Apoptose
Os inibidores da apoptose são compostos que previnem ou retardam o processo de morte celular programada, conhecido como apoptose. Esses inibidores são vitais no estudo dos mecanismos de sobrevivência celular e são usados para investigar doenças onde a apoptose é desregulada, como câncer, distúrbios neurodegenerativos e doenças autoimunes. Ao modular a apoptose, esses inibidores podem ajudar no desenvolvimento de terapias destinadas a controlar a morte celular. Na CymitQuimica, oferecemos uma ampla seleção de inibidores da apoptose de alta qualidade para apoiar sua pesquisa em biologia celular, oncologia e áreas relacionadas.
Subcategorias de "Apoptose"
- ASK(9 produtos)
- BCL(1 produtos)
- Caspase(154 produtos)
- FOXO1(2 produtos)
- IAP(67 produtos)
- Mdm2(12 produtos)
- PD-1/PD-L1(134 produtos)
- PDK(9 produtos)
- PERK(23 produtos)
- Serina/treonina quinase(17 produtos)
- Survivina(14 produtos)
- TNF(93 produtos)
- c-RET(61 produtos)
- p53(63 produtos)
Exibir 6 mais subcategorias
Foram encontrados 6223 produtos de "Apoptose"
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Antiproliferative agent-27
Antiproliferative Agent-27 (Compound 11) is a notable antiproliferative agent that markedly diminishes tumor cell colony formation and induces apoptosis,Fórmula:C26H40FNO6SPureza:98%Cor e Forma:SolidPeso molecular:513.66Ferroptosis-IN-1
Ferroptosis-IN-1, a diterpene derived from A.Fórmula:C22H34O5Pureza:98%Cor e Forma:SolidPeso molecular:378.5Apoptosis inducer 26
Apoptosisinducer 26 (compound [AgCl(dap2SH)(PPh3)2]) is a mononuclear Ag(I) ligand-based autophagy inducer that exhibits antibacterial and anticancer activities against various bacterial strains and cancer cell lines. This compound facilitates the accumulation of Ag(I) ions in the periphery of bacteria, effectively inhibiting the growth of both Gram-positive (+) and Gram-negative (-) bacteria. Additionally, Apoptosisinducer 26 can intercalate between the base pairs of CT DNA, inducing apoptosis in A549 cells. It also possesses radical scavenging properties, which helps prevent oxidative stress.Fórmula:C40H36AgClN4P2SCor e Forma:SolidPeso molecular:810.07Antitumor agent-112
Antitumor agent-112 (compound 3a) is a potent antitumor agent that induces apoptosis and exhibits cytotoxic activity on A549 cells, with an IC50 value of 91.35Fórmula:C18H17ClN4O2SPureza:98%Cor e Forma:SolidPeso molecular:388.87LS-106
LS-106 is an orally active, effective epidermal growth factor receptor (EGFR) inhibitor displaying antitumor activity both in vitro and in vivo. It inhibits the kinase activities of EGFR19del/T790M/C797S and EGFRL858R/T790M/C797S, with IC50 values of 2.4 nmol/L and 3.1 nmol/L, respectively, demonstrating stronger inhibition than Osimertinib. LS-106 induces cell apoptosis (Apoptosis), suppresses the proliferation of tumor cells carrying EGFR19del/T790M/C797S, and results in significant tumor reduction in a C797S mutant xenograft model.Fórmula:C24H28BrClN5OPCor e Forma:SolidPeso molecular:548.84c-Met/HDAC-IN-4
c-Met/HDAC-IN-4, a dual inhibitor of c-Met/HDAC, exhibits an IC 50 value of 28.92 nM for c-Met. This compound effectively induces G 0 /G 1 phase cell cycle arrest and apoptosis in MDA-MB-231 breast cancer cells. Additionally, c-Met/HDAC-IN-4 suppresses both the proliferation and invasion of breast cancer cell lines.Fórmula:C37H36N8OCor e Forma:SolidPeso molecular:608.73ZX782
ZX782 acts as a GPX4 protein degrader and an inducer of ferroptosis (Ferroptosis), targeting GPX4 for destruction via both the ubiquitin-proteasome system and the autophagy-lysosome pathway. Following the degradation of GPX4 induced by ZX782, there is a significant increase in the accumulation of lipid reactive oxygen species (ROS) in HT1080 cells.Fórmula:C39H48ClN5O8Cor e Forma:SolidPeso molecular:750.28Pyridinium bisretinoid A2E TFA
CAS:Pyridinium bisretinoid A2E (A2E) TFA, a fluorophore derived from retinal pigment epithelium (RPE) lipofuscin, initiates blue-light-induced apoptosis, mediatesFórmula:C44H58F3NO3Pureza:98%Cor e Forma:SolidPeso molecular:705.93ROS inducer 4
Compound TE3, also known as ROS inducer 4, serves as a mitochondrial inhibitor. This compound induces a variety of mitochondria-related physiological alterations in tumors, including mitochondrial fragmentation, intense generation and accumulation of ROS, reduced mitochondrial membrane potential, and lower ATP content. Additionally, it activates ROS-mediated apoptotic signaling within mitochondria.Fórmula:C49H62BrO4PCor e Forma:SolidPeso molecular:825.89TAT-BH4 (Bcl-xL)
TAT-BH4 (Bcl-xL), primarily localized at the mitochondria, inhibits apoptotic cell death.Fórmula:C159H268N58O45Pureza:98%Cor e Forma:SolidPeso molecular:3712.19HDAC-IN-77
HDAC-IN-77 (HL-5s), an HDAC inhibitor, has the capability to induce ferroptosis and suppress the Nrf2/HO-1 signaling pathway. This compound is utilized in cancer research.Fórmula:C22H26N4O2SCor e Forma:SolidPeso molecular:410.53TOFA-Plasmalogen
TOFA-Plasmalogen (compound 1), a derivative of glyceraldehyde, exhibits ferroptosis-inducing properties. This compound promotes lipid peroxidation in cell membranes, leading to cytotoxic effects with an inhibition concentration (IC 50 = 32.87 μM).Fórmula:C33H62NO7PCor e Forma:SolidPeso molecular:615.82fac-[Re(CO)3(L6)(H2O)][NO3]
Compound 6, fac-[Re(CO)3(L6)(H2O)][NO3], a rhenium(I) tricarbonyl aqua complex, serves as an anticancer agent by disrupting mitochondrial function.Fórmula:C24H14N5O7ReSPureza:98%Cor e Forma:SolidPeso molecular:702.67PI3K/AKT-IN-4
PI3K/AKT-IN-4 (compound 3), a diterpenoid extracted from the roots and rhizomes of Salvia castanea Dielsf., exhibits antitumor properties by inhibiting cell viability and proliferation (IC 50 =4.72 μM) and promoting apoptosis in Hep3B cells. This compound obstructs the G0/G1 phase of the cell cycle, triggers mitochondrial dysfunction, and induces oxidative stress. Moreover, PI3K/AKT-IN-4 combats hepatocellular carcinoma through the inhibition of the PI3K-Akt signaling pathway and by interacting with PARP1 and CDK2 targets.Fórmula:C19H26O2Cor e Forma:SolidPeso molecular:286.41GPX4-IN-14
GPX4-IN-14 (compound 2c) acts as a GPX4 inhibitor, exhibiting both free radical scavenging activity (with a maximum scavenging rate of 72.52%) and anti-tumor proliferation activity in vitro. This compound targets GPX4 protein, elevating lipid peroxide and intracellular Reactive Oxygen Species (ROS) levels, which induces ferroptosis and contributes to its anti-tumor proliferation effects.Fórmula:C26H39NO8SeCor e Forma:SolidPeso molecular:572.55Anticancer agent 133
Compound Rh2 (Anticancer agent 133) is a cytotoxic and antimetastatic agent that induces cell cycle arrest, apoptosis, and autophagy.Fórmula:C24H19Cl3N5ORhPureza:98%Cor e Forma:SolidPeso molecular:602.71GBM CSCs-IN-1
GBM CSCs-IN-1 (Compound (−)-20), a rocaglate derivative, potently inhibits glioblastoma stem cells (GBM CSCs) and exhibits an EC50 of 45 nM by targeting the RNA helicase DDX3. Additionally, it induces apoptosis in these cells.Fórmula:C28H29BrN2O8SCor e Forma:SolidPeso molecular:633.51Antitumor photosensitizer-8
Antitumor agent-187 (compound I3), a photosensitizer derived from 5,15-diarylporphyrin, exhibits anticancer activity with a peak absorption wavelength of ~668 nm. This compound induces apoptosis and is applicable in photodynamic therapy (PDP). It selectively accumulates in tumor sites and possesses real-time fluorescence imaging capabilities.Fórmula:C52H34N4O6Cor e Forma:SolidPeso molecular:810.85BTK-IN-37
BTK-IN-37 (compound 8d), a BTK inhibitor, demonstrates potent apoptotic effects on cancer cells by targeting BTK with K_i and IC_50 values of 5.07 nM and 3.6 nM, respectively. Additionally, this compound selectively promotes the enrichment of genes associated with necroptosis and pyroptosis.Fórmula:C29H29N9O4SCor e Forma:SolidPeso molecular:599.66Antimycin A2c
Anticancer Agent 141 (Compound AE), an antimycin alkaloid, exhibits inhibitory potential against HPV-infected cervical cancer.Fórmula:C28H40N2O9Pureza:98%Cor e Forma:SolidPeso molecular:548.63A-1208746
CAS:A-1208746 is an inhibitor of MCL-1 with a Ki value of 0.454 nM. This compound effectively activates caspase-3/-7, induces apoptosis in H929 cells, and reduces mitochondrial membrane potential. Additionally, A-1208746 synergizes with Navitoclax, making it applicable in cancer research.Fórmula:C45H52N6O7SCor e Forma:SolidPeso molecular:821Ferroptosis-IN-3
Ferroptosis-IN-3 (Compound 25), a ferroptosis inhibitor, demonstrates potent activity by inhibiting RSL3-induced ferroptosis in HT-1080 cells (EC50: 8.6 nM).Pureza:98%Cor e Forma:Odour SolidhCAIX/XII-IN-13
hCAIX/XII-IN-13 functions as an inhibitor targeting specific human carbonic anhydrases (hCA) IX and XII, crucial in tumor-related processes. Demonstrating efficacy, this compound offers inhibitory K i values of 0.08 µM for IX and 0.06 µM for XII. Additionally, under hypoxic conditions, hCAIX/XII-IN-13 enhances the effectiveness of Doxorubicin on MCF-7 cells by promoting G2/M phase cell cycle arrest and increasing apoptosis.Fórmula:C25H16N6O6SCor e Forma:SolidPeso molecular:528.5Caerin 1.1 TFA
Caerin 1.1 TFA, a host defense peptide derived from the Australian tree frog Litoria's glandular secretions, exhibits anti-proliferative effects on HeLa cellsPureza:98%Cor e Forma:Odour Solid1-Methyl-1H-pyrrolo[2,3-b]pyridine
CAS:1-Methyl-1H-pyrrolo[2,3-b]pyridine exhibits cytotoxicity against MCF-7 cells and can be used in related research in the field of life sciences.Fórmula:C8H8N2Pureza:98.89%Cor e Forma:SolidPeso molecular:132.16Anti-inflammatory agent 45
Compound 2v (Anti-inflammatory agent 45) demonstrates anticancer properties with direct inhibitory impacts on the proliferation of various blood malignancies,Fórmula:C25H22BrNO6Pureza:98%Cor e Forma:SolidPeso molecular:512.35BAY 1892005
CAS:BAY 1892005 is a p53 protein modulator that targets the p53 condenser for the study of diseases associated with misfolded p53 proteinFórmula:C11H8ClFN2OSPureza:99.42%Cor e Forma:SoildPeso molecular:270.71AEG 3482
CAS:AEG 3482 blocks JNK, induces HSP70, binds HSP90, and boosts HSP25 expression, preventing cell death.
Fórmula:C10H8N4O2S2Pureza:99.76%Cor e Forma:SolidPeso molecular:280.33p53-Mdm2 inhibitor 4
CAS:p53-Mdm2 inhibitor 4 inhibits the p53-MDM2 protein-protein interaction.Fórmula:C23H20FN3O3Pureza:98.66%Cor e Forma:SoildPeso molecular:405.42Furazolidone
CAS:Furazolidone (Furoxone), a nitrofuran derivative, inhibits AML1-ETO transformed cells with IC50 value of 12.7 μM.Fórmula:C8H7N3O5Pureza:99.96%Cor e Forma:Yellow Crystals From Dmf (N N-Dimethylformamide) SolidPeso molecular:225.16DB2313
CAS:DB2313 is a potent PU.1 inhibitor (IC50=14 nM) that disrupts gene binding, induces AML cell apoptosis, and has anticancer properties.
Fórmula:C42H41FN8O2Pureza:98.63% - 99.29%Cor e Forma:SolidPeso molecular:708.83Oligomycin B
CAS:Oligomycin B is an antibiotic isolated from marine Streptomyces, is an eukaryotic ATP synthase inhibitor, induces apoptosis.Fórmula:C45H72O12Pureza:98%Cor e Forma:SolidPeso molecular:805.05Thymidine 3',5'-disphosphate
CAS:pdTp is a highly selective, small-molecule miRNA regulatory complex RISC subunit SND1 inhibitor.Fórmula:C10H16N2O11P2Cor e Forma:SolidPeso molecular:402.19TS-24
CAS:TS-24 is a cysteine protease histone S (CTSS) inhibitor that promotes BRCA1-mediated apoptosis.
Fórmula:C20H15NO2Pureza:99.41%Cor e Forma:SoildPeso molecular:301.34BK60106
BK60106 is a selective and direct inhibitor of the transmembrane protein CD99, which causes cell death in Ewing Sarcoma cells.Fórmula:C15H15FN6O3Pureza:99.30% - >99.99%Cor e Forma:SolidPeso molecular:346.32MS1943
CAS:MS1943 is a orally bioavailable EZH2 selective degrader(IC50 of 120 nM).Fórmula:C42H54N8O3Pureza:95.41% - 95.82%Cor e Forma:SolidPeso molecular:718.93Ref: TM-T13780
1mg39,00€2mg52,00€5mg84,00€1mL*10mM (DMSO)120,00€10mg130,00€25mg250,00€50mg439,00€100mg802,00€200mg1.324,00€5-LOX-IN-2
CAS:5-LOX-in-2: a 5-lipoxygenase inhibitor with IC50 of 0.33 μM, reduces kidney cancer cell activity, induces apoptosis.Fórmula:C17H16O4Pureza:98.74%Cor e Forma:SoildPeso molecular:284.31Endoplasmic Reticulum Stress Compound Library
A unique collection of 193 endoplasmic reticulum stress (ER stress) related compounds used for high throughput screening (HTS) and high content screening (HCS);Cor e Forma:Odour SolidRef: TM-L9700
1mgA consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarApoptosis Compound Library
A unique collection of 1760 apoptosis-related compounds for apoptosis research, research in tumorigenesis, and anti-cancer drug screening;Cor e Forma:Odour SolidRef: TM-L9000
1mgA consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarRagifilimab
CAS:Ragifilimab (INCAGN-1876), a GITR-targeting agonist antibody, may treat advanced solid tumors.
Pureza:SDS-PAGE:95% SEC-HPLC:99.99%Cor e Forma:LiquidPeso molecular:146.46 kDa1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(7-(1-methyl-1H-pyrazol-4-yl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl)urea
CAS:1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(7-(1-methyl-1H-pyrazol-4-yl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl)urea 是一种能够激动 TNF-α的化合物，可以诱导细胞分泌 TNF-α。Fórmula:C24H21ClF3N5OPureza:98.37% - 98.57%Cor e Forma:SoildPeso molecular:487.9CWI1-2
CAS:CWI1-2 is a potent IGF2BP2 inhibitor that inhibits its interaction with M6A-modified target transcripts by binding IGF2BP2.Fórmula:C22H17Cl3N6O3Pureza:98.27%Cor e Forma:SoildPeso molecular:519.77Anti-inflammatory agent 35
CAS:Anti-inflammatory agent 35 is a potent anti-inflammatory agent.Fórmula:C27H29NO8Pureza:99.98%Cor e Forma:SoildPeso molecular:495.52Enpp/Carbonic anhydrase-IN-2
CAS:Enpp/Carbonic anhydrase-IN-2 is a potent dual inhibitor of Enpp and carbonic anhydrase, inhibiting NPP1, NPP2, NPP3, CA-IX, CA-XII, with IC50 values of 1.13, 1.Fórmula:C23H24FNO4SPureza:99.46%Cor e Forma:SoildPeso molecular:429.5Ref: TM-T77631
1mg44,00€5mg90,00€1mL*10mM (DMSO)96,00€10mg145,00€25mg236,00€50mg338,00€100mg460,00€200mg622,00€TNF-α-IN-9
CAS:TNF-α-IN-9 is an NDM-1 inhibitor-3 analog and is a TNF-α inhibitor.TNF-α-IN-9 shows low inhibitory activity.Fórmula:C17H14O4Pureza:99.21%Cor e Forma:SoildPeso molecular:282.29CLEFMA
CAS:CLEFMA has anti-proliferative activity. CLEFMA inhibits tumor growth associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects.Fórmula:C23H17Cl2NO4Pureza:99.00%Cor e Forma:SolidPeso molecular:442.29Ref: TM-T9582
1mg64,00€5mg131,00€1mL*10mM (DMSO)149,00€10mg188,00€25mg299,00€50mg427,00€100mg575,00€200mg750,00€Cathepsin B
CAS:Cathepsin B, a cysteine protease located within the subcellular endosomes and lysosomal compartments, mediates apoptosis and can be used in cancer research.Cor e Forma:SolidPROTAC 20S proteasome subunit β5 degrader 1
PROTAC 20S proteasome subunit β5 degrader 1 (compound 12f) serves as a targeted degrader of the 20S proteasome subunit β5, exhibiting a DC50 value of 0.11 μM in FaDu cells. This compound disrupts the cell cycle and promotes apoptosis (apoptosis), while inhibiting cell proliferation and migration in both FaDu and KM3/BTZ cells. It is applicable for research into resistance to Bortezomib in pharyngeal carcinoma and multiple myeloma.Cor e Forma:Odour SolidEGFR/VEGFR2-IN-1
EGFR/VEGFR2-IN-1 (Compound 10e) serves as an inhibitor for VEGFR-2 and EGFR, with respective IC50 values of 0.26 and 0.14 μM. It inhibits microtubule protein polymerization with an IC50 of 40.9 μM and induces cell apoptosis (Apoptosis). EGFR/VEGFR2-IN-1 is applicable in research related to anti-leukemia and anti-lymphoma treatments.Cor e Forma:Odour SolidPQ401
CAS:PQ401 (IGF-1R Inhibitor II) suppresses autophosphorylation of IGF-1R domain(IC50<1 μM).Fórmula:C18H16ClN3O2Pureza:99.77%Cor e Forma:SolidPeso molecular:341.79FLT3/HDAC-IN-1
FLT3/HDAC-IN-1 is a dual inhibitor targeting FLT3 and HDAC, with IC50 values of 30.4 nM for FLT3 and 52.4, 14.7 nM for HDAC1/3, respectively. It induces apoptosis in MV-4-11 cells and exhibits antiproliferative effects against BaF3 cells transformed by FLT3 mutations. FLT3/HDAC-IN-1 is useful for research on refractory solid tumors and hematological malignancies.Cor e Forma:Odour SolidKSRP-IN-1
KSRP-IN-1 (compound 8) acts as an inhibitor of KSRP, inducing cell cycle arrest and apoptosis (Apoptosis). This compound demonstrates antitumor activity.Cor e Forma:Odour SolidFA4-Cu
FA4-Cu is a compound formed from the effective pancreatic cancer inhibitor FA4 and Cu(II), which can induce apoptosis by triggering ER and mitochondrial stress.Fórmula:C27H33Cl2CuN5O2SCor e Forma:SolidPeso molecular:626.1Δ8-Tetrahydrocannabinoquinone
CAS:Δ8-Tetrahydrocannabinoquinone (HU-336) is a potent anti-angiogenic agent that inhibits angiogenesis by directly inducing apoptosis in vascular endothelial cells. It achieves this without altering the expression of pro-angiogenic and anti-angiogenic cytokines and receptors. Δ8-Tetrahydrocannabinoquinone also shows significant effectiveness against tumor xenografts in nude mice.Fórmula:C21H28O3Cor e Forma:SolidPeso molecular:328.45Ferroptosis inducer-6
CAS:Ferroptosisinducer 6 (6d) is an inducer of ferroptosis (ferroptosis) that exhibits potent potential for Type I/II photodynamic therapy by inducing ROS production, oxidative stress, and mitochondrial damage. Additionally, it demonstrates antitumor activity.Fórmula:C69H78F12N12P2RuCor e Forma:SolidPeso molecular:1466.44iNOs-IN-5
iNOs-IN-5 (Compound BN-4) is an inhibitor of iNOS with an IC50 value of 0.1707 μM, effectively reducing NO expression in RAW264.7 cells stimulated by LPS (HT-D1056). It further diminishes the expression of ROS and lactate dehydrogenase induced by hypoxic injury, displaying anti-necrotic and anti-apoptotic properties. In an SD rat model, iNOs-IN-5 exhibits neuroprotective effects against cerebral ischemia and is capable of crossing the blood-brain barrier.Cor e Forma:Odour SolidhCAIX-IN-23
hCAIX-IN-23 (Compound 27) is a human carbonic anhydrase (hCA) inhibitor with Ki values of 10.4 nM for hCA IX and 8.5 nM for hCA XII. It not only inhibits hCA activity but also releases NO, exerting dual anti-tumor effects. By reducing the expression of hCA IX and iron regulatory proteins, hCAIX-IN-23 regulates mitochondrial caspase activity and the ferroptosis pathway, thereby inducing apoptosis. This compound is utilized in research focused on renal cancer.Cor e Forma:Odour SolidPROTAC Mcl1 degrader-1
CAS:PROTAC Mcl1 degrader-1 is a Cereblon ligand-based targeted chimeric protein degrader (PROTAC) and an Mcl-1 inhibitor, useful in cancer research.Fórmula:C45H45BrN6O8SPureza:98.74%Cor e Forma:SolidPeso molecular:909.84EGFR-IN-151
EGFR-IN-151 (Compound 10) inhibits EGFR and its downstream signaling pathways ERK/STAT3. It effectively suppresses the proliferation of various lung cancer cells, with IC50 values of 11.7, 5.19, 7.32, and 1.53 μM for NCI-H1781, HCC827, NCI-H3255, and NCI-H1975, respectively. Additionally, EGFR-IN-151 hinders colony formation and cell migration in H1975, induces G1 phase cell cycle arrest, and triggers apoptosis in H1975 cells.Cor e Forma:Odour SolidUSP7-IN-9
USP7-IN-9 is a potent USP7 inhibitor (IC50 = 40.8 nM), induces apoptosis, arrests RS4;11 cells, and modulates key oncoproteins.Fórmula:C32H33ClF6N6O8Cor e Forma:SolidPeso molecular:779.08Maceneolignan A
CAS:Maceneolignan A, a natural product isolated from the aril of Myristica fragrans (Myristicaceae), inhibits β-hexosaminidase release in RBL-2H3 cells, exhibitingFórmula:C21H24O5Cor e Forma:SolidPeso molecular:356.41DB818 dihydrochloride
DB818 dihydrochloride is the dihydrochloride salt form of DB818. It acts as an inhibitor of Homeobox A9 (HOXA9). By reducing the formation of the HOXA9-DNA complex, DB818 dihydrochloride inhibits the growth of AML cell lines OCI/AML3, MV4-11, and THP-1 and induces cell apoptosis (apoptosis).Cor e Forma:Odour Solidp53 and MDM2 proteins-interaction-inhibitor dihydrochloride
p53 and MDM2 proteins-interaction-inhibitor dihydrochloride is a interaction inhibitor between p53 and MDM2 proteins.Fórmula:C40H51Cl4N5O4Pureza:98%Cor e Forma:SolidPeso molecular:807.68CDK-IN-14
CDK-IN-14 (B34) is a CDK2 inhibitor (IC50=0.097 μM) that exhibits anti-hepatocellular carcinoma activity. It inhibits the cell cycle in HepG-2 cancer cells and induces apoptosis (apoptosis) through a caspase-mediated mechanism.Cor e Forma:Odour SolidCDK/HDAC-IN-4
CDK/HDAC-IN-4 is a highly selective dual inhibitor of cyclin-dependent kinase (CDK) and histone deacetylase (HDAC), with IC50 values of 88.4 nM and 168.9 nM, respectively. This compound exhibits antiproliferative effects in both hematologic and solid tumor cells. Additionally, CDK/HDAC-IN-4 induces apoptosis and S-phase cell cycle arrest in MV-4-11 cells. It has also demonstrated significant antitumor efficacy in an MV-4-11 xenograft model.Cor e Forma:Odour SolidBcl-2-IN-22
Bcl-2-IN-22 (compound 1), a gold (I) NHC complex, exhibits anticancer activity. It induces cell death (apoptosis) via the mitochondrial pathway with an IC50 value of 0.014 μM. Additionally, Bcl-2-IN-22 targets members of the BCL-2 family, promoting apoptosis and sensitization in multidrug-resistant leukemia cells overexpressing BCL-2.Cor e Forma:Odour SolidCV-4-26
CV-4-26 (Compound 22) acts as a covalent inhibitor of TEAD. By inhibiting YAP/TEAD-driven transcription, it diminishes the expression of CTGF and CYR61. Furthermore, CV-4-26 impedes colony formation in Huh7 and HepG2 cells, inducing cell cycle arrest and apoptosis (apoptosis). This compound demonstrates anti-tumoral activity against hepatocellular carcinoma (HCC) and hepatoblastoma (HB).Cor e Forma:Odour SolidPomalidomide-C5-Dovitinib
CAS:Pomalidomide-C5-Dovitinib (compound 2) is a PROTAC that links Pomalidomide and Dovitinib via a CRBN connector, exhibiting potent antiproliferative activity inFórmula:C39H38FN9O6Pureza:98%Cor e Forma:SolidPeso molecular:747.77TNF-α (31-45), human
CAS:TNF-α (31-45), human is a peptide of tumor necrosis factor-α.Fórmula:C69H122N26O22Pureza:98%Cor e Forma:SolidPeso molecular:1667.895MitoTam bromide, hydrobromide
CAS:MitoTam bromide hydrobromide is an electron transport chain (ETC) inhibitor.Fórmula:C52H60Br2NOPPureza:98%Cor e Forma:SolidPeso molecular:905.821-Alaninechlamydocin
CAS:1-Alaninechlamydocin, a fungal metabolite from Tolypocladium sp., inhibits HDACs and reduces cell proliferation with GI50s 5.3-14 nM.
Fórmula:C27H36N4O6Cor e Forma:SolidPeso molecular:512.607TV 3279
CAS:TV 3279 is a ChE-MAI inhibitor with neuroprotection via anti-apoptotic protein induction and blocks pro-apoptotic enzymes in cells.
Fórmula:C16H20N2O2Pureza:97%Cor e Forma:SoildPeso molecular:272.34SFI003
CAS:SFI003 is a novel SRSF3 inhibitor that exerts anticancer activity against colorectal cancer by modulating the SRSF3 / DHCR24 / ROS axis and driving apoptosis inFórmula:C19H17N5OSPureza:99.44%Cor e Forma:SoildPeso molecular:363.44Ref: TM-T72068
1mg75,00€5mg164,00€1mL*10mM (DMSO)172,00€10mg255,00€25mg495,00€50mg712,00€100mg973,00€200mg1.341,00€RIPK1-IN-17
CAS:RIPK1-IN-17 is a dual inhibitor of RIPK1 and RIPK3 inhibits necrosis by inhibiting phosphorylation of RIPK1, RIPK3 and MLKL,in a tnf-induced inflammation model.Fórmula:C26H19F4N3O3SPureza:95.22%Cor e Forma:SolidPeso molecular:529.51Tubulin/AKT1-IN-1
Tubulin/AKT1-IN-1 (Compound D1-1) serves as an inhibitor of both tubulin polymerization and AKT pathway activation, effectively suppressing proliferation andFórmula:C38H34ClNO11Pureza:98%Cor e Forma:SolidPeso molecular:716.13FPR1 antagonist 1
Compound 24a, an FPR1 antagonist, demonstrates potent inhibition of the formyl peptide receptor 1 (FPR1) with an IC50 value of 25 nM.Fórmula:C25H28O5Cor e Forma:SolidPeso molecular:408.49Ferroptosis-IN-12
Ferroptosis-IN-12 (Cpd-A1) is an inhibitor of ferroptosis. It effectively suppresses ferroptosis in mouse renal tubular epithelial cells (mTECs) treated with Erastin and improves renal function in dose-dependent manners in mouse models of acute kidney injury (AKI) induced by ischemia/reperfusion (I/R) or cecal ligation and puncture (CLP). This compound also reduces renal tubular damage and eliminates inflammation. Exhibiting good plasma stability and high distribution in renal tissues during pharmacokinetic studies in mice, Ferroptosis-IN-12 shows promising potential for research in the field of AKI.Cor e Forma:Odour SolidARD-61
CAS:ARD-61: potent PROTAC, degrades AR/PR in AR+ cancers, triggers apoptosis, inhibits tumor growth in mice.Fórmula:C61H71ClN8O7SCor e Forma:SolidPeso molecular:1095.8PARP1/BRD4-IN-3
PARP1/BRD4-IN-3 (compound HF4) is an effective inhibitor of BRD4 and PARP1, with IC50 values of 1210 nM and 2019 nM respectively. The compound exhibits antiproliferative activity, induces apoptosis (apoptosis) and cell cycle arrest at the G0/G1 phase. Additionally, PARP1/BRD4-IN-3 causes DNA damage and reduces the expression of the Rad51 protein, demonstrating anti-tumor activity.Cor e Forma:Odour Solid84-B10
CAS:84-B10 provides protection in cisplatin-induced acute kidney injury, reversing lipid peroxidation accumulation and downregulation of key ferroptosis inhibitors.Fórmula:C25H22F3NO5Pureza:99.76%Cor e Forma:SolidPeso molecular:473.44Ref: TM-T75268
1mg47,00€5mg92,00€1mL*10mM (DMSO)92,00€10mg152,00€25mg289,00€50mg447,00€100mg670,00€200mg888,00€Photosensitizer-6
CAS:Photosensitizer-6 (Compound 4) is a metal ion complex that inhibits TrxR. It induces apoptosis in 4T1 cells, targeting cancer cells and eliminating tumors through chemophototherapy and immunogenic cell death under illumination. Additionally, Photosensitizer-6 can be utilized for tumor imaging.Fórmula:C47H35AuF6N4P2SCor e Forma:SolidPeso molecular:1060.78MS41
CAS:MS41 is a selective eleven-nineteen leukemia (ENL) PROTAC degrader, with DC50s values of 3.50 nM (MV4;11), 2.84 nM (SEMK2), 3.03 nM (Jurkat), and 26.58 nM (KASUMI1). This compound effectively inhibits the growth of ENL-dependent leukemia cells, induces G1 cell cycle arrest, and increases cellular apoptosis (Apoptosis). Additionally, MS41 reduces chromatin occupancy related to ENL-mediated transcription elongation mechanisms and suppresses the expression of oncogenes and the progression of leukemia.Fórmula:C56H70N8O9SCor e Forma:SolidPeso molecular:1031.27JC2-11
CAS:JC2-11 is an anti-inflammatory agent blocking NLRC 4, AIM 2, ROS production, caspase-1 activity, and reducing GSDMD, IL-1β, and LDH in vesicles.
Fórmula:C17H15FO4Pureza:98.6%Cor e Forma:SoildPeso molecular:302.3Prodigiosin hydrochloride
CAS:Prodigiosin hydrochloride is a bioactive red pigment from bacteria with antibacterial, antifungal, anticancer properties, and inhibits Wnt/β-catenin.Fórmula:C20H26ClN3OCor e Forma:SolidPeso molecular:359.9Anticancer agent 272
Anticanceragent 272 (Compound 2) is an anticancer agent demonstrating significant activity against bladder cancer cells (T-24) with an IC50 of 2.81 μM. It depletes glutathione (GSH) through a Fenton-like reaction, generating reactive oxygen species (ROS) and hydroxyl radicals (•OH), thereby inducing apoptosis and ferroptosis. Anticanceragent 272 enhances chemodynamic therapy (CDT) and promotes tumor cell death through mitochondrial dysfunction and autophagy. It holds potential for further research in bladder cancer.Fórmula:C26H34Br2Cl4Cu2N8Cor e Forma:SolidPeso molecular:881.86192Arisostatin A
CAS:Arisostatin A is a secondary metabolite produced by microorganisms, recognized as an antibiotic (antibiotic) with activity against Gram-positive bacteria. This compound also exhibits potent antitumor properties. It induces apoptosis (apoptosis) by activating caspase-3 and generating reactive oxygen species (ROS) in AMC-HN-4 cells.Fórmula:C69H100N2O24Cor e Forma:SolidPeso molecular:1341.53HSP90-IN-18
HSP90-IN-18 inhibits Hsp90 with 0.39 μM IC50, useful for viral, neurodegenerative, and inflammatory research.Fórmula:C25H33FO3Cor e Forma:SolidPeso molecular:400.53GPX4-IN-6
CAS:GPX4-IN-6 is a GPX4 inhibitor with antitumor activity.GPX4-IN-6 induces iron death and is used for the treatment and prevention of triple-negative breast cancerFórmula:C18H17BrFNO5Pureza:99.54%Cor e Forma:SoildPeso molecular:426.23MDMX/MDM2-IN-2
MDMX/MDM2-IN-2 is a potent dual inhibitor of p53-MDM2/MDMX, demonstrating dissociation constants (Kis) of 0.23 μM for MDM2 and 2.45 μM for MDMX.Fórmula:C28H25Cl3FN3O3Cor e Forma:SolidPeso molecular:576.87TG101209 analog 1
TG101209 analog 1 (Compound 8h) serves as an inhibitor of BUB1B, exhibiting an IC50 of 10.36 μM. It also possesses cytotoxic properties, demonstrated by an IC50 of 1.347 μM against Caki-1 cells, and can induce necrosis and apoptosis.Fórmula:C24H31N5O5SCor e Forma:SolidPeso molecular:501.598RIPK2-IN-2
CAS:RIPK2-IN-2, a RIP2 kinase PROTAC inhibitor, blocks proinflammatory signaling in autoinflammatory diseases.Fórmula:C53H65FN14O7S2Cor e Forma:SolidPeso molecular:1093.3P53/TLR2 modulator-1
P53/TLR2 modulator-1 (Compound Z9) is an agent that targets both the P53 pathway and TLR2, exhibiting radioprotective properties. It mitigates apoptosis by inhibiting radiation-induced expression of P53 and Bax. Concurrently, it enhances the TLR2 pathway by upregulating downstream proteins MyD88 and P65, which promotes secretion of cytokines like IL-6, providing radioprotective effects. P53/TLR2 modulator-1 shows significant radioprotective activity in AHH-1 and HUVECs cells, enhances survival rates in C57BL/6J mice exposed to lethal radiation doses, and alleviates radiation-induced damage to their hematopoietic system, intestinal villi, and spleen. It is applicable for research on radiation-related diseases.Cor e Forma:Odour SolidPhotosensitizer-3
CAS:Photosensitizer-3, generates single-linear oxygen upon near-infrared light excitation in combination with FAP,potent and selective killing cancer cells.Fórmula:C29H33ClI2N2O3Pureza:99.61%Cor e Forma:SolidPeso molecular:746.85UCM-1336
CAS:UCM-1336 (3,3′-(Octylimino)bis[N-phenylpropanamide]) is a potent ICMT inhibitor with an IC50 of 2 μM which is selective against the other enzymes involved inFórmula:C26H37N3O2Pureza:98.86%Cor e Forma:SolidPeso molecular:423.59RO7567132
RO7567132 is a bispecific antibody that binds and agonizes LTBR bivalently while binds and antagonizes FAP monovalently, inducing the formation of local TLS.Cor e Forma:Odour LiquidNTR 368
CAS:cytoplasmic peptide of the neurotrophin receptor p75NTRFórmula:C69H124N22O19Pureza:98%Cor e Forma:SolidPeso molecular:1565.86anti-TNBC agent-1
CAS:anti-TNBC agent-1 targets TNBC effectively, with IC50 of 0.20-0.27 μM, inducing apoptosis and G1 arrest in SUM-159 cells.Fórmula:C26H30O7Cor e Forma:SolidPeso molecular:454.51MPT0B014
CAS:MPT0B014 is a potent tubulin polymerization inhibitor. MPT0B014 can induce cancer cell apoptosis.
Fórmula:C19H17NO4Pureza:99.52%Cor e Forma:SolidPeso molecular:323.34Calphostin C
CAS:Calphostin C is a protein kinase C inhibitor.Fórmula:C44H38O14Pureza:98%Cor e Forma:Red To Brown PowderPeso molecular:790.76Ac-LEHD-AMC
CAS:Ac-LEHD-AMC, a fluorogenic caspase-9 substrate, releases fluorescent AMC upon cleavage, aiding caspase-9 activity measurement.Fórmula:C33H41N7O11Cor e Forma:SolidPeso molecular:711.729
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