Apoptose
Os inibidores da apoptose são compostos que previnem ou retardam o processo de morte celular programada, conhecido como apoptose. Esses inibidores são vitais no estudo dos mecanismos de sobrevivência celular e são usados para investigar doenças onde a apoptose é desregulada, como câncer, distúrbios neurodegenerativos e doenças autoimunes. Ao modular a apoptose, esses inibidores podem ajudar no desenvolvimento de terapias destinadas a controlar a morte celular. Na CymitQuimica, oferecemos uma ampla seleção de inibidores da apoptose de alta qualidade para apoiar sua pesquisa em biologia celular, oncologia e áreas relacionadas.
Subcategorias de "Apoptose"
- ASK(9 produtos)
- BCL(1 produtos)
- Caspase(154 produtos)
- FOXO1(2 produtos)
- IAP(67 produtos)
- Mdm2(12 produtos)
- PD-1/PD-L1(134 produtos)
- PDK(9 produtos)
- PERK(23 produtos)
- Serina/treonina quinase(17 produtos)
- Survivina(14 produtos)
- TNF(93 produtos)
- c-RET(61 produtos)
- p53(63 produtos)
Exibir 6 mais subcategorias
Foram encontrados 6223 produtos de "Apoptose"
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Thalidomide-NH-C8-NH2 hydrochloride
CAS:Thalidomide-based E3 ligase ligand-linker for PROTAC, with cereblon ligand and C8-NH2 hydrochloride.Fórmula:C21H29ClN4O4Cor e Forma:SolidPeso molecular:436.94RAR/RXR agonist-1
Compound 7, also known as RAR/RXR agonist-1, is a chlorinated isomer of retinoic acid and acts as a selective RARα agonist and a partial RXRα agonist. It is capable of activating RXRα, thereby inducing G2/M arrest and apoptosis in cancer cells.Fórmula:C25H27ClO3Cor e Forma:SolidPeso molecular:410.93p53 and MDM2 proteins-interaction-inhibitor dihydrochloride
p53 and MDM2 proteins-interaction-inhibitor dihydrochloride is a interaction inhibitor between p53 and MDM2 proteins.Fórmula:C40H51Cl4N5O4Pureza:98%Cor e Forma:SolidPeso molecular:807.68Thalidomide-O-PEG4-amine
CAS:Thalidomide-O-PEG4-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].Fórmula:C23H31N3O9Pureza:98%Cor e Forma:SolidPeso molecular:493.51Theophyllol
CAS:Theophyllol (theophylline sodium acetate) can alter calcium levels in subcellular fractions of rat brain cortex.Fórmula:C9H10N4Na2O4Cor e Forma:SolidPeso molecular:284.18DAPK Substrate Peptide TFA
DAPK Substrate Peptide TFA is a synthetic peptide that serves as a substrate for the enzyme death-associated protein kinase (DAPK), exhibiting a MichaelisFórmula:C72H116F3N25O19Cor e Forma:SolidPeso molecular:1692.84BWA-522
BWA-522 is a small molecule, orally available protein-targeting chimera (PROTAC) that potentates the degradation of both full-length androgen receptor (AR-FL)Fórmula:C43H51ClN4O7Pureza:98%Cor e Forma:SolidPeso molecular:771.34Anti-inflammatory agent 95
Anti-inflammatory agent 95 (Compound 2e) is a compound with potent anti-inflammatory properties, showing significant inhibition of NO production in LPS-induced RAW 264.7 mouse macrophages, with an IC50 of 8.8 μM. It also effectively suppresses the secretion of TNF-α and IL-1β, achieving inhibition rates of 60% and greater than 90% at 100 μM, respectively. Anti-inflammatory agent 95 holds promise for research into inflammatory diseases.Fórmula:C16H21NO4Cor e Forma:SolidPeso molecular:291.34EPZ020411 hydrochloride
CAS:EPZ020411 hydrochloride is a selective and potent small molecule PRMT6 inhibitor with an IC50 value of 10 nM.Fórmula:C25H39ClN4O3Pureza:99.88%Cor e Forma:SolidPeso molecular:479.05Ref: TM-T22325
1mg57,00€5mg124,00€1mL*10mM (DMSO)138,00€10mg203,00€25mg350,00€50mg533,00€100mg763,00€FOXO4-DRI
CAS:FOXO4-DRI: a peptide blocking FOXO4/p53 interaction; induces senescent cells' apoptosis.Fórmula:C228H388N86O64Cor e Forma:SolidPeso molecular:5358.06Camrelizumab
CAS:Camrelizumab (SHR-1210) is a human IgG4-κ monoclonal antibody with high affinity and directed against PD-1.Camrelizumab binds PD-1 with a binding affinity of up
Pureza:95% - 98.6%Cor e Forma:LiquidPeso molecular:143.7 kDaHDSI-18
HDSI-18 is an orally active selective inhibitor of HDAC6 with an IC50 of 1.6 nM. It exhibits cytotoxic effects against K562, MV4-11, MOLM-13, THP-1, and Jurkat cells with IC50 values of 0.48, 0.58, 0.91, 1.79, and 4.31 μM, respectively. HDSI-18 can activate Caspase-3, induce mitochondrial depolarization, and trigger apoptosis (Apoptosis), demonstrating antitumor activity.Fórmula:C28H28N4O5Cor e Forma:SolidPeso molecular:500.20597BRD4 Inhibitor-38
BRD4 Inhibitor-38 (Compound 25) is an orally active BRD4 inhibitor, exhibiting IC50 values of 3.64 μM for BRD4 BD1 and 0.12 μM for BRD4 BD2. It also demonstrates anti-inflammatory properties, with an IC50 value of 1.98 μM for nitric oxide (NO) production.Fórmula:C19H18N2O4Cor e Forma:SolidPeso molecular:338.357VEGFR-2-IN-64
VEGFR-2-IN-64 (Compound 28) is an inhibitor of VEGFR2 with an IC50 of 27.8 nM. It suppresses the proliferation of cancer cells A549, T-47D, and Caco-2, exhibits anti-migration and anti-colony formation activities in T-47D cells, and induces apoptosis in T-47D cells.Fórmula:C72H123N9O6Cor e Forma:SolidPeso molecular:1210.8Polyphyllin G
CAS:Polyphyllin G (Polyphyllin VII), the the main member of polyphyllin family, shows strong anticancer activity against several carcinomas.Fórmula:C51H84O22Pureza:98%Cor e Forma:SolidPeso molecular:1049.21Tubulin polymerization-IN-45
Tubulin polymerization-IN-45, a tubulin-targeting agent, acts as a tubulin polymerization inhibitor by binding to the tubulin's colchicine site.Fórmula:C20H18N4O3Cor e Forma:SolidPeso molecular:362.38CWI1-2
CAS:CWI1-2 is a potent IGF2BP2 inhibitor that inhibits its interaction with M6A-modified target transcripts by binding IGF2BP2.Fórmula:C22H17Cl3N6O3Pureza:98.27%Cor e Forma:SoildPeso molecular:519.77Ferroptosis-IN-17
Ferroptosis-IN-17 (Compound 18) is an inhibitor of ferroptosis with an EC50 value of 0.57 μM. It effectively reduces the accumulation of intracellular ferrous ions and lipid peroxidation while restoring levels of glutathione (GSH) and glutathione peroxidase 4 (GPX4). In rat plasma, Ferroptosis-IN-17 demonstrates good solubility and notable metabolic stability. This compound holds potential for research in tumor suppression, neurodegenerative diseases, and cardiovascular disorders.Fórmula:C21H26N4O5SCor e Forma:SolidPeso molecular:446.521,2,3,4-Tetrahydronaphthalen-2-ol
CAS:1,2,3,4-Tetrahydronaphthalen-2-ol exhibits weak inhibitory activity against Bcl-xL and is widely used in biochemical experiments and drug synthesis research.Fórmula:C10H12OCor e Forma:SolidPeso molecular:148.2Antagonist G TFA
Potent vasopressin blocker, Antagonist G TFA also mildly inhibits GRP & Bradykinin, triggers AP-1, enhances chemo response.Fórmula:C51H67F3N12O8SCor e Forma:SolidPeso molecular:1065.21MitoTam bromide, hydrobromide
CAS:MitoTam bromide hydrobromide is an electron transport chain (ETC) inhibitor.Fórmula:C52H60Br2NOPPureza:98%Cor e Forma:SolidPeso molecular:905.82UZH1a
CAS:UZH1a: METTL3 inhibitor, IC50 280 nM, used for epitranscriptomic modulation and has antitumor properties.Fórmula:C32H42N6O3Cor e Forma:SoildPeso molecular:558.711-Alaninechlamydocin
CAS:1-Alaninechlamydocin, a fungal metabolite from Tolypocladium sp., inhibits HDACs and reduces cell proliferation with GI50s 5.3-14 nM.
Fórmula:C27H36N4O6Cor e Forma:SolidPeso molecular:512.607Solasodine hydrochloride
CAS:Solasodine hydrochloride (90 μM; 2 days) treatment induced significant budding in P19 cells. This compound strongly stimulated the expression of various neuronal markers, including βIII-tubulin, synaptophysin, MAP2, ChAT, and the neural progenitor marker doublecortin. Predominantly, Solasodine hydrochloride directed the differentiation of P19 cells towards neuronal pathways.Fórmula:C27H44ClNO2Cor e Forma:SolidPeso molecular:450.1Ac-DNLD-CHO
CAS:Ac-DNLD-CHO (Ac-Asp-Asn-Leu-Asp-CHO) is an inhibitor of Caspase-3/7, exhibiting IC50 values of 9.89 nM and 245 nM, and approximate Ki values of 0.68 nM and 55.7Fórmula:C20H31N5O10Pureza:98%Cor e Forma:SolidPeso molecular:501.49PD-1/PD-L1-IN-51
PD-1/PD-L1-IN-51 (Compound III-4) is an inhibitor of PD-1/PD-L1 (IC50: hPD-L1 at 2.9 nM). It binds directly to PD-L1, blocking the interaction between PD-1 and PD-L1, and enhancing the release of IFN-γ. Additionally, PD-1/PD-L1-IN-51 exhibits antitumor activity.Cor e Forma:Odour Solidβ-Glucuronide-dPBD-PEG5-NH2
CAS:β-Glucuronide-dPBD-PEG5-NH2 is a β-glucuronide-linked pyrrolobenzodiazepine dimer that functions as a proagent for the synthesis of the antibody-drug conjugateFórmula:C78H101N7O35Cor e Forma:SolidPeso molecular:1696.66Ferroptosis-IN-16
Ferroptosis-IN-16 (Compound 13l) acts as a specific inhibitor of ferroptosis, demonstrating EC50 values of 0.7 nM in ES-2 cells and 0.9 nM in LX-2 cells. It effectively alleviates acute liver injury induced by Acetaminophen in mouse models and shows excellent metabolic stability in mouse liver microsomes.Fórmula:C26H23N5OCor e Forma:SolidPeso molecular:421.49PROTAC FLT3/CDK9 degrader-1
Potent PROTAC degrader for FLT3/CDK9, induces apoptosis, and shows promise for FLT3-ITD mutated AML research.Fórmula:C48H62N12O7Cor e Forma:SolidPeso molecular:919.08ZC0109
ZC0109 inhibits IDO1 (50 nM) & TrxR1 (3.0 μM), induces ROS, arrests G1/S phase, causing cancer cell apoptosis.Fórmula:C22H20BrFN8O4SCor e Forma:SolidPeso molecular:591.41Human PD-L1 inhibitor V
CAS:Human PD-L1 Inhibitor V is a peptide that binds to the human PD-1 protein with an affinity characterized by a dissociation constant (Kd) of 3.32 μM, effectivelyFórmula:C65H104N20O18SPureza:98%Cor e Forma:SolidPeso molecular:1485.71LSD1-IN-24
CAS:LSD1-IN-24 is a selective and potent LSD1 inhibitor with an IC50 value of 0.247 μM.LSD1-IN-24 induces PD-L1 expression and enhances the T cell killing responseFórmula:C18H20N2OSPureza:99.61%Cor e Forma:SoildPeso molecular:312.43Ref: TM-T67871
1mg34,00€5mg77,00€1mL*10mM (DMSO)84,00€10mg110,00€25mg212,00€50mg349,00€100mg532,00€200mg705,00€Antibiotic DC 81
CAS:DC 81: Streptomyces-derived antitumor antibiotic, potent nucleic acid synthesis inhibitor, binds DNA sequences, forms covalent adducts.Fórmula:C13H14N2O3Cor e Forma:SolidPeso molecular:246.26PF-543
CAS:PF-543 (Sphingosine Kinase 1 Inhibitor II), a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.Fórmula:C27H31NO4SPureza:99.02%Cor e Forma:SolidPeso molecular:465.6RIPK1-IN-17
CAS:RIPK1-IN-17 is a dual inhibitor of RIPK1 and RIPK3 inhibits necrosis by inhibiting phosphorylation of RIPK1, RIPK3 and MLKL,in a tnf-induced inflammation model.Fórmula:C26H19F4N3O3SPureza:95.22%Cor e Forma:SolidPeso molecular:529.51SDH-IN-26
SDH-IN-26 (Compound C3) is a succinate dehydrogenase (SDH) inhibitor with significant inhibitory activity against various plant pathogenic fungi, including solanrhizoctonia and Botrytis cinerea. It exhibits an EC50 value of 0.270 μg/mL against solanrhizoctonia. SDH-IN-26 compromises fungal cell membrane integrity, increases membrane permeability, disrupts cell structure, reduces mitochondrial count, and affects normal hyphal growth. It also decreases mitochondrial membrane potential, inducing apoptosis. SDH-IN-26 holds potential for studying plant diseases caused by fungi.Cor e Forma:Odour SolidCOG-1410 acetate
COG-1410 acetate is an apolipoprotein E-derived peptide and can be used in studies about neurological diseases.Fórmula:C66H125N21O16Pureza:99.61%Cor e Forma:SolidPeso molecular:1468.83STAT3-D11-PROTAC-VHL
STAT3-D11-PROTAC-VHL (Compound D11-PROTAC) is a PROTAC degrader targeting signal transducer and activator of transcription 3 (STAT3). It demonstrates anti-tumor activity with IC50 values of 1335 nM in HeLa cells and 1973 nM in MCF-7 cells. The compound binds to the DNA binding domain of STAT3, recruits the E3 ligase VHL to form a ternary complex, leading to ubiquitination and subsequent proteasomal degradation of STAT3. Additionally, STAT3-D11-PROTAC-VHL inhibits tumor cell growth, induces cell cycle arrest and apoptosis (apoptosis), and suppresses tumor immune evasion.Cor e Forma:Odour Solid8-hydroxy Efavirenz
CAS:8-hydroxy Efavirenz, a main efavirenz metabolite by CYP2B6, causes apoptosis in rat neurons at 0.01 μM.Fórmula:C14H9ClF3NO3Cor e Forma:SolidPeso molecular:331.68L-threo-PPMP
CAS:L-threo-PPMP blocks GlcT, curbs glycosphingolipid creation, and triggers cell death, showing anti-cancer effects.Fórmula:C29H50N2O3Cor e Forma:SolidPeso molecular:474.731-(4-chloro-3-(trifluoromethyl)phenyl)-3-(7-(1-methyl-1H-pyrazol-4-yl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl)urea
CAS:1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(7-(1-methyl-1H-pyrazol-4-yl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl)urea 是一种能够激动 TNF-α的化合物，可以诱导细胞分泌 TNF-α。Fórmula:C24H21ClF3N5OPureza:98.37% - 98.57%Cor e Forma:SoildPeso molecular:487.9RIPK2-IN-4
RIPK2-IN-4 is a potent and specific inhibitor of RIPK2 with an IC50 value of 5 nM.Fórmula:C16H10N6S2Peso molecular:350.04084Nemorosone
CAS:Nemorosone, a PPAP from C. rosea, inhibits neuroblastoma and pancreatic cancer cell growth, induces apoptosis, and reduces mouse xenograft tumors.Fórmula:C33H42O4Cor e Forma:SolidPeso molecular:502.695IDH1/2-IN-1
IDH1/2-IN-1 (Compound 6b) is a dual inhibitor of IDH1(R132H)/IDH2(R140Q) with IC50 values of 0.22 μM and 1.6 μM, respectively. This compound effectively inhibits tumor growth by suppressing tumor cell proliferation and activating antioxidative enzymes to enhance host defense. Additionally, IDH1/2-IN-1 reduces inflammation and promotes apoptosis, demonstrating significant anti-tumor activity. It is also utilized in leukemia research.Cor e Forma:Odour SolidKB02-SLF
KB02-SLF, a molecular glue, degrades nuclear FKBP12 by modifying E3 ligase DCAF16 and extends protein degradation.Fórmula:C50H65ClN4O12Pureza:98%Cor e Forma:SolidPeso molecular:949.52Ac-Trp-Glu-His-Asp-Aldehyde
CAS:Ac-Trp-Glu-His-Asp-Aldehyde is a powerful and selective inhibitor of caspase-1, demonstrating a K_i value of 56 pM [1] [2].Fórmula:C28H33N7O9Cor e Forma:SolidPeso molecular:611.6Pantinin-1
CAS:Pantinin-1 is an antimicrobial peptide found in the venom of the emperor scorpion (Pandinus imperator). This compound exhibits strong antibacterial activity against Gram-positive bacteria and fungi, but has weaker effects on Gram-negative bacteria. Additionally, Pantinin-1 demonstrates very low hemolytic activity on human red blood cells and possesses anticancer properties, specifically inducing apoptosis in tumor cells.Fórmula:C75H119N17O18Cor e Forma:SolidPeso molecular:1546.85Photosensitizer-6
CAS:Photosensitizer-6 (Compound 4) is a metal ion complex that inhibits TrxR. It induces apoptosis in 4T1 cells, targeting cancer cells and eliminating tumors through chemophototherapy and immunogenic cell death under illumination. Additionally, Photosensitizer-6 can be utilized for tumor imaging.Fórmula:C47H35AuF6N4P2SCor e Forma:SolidPeso molecular:1060.78IETD-CHO TFA
IETD-CHO TFA (Caspase-8-IN-1) functions as a potent inhibitor of caspase-8 [1].Fórmula:C95H162N20O26·xC2HF3O2Pureza:98%Cor e Forma:SolidPeso molecular:2000.42 (free acid)Aspidin BB
CAS:Aspidin BB, a phloroglucinol from Dryopteris, inhibits cancer by causing cell cycle arrest and apoptosis in HO-8910 cells.Fórmula:C25H32O8Cor e Forma:SolidPeso molecular:460.52ZS3-046
ZS3-046 is a TAF1 PROTAC degrader that facilitates the ubiquitination and subsequent degradation of TAF1. It can activate p53 and induce apoptosis in acute myeloid leukemia (AML) cells. Additionally, ZS3-046 demonstrates anti-tumor efficacy in AML xenograft mouse models.Fórmula:C49H57N9O7Cor e Forma:SolidPeso molecular:883.4381N-Deshydroxyethyl Dasatinib
CAS:N-Deshydroxyethyl Dasatinib (N-Deshydroxyethyl BMS-354825) is a metabolite of Dasatinib, a dasatinib-based molecule that degrades ABL by binding to the IAPFórmula:C20H22ClN7OSPureza:95.96%Cor e Forma:SolidPeso molecular:443.95Ref: TM-T18750
1mg52,00€5mg111,00€1mL*10mM (DMSO)127,00€10mg170,00€25mg294,00€50mg425,00€100mg583,00€200mg790,00€Ragifilimab
CAS:Ragifilimab (INCAGN-1876), a GITR-targeting agonist antibody, may treat advanced solid tumors.
Pureza:SDS-PAGE:95% SEC-HPLC:99.99%Cor e Forma:LiquidPeso molecular:146.46 kDa3MB-PP1
CAS:3MB-PP1 is a bulky purine analog and a Polo-like kinase 1 (Plk1) inhibitor.Fórmula:C17H21N5Pureza:99.96%Cor e Forma:White SolidPeso molecular:295.38Ref: TM-T21678
500mgA consultar5mg50,00€1mL*10mM (DMSO)55,00€10mg92,00€25mg166,00€50mg255,00€100mg374,00€FB49
FB49 is a selective Bcl-2-associated athanogene 3 (BAG3) inhibitor with a Ki of 45 μM.Fórmula:C17H18N2O6SPureza:98%Cor e Forma:SolidPeso molecular:378.4Fluorescein-diisobutyrate-6-amide
CAS:Fluorescein-diisobutyrate-6-amide, a powerful inducer of ferroptosis, shows promise for cancer research applications [1].Fórmula:C62H61ClN6O16Cor e Forma:SolidPeso molecular:1181.632,4-D sodium salt
CAS:Sodium 2,4-dichlorophenoxyacetate: selective herbicide, controls broadleaf weeds by disrupting growth and protein/DNA synthesis.Fórmula:C8H5Cl2NaO3Cor e Forma:SolidPeso molecular:243.02Ac-AAVALLPAVLLALLAP-LEVD-CHO
CAS:Ac-AAVALLPAVLLALLAP-LEVD-CHO is a cell-permeable inhibitor of caspase-4 that exhibits antitumor activity [1].Fórmula:C96H164N20O25Pureza:98%Cor e Forma:SolidPeso molecular:1998.45Prodigiosin hydrochloride
CAS:Prodigiosin hydrochloride is a bioactive red pigment from bacteria with antibacterial, antifungal, anticancer properties, and inhibits Wnt/β-catenin.Fórmula:C20H26ClN3OCor e Forma:SolidPeso molecular:359.9HC Toxin
CAS:HC Toxin: cyclic tetrapeptide, reversible HDAC inhibitor (IC50=30 nM), upregulates 15-lipoxygenase-1, induces fetal hemoglobin, from C. carbonum.Fórmula:C21H32N4O6Cor e Forma:SolidPeso molecular:436.509CDK9-IN-24
CDK9-IN-24 (compound 21a) is a potent and selective inhibitor of CDK9 that exhibits a pronounced inhibitory impact on tumor proliferation.Fórmula:C27H31N3O4Pureza:98%Cor e Forma:SolidPeso molecular:461.55F1324
F1324: potent BCL6 inhibitor, IC50=1nM, binding t1/2=441s, strongly inhibits BCL6 PPI.Fórmula:C83H121N21O20SPureza:98%Cor e Forma:SolidPeso molecular:1765.04(±)-Indoxacarb
CAS:(±)-Indoxacarb is a pyrazoline insecticide with insecticidal activity and cytotoxicity, blocks sodium channels in insect neurons, and can induce apoptosis.
Fórmula:C22H17ClF3N3O7Cor e Forma:SolidPeso molecular:527.83A011
A011, a potent and selective ataxia-telangiectasia mutated (ATM) inhibitor, exhibits an IC50 of 1.0 nM and triggers apoptosis as well as G2/M phase cell cycleFórmula:C27H28N6OPureza:98%Cor e Forma:SolidPeso molecular:452.55BKM1644
CAS:BKM1644 is an effective inhibition of the proliferation of metastatic, castration-resistant PCa (mCRPC) cells.Fórmula:C34H37Cl2F5N2O9P2Pureza:98%Cor e Forma:SolidPeso molecular:845.51HSP90-IN-18
HSP90-IN-18 inhibits Hsp90 with 0.39 μM IC50, useful for viral, neurodegenerative, and inflammatory research.Fórmula:C25H33FO3Cor e Forma:SolidPeso molecular:400.53GPX4-IN-6
CAS:GPX4-IN-6 is a GPX4 inhibitor with antitumor activity.GPX4-IN-6 induces iron death and is used for the treatment and prevention of triple-negative breast cancerFórmula:C18H17BrFNO5Pureza:99.54%Cor e Forma:SoildPeso molecular:426.23CRM1-IN-2
CRM1-IN-2 (Compound KL2) is a noncovalent inhibitor that targets CRM1, localizing it to the nuclear periphery, depleting its nuclear presence, and inhibitingFórmula:C29H48N2O5Pureza:98%Cor e Forma:SolidPeso molecular:504.7DB2115 tertahydrochloride
CAS:DB2115 (tertahydrochloride) inhibits PU.1, key in leukemia; potential for cancer research.
Fórmula:C32H34Cl4N8O2Cor e Forma:SolidPeso molecular:704.48Shepherdin (79-87)
CAS:Shepherdin 79-87: Amino acid fragment 79-87 of Hsp90/Survivin antagonist with anticancer properties.Fórmula:C41H64N12O12SPureza:98%Cor e Forma:SolidPeso molecular:949.09MDMX/MDM2-IN-2
MDMX/MDM2-IN-2 is a potent dual inhibitor of p53-MDM2/MDMX, demonstrating dissociation constants (Kis) of 0.23 μM for MDM2 and 2.45 μM for MDMX.Fórmula:C28H25Cl3FN3O3Cor e Forma:SolidPeso molecular:576.87Pipernonaline
CAS:Pipernonaline is a useful organic compound for research related to life sciences. The catalog number is T124000 and the CAS number is 88660-10-0.Fórmula:C21H27NO3Cor e Forma:SolidPeso molecular:341.451Apoptosis inducer 28
Apoptosisinducer 28 (Compound X1) is an apoptosis inducer with demonstrated in vitro anticancer activity. It arrests the cell cycle at the G1 phase, promoting cell death and inducing apoptosis by disrupting the mitochondrial membrane potential.Cor e Forma:Odour SolidCDK2-IN-45
CDK2-IN-45 is a CDK2 inhibitor with an IC50 value of 0.64 μM. It effectively inhibits the proliferation of DU-145 and PC-3 cell lines, with IC50 values of 2.20 μM and 4.17 μM, respectively. Additionally, CDK2-IN-45 induces G0/G1 phase cell cycle arrest and apoptosis. It is utilized in prostate cancer research.Fórmula:C25H16ClN5SCor e Forma:SolidPeso molecular:453.95Jacaric Acid
CAS:Conjugated 18-C ω-6 fatty acid from Jacaranda seeds, induces cancer cell apoptosis via oxidative stress; metabolizes to cytotoxic CLA.Fórmula:C18H30O2Cor e Forma:SolidPeso molecular:278.436Anticancer agent 273
Anticanceragent 273 (Compound 9q) is an effective anticancer compound identified from matrine. It inhibits cancer cell proliferation, with an IC50 of 4.48 μM against HeLa cells. Anticanceragent 273 exerts its anticancer effects by modulating PI3K/AKT expression and activating activating transcription factor 4 (ATF4), which induces endoplasmic reticulum stress and triggers apoptosis. It holds potential for cancer research, including cervical cancer.Cor e Forma:Odour Solid2-Methylbiphenyl-oxadiazole-NH-Ph-CHO
CAS:2-Methylbiphenyl-oxadiazole-NH-Ph-CHO functions as a PD-L1 ligand for AUTACPD-L1degrader-3. It is also applicable in the synthesis of AUTAC.Fórmula:C22H17N3O2Cor e Forma:SolidPeso molecular:355.39GSK-3β inhibitor 15
GSK-3β inhibitor 15 (Compound 54), with an IC50 of 3.4 nM, effectively suppresses Aβ 1-42-induced phosphorylation of GSK-3β and tau protein, as well as LPS-Fórmula:C17H16N6OSCor e Forma:SolidPeso molecular:352.41FL118
CAS:FL118 is a novel survivin inhibitor that inhibits cancer stem cell-like properties.FL118 is a novel camptothecin analog with anticancer activity that inhibitsFórmula:C21H16N2O6Pureza:97.14%Cor e Forma:SoildPeso molecular:392.36Ac-VDVAD-CHO TFA
Ac-VDVAD-CHO (TFA) is a caspase-2/3 inhibitor with IC50 values of 46 nM and 15 nM, respectively.Cor e Forma:Odour SolidPD-L1 ligand 1
PD-L1 ligand 1 is classified as a PROTAC-targeted protein ligand, primarily utilized as a degradation agent for PD-L1.Cor e Forma:Odour SolidLon-TK
Lon-TK is a glycolysis inhibitor of LTB, linked with a linker conjugate. LTB is an intelligent responsive prodrug, comprised of Lonidamine (Lon) and a PD-L1 inhibitor (BMS-1), which are connected through a thioketal linkage. It effectively inhibits glycolytic metabolism in tumor cells and blocks the PD-1/PD-L1 immune escape pathway. Lon-TK holds potential for use in photodynamic-enhanced immunotherapy research.Fórmula:C24H28Cl2N2O3S2Cor e Forma:SolidPeso molecular:527.53Varlilumab
CAS:Varlilumab (CDX-1127) is a novel human IgG1 anti-CD27 monoclonal antibody. Varlilumab has antitumor activity and can be used to study advanced solid tumors.Pureza:SDS-PAGE:95% SEC-HPLC:98.65%Cor e Forma:LiquidPeso molecular:146 kDaTG101209 analog 1
TG101209 analog 1 (Compound 8h) serves as an inhibitor of BUB1B, exhibiting an IC50 of 10.36 μM. It also possesses cytotoxic properties, demonstrated by an IC50 of 1.347 μM against Caki-1 cells, and can induce necrosis and apoptosis.Fórmula:C24H31N5O5SCor e Forma:SolidPeso molecular:501.598YN14-H
YN14-H is a PROTAC degrader that targets KRASG12C. It effectively inhibits the growth of NCI-H358 and MIA PaCa-2 cells, with IC50 values of 0.042 μM and 0.021 μM, respectively, and DC50 values of 28.9 nM and 18.1 nM. YN14-H significantly induces apoptosis and suppresses cell migration. It demonstrates favorable pharmacokinetics and excellent in vivo antitumor activity.Cor e Forma:Odour SolidResistomycin
CAS:Resistomycin (Geliomycin), a pentacyclic polyketide antibiotic, exhibits potent anticancer properties by triggering apoptosis.
Fórmula:C22H16O6Pureza:99.34%Cor e Forma:SolidPeso molecular:376.36Ref: TM-T21820
1mg107,00€2mg153,00€5mg239,00€10mg353,00€25mg563,00€50mg758,00€100mg1.008,00€200mg1.359,00€Ac-VDQQD-pNA
CAS:Ac-VDQQD-pNA serves as a substrate for Caspase 2, which cleaves it to yield the yellow compound pNA (p-nitroaniline).Fórmula:C31H43N9O14Cor e Forma:SolidPeso molecular:765.73CS4
CS4 is a selective HDAC inhibitor, with IC50 values for HDAC1, HDAC6, HDAC8, HDAC4, and HDAC11 reported as 38 nM, 12 nM, 5.8 μM, 19 μM, and 61 μM, respectively. It enhances the acetylation of α-tubulin and histone 3 (histone 3). Additionally, CS4 activates PPARγ and blocks glycolysis (glycolysis). It induces cell cycle arrest at the G2 phase and triggers apoptosis (apoptosis), exhibiting anticancer effects both in vitro and in vivo.Cor e Forma:Odour SolidPD1-PDL1-IN 1 TFA
PD1-PDL1-IN 1 TFA (compound 16) is a potent inhibitor of programmed cell death 1 (PD-1), functioning as an immune modulator [1].Fórmula:C16H24F3N7O8Cor e Forma:SolidPeso molecular:499.4D5B
D5B is an effective and selective PD-L1 inhibitor that has been modified with DBCO. It degrades PD-L1 in 4T1 and B16-F10 tumor cells with EC50 values of 5.4 μM and 6.2 μM, respectively. D5B can block the PD-L1/PD-1 interaction and exhibits antitumor activity.Fórmula:C58H66N2O12Cor e Forma:SolidPeso molecular:983.15anti-TNBC agent-9
Anti-TNBC agent-9 (Compound 3as) is an anticancer agent used for treating triple-negative breast cancer (TNBC). It exhibits significant inhibitory activity against MDA-MB-453 cells, with an IC50 value of 8.5 μM. Anti-TNBC agent-9 impedes tumor cell migration by upregulating E-cadherin and downregulating N-cadherin, matrix metalloproteinase 2 (MMP2), and MMP9. Additionally, it inhibits tumor cell proliferation by inducing apoptosis, achieved through the increased expression of pro-apoptotic protein BAX and decreased expression of anti-apoptotic protein BCL-2.Cor e Forma:Odour SolidEnterodiol
Enterodiol is a natural product that can be used as a reference standard.Fórmula:C18H22O4Cor e Forma:SolidPeso molecular:302.37S65487 hydrochloride
CAS:S65487 (VOB560) hydrochloride, a potent and selective Bcl-2 inhibitor, is effective against BCL-2 mutations, including G101V and D103Y.Fórmula:C41H42Cl2N6O4Cor e Forma:SolidPeso molecular:753.73Ganoderic acid T1
Ganoderic acid T1, a derivative of Ganoderic acid T, triggers cancer cell apoptosis by boosting ROS and activating caspases.Fórmula:C34H50O7Cor e Forma:SolidPeso molecular:570.76RhoA-ROCK-IN-1
RhoA-ROCK-IN-1 (Compound b19) is an inhibitor of the RhoA/ROCK pathway. It significantly inhibits cell proliferation, migration, and invasion, while promoting cell apoptosis (apoptosis). RhoA-ROCK-IN-1 exhibits strong anticancer activities by inhibiting the RhoA/ROCK pathway.Fórmula:C24H23N3O4SCor e Forma:SolidPeso molecular:449.52LP23
LP23, a non-arylmethylamine PD-1/PD-L1 inhibitor (IC 50: 16.7 nM), exhibits anti-tumor activity through the restoration of immune cell function in HepG2/JurkatFórmula:C27H27N3O5SPureza:98%Cor e Forma:SolidPeso molecular:505.59Pimagedine
CAS:Pimagedine is a prototype therapeutic agent for the prevention of formation of advanced glycation endproducts.Fórmula:CH6N4Cor e Forma:SolidPeso molecular:74.09SLF-amido-C2-COOH
CAS:SLF-amido-C2-COOH is a synthetic ligand for FKBP (SLF), and can be used in the synthesis of PROTACs.Fórmula:C34H44N2O9Pureza:95.8%Cor e Forma:SolidPeso molecular:624.72Collismycin A
CAS:Collismycin A, from Streptomyces, has antibacterial, antiproliferative, and neuroprotective effects. It inhibits various cancer cells and is iron-complexing.Fórmula:C13H13N3O2SCor e Forma:SolidPeso molecular:275.33Violacein
CAS:Violacein, a purple antibacterial and antiprotozoal compound from C. violaceum, effective against Gram-positive bacteria and P. falciparum.
Fórmula:C20H13N3O3Cor e Forma:SolidPeso molecular:343.34
