Apoptose
Os inibidores da apoptose são compostos que previnem ou retardam o processo de morte celular programada, conhecido como apoptose. Esses inibidores são vitais no estudo dos mecanismos de sobrevivência celular e são usados para investigar doenças onde a apoptose é desregulada, como câncer, distúrbios neurodegenerativos e doenças autoimunes. Ao modular a apoptose, esses inibidores podem ajudar no desenvolvimento de terapias destinadas a controlar a morte celular. Na CymitQuimica, oferecemos uma ampla seleção de inibidores da apoptose de alta qualidade para apoiar sua pesquisa em biologia celular, oncologia e áreas relacionadas.
Subcategorias de "Apoptose"
- ASK(6 produtos)
- BCL(11 produtos)
- Caspase(125 produtos)
- FOXO1(3 produtos)
- IAP(66 produtos)
- Mdm2(12 produtos)
- PD-1/PD-L1(125 produtos)
- PDK(9 produtos)
- PERK(25 produtos)
- Serina/treonina quinase(15 produtos)
- Survivina(13 produtos)
- TNF(92 produtos)
- c-RET(51 produtos)
- p53(62 produtos)
Exibir 6 mais subcategorias
Foram encontrados 5599 produtos de "Apoptose"
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SB 706504
CAS:<p>SB 706504 is an effective p38 MAPK inhibitor that suppresses inflammatory gene expression in macrophages and inhibits TNFα production in COPD.</p>Fórmula:C24H19F3N8OPureza:98.686%Cor e Forma:SolidPeso molecular:492.46Mcl1-IN-9
CAS:<p>Mcl1-IN-9 is a potent myeloid cell leukemia-1 (Mcl-1) Inhibitor with an IC50 of 446 nM in reengineered BCR-ABL+ B-ALL cells and a Ki of 0.03 nM.</p>Fórmula:C37H39ClN4O4Pureza:98%Cor e Forma:SolidPeso molecular:639.18AK301
CAS:<p>AK301 is a potent and selective inhibitor of tubulin polymerization and an effective sensitizer of cancer cells to apoptotic ligands (EC50 < 200 nM).</p>Fórmula:C19H21ClN2O2Pureza:99.27%Cor e Forma:SolidPeso molecular:344.84ARP 101
CAS:<p>ARP 101 is a selective matrix metalloproteinase-2 (MMP-2) inhibitor with anticancer activity.</p>Fórmula:C20H26N2O5SPureza:98.26%Cor e Forma:SolidPeso molecular:406.5Selicrelumab
CAS:<p>Selicrelumab (RG-7876) is an antibody targeting CD40 with potential anti-tumor activity for the study of pancreatic cancer.</p>Pureza:98.7% (SDS-PAGE); 95.2% (SEC-HPLC) - 98.7% (SDS-PAGE); 95.2% (SEC-HPLC)Cor e Forma:LiquidATAD2-IN-1
CAS:<p>ATAD2-IN-1 (compound 19f) serves as a potent ATAD2 inhibitor (IC 50: 0.27 μM), capable of inducing apoptosis. Additionally, it suppresses c-Myc activation and impedes the migration of BT-549 cells [1].</p>Fórmula:C22H26N6O5Cor e Forma:SolidPeso molecular:454.48cRIPGBM
CAS:<p>cRIPGBM induces apoptosis in GBM CSCs by targeting RIPK2, with an EC50 of 68 nM in GBM-1 cells.</p>Fórmula:C26H20FN2O2Pureza:98%Cor e Forma:SolidPeso molecular:411.45(R)-STU104
CAS:<p>(R)-STU104 is a TAK1-MKK3 protein-protein interaction (PPI) inhibitor. (R)-STU104 is a candidate compound for the treatment of ulcerative colitis.</p>Fórmula:C18H18O4Pureza:98.91% - 99.42%Cor e Forma:SolidPeso molecular:298.33hGGPPS-IN-2
CAS:<p>hGGPPS-IN-2, a C2-ThP-BP analogue, inhibits hGGPPS, targets MM cells, induces apoptosis, and has anti-myeloma effects.</p>Fórmula:C20H18FN5O7P2SCor e Forma:SolidPeso molecular:553.4VU 0364739 hydrochloride
CAS:<p>VU 0364739 hydrochloride (VU 0364739 HCl) is a phospholipase D2 (PLD2) inhibitor that induces apoptosis and can be used in cancer research.</p>Fórmula:C26H28ClFN4O2Pureza:99.36%Cor e Forma:SolidPeso molecular:482.98STAT3-IN-11
CAS:<p>STAT3-IN-11 is a STAT3 inhibitor.STAT3-IN-11 promotes apoptosis in cancer cells and is a candidate compound for the treatment of cancer.</p>Fórmula:C20H17NO4Pureza:98.3%Cor e Forma:SolidPeso molecular:335.35SMBA1
CAS:<p>SMBA1 is a Bax agonist with antitumor activity that can induce cell cycle arrest and apoptosis in malignant glioma cells.</p>Fórmula:C20H13NO3Pureza:99.2%Cor e Forma:SolidPeso molecular:315.32VU0285655-1
CAS:<p>VU0285655-1, a PLD2 inhibitor, halts PLD2-deficient cell growth and protects against high glucose-induced cell death. Used in diabetic retinopathy research.</p>Fórmula:C25H27N5O2Pureza:99.73%Cor e Forma:SolidPeso molecular:429.51Mcl-1 inhibitor 10
CAS:<p>Mcl-1 inhibitor10 (compound 43) is a relatively potent MCL-1 inhibitor with an IC50 of 0.67 μM. It interacts with a specific binding site on the MCL-1 protein, disrupting its pro-survival signals and inducing apoptosis in cancer cells. This compound is useful for research on MCL-1-dependent cancers.</p>Fórmula:C21H15F3O4Cor e Forma:SolidPeso molecular:388.34CFM 4
CAS:CFM 4 is a potent small molecule CARP-1/APC-2 antagonist that prevents CARP-1 from binding to APC-2, contributes to G2M cell cycle arrest, and induces apoptosisFórmula:C22H16ClN3OSPureza:98.16%Cor e Forma:SolidPeso molecular:405.9(S)-Elobixibat
CAS:<p>(S)-Elobixibat is the S-isomer of Elobixibat. It is an orally active inhibitor of Apical Sodium-Dependent Bile (IBAT) and can reduce LDL cholesterol, increase serum GLP-1, and promote colonic motility. This compound shows potential for treating metabolic syndrome and can be studied for constipation, dyslipidemia, non-alcoholic hepatitis, and liver tumors.</p>Fórmula:C36H45N3O7S2Cor e Forma:SolidPeso molecular:695.89RSH-7
CAS:<p>RSH-7 is a potent dual inhibitor of BTK and FLT3, with IC50s of 47 and 12 nM, respectively.RSH-7 has antiproliferative and antitumor activities, inducing</p>Fórmula:C22H25FN8OPureza:98.31%Cor e Forma:SolidPeso molecular:436.49Infliximab
CAS:<p>Infliximab is a chimeric monoclonal antibody that inhibits TNF-α. Infliximab can be used to treat Crohn's disease and rheumatoid arthritis. Cost-effective and quality-assured.</p>Pureza:98% - 99.70%Cor e Forma:LiquidPeso molecular:149 kDa3-(3-Phenoxybenzyl)amino-β-carboline
CAS:<p>3-(3-Phenoxybenzyl)amino-β-carboline is a highly effective tubulin inhibitor, selectively degrading αβ-tubulin heterodimers.</p>Fórmula:C24H19N3OCor e Forma:SolidPeso molecular:365.43GLUT4-IN-2
CAS:<p>GLUT4-IN-2, selective GLUT4 blocker; IC50: 6.8μM (GLUT4), 11.4μM (GLUT1). Induces apoptosis, G0/G1 arrest, has antitumor effects.</p>Fórmula:C17H11N3O4S2Pureza:99.90%Cor e Forma:SolidPeso molecular:385.42Targapremir-210
CAS:<p>Targapremir-210 (TGP-210) is a miRNA-210 (miRNA-210) inhibitor that inhibits pre-miR-210 processing and induces apoptosis in breast cancer cells.</p>Fórmula:C32H36N10O2Pureza:98%Cor e Forma:SolidPeso molecular:592.69GY1-22
CAS:<p>GY1-22, an inhibitor targeting the DNAJA1-mutP53 R175H interaction pocket, holds potential for cancer research applications.</p>Fórmula:C23H20N4OSCor e Forma:SolidPeso molecular:400.5Tubulin polymerization-IN-14
CAS:<p>Tubulin-IN-14 (20a) inhibits polymerization (IC50=3.15μM), has anti-cancer and anti-vascular effects, inducing cell death.</p>Fórmula:C15H15ClN2O2Cor e Forma:SolidPeso molecular:290.74CT-1
CAS:<p>CT-1 is a DNA minor groove ligand and causes p53-dependent breast cancer cell apoptosis.</p>Fórmula:C29H23F3N4OPureza:99.79%Cor e Forma:SolidPeso molecular:500.51HDAC-IN-42
CAS:<p>HDAC-IN-42, a potent HDAC inhibitor: IC50 - 0.19μM (HDAC1), 4.98μM (HDAC6); halts cancer cell growth, triggers apoptosis & G2/M arrest.</p>Fórmula:C20H15NO7Cor e Forma:SolidPeso molecular:381.34Antitumor agent-55
CAS:<p>Antitumor agent-55 (5q) inhibits PC3 (IC50: 0.91 μM), blocks G1/S phase, induces apoptosis, and halts migration.</p>Fórmula:C32H34N6O4SCor e Forma:SolidPeso molecular:598.72CA224
CAS:<p>CA224: selective oral Cdk4-cyclin D1 inhibitor, IC50=6.2μM, promotes apoptosis, has antitumor effects.</p>Fórmula:C24H22N2OCor e Forma:SolidPeso molecular:354.44Vin-F03
CAS:<p>Vin-F03 protects pancreatic β-cells in type 2 diabetes research with an EC50 of 0.27 μM and prevents STZ-induced apoptosis.</p>Fórmula:C22H29N3Cor e Forma:SolidPeso molecular:335.49DNL343
CAS:<p>DNL343 is an eIF2B activator that inhibits stress granule (SG) assembly induced by the C9ORF72 dipeptide repeat.</p>Fórmula:C20H19ClF3N3O4Pureza:99.96%Cor e Forma:SolidPeso molecular:457.83Theophylline sodium glycinate
CAS:<p>Theophylline sodium glycinate inhibits PDE3, treats asthma/COPD, blocks adenosine receptors, activates HDAC, reduces inflammation and induces apoptosis.</p>Fórmula:C9H12N5NaO4Cor e Forma:SolidPeso molecular:277.216IQDMA
CAS:<p>IQDMA is an inhibitor of the transcription factor STAT5.</p>Fórmula:C19H20N4Cor e Forma:SolidPeso molecular:304.39RET-IN-16
CAS:<p>RET-IN-16: Selective RET inhibitor, IC50s 3.98-15.05 nM for various RET mutations; anticancer properties.</p>Fórmula:C31H29F3N8O2Cor e Forma:SolidPeso molecular:602.61AZD-5991 Racemate
CAS:<p>AZD-5991 Racemate is the racemate of AZD-5991. (Rac)-AZD-5991 is a novel Mcl-1 inhibitor induces upregulation of BCL2,BCL-XL, CMYC and MCL1 in AML cell lines.</p>Fórmula:C35H34ClN5O3S2Cor e Forma:SolidPeso molecular:672.26SEC
CAS:<p>SEC triggers ANXA7 GTPase via AMPK/mTORC1/STAT3, causing ITGB4-driven apoptosis in ITGB4-high cancer cells.</p>Fórmula:C22H23ClN2O5Cor e Forma:SolidPeso molecular:430.88RIP1 kinase inhibitor 5
CAS:<p>RIP1 kinase inhibitor 5 (example 1) serves as a potent regulator of tumor immunity by inhibiting RIP1, functioning similarly to SIR1-365 (compound 13) in</p>Fórmula:C13H17F2NO2Pureza:98%Cor e Forma:SolidPeso molecular:257.28FD223
CAS:<p>FD223, a PI3Kδ inhibitor, is highly potent (IC50=1 nM) and selective, limiting AML cell growth by causing G1 arrest.</p>Fórmula:C17H12ClN5O2SCor e Forma:SolidPeso molecular:385.83WK-298
CAS:<p>WK-298 is an effective MDM2/MDMX-p53 interaction inhibitor.</p>Fórmula:C35H38Cl2N6OPureza:98%Cor e Forma:SolidPeso molecular:629.62ANO1-IN-3
CAS:<p>ANO1-IN-3 (Compound 3n) can induces apoptosis that is a potent and selective inhibitor of ANO1 with an IC 50 of 1.23 μM [1].</p>Fórmula:C20H17NO3Cor e Forma:SolidPeso molecular:319.35SCAL-255
CAS:<p>SCAL-255 is a mitochondrial complex I (CI) inhibitor, exhibiting potent inhibition with an IC50 of 1.14 μM.</p>Fórmula:C27H28F3N5O3Pureza:98%Cor e Forma:SolidPeso molecular:527.54Rohinitib
CAS:<p>Rohinitib, an eIF4A inhibitor, triggers apoptosis in AML cells and lessens tumor load in models.</p>Fórmula:C29H31NO8Cor e Forma:SolidPeso molecular:521.56MMP-9-IN-3
CAS:<p>MMP-9-IN-3: MMP-9/AKT inhibitor (IC50: 5.56/2.11 nM), forms H-bonds, cytotoxic, induces apoptosis, used in cancer research.</p>Fórmula:C29H25N3O4Cor e Forma:SolidPeso molecular:479.53ZMF-10
CAS:<p>ZMF-10 inhibits PAK1 (IC50: 174 nM), PAK2, PAK3; affects apoptosis, ER stress, migration in cancer studies.</p>Fórmula:C19H17F6N7OCor e Forma:SolidPeso molecular:473.38αβ-Tubulin-IN-1
CAS:<p>αβ-Tubulin-IN-1 is a potent and orally active inhibitor of αβ-Tubulin.</p>Fórmula:C25H19N3O3Cor e Forma:SolidPeso molecular:409.44CT1-3
CAS:<p>CT1-3 is a potent anti-cancer compound targeting JNK/Bcl-2 pathways, blocking EMT in HCCs, and is non-toxic to liver/kidneys in mice.</p>Fórmula:C25H29NO3S2Cor e Forma:SolidPeso molecular:455.63SAR125844
CAS:<p>SAR125844, a potent and highly selective inhibitor of the MET receptor tyrosine kinase (RTK), for intravenous administration. (IC50 value of 4.2 nmol/L)</p>Fórmula:C25H23FN8O2S2Pureza:98.73%Cor e Forma:SolidPeso molecular:550.63ADU-S100
CAS:<p>ADU-S100 (MIW815) is a STING agonist that significantly induces the production of IFN-β,TNF-α,IL-6,and MCP-1,induces TBK1 and IRF3 phosphorylation,antitumour.</p>Fórmula:C20H24N10O10P2S2Pureza:99.83%Cor e Forma:SolidPeso molecular:690.54HI5
CAS:<p>HI5: potent tubulin/IDO inhibitor, IC50 70 nM (HeLa), blocks kynurenine, G2/M arrest, spurs T cell activity, & triggers apoptosis.</p>Fórmula:C42H43N5O8Cor e Forma:SolidPeso molecular:745.82GW837016X
CAS:<p>GW837016X, also known as NEU-391, is a potent inhibitor of protozoan parasite proliferation.</p>Fórmula:C25H20ClFN4OSCor e Forma:SolidPeso molecular:478.97Anti-inflammatory agent 47
CAS:<p>Flo8, an anti-inflammatory and antioxidant agent, effectively suppresses the release of reactive oxygen species (ROS) and nitric oxide (NO) while inhibiting</p>Fórmula:C25H18N2O3Pureza:98%Cor e Forma:SolidPeso molecular:394.42PHA-680626
CAS:<p>PHA-680626 is a PLK inhibitor, effective on resistant leukemia cells, with IC50: Plk1 (0.53 μM), Plk2 (0.07 μM), Plk3 (1.61 μM).</p>Fórmula:C23H26N6O2SCor e Forma:SolidPeso molecular:450.56LG308
CAS:<p>LG308, a synthetic compound, has anti-tumor properties, inducing apoptosis and mitotic arrest, thereby suppressing prostate cancer growth.</p>Fórmula:C19H17FN2OCor e Forma:SolidPeso molecular:308.35NF-κB-IN-5
CAS:<p>NF-κB-IN-5 (compound 4d) is an orally active NF-κB inhibitor.</p>Fórmula:C23H27N3O4Cor e Forma:SolidPeso molecular:409.48Tubulin polymerization-IN-22
CAS:<p>Tubulin polymerization-IN-22 inhibits tubulin (IC50=8.1μM), blocks G2/M phase, and triggers apoptosis.</p>Fórmula:C19H16O4Cor e Forma:SolidPeso molecular:308.33Jolkinolide B
CAS:<p>Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud.</p>Fórmula:C20H26O4Pureza:99.39% - 99.7%Cor e Forma:SolidPeso molecular:330.42VEGFR-2-IN-23
CAS:<p>VEGFR-2-IN-23 (11b) is a potent VEGFR-2 inhibitor with an IC50 of 0.34 nM, exhibits antitumor effects, and causes G1 cell cycle arrest.</p>Fórmula:C22H15N5O2Cor e Forma:SolidPeso molecular:381.39PTG-0861
CAS:<p>PTG-0861 is a selective HDAC6 inhibitor with an IC50 of 5.92 nm, promising for hematological cancer research.</p>Fórmula:C15H9F5N2O3Cor e Forma:SolidPeso molecular:360.24MDM2-p53-IN-16
CAS:<p>MDM2-p53-IN-16 inhibits p53/MDM2 complex (IC 50 = 4.3 nM), triggers p53, causes GBM cell apoptosis, useful in cancer research.</p>Fórmula:C32H33N3O5Cor e Forma:SolidPeso molecular:539.62CMLD012073
CAS:<p>CMLD012073: Potent eIF4A inhibitor, halts eukaryotic translation; IC50 10 nM in NIH/3T3 cells.</p>Fórmula:C30H30N2O7Pureza:98%Cor e Forma:SolidPeso molecular:530.57CCT373566
CAS:<p>CCT373566: potent BCL6 degrader, oral, IC50 2.2 nM; hinders cell growth in vitro & shrinks tumors in vivo.</p>Fórmula:C26H29ClF2N6O3Cor e Forma:SolidPeso molecular:547Apoptotic agent-3
CAS:<p>"Apoptotic agent-3 targets Bcl-2/Bax, activates caspase-3, and has anti-proliferative properties for cancer research."</p>Fórmula:C31H21N5OSCor e Forma:SolidPeso molecular:511.6Nampt-IN-3
CAS:<p>Nampt-IN-3 simultaneously inhibit nicotinamide phosphoribosyltransferase (NAMPT) and HDAC (IC50s of 31 nM and 55 nM, respectively).</p>Fórmula:C29H25N7O2Pureza:98%Cor e Forma:SolidPeso molecular:503.55CCT373567
CAS:<p>CCT373567 is a potent degrader of the transcriptional repressor BCL6 (IC50: 2.9 nM) and exhibits anti-proliferative effects.</p>Fórmula:C26H29ClF2N6O3Cor e Forma:SolidPeso molecular:547Topoisomerase II inhibitor 3
CAS:<p>Acridone-based Topoisomerase II inhibitor 3 targets topo IIα/β (IC50: 0.17μM α, 0.23μM β), causes DNA damage, and induces apoptosis.</p>Fórmula:C18H20N4O4Cor e Forma:SolidPeso molecular:356.38CYD-2-11
CAS:<p>CYD-2-11 is an effective and selective Bax agonist. It acts by targeting the structural pocket proximal to S184 in the C-terminal region of Bax.</p>Fórmula:C22H18N2O3Cor e Forma:SolidPeso molecular:358.39TrxR inhibitor D9
CAS:<p>TrxR-IN-D9 is a novel inhibitor of thioredoxin reductase (TrxR).</p>Fórmula:C25H20AuOPSCor e Forma:SolidPeso molecular:596.43p53 Activator 2
CAS:<p>p53 Activator 2 binds to DNA, breaks it, halts cell cycle at G2/M, triggers apoptosis, reduces Bcl-2/Bcl-xL, IC50: 1.73μM against MGC-803.</p>Fórmula:C20H21N5O2Cor e Forma:SolidPeso molecular:363.41RIPK1-IN-13
CAS:<p>RIPK1-IN-13 inhibits RIPK1 (IC50=1139 nM), potentially blocking necrosis and treating inflammation.</p>Fórmula:C21H20ClN3O3Cor e Forma:SolidPeso molecular:397.85PDE5/HDAC-IN-1
CAS:<p>PDE5/HDAC-IN-1 is a potent inhibitor of phosphodiesterase 5 (PDE5) and HDAC, with IC50 values of 46.3 nM and 14.5 nM, respectively.</p>Fórmula:C27H29BrN4O4Cor e Forma:SolidPeso molecular:553.45Antitumor agent-53
CAS:<p>Antitumor agent-53 hinders tumor growth, induces G2/M cell cycle arrest, and triggers apoptosis via PI3K/AKT in HGC-27 cells.</p>Fórmula:C24H18FN3OCor e Forma:SolidPeso molecular:383.42SAHA-OH
CAS:<p>SAHA-OH selectively inhibits HDAC6 (IC50 = 23 nM) with 10-47x preference over HDACs 1, 2, 3, 8, and reduces inflammation and macrophage apoptosis.</p>Fórmula:C15H22N2O4Pureza:98%Cor e Forma:SolidPeso molecular:294.35EGFR-IN-51
CAS:<p>EGFR-IN-51 effectively inhibits EGFR and mutations with IC50s of 0.493-461.63 μM; it induces apoptosis in cancer cells.</p>Fórmula:C21H15N3O2SCor e Forma:SolidPeso molecular:373.43S130
CAS:<p>S130 is a high affinity, selectiveATG4B (a major cysteine protease) inhibitor (IC50 of 3.24 μM).It suppresses autophagy flux.</p>Fórmula:C24H25N3O2Pureza:98%Cor e Forma:SolidPeso molecular:387.47ATSP-7041
CAS:<p>ATSP-7041 is a novel potent and selective dual inhibitor of mdm2 (ki = 0.9 nm) and mdmx (ki = 7 nm)</p>Fórmula:C87H125N17O21Cor e Forma:SolidPeso molecular:1745.02Perillic acid
CAS:<p>Perillic acid, a perillyl alcohol metabolite, induces lung cancer cell arrest, apoptosis, and has anti-HSV-1 and immune-modulating effects.</p>Fórmula:C10H14O2Cor e Forma:SolidPeso molecular:166.22GEM144
CAS:<p>GEM144: oral POLA1/HDAC11 inhibitor; boosts p53, p21; halts G1/S cycle; triggers cell death.</p>Fórmula:C28H31NO5Cor e Forma:SolidPeso molecular:461.55BMS-37
CAS:<p>BMS-37 is a novel inhibitor of PD-1/PD-L1 immune checkpoint.</p>Fórmula:C27H32N2O4Cor e Forma:SolidPeso molecular:448.55Cadein1
<p>Cadein1, an isoquinolinium derivative, induces G2/M phase delay and caspase-dependent apoptosis in cancer cells lacking functional p53.</p>Fórmula:C33H48F2INO2Cor e Forma:SolidPeso molecular:655.64RO2468
CAS:<p>RO2468 is a potent and orally active inhibitor of the p53-MDM2.</p>Fórmula:C30H30Cl2FN5O4Pureza:98%Cor e Forma:SolidPeso molecular:614.49TH-Z835
CAS:<p>TH-Z835 is a selective inhibitor for the KRAS (G12D) mutation, demonstrating an inhibitory concentration (IC50) of 1.6 μM.</p>Fórmula:C30H38N6OPureza:98%Cor e Forma:SolidPeso molecular:498.66ZC0101
CAS:<p>ZC0101: potent oral IDO1/TrxR inhibitor. IC50: 0.084/7.98 μM. Induces apoptosis, ROS in cancer cells.</p>Fórmula:C17H15N3O2Cor e Forma:SolidPeso molecular:293.32VMY-1-103
CAS:<p>VMY-1-103: a strong CDK inhibitor better than purvalanol B; halts prostate/breast cancer cell growth, induces apoptosis, may treat medulloblastoma.</p>Fórmula:C34H42ClN9O4SCor e Forma:SolidPeso molecular:708.27ZT55
CAS:<p>ZT55: Oral JAK2 inhibitor, IC50: 0.031 μM, hinders JAK2 V617F HEL cell growth, induces apoptosis, arrests cell cycle, effective in mice HEL tumor studies.</p>Fórmula:C17H16N2O3Cor e Forma:SolidPeso molecular:296.32Semapimod
CAS:<p>Semapimod is an inhibitor of proinflammatory cytokine production, capable of suppressing TNF-α, IL-1β, and IL-6.</p>Fórmula:C34H52N18O2Cor e Forma:SolidPeso molecular:744.9CRA-026440
CAS:<p>CRA-026440(PCI-34051) is a highly potent HDAC inhibitor with inhibitory effects on HDAC1, HDAC2, HDAC3, HDAC6, HDAC8 and HDAC10 with Ki values of 4,14,11,15,7</p>Fórmula:C23H24N4O4Pureza:96.42%Cor e Forma:SolidPeso molecular:420.46IDO1/TDO-IN-1
CAS:<p>IDO1/TDO-IN-1 (30) inhibits IDO1 (Ki=0.23μM) & TDO (Ki=0.73μM); induces apoptosis via Bcl-2/Bax.</p>Fórmula:C21H16O6Cor e Forma:SolidPeso molecular:364.35TRK-IN-23
CAS:<p>TRK-IN-23 (compound 24b) is a potent, orally active inhibitor of TRK with IC50s of 0.5 nM for TRKA, 9 nM for TRKC, 14 nM for TRKA G595R, 4.4 nM for TRKA F589L,</p>Fórmula:C20H17FN4O2Pureza:98%Cor e Forma:SolidPeso molecular:364.37Anticancer agent 72
CAS:<p>Compound 8c inhibits K+ channel and induces apoptosis, showing promise as an anticancer agent.</p>Fórmula:C20H19N7O2Cor e Forma:SolidPeso molecular:389.41LY5
CAS:<p>LY5 is an inhibitor of STAT3 that acts by inhibiting cell viability, cell migration, and angiogenesis in medulloblastoma cells.</p>Fórmula:C15H11N3O4SPureza:98%Cor e Forma:SolidPeso molecular:329.33Mcl1-IN-3
CAS:<p>Mcl1-IN-3 is an Mcl1 inhibitor. It has an IC50 and Ki of 0.67 and 0.13 μM, respectively.</p>Fórmula:C27H22ClN3O4Pureza:98%Cor e Forma:SolidPeso molecular:487.93PARP-1-IN-2
CAS:<p>PARP-1-IN-2 is a potent PARP1 inhibitor that crosses the blood-brain barrier (IC50: 149 nM).PARP-1-IN-2 showed significant antiproliferative activity against</p>Fórmula:C22H15Cl2N3O2Pureza:98.82%Cor e Forma:SolidPeso molecular:424.28RIPK1-IN-15
CAS:<p>RIPK1-IN-15 (Compound 2.5) is a potent RIPK1 inhibitor that has the potential in neurodegenerative, autoimmune, and inflammatory diseases research [1].</p>Fórmula:C19H19N3O2Cor e Forma:SolidPeso molecular:321.37CDK/HDAC-IN-2
CAS:<p>CDK/HDAC-IN-2 inhibits HDAC1,2,3, CDK1,2, induces G2/M arrest, apoptosis, and shows anti-tumor effects.</p>Fórmula:C25H20Cl2N6O3Cor e Forma:SolidPeso molecular:523.37GGTI-2154
CAS:<p>GGTI-2154 is a potent, selective geranylgeranyltransferase I (GGTase I) inhibitor, boasting an IC50 of 21 nM and demonstrating over 200-fold selectivity against</p>Fórmula:C24H28N4O3Cor e Forma:SolidPeso molecular:420.5VRT-043198
CAS:<p>VRT-043198, a VX-765 metabolite, is a potent ICE/caspase-1 inhibitor, crossing the blood-brain barrier with K i of 0.8/0.6 nM.</p>Fórmula:C22H29ClN4O6Cor e Forma:SolidPeso molecular:480.94Bcl-2/Mcl-1-IN-3
CAS:<p>Bcl-2/Mcl-1-IN-3 is a Bcl-2/Mcl-1 inhibitor that acts on Mcl-1 (Ki: 0.14 μM) and Bcl-2 (Ki: 0.23 μM) and can be used in cancer research.</p>Fórmula:C27H26ClNO4Cor e Forma:SolidPeso molecular:463.95IST5-002
CAS:<p>IST5-002: Potent Stat5a/b blocker, IC50 1.5μM/3.5μM, targets prostate cancer & CML.</p>Fórmula:C17H20N5O7PPureza:99.36%Cor e Forma:SolidPeso molecular:437.34PI3Kδ-IN-11
CAS:<p>PI3Kδ-IN-11 is a potent and selective PI3Kδ inhibitor (IC50: 27.5 nM) that dose-dependently blocks PI3K/Akt pathway activity.</p>Fórmula:C27H21N5OCor e Forma:SolidPeso molecular:431.49PI3K-IN-33
CAS:<p>PI3K-IN-33 selectively inhibits PI3K-α/β/δ, blocks G2/M, induces apoptosis, for leukemia research.</p>Fórmula:C23H21BrN6O2Cor e Forma:SolidPeso molecular:493.36CMC2.24
CAS:<p>CMC2.24 inhibits Ras and ERK1/2, fights pancreatic tumors in mice, blocks MMPs (IC50: 2-69 µM), and reduces osteoarthritis by stabilizing cartilage.</p>Fórmula:C26H21NO5Cor e Forma:SolidPeso molecular:427.45Vin-C01
CAS:<p>Vin-C01, a potent protector of pancreatic β-cells (EC50=0.22μM), aids in type 2 diabetes research by preventing STZ-induced β-cell apoptosis.</p>Fórmula:C20H24N2OCor e Forma:SolidPeso molecular:308.42
