Apoptose
Os inibidores da apoptose são compostos que previnem ou retardam o processo de morte celular programada, conhecido como apoptose. Esses inibidores são vitais no estudo dos mecanismos de sobrevivência celular e são usados para investigar doenças onde a apoptose é desregulada, como câncer, distúrbios neurodegenerativos e doenças autoimunes. Ao modular a apoptose, esses inibidores podem ajudar no desenvolvimento de terapias destinadas a controlar a morte celular. Na CymitQuimica, oferecemos uma ampla seleção de inibidores da apoptose de alta qualidade para apoiar sua pesquisa em biologia celular, oncologia e áreas relacionadas.
Subcategorias de "Apoptose"
- ASK(6 produtos)
- BCL(11 produtos)
- Caspase(127 produtos)
- FOXO1(3 produtos)
- IAP(65 produtos)
- Mdm2(12 produtos)
- PD-1/PD-L1(126 produtos)
- PDK(9 produtos)
- PERK(24 produtos)
- Serina/treonina quinase(15 produtos)
- Survivina(13 produtos)
- TNF(91 produtos)
- c-RET(51 produtos)
- p53(62 produtos)
Exibir 6 mais subcategorias
Foram encontrados 5622 produtos de "Apoptose"
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SMIP34
CAS:<p>SMIP34 is an inhibitor of PELP1, binding to this target with a dissociation constant (Kd) of 37.4 μM. It demonstrates efficacy in inhibiting the proliferation of cancer cells and tumor progression. Specifically, SMIP34 is effective in breast cancer research, showing activity against wild-type (WT), mutant (MT) estrogen receptor-positive (ER+), and treatment-resistant (TR)-ER+ breast cancers.</p>Fórmula:C25H32ClN5O3Cor e Forma:SolidPeso molecular:486.01PD-1-IN-17 TFA
<p>PD-1-IN-17 TFA is a potent PD-1 inhibitor, blocking 92% of splenocyte growth at 100 nM.</p>Fórmula:C15H23F3N6O9Cor e Forma:SolidPeso molecular:488.37XIAP degrader-1
<p>XIAP degrader-1 is a small primary amine molecule that promotes the degradation of X-linked apoptosis inhibitory protein (XIAP).</p>Fórmula:C34H45N5O4Cor e Forma:SolidPeso molecular:587.75Antitumor agent-202
CAS:<p>Antitumor agent-202 is a stabilizer of the p53Y220C mutant, selectively inhibiting the proliferation of tumor cells carrying the p53Y220C mutation. It is applicable for research focused on cancers associated with the p53 Y220C mutation.</p>Fórmula:C17H13NOCor e Forma:SolidPeso molecular:247.291Antitumor agent-42
<p>Antitumor agent-42 inhibits microtubule multimerisation and NO release, exhibiting anti-angiogenic, colony-forming and apoptosis-inducing effects.</p>Fórmula:C24H19BrN2O8SCor e Forma:SolidPeso molecular:575.39CHI-KAT8i5
CAS:<p>CHI-KAT8i5 is a selective inhibitor of KAT8 with a KD of 19.72 μM. It induces apoptosis (Apoptosis) in a dose-dependent manner. CHI-KAT8i5 can inhibit tumor growth in esophageal squamous cell carcinoma, colon cancer, melanoma, gastric cancer, non-small cell adenocarcinoma, and liver cancer.</p>Fórmula:C23H29N3O5S3Cor e Forma:SolidPeso molecular:523.688NLRP3-IN-28
CAS:NLRP3-IN-28 (compound N77) serves as a potent inhibitor of NLRP3, effectively blocking Nigericin-induced pyroptosis with an EC50 of 0.07μM. Additionally, it mitigates inflammatory reactions in vivo [1].Fórmula:C12H9F3N2O3SCor e Forma:SolidPeso molecular:318.27GGTI298
CAS:<p>GGTI298 is a potent GGTase I inhibitor; IC50 3μM for Rap1A, >20μM for Ha-Ras.</p>Fórmula:C27H33N3O3SPureza:98%Cor e Forma:SolidPeso molecular:479.63WEHI-539
CAS:WEHI-539 is a selective Bcl-XL inhibitor (IC50: 1.1 nM).Fórmula:C31H29N5O3S2Pureza:98%Cor e Forma:SolidPeso molecular:583.72Thalidomide-NH-amido-PEG2-C2-NH2
CAS:<p>Thalidomide-NH-amido-PEG2-C2-NH2 is a synthetic E3 ligase ligand-linker conjugate comprising a Thalidomide-based cereblon ligand and a linker. It is utilized in the synthesis of PROTACs.</p>Fórmula:C21H27N5O7Peso molecular:461.47Thalidomide-O-PEG4-amine TFA
CAS:Thalidomide-O-PEG4-amine TFA is a synthetic E3 ligase ligand-linker conjugate, composed of a cereblon ligand derived from Thalidomide and a single linker.Fórmula:C25H32F3N3O11Peso molecular:607.53Caspase-3 activator 4
CAS:<p>Caspase-3 Activator 4 (compound 4o) is an effective caspase-3 activator that can cross the blood-brain barrier. This compound exhibits antiproliferative activity and can induce cell apoptosis (apoptosis). Additionally, Caspase-3 Activator 4 enhances the gene expression of TNF-α and reduces the expression of cleaved caspase-3/caspases 3.</p>Fórmula:C31H27N5O3Cor e Forma:SolidPeso molecular:517.58MTX-216
CAS:<p>MTX-216 is an ATP-competitive inhibitor targeting both PI3K and EGFR. It simultaneously inhibits Ki-67 and ribosomal S6 phosphorylation, inducing apoptosis in NF1LOF cells. Additionally, MTX-216 suppresses SYK kinase activity with an IC50 of 281 nM. This compound is applicable for melanoma research.</p>Fórmula:C22H14Cl2FN5O2SCor e Forma:SolidPeso molecular:502.348Topoisomerase I/II inhibitor 3
<p>Topoisomerase I/II inhibitor 3 suppresses cell growth and induces apoptosis in liver cancer by blocking PI3K/Akt/mTOR.</p>Fórmula:C24H24N2O4Cor e Forma:SolidPeso molecular:404.46PAK4-IN-5
<p>PAK4-IN-5 (Compound 12i) is a potent inhibitor of PAK4 (IC50: PAK4 at 7.68 nM, PAK1 at 1872.01 nM) that forms stable interactions with the PAK4 enzyme. This compound effectively inhibits the proliferation and migration potential of MDA-MB-231 cells by hindering the phosphorylation of PAK4 and LIMK1. Additionally, PAK4-IN-5 arrests the cell cycle in the G0/G1 phase, induces apoptosis, and prompts the production of reactive oxygen species. The LD50 in mice is greater than 500 mg/kg (oral).</p>Fórmula:C31H28ClN5OCor e Forma:SolidPeso molecular:522.04Topo I-IN-1
<p>Topo I-IN-1 (14d) is a powerful Topo I inhibitor with antitumor effects and DNA intercalation, inducing apoptosis.</p>Fórmula:C20H14BrN3O2Cor e Forma:SolidPeso molecular:408.25ER covalent antagonist-1
CAS:<p>ER covalent antagonist-1 (Compound 39D) acts as an antagonist of the estrogen receptor α (ERα). This compound inhibits the proliferation of ERα-positive MCF-7 cells with an IC50 of 0.98 μM, induces cell cycle arrest at the G0/G1 phase, and triggers apoptosis. Additionally, ER covalent antagonist-1 demonstrates antitumor activity in mouse models.</p>Fórmula:C33H32N2O5SCor e Forma:SolidPeso molecular:568.683ASCT2-IN-1
CAS:ASCT2-IN-1 (compound 20k) is an inhibitor of ASCT2, demonstrating IC50 values of 5.6 μM in A549 cells and 3.5 μM in HEK293 cells. It induces apoptosis and inhibits tumor growth.Fórmula:C36H32Cl2N2O4Peso molecular:627.56L5-DA
<p>L5-DA, a G-quadruplex ligand, stabilizes G4s in HeLa cells, induces apoptosis, and is cytotoxic with an IC50 of 4.3 μM.</p>Fórmula:C32H34N6O2Cor e Forma:SolidPeso molecular:534.65MDK-3345
CAS:MDK-3345 is a reversible covalent inhibitor for Mcl-1.Fórmula:C36H34BN3O7Pureza:98%Cor e Forma:SolidPeso molecular:631.48
