Fórmula:C83H121N21O20SPureza:98%Cor e Forma:SolidPeso molecular:1765.047-epi-Isogarcinol
CAS:7-epi-Isogarcinol, a PPAP, hinders STAT3 to induce apoptosis and curbs cell migration with moderate antiproliferative effects.Fórmula:C38H50O6Cor e Forma:SolidPeso molecular:602.8PRMT5-IN-33
PRMT5-IN-33 (compound A8) is a selective inhibitor of PRMT5 that competes with SAM, exhibiting an IC50 of 10.9 nM. It induces apoptosis and inhibits the proliferation of Z-138 and MOLM-13 cells, demonstrating antitumor activity.Fórmula:C25H24BrN5O3SPeso molecular:553.07832PD-L1-IN-5
PD-L1-IN-5 (X22) is an orally active PD-L1 inhibitor with an IC50 of 785.6 nM, demonstrating antitumor activity in vivo.RIPK1-IN-22
RIPK1-IN-13 (compound 28) is a selective inhibitor of receptor-interacting serine/threonine-protein kinase 1 (RIPK1), showing a pKi of 7.66 as measured by the ADP-Glo kinase assay. It exhibits inhibitory effects in human leukemia U937 cells with a pIC50 of 7.2.Fórmula:C22H22N4O3SPeso molecular:422.14126Nauclefine
CAS:Nauclefine, a plant alkaloid, triggers cancer cell death through PDE3A-SLFN12, binding but not inhibiting PDE3A.Fórmula:C18H13N3OPureza:99.92%Cor e Forma:SolidPeso molecular:287.32OPBP-1
OPBP-1 is a D-peptide developed through phage display screening, molecular docking, and molecular dynamics simulations. It exhibits high stability, strong antitumor activity, and oral bioavailability. OPBP-1 selectively binds to the PD-L1 protein, significantly blocking the interaction between PD-1 and PD-L1, which helps restore and enhance T lymphocyte function while reducing the proportion of myeloid-derived suppressor cells (MDSCs), counteracting tumor-induced immune evasion. OPBP-1 is applicable for research in cancer immunotherapy.Fórmula:C64H92N20O19SPeso molecular:1476.65683PROTAC GPX4 degrader-2
PROTACGPX4 degrader-2 (compound 18a) is a proteolysis-targeting chimera (PROTAC) that targets the degradation of glutathione peroxidase 4 (GPX4), with a DC50, 48h value of 1.68 μM. It induces the accumulation of lipid peroxides and mitochondrial depolarization, subsequently triggering ferroptosis. Additionally, PROTACGPX4 degrader-2 exhibits antiproliferative activity.Fórmula:C50H61ClN8O9Peso molecular:952.425MX106-4C
MX106-4C is a survivin inhibitor that selectively targets ABCB1-positive colorectal cancer cells. It can work synergistically with Doxorubicin for enhanced anticancer effects or restore Doxorubicin sensitivity in drug-resistant ABCB1 cells.Fórmula:C23H25BrN2O2Peso molecular:440.10994EGFR-PK/JNK-2-IN-1
EGFR-PK/JNK-2-IN-1 (Compound 6c) is a dual inhibitor of EGFR-PK and JNK-2, with IC50 values of 2.7 and 3.0 μM, respectively. It can induce apoptosis and cause cell cycle arrest at various stages. This compound is applicable in cancer research.Fórmula:C22H17ClN4O3SPeso molecular:452.07099Anticancer agent 178
Anticanceragent 178 (compound C2) is a potent anticancer compound. It effectively inhibits the proliferation and metabolic activity of MDA-MB 231 cells, with IC50 values of 1.1 and 4.2 μM, respectively. Additionally, Anticanceragent 178 induces ferroptosis and necroptosis in cells.Fórmula:C32H30ClFeN2O6Peso molecular:629.11418HDAC6-IN-28
HDAC6-IN-28 (compound 10C) is a potent inhibitor of HDAC6 with an IC50 of 261 nM. It significantly induces apoptosis in B16-F10 cells and causes S phase arrest. Additionally, HDAC6-IN-28 effectively increases the expression of acetylated-α-tubulin both in vitro and in vivo.Fórmula:C23H16FN3O2Peso molecular:385.12265Gemcitabine-13C,15N2 hydrochloride
CAS:Gemcitabine-13C,15N2(hydrochloride) is the 13C and 15N labeled version of Gemcitabine hydrochloride. Gemcitabine Hydrochloride (LY 188011 Hydrochloride) functions as a nucleoside antimetabolite analog and antineoplastic agent. It interrupts DNA synthesis and repair, which leads to autophagy and apoptosis in cells.Fórmula:C9H12ClF2N3O4Cor e Forma:SolidPeso molecular:302.64
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