Apoptose
Os inibidores da apoptose são compostos que previnem ou retardam o processo de morte celular programada, conhecido como apoptose. Esses inibidores são vitais no estudo dos mecanismos de sobrevivência celular e são usados para investigar doenças onde a apoptose é desregulada, como câncer, distúrbios neurodegenerativos e doenças autoimunes. Ao modular a apoptose, esses inibidores podem ajudar no desenvolvimento de terapias destinadas a controlar a morte celular. Na CymitQuimica, oferecemos uma ampla seleção de inibidores da apoptose de alta qualidade para apoiar sua pesquisa em biologia celular, oncologia e áreas relacionadas.
Subcategorias de "Apoptose"
- ASK(9 produtos)
- BCL(1 produtos)
- Caspase(154 produtos)
- FOXO1(2 produtos)
- IAP(67 produtos)
- Mdm2(12 produtos)
- PD-1/PD-L1(137 produtos)
- PDK(9 produtos)
- PERK(23 produtos)
- Serina/treonina quinase(18 produtos)
- Survivina(14 produtos)
- TNF(94 produtos)
- c-RET(61 produtos)
- p53(63 produtos)
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Foram encontrados 6231 produtos de "Apoptose"
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PD-L1-IN-5
PD-L1-IN-5 (X22) is an orally active PD-L1 inhibitor with an IC50 of 785.6 nM, demonstrating antitumor activity in vivo.ASR-488
CAS:ASR-488, an activator of the mRNA-binding protein CPEB1, promotes apoptosis and suppresses the growth of bladder cancer [1].Fórmula:C33H40O7SCor e Forma:SolidPeso molecular:580.73Dehydrobruceine B
CAS:Dehydrobruceine B, from Brucea javanica, enhances Cisplatin-induced apoptosis by affecting AIF, Bax, and Keap1-Nrf2.Fórmula:C23H26O11Cor e Forma:SolidPeso molecular:478.45PROTAC FLT3/CDK9 degrader-1
Potent PROTAC degrader for FLT3/CDK9, induces apoptosis, and shows promise for FLT3-ITD mutated AML research.Fórmula:C48H62N12O7Cor e Forma:SolidPeso molecular:919.08Apoptosis inducer 26
Apoptosisinducer 26 (compound [AgCl(dap2SH)(PPh3)2]) is a mononuclear Ag(I) ligand-based autophagy inducer that exhibits antibacterial and anticancer activities against various bacterial strains and cancer cell lines. This compound facilitates the accumulation of Ag(I) ions in the periphery of bacteria, effectively inhibiting the growth of both Gram-positive (+) and Gram-negative (-) bacteria. Additionally, Apoptosisinducer 26 can intercalate between the base pairs of CT DNA, inducing apoptosis in A549 cells. It also possesses radical scavenging properties, which helps prevent oxidative stress.Fórmula:C40H36AgClN4P2SCor e Forma:SolidPeso molecular:810.07LS-106
LS-106 is an orally active, effective epidermal growth factor receptor (EGFR) inhibitor displaying antitumor activity both in vitro and in vivo. It inhibits the kinase activities of EGFR19del/T790M/C797S and EGFRL858R/T790M/C797S, with IC50 values of 2.4 nmol/L and 3.1 nmol/L, respectively, demonstrating stronger inhibition than Osimertinib. LS-106 induces cell apoptosis (Apoptosis), suppresses the proliferation of tumor cells carrying EGFR19del/T790M/C797S, and results in significant tumor reduction in a C797S mutant xenograft model.Fórmula:C24H28BrClN5OPCor e Forma:SolidPeso molecular:548.84NSC90616
NSC90616 is a mutant p53 rescue compound [1] .Fórmula:C23H30FNa2O9PCor e Forma:SolidPeso molecular:546.43sEH inhibitor-19
sEH inhibitor-19 (Compound (R)-14i) is an orally active soluble epoxide hydrolase (sEH) inhibitor with an IC50 of 1.2 nM. This compound suppresses the expression of TNF-α and IL-6 and exhibits anti-inflammatory effects in mouse models of acute pancreatitis and Carrageenan-induced edema.Fórmula:C28H28F3N3O4Cor e Forma:SolidPeso molecular:527.535PROTAC GPX4 degrader-4
CAS:PROTACGPX4 degrader-4 is a GPX4 PROTAC degrader with a DC50 of 5.32 nM. It inhibits the activity of cancer cell lines RT4, T24, and J82 with IC50 values of 0.09, 2.97, and 7.58 μM, respectively. This compound elevates lipid ROS levels and induces ferroptosis in T24 and RT4 cells. In T24 tumor-bearing BALB/c nude mouse models, PROTACGPX4 degrader-4 demonstrates antitumor activity. It is applicable to bladder cancer research.Fórmula:C43H58N2O13Cor e Forma:SolidPeso molecular:810.93FR900359
CAS:FR900359 is a macrocyclic Gq protein inhibitor that inhibits melanoma cell proliferation and can be used to study asthma, inflammation and cancer.Fórmula:C49H75N7O15Pureza:98%Cor e Forma:SolidPeso molecular:1002.16MS105
CAS:MS105 is an orally active, selective protein tyrosine kinase 6 (PTK6) PROTAC degrader. It recruits the VHL E3 ligase through a VHL ligand fragment, facilitating ubiquitination and proteasomal degradation of PTK6, thereby inhibiting the proliferation and migration of breast cancer cells and inducing apoptosis (apoptosis). MS105 is a promising compound for breast cancer research.Fórmula:C56H70FN13O6SCor e Forma:SolidPeso molecular:1072.30Milademetan tosylate hydrate
CAS:Milademetan tosylate hydrate, an oral MDM2 inhibitor targeting AML and solid tumors, induces G1 arrest and apoptosis.Fórmula:C37H44Cl2FN5O8SCor e Forma:SolidPeso molecular:808.74Chloranthalactone B
CAS:Chloranthalactone B, a sesquiterpenoid from Sarcandra glabra, inhibits inflammation via AP-1 & p38 MAPK.Fórmula:C15H16O3Cor e Forma:SolidPeso molecular:244.29A-1248767
CAS:A-1248767, a derivative of A-1210477, is an MCL-1 inhibitor (IC50=23.9 nM; Ki=0.41 nM) known for its anticancer properties. It binds to MCL-1 with high affinity, induces an increase in MCL-1 protein levels inside cells, and promotes apoptosis in tumor cells.Fórmula:C47H55N7O6Cor e Forma:SolidPeso molecular:813.98RET-IN-4
CAS:RET-IN-4: Oral RET inhibitor, IC50 ~1 nM for variants. Selective over JAK2/FLT3. Potent anticancer use.Fórmula:C27H31FN10O2Cor e Forma:SolidPeso molecular:546.611MKC-1
CAS:MKC-1 (Ro-31-7453) is an oral bisindolylmaleimide inhibitor that disrupts tubulin polymerization, potentially halting cancer cell division.Fórmula:C22H16N4O4Pureza:99.63% - 99.85%Cor e Forma:SolidPeso molecular:400.39Ref: TM-T9831
500mgA consultar1mg54,00€5mg118,00€1mL*10mM (DMSO)127,00€10mg168,00€25mg293,00€50mg423,00€100mg588,00€Anagrelide hydrochloride monohydrate
CAS:Anagrelide HCl monohydrate is a platelet-reducing imidazoquinazoline for ET and PV research.Fórmula:C10H10Cl3N3O2Cor e Forma:SolidPeso molecular:310.56Ganglioside GD3 disodium salt
CAS:Ganglioside GD3 disodium salt is a melanoma-associated antigen often targeted in immune therapy for melanomas.Fórmula:C70H123N3Na2O29Cor e Forma:SolidPeso molecular:1516.71Vinepidine sulfate
CAS:Vinepidine (LY-119863) sulfate, a derivative of vincristine, exhibits antitumor activity .Fórmula:C46H58N4O13SCor e Forma:SolidPeso molecular:907.04NS3694
CAS:NS3694 is an inhibitor of apoptosis and inhibits apoptosome formation and caspase activation.Fórmula:C15H10ClF3N2O3Pureza:99.83%Cor e Forma:SolidPeso molecular:358.7Ref: TM-T22119
1mg37,00€2mg52,00€5mg79,00€1mL*10mM (DMSO)87,00€10mg111,00€25mg227,00€50mg329,00€100mg512,00€500mg1.093,00€IDH1/2-IN-1
IDH1/2-IN-1 (Compound 6b) is a dual inhibitor of IDH1(R132H)/IDH2(R140Q) with IC50 values of 0.22 μM and 1.6 μM, respectively. This compound effectively inhibits tumor growth by suppressing tumor cell proliferation and activating antioxidative enzymes to enhance host defense. Additionally, IDH1/2-IN-1 reduces inflammation and promotes apoptosis, demonstrating significant anti-tumor activity. It is also utilized in leukemia research.Cor e Forma:Odour SolidAc-FEID-CMK
Ac-FEID-CMK: Potent inhibitor for zebrafish GSDMEb, reduces pyroptosis, and lessens septic AKI.Fórmula:C27H37ClN4O9Cor e Forma:SolidPeso molecular:597.06ERK-IN-6
ERK-IN-6, a potent agent, inhibits ESCC growth and induces apoptosis through the ERK pathway.Fórmula:C19H18BrN3O3SCor e Forma:SolidPeso molecular:448.33Azalamellarin N
CAS:Azalamellarin N is a pyroptosis inhibitor that exhibits varying inhibitory effects on different pyroptosis inducers. It functions by targeting molecules upstream of NLRP3 inflammasome activation, instead of directly affecting the components of the NLRP3 inflammasome. Its inhibitory potency against various inducers is ranked as follows: Nigericin > R837 [1].Fórmula:C28H22N2O7Cor e Forma:SolidPeso molecular:498.48Boc-Asp(OBzl)-CMK
CAS:Boc-Asp(OBzl)-CMK, an inhibitor of IL-1 converting enzyme (ICE, caspase1), prevents the death of CHP100 neuroblastoma cells and inhibits IL-1β release induced by the viral coat protein [1].Fórmula:C17H22ClNO5Cor e Forma:SolidPeso molecular:355.81Thalidomide-NH-PEG2-COOH
CAS:Thalidomide-NH-PEG2-COOH: a synthesized E3 ligase ligand-linker with cereblon ligand and PROTAC linker.Fórmula:C20H23N3O8Cor e Forma:SolidPeso molecular:433.417Human PD-L1 inhibitor III
CAS:Human PD-L1 inhibitor III is a human PD-L1 inhibitor.Fórmula:C97H155N29O29SCor e Forma:SolidPeso molecular:2223.54(Rac)-BIO8898
CAS:(Rac)-BIO8898 is a chemical compound that serves as an inhibitor of the co-stimulatory interaction between CD40 and CD154.Fórmula:C53H64N8O6Cor e Forma:SolidPeso molecular:909.13Ch282-5
CAS:Ch282-5, an orally active inhibitor targeting the Bcl-2 protein, promotes mitochondria-dependent apoptosis (Apoptosis) by disrupting mitophagy and the mTOR pathway. It demonstrates antiproliferative effects on colorectal cancer cells, effective both in vitro and in vivo, while also inhibiting metastasis. Further, Ch282-5 augments Oxaliplatin-induced autophagy (Autophagy) by downregulating Mcl-1 protein and raising platelet count, which helps mitigate the adverse effects of Navitoclax.Fórmula:C34H34N2Na2O14S2Cor e Forma:SolidPeso molecular:804.75Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2
Thalidomide-PEG conjugate for E3 ligase in PROTACs; has cereblon ligand and 3-unit PEG linker.Fórmula:C27H35F3N4O11Pureza:98%Cor e Forma:SolidPeso molecular:648.58YX0798
YX0798 is a selective, orally active CDK9 inhibitor (Kd: 0.28 nM). It downregulates the oncogenic protein c-MYC and the pro-survival protein MCL-1. YX0798 disrupts the cell cycle and causes transcriptome reprogramming, ultimately leading to apoptosis. The compound exhibits antitumor activity.Fórmula:C21H19ClF3N5O2Cor e Forma:SolidPeso molecular:465.86CDK2-IN-45
CDK2-IN-45 is a CDK2 inhibitor with an IC50 value of 0.64 μM. It effectively inhibits the proliferation of DU-145 and PC-3 cell lines, with IC50 values of 2.20 μM and 4.17 μM, respectively. Additionally, CDK2-IN-45 induces G0/G1 phase cell cycle arrest and apoptosis. It is utilized in prostate cancer research.Fórmula:C25H16ClN5SCor e Forma:SolidPeso molecular:453.95Thalidomide-O-C4-COOH
CAS:Thalidomide-O-C4-COOH is a synthetic E3 ligase linker derived from Thalidomide for PROTAC tech.Fórmula:C18H18N2O7Cor e Forma:SolidPeso molecular:374.3447Carbonic anhydrase inhibitor 33
Carbonic anhydrase inhibitor33 (11D) is a dual inhibitor that targets both CA (carbonic anhydrase) IX/XII and CDK6. It exhibits Ki values of 19.7 nM for hCA IX and 26.1 nM for hCA XII. Additionally, Carbonic anhydrase inhibitor33 (11D) can induce G1 phase cell cycle arrest and apoptosis, making it relevant for research in non-small cell lung cancer (NSCLC).Fórmula:C19H15FN6O2SCor e Forma:SolidPeso molecular:410.09612FL118
CAS:FL118 is a novel survivin inhibitor that inhibits cancer stem cell-like properties.FL118 is a novel camptothecin analog with anticancer activity that inhibitsFórmula:C21H16N2O6Pureza:97.14%Cor e Forma:SoildPeso molecular:392.36MRIA9
CAS:MRIA9 inhibits SIK1/2/3 & PAK2/3 with IC50: SIK1 (516 nM), SIK2 (180 nM), SIK3 (127 nM); ATP-competitive.Fórmula:C24H22ClFN6O3Cor e Forma:SolidPeso molecular:496.92Bim BH3, Peptide IV
CAS:This Bim peptide belongs to the pro-apoptotic group of the Bcl-2 family of proteins.Fórmula:C145H222N44O41SPureza:98%Cor e Forma:SolidPeso molecular:3269.65Reproxalap
CAS:Reproxalap (NS-2) is a dry eye treatment that neutralizes aldehydes like malondialdehyde.
Fórmula:C12H13ClN2OPureza:99.4% - 99.97%Cor e Forma:SolidPeso molecular:236.7Ac-Trp-Glu-His-Asp-Aldehyde
CAS:Ac-Trp-Glu-His-Asp-Aldehyde is a powerful and selective inhibitor of caspase-1, demonstrating a K_i value of 56 pM [1] [2].Fórmula:C28H33N7O9Cor e Forma:SolidPeso molecular:611.6cis-Clovamide
CAS:cis-Clovamide is a naturally occurring phenolic compound with noteworthy antioxidant, anti-inflammatory, and antiapoptotic properties.Fórmula:C18H17NO7Cor e Forma:SolidPeso molecular:359.3344-Nitrothalidomide
CAS:4-Nitrothalidomide is a modified form of thalidomide that inhibits the growth and proliferation of HUVEC cells and is commonly used in the synthesis of pomalidomide, which has anticancer potential.Fórmula:C13H9N3O6Pureza:99.94%Cor e Forma:SolidPeso molecular:303.23Bcl-2-IN-4
CAS:Bcl-2-IN-4: potent, selective, oral Bcl-2 inhibitor with 1.5 nM IC50, >200x selectivity over Bcl-xL.Fórmula:C46H50ClN9O7SCor e Forma:SolidPeso molecular:908.46GSK-1070916
CAS:GSK-1070916 (GSK-1070916A) is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM.Fórmula:C30H33N7OPureza:99.73%Cor e Forma:SolidPeso molecular:507.63PDE4D inhibitor 1
PDE4-IN-1 is a PDE4 inhibitor characterized by high potency (IC50: 8.6 nM) and superior selectivity over other PDE subtypes. This compound inhibits the release of inflammatory cytokines and chemokines. Additionally, PDE4-IN-1 significantly restores the damaged cAMP-CREB signaling pathway, inhibits proliferation, and promotes differentiation to reverse psoriasis formation.Cor e Forma:Odour Solid(E/Z)-Eltrombopag 13C4
CAS:(E/Z)-Eltrombopag 13C4 is a mix of E/Z isotopologues, both 13C-labeled TPO receptor agonists for thrombocytopenia.Fórmula:C25H22N4O4Cor e Forma:SolidPeso molecular:446.444Antagonist G TFA
Potent vasopressin blocker, Antagonist G TFA also mildly inhibits GRP & Bradykinin, triggers AP-1, enhances chemo response.Fórmula:C51H67F3N12O8SCor e Forma:SolidPeso molecular:1065.21FOXO4-DRI
CAS:FOXO4-DRI: a peptide blocking FOXO4/p53 interaction; induces senescent cells' apoptosis.Fórmula:C228H388N86O64Cor e Forma:SolidPeso molecular:5358.06EGFR/DHFR-IN-2
EGFR/DHFR-IN-2 (9b) is a dual inhibitor of h-DHFR/EGFR TK, exhibiting IC50 values of 0.192 μM for h-DHFR and 0.109 μM for EGFR. It causes cell cycle arrest at the G1/S phase and induces apoptosis. Additionally, EGFR/DHFR-IN-2 (9b) is a potential inhibitor of CYP2C9 and CYP3A4. This compound can be utilized in cancer research.Fórmula:C24H16N4O5Cor e Forma:SolidPeso molecular:440.11207DAPK Substrate Peptide TFA
DAPK Substrate Peptide TFA is a synthetic peptide that serves as a substrate for the enzyme death-associated protein kinase (DAPK), exhibiting a MichaelisFórmula:C72H116F3N25O19Cor e Forma:SolidPeso molecular:1692.84SSE1806
SSE1806, a podophyllotoxin derivative (a natural antimitotic agent), functions as a microtubule/tubulin inhibitor, exhibiting potent anticancer andFórmula:C21H18N2O5Cor e Forma:SolidPeso molecular:378.38PROTAC CDK4/6 degrader 1
CAS:PROTAC CDK4/6 degrader 1 (Compound 7f) is a dual degrader of CDK4 and CDK6, with DC50 values of 10.5 nM and 2.5 nM, respectively. This compound effectively inhibits proliferation in Jurkat cells (IC50 of 0.18 μM), induces cell cycle arrest during the G1 phase, and triggers cell apoptosis (apoptosis).Fórmula:C41H47N11O6Cor e Forma:SolidPeso molecular:789.88RPS6-IN-1
RPS6-IN-1 (Compound 22o) inhibits cell migration and induces apoptosis (increasing the expression of Bax, p53, cleaved-caspase 3, and cleaved-PARP). It reduces mitochondrial membrane potential and activates autophagy (Autophagy) through the PI3K-Akt-mTOR signaling pathway, damaging mitochondria and lysosomes within the cell and causing endoplasmic reticulum stress. RPS6-IN-1 also inhibits the phosphorylation of RPS6. Notably, RPS6-IN-1 is a low systemic toxicity anticancer agent.Cor e Forma:Odour Solid5-Fluorouracil-13C,15N2
CAS:5-Fluorouracil-13C,15N2 is a standard for quantifying 5-fluorouracil via GC/LC-MS and blocks DNA synthesis, causing cell apoptosis.Fórmula:C4H3FN2O2Cor e Forma:SolidPeso molecular:133.057Necroptosis-IN-4
Necroptosis-IN-4 is an effective inhibitor of necroptosis, specifically targeting RIP kinase 1 (RIPK1) without inhibitory activity against RIPK3. It exhibits weak inhibitory effects on VEGFR1/2 and PDGFR-α.Cor e Forma:Odour SolidPROTAC NCOA4 degrader-1
PROTACNCOA4 degrader-1 (Compound V3) is a PROTAC-based degrader of NCOA4, exhibiting a DC50 of 3 nM in HeLa cells. Besides acting as a ferroptosis inhibitor, this compound effectively reduces the levels of NCOA4 and decreases intracellular ferrous (Fe2+) levels. Moreover, PROTACNCOA4 degrader-1 ameliorates liver damage in a CCl4-induced acute liver injury model.Cor e Forma:Odour SolidhCAIX-IN-13
CAS:hCAIX-IN-13 (Pt2) inhibits CAIX with 6.57 μM IC50, curbs cancer cell growth, and induces apoptosis for cancer research.Fórmula:C37H33F3N6O7PtS2Cor e Forma:SolidPeso molecular:989.9MY-943
MY-943, a potent inhibitor of tubulin polymerization and LSD1, exhibits anticancer properties by inducing G2/M phase arrest, promoting apoptosis, andFórmula:C30H36N4O6S2Cor e Forma:SolidPeso molecular:612.76Azurin p28 peptide
CAS:Azurin p28 peptide, a tumor-penetrating antitumor agent, stabilizes p53 by reducing its proteasomal degradation via the formation of a p28:p53 complex.
Fórmula:C122H197N31O47S2Cor e Forma:SolidPeso molecular:2914.183-Hydroxyterphenyllin
CAS:3-Hydroxyterphenyllin from A. candidus is a fungal compound with antioxidant, anticancer, antibacterial, and antiviral effects.Fórmula:C20H18O6Cor e Forma:SolidPeso molecular:354.35LL-K9-3
CAS:LL-K9-3, a selective hydrophobic tagging technology (HyT)-based degrader, specifically targets the CDK9-cyclin T1 complex, displaying DC50 values of 589 nM forFórmula:C31H49N5O6S3Cor e Forma:SolidPeso molecular:683.94BODIPY FL thalidomide
CAS:BODIPY FL thalidomide is a fluorescent probe that binds human cereblon protein with high affinity, exhibiting a dissociation constant (Kd) of 3.6 nM [1].Fórmula:C37H43BF2N6O7Cor e Forma:SolidPeso molecular:732.58fac-[Re(CO)3(L3)(H2O)][NO3]
Fac-[Re(CO)3(L3)(H2O)][NO3] (Compound 3), a rhenium(I) tricarbonyl aqua complex, acts as an anticancer agent through the induction of mitochondrial dysfunction.Fórmula:C25H17N6O8ReCor e Forma:SolidPeso molecular:715.64Thalidomide-Piperazine 5-fluoride hydrochloride
CAS:Thalidomide-Piperazine 5-fluoride hydrochloride, a derivative of the cereblon (CRBN) inhibitor Thalidomide, serves as a ligand for E3 ubiquitin ligase (Ligands for E3 Ligase), facilitating the synthesis of PROTACs [1].Fórmula:C17H18ClFN4O4Cor e Forma:SolidPeso molecular:396.8XIAP BIR2/BIR2-3 inhibitor-1
CAS:XIAP BIR2/BIR2-3 inhibitor-1 (compound 3) serves as a potent dual inhibitor targeting BIR2 and BIR2-3 domains, with IC50 values of 1.9 nM and 0.8 nM, respectively. This compound is utilized in cancer research studies [1].Fórmula:C72H96N16O14Cor e Forma:SolidPeso molecular:1409.63Beclin1-Bcl-2 interaction inhibitor 1
Beclin1-Bcl-2 Interaction Inhibitor 1 effectively disrupts the binding of Beclin 1 to Bcl-2, and is utilized in cancer and neurodegeneration research [1].Cor e Forma:Odour SolidAntiproliferative agent-42
Antiproliferative Agent-42 (Compound 7m), a dihydrodipyrrolo compound, exhibits antiproliferative activity against the Panc-1 cell line, with an IC 50 of 12.54Cor e Forma:Odour SolidPipermethystine
Pipermethystine is a useful organic compound for research related to life sciences and the catalog number is T124340.Fórmula:C16H17NO4Cor e Forma:SolidPeso molecular:287.315iNOS/TopoI-IN-1
Compound AuL9, also known as iNOS/TopoI-IN-1, is a multi-target hybrid molecule possessing anti-tumor, anti-inflammatory, and antioxidant properties. This compound effectively inhibits the growth of MCF-7 and MDA MB-231 breast cancer cells in vitro, exhibiting IC50 values of 3.5 μM and 6.3 μM respectively. It also prompts DNA damage and apoptosis in these cells by inhibiting human topoisomerase I (TopoI) with a K_i of 2.72 μM. Additionally, iNOS/TopoI-IN-1 reduces the expression of iNOS by suppressing the activation of NF-kB, with a K_i of 1.49 μM.Fórmula:C34H40AuBrCl2N3OSCor e Forma:SolidPeso molecular:886.54Antitumor photosensitizer-6
CAS:Compound Ru2 (Antitumor photosensitizer-6) exhibits synergistic type I/II photosensitization and photocatalytic activities under illumination at 595 nm. It causes oxidative redox imbalance within cells, affecting biosynthesis and metabolic processes, leading to cell apoptosis (Apoptosis). Compound Ru2 is applicable in studies of photodynamic therapy (PDT).Fórmula:C74H46F26N14P4Ru2S3Cor e Forma:SolidPeso molecular:2047.44EGFR kinase inhibitor 7
EGFRkinase inhibitor 7 (compound 18i) is an EGFR inhibitor with an IC50 of 42.3 nM, exhibiting anticancer properties. This compound demonstrates significant in vitro cytotoxicity and capacity to induce apoptosis. Furthermore, EGFRkinase inhibitor 7 displays anti-proliferative activity against human colon cancer cell line HCT116 and human non-small cell lung cancer cell line A549, with IC50 values of 4.82 µM and 1.43 µM, respectively.Fórmula:C28H26Cl2FN3O3SSeCor e Forma:SolidPeso molecular:653.45PI3K/AKT-IN-4
PI3K/AKT-IN-4 (compound 3), a diterpenoid extracted from the roots and rhizomes of Salvia castanea Dielsf., exhibits antitumor properties by inhibiting cell viability and proliferation (IC 50 =4.72 μM) and promoting apoptosis in Hep3B cells. This compound obstructs the G0/G1 phase of the cell cycle, triggers mitochondrial dysfunction, and induces oxidative stress. Moreover, PI3K/AKT-IN-4 combats hepatocellular carcinoma through the inhibition of the PI3K-Akt signaling pathway and by interacting with PARP1 and CDK2 targets.Fórmula:C19H26O2Cor e Forma:SolidPeso molecular:286.41GPX4-IN-14
GPX4-IN-14 (compound 2c) acts as a GPX4 inhibitor, exhibiting both free radical scavenging activity (with a maximum scavenging rate of 72.52%) and anti-tumor proliferation activity in vitro. This compound targets GPX4 protein, elevating lipid peroxide and intracellular Reactive Oxygen Species (ROS) levels, which induces ferroptosis and contributes to its anti-tumor proliferation effects.Fórmula:C26H39NO8SeCor e Forma:SolidPeso molecular:572.55PROTAC-O4I2
CAS:PROTAC-O4I2, a PROTAC ligand targeting splicing factor 3B1 (SF3B1), induced FLAG-SF3B1 degradation in K562 cells with an IC50 value of 0.244 μM.Fórmula:C29H29ClN6O5SPureza:97.45%Cor e Forma:SolidPeso molecular:609.1Ref: TM-T74186
1mg56,00€5mg119,00€1mL*10mM (DMSO)133,00€10mg178,00€25mg409,00€50mg710,00€100mg1.153,00€500mg2.322,00€GBM CSCs-IN-1
GBM CSCs-IN-1 (Compound (−)-20), a rocaglate derivative, potently inhibits glioblastoma stem cells (GBM CSCs) and exhibits an EC50 of 45 nM by targeting the RNA helicase DDX3. Additionally, it induces apoptosis in these cells.Fórmula:C28H29BrN2O8SCor e Forma:SolidPeso molecular:633.51Antitumor photosensitizer-8
Antitumor agent-187 (compound I3), a photosensitizer derived from 5,15-diarylporphyrin, exhibits anticancer activity with a peak absorption wavelength of ~668 nm. This compound induces apoptosis and is applicable in photodynamic therapy (PDP). It selectively accumulates in tumor sites and possesses real-time fluorescence imaging capabilities.Fórmula:C52H34N4O6Cor e Forma:SolidPeso molecular:810.85BTK-IN-37
BTK-IN-37 (compound 8d), a BTK inhibitor, demonstrates potent apoptotic effects on cancer cells by targeting BTK with K_i and IC_50 values of 5.07 nM and 3.6 nM, respectively. Additionally, this compound selectively promotes the enrichment of genes associated with necroptosis and pyroptosis.Fórmula:C29H29N9O4SCor e Forma:SolidPeso molecular:599.666-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile
CAS:6-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile is a PDK1 inhibitor with anticancer and antiproliferative activity that can be used to studyFórmula:C9H6BrN3OPureza:99.81%Cor e Forma:SolidPeso molecular:252.07A-1208746
CAS:A-1208746 is an inhibitor of MCL-1 with a Ki value of 0.454 nM. This compound effectively activates caspase-3/-7, induces apoptosis in H929 cells, and reduces mitochondrial membrane potential. Additionally, A-1208746 synergizes with Navitoclax, making it applicable in cancer research.Fórmula:C45H52N6O7SCor e Forma:SolidPeso molecular:821PERK-IN-4
CAS:PERK-IN-4 is a potent and selective PERK inhibitor with an IC50 value of 0.3 nM.PERK-IN-4 can be used in the study of cancer and neurological disorders.Fórmula:C24H19F4N5OPureza:99.44% - 99.49%Cor e Forma:SolidPeso molecular:469.43hCAIX/XII-IN-13
hCAIX/XII-IN-13 functions as an inhibitor targeting specific human carbonic anhydrases (hCA) IX and XII, crucial in tumor-related processes. Demonstrating efficacy, this compound offers inhibitory K i values of 0.08 µM for IX and 0.06 µM for XII. Additionally, under hypoxic conditions, hCAIX/XII-IN-13 enhances the effectiveness of Doxorubicin on MCF-7 cells by promoting G2/M phase cell cycle arrest and increasing apoptosis.Fórmula:C25H16N6O6SCor e Forma:SolidPeso molecular:528.51-Methyl-1H-pyrrolo[2,3-b]pyridine
CAS:1-Methyl-1H-pyrrolo[2,3-b]pyridine exhibits cytotoxicity against MCF-7 cells and can be used in related research in the field of life sciences.Fórmula:C8H8N2Pureza:98.89%Cor e Forma:SolidPeso molecular:132.16ReACp53 acetate
ReACp53 acetate could inhibit p53 amyloid formation and rescue p53 function in cancer cell lines.Fórmula:C110H210N52O26Pureza:99.55%Cor e Forma:SolidPeso molecular:2677.18FW-1
FW-1 is a type I inhibitor of FLT3, with an IC50 of approximately 1 μM. It exhibits cytotoxic effects in FLT3-mutant AML cells, causes cell cycle arrest at the G0/G1 phase, and induces apoptosis in MV4-11 and MOLM-13 cells.Fórmula:C24H27N7OCor e Forma:SolidPeso molecular:429.517RMC-4998 formic
RMC-4998 formic is an orally active inhibitor targeting the GTP-bound state of the KRASG12C mutant. It forms a trimeric complex with intracellular CYPA and the activated KRASG12C mutant, displaying an IC50 value of 28 nM. This compound inhibits ERK signaling and induces apoptosis in KRASG12C mutant cancer cells and is utilized in tumor research.Cor e Forma:Odour SolidLisaftoclax
CAS:Lisaftoclax, an oral Bcl-2/Bcl-xl inhibitor (IC50: 2 nM & 5.9 nM), treats CLL by promoting leukemia cell death.Fórmula:C45H48ClN7O8SPureza:97.14% - 99.66%Cor e Forma:SolidPeso molecular:882.42Ref: TM-T10483
1mg177,00€5mg394,00€1mL*10mM (DMSO)558,00€10mg565,00€25mg837,00€50mg1.121,00€100mg1.520,00€AEG 3482
CAS:AEG 3482 blocks JNK, induces HSP70, binds HSP90, and boosts HSP25 expression, preventing cell death.
Fórmula:C10H8N4O2S2Pureza:99.76%Cor e Forma:SolidPeso molecular:280.33SPOP-IN-6lc
CAS:SPOP-IN-6lc is a SPOP inhibitor with oncogenic effects in renal cancer cells.SPOP-IN-6lc can be used to study apoptosis.
Fórmula:C26H31N7O2SPureza:99.19%Cor e Forma:SolidPeso molecular:505.64AZD5582 TFA
AZD5582 TFA is a potent IAP antagonist that binds to the BIR3 domain of cIAP1, cIAP2, and XIAP with IC50 values of 15, 21, and 15 nM, respectively.AZD5582 TFAFórmula:C60H79F3N8O10Pureza:99.89%Cor e Forma:SoildPeso molecular:1129.31Ref: TM-T36201L
1mg55,00€5mg96,00€1mL*10mM (DMSO)144,00€10mg149,00€25mg259,00€50mg442,00€100mg647,00€Furazolidone
CAS:Furazolidone (Furoxone), a nitrofuran derivative, inhibits AML1-ETO transformed cells with IC50 value of 12.7 μM.Fórmula:C8H7N3O5Pureza:99.96%Cor e Forma:Yellow Crystals From Dmf (N N-Dimethylformamide) SolidPeso molecular:225.16DB2313
CAS:DB2313 is a potent PU.1 inhibitor (IC50=14 nM) that disrupts gene binding, induces AML cell apoptosis, and has anticancer properties.
Fórmula:C42H41FN8O2Pureza:98.63% - 99.29%Cor e Forma:SolidPeso molecular:708.83Ferroptosis-IN-16
Ferroptosis-IN-16 (Compound 13l) acts as a specific inhibitor of ferroptosis, demonstrating EC50 values of 0.7 nM in ES-2 cells and 0.9 nM in LX-2 cells. It effectively alleviates acute liver injury induced by Acetaminophen in mouse models and shows excellent metabolic stability in mouse liver microsomes.Fórmula:C26H23N5OCor e Forma:SolidPeso molecular:421.49Thalidomide 4'-oxyacetamide-alkylC1-PEG3-alkylC3-amine
CAS:Cereblon ligand for PROTAC R&D; has E3 ligase, alkylC1-PEG3-alkylC3 linker, terminal amine. Part of Arvinas-licensed tool molecules.Fórmula:C25H35ClN4O9Cor e Forma:SolidPeso molecular:571.02TS-24
CAS:TS-24 is a cysteine protease histone S (CTSS) inhibitor that promotes BRCA1-mediated apoptosis.
Fórmula:C20H15NO2Pureza:99.41%Cor e Forma:SoildPeso molecular:301.34VPC-70063
CAS:VPC-70063 (Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-) is an inhibitor of c-Myc-MAX.Fórmula:C16H12F6N2SPureza:99.98%Cor e Forma:SolidPeso molecular:378.34Ref: TM-T60019
1mg49,00€5mg101,00€1mL*10mM (DMSO)130,00€10mg152,00€25mg268,00€50mg385,00€100mg560,00€200mg790,00€HNPMI
CAS:HNPMI is an epidermal growth factor receptor inhibitor that promotes apoptosis and is used in the study of colorectal cancer.Fórmula:C22H20N2O3Pureza:97.19%Cor e Forma:SoildPeso molecular:360.41Apoptosis Compound Library
A unique collection of 1760 apoptosis-related compounds for apoptosis research, research in tumorigenesis, and anti-cancer drug screening;Cor e Forma:Odour SolidRef: TM-L9000
1mgA consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarVarlilumab
CAS:Varlilumab (CDX-1127) is a novel human IgG1 anti-CD27 monoclonal antibody. Varlilumab has antitumor activity and can be used to study advanced solid tumors.Pureza:SDS-PAGE:95% SEC-HPLC:98.65%Cor e Forma:LiquidPeso molecular:146 kDaCWI1-2
CAS:CWI1-2 is a potent IGF2BP2 inhibitor that inhibits its interaction with M6A-modified target transcripts by binding IGF2BP2.Fórmula:C22H17Cl3N6O3Pureza:98.27%Cor e Forma:SoildPeso molecular:519.77Apoptosis inducer 32
Apoptosisinducer 32 (Compound 7g) is an apoptosis inducer with a KD of 42 μM, demonstrating antitumor activity by causing significant morphological changes, such as membrane blebbing, nuclear fragmentation, and apoptotic body formation, in MDA-MB-231 cells. The IC50 values for Apoptosisinducer 32 are 4.77 μM in MCF-7 cells, 6.56 μM in MDA-MB-231 cells, and 337.8 μM in HEK cells.Fórmula:C29H27Cl2N3O8Cor e Forma:SolidPeso molecular:616.45Curzerene
CAS:Curzerene, a sesquiterpene compound derived from the rhizome of Curculigo orchioides Gaertn, possesses potent anti-cancer properties.Fórmula:C15H20OPureza:97.07%Cor e Forma:SolidPeso molecular:216.32
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