Apoptose
Os inibidores da apoptose são compostos que previnem ou retardam o processo de morte celular programada, conhecido como apoptose. Esses inibidores são vitais no estudo dos mecanismos de sobrevivência celular e são usados para investigar doenças onde a apoptose é desregulada, como câncer, distúrbios neurodegenerativos e doenças autoimunes. Ao modular a apoptose, esses inibidores podem ajudar no desenvolvimento de terapias destinadas a controlar a morte celular. Na CymitQuimica, oferecemos uma ampla seleção de inibidores da apoptose de alta qualidade para apoiar sua pesquisa em biologia celular, oncologia e áreas relacionadas.
Subcategorias de "Apoptose"
- ASK(6 produtos)
- BCL(11 produtos)
- Caspase(125 produtos)
- FOXO1(3 produtos)
- IAP(66 produtos)
- Mdm2(12 produtos)
- PD-1/PD-L1(125 produtos)
- PDK(9 produtos)
- PERK(25 produtos)
- Serina/treonina quinase(15 produtos)
- Survivina(13 produtos)
- TNF(92 produtos)
- c-RET(51 produtos)
- p53(62 produtos)
Exibir 6 mais subcategorias
Foram encontrados 5600 produtos de "Apoptose"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
ZSH-512
CAS:<p>ZSH-512 is a potent inhibitor of RARγ with antiproliferative properties. It induces apoptosis and reduces the expression of CD133, NANOG, SOX2, and EPCAM proteins. ZSH-512 exhibits anticancer activity and shows potential for colorectal cancer research.</p>Fórmula:C20H21N3O3SCor e Forma:SolidPeso molecular:383.464YCW-E11
CAS:<p>YCW-E11 is an antiapoptotic Bcl-2 family proteins inhibitor.</p>Fórmula:C25H21Cl2N3O6S2Pureza:98%Cor e Forma:SolidPeso molecular:594.49Ferroptosis-IN-15
CAS:<p>Ferroptosis-IN-15 (compound 12) serves as an effective inhibitor of ferroptosis, exhibiting EC50 values of 0.76 μM and 0.67 μM in A375 cells and 786-O cells, respectively. It acts as a potential iron chelator and radical-scavenging antioxidant.</p>Fórmula:C17H14O5Cor e Forma:SolidPeso molecular:298.29Coprostanone
CAS:<p>Coprostanone (5β-cholestan-3-one) is an active metabolite of hydroxycholesterol and cholesterol. It induces apoptosis in primary gallbladder epithelial cells in dogs. Coprostanone holds potential for research into colon cancer or adenomatous polyps.</p>Fórmula:C27H46OCor e Forma:SolidPeso molecular:386.654SMIP34
CAS:<p>SMIP34 is an inhibitor of PELP1, binding to this target with a dissociation constant (Kd) of 37.4 μM. It demonstrates efficacy in inhibiting the proliferation of cancer cells and tumor progression. Specifically, SMIP34 is effective in breast cancer research, showing activity against wild-type (WT), mutant (MT) estrogen receptor-positive (ER+), and treatment-resistant (TR)-ER+ breast cancers.</p>Fórmula:C25H32ClN5O3Cor e Forma:SolidPeso molecular:486.01PI3K-IN-58
CAS:<p>PI3K-IN-58 (Compound 17f) is an inhibitor of PI3Kα with an IC50 value of 0.039 μM. It shows significant antiproliferative effects on PC-3, 22RV1, MDA-MB-231, and MDA-MB-453 cell lines with IC50 values of 3.48 μM, 1.06 μM, 2.21 μM, and 0.93 μM, respectively. PI3K-IN-58 induces apoptosis by downregulating the expression of anti-apoptotic proteins Bcl-XL and Bcl-2 while upregulating the expression of the pro-apoptotic protein BAX. This compound is applicable for research in cancer targeting through PI3K pathways.</p>Fórmula:C22H22N6O3SCor e Forma:SolidPeso molecular:450.51Etalocib sodium
CAS:Etalocib (LY293111) sodium is an orally active leukotriene B4 (LTB4) receptor antagonist with a Ki value of 25 nM for inhibiting [3H]LTB4 binding. It exhibits an IC50 of 20 nM against LTB4-induced calcium mobilization. Additionally, Etalocib sodium can induce apoptosis.Fórmula:C33H32FNaO6Cor e Forma:SolidPeso molecular:566.59DL-Buthionine-(S,R)-sulfoximine hydrochloride
<p>DL-Buthionine-(S,R)-sulfoximine hydrochloride (Buthionine sulfoximine hydrochloride) is a potent and specific glutamylcysteine synthetase biosynthesis inhibitor</p>Fórmula:C8H19ClN2O3SCor e Forma:SolidPeso molecular:258.77T0080
CAS:<p>T0080 is an FPR-1 antagonist. It reduces apoptosis (Apoptosis) and inhibits the production of reactive oxygen species (ROS) and pro-inflammatory cytokines (TNF-α and IL-1β) in plaque macrophages within ApoE−/− mouse models, thereby slowing the progression of atherosclerosis.</p>Fórmula:C24H22F3N3O3Cor e Forma:SolidPeso molecular:457.45BRD-K44839765
CAS:<p>BRD-K44839765 selectively targets Bcl-2, exhibiting an IC50 of 5.6 μM in IMR-90 cells. This compound is also orally active.</p>Fórmula:C23H19N3O2S2Cor e Forma:SolidPeso molecular:433.55BRD-K20733377
CAS:<p>BRD-K20733377 is a Bcl-2 inhibitor that exhibits selective cytotoxicity toward senescent cells, specifically inhibiting the activity of etoposide-induced senescent IMR-90 cells with an IC50 of 10.7 μM. Additionally, BRD-K20733377 reduces the mRNA expression of aging-related genes p16, p21, and KI67 in aged mouse models.</p>Fórmula:C23H18N4O3SCor e Forma:SolidPeso molecular:430.48HDAC-IN-81
CAS:<p>HDAC-IN-81 (Compound 11g) is an HDAC inhibitor capable of effectively inhibiting HDAC1 with an IC50 value of 4.5 nM. Additionally, it exhibits anticancer activity by inhibiting cell proliferation and can induce cell apoptosis (apoptosis).</p>Fórmula:C20H27N3O3Cor e Forma:SolidPeso molecular:357.45Flonoltinib sulfate
CAS:<p>Flonoltinib maleate is an orally active dual inhibitor of JAK2/FLT3, with IC50 values of 0.7 nM for JAK2, 4 nM for FLT3, 26 nM for JAK1, and 39 nM for JAK3. It exhibits anticancer properties.</p>Fórmula:C25H36FN7O5SCor e Forma:SolidPeso molecular:565.661AQX-435
CAS:<p>AQX-435 activates SHIP1, inhibits PI3K in BCR signaling, induces apoptosis in B cells, and slows lymphoma growth.</p>Fórmula:C27H34N2O4Cor e Forma:SolidPeso molecular:450.57Bcl-2-IN-3
CAS:<p>Bcl-2-IN-3 (Compound 10) is an inhibitor of Bcl-2, utilized in cancer research.</p>Fórmula:C16H16N2O4Cor e Forma:SolidPeso molecular:300.31BRD-K56819078
CAS:<p>BRD-K56819078, a Bcl-2 inhibitor, significantly reduces the burden of senescent cells and the mRNA expression of aging-related genes in the kidneys. It exerts its anti-aging effects by inhibiting cell apoptosis (apoptosis).</p>Fórmula:C24H20FN3O4S2Cor e Forma:SolidPeso molecular:497.56UCN-01
CAS:<p>inhibitor of Akt, protein kinase C, PDK1 and cyclin-dependent kinases</p>Fórmula:C28H26N4O4Pureza:98%Cor e Forma:SolidPeso molecular:482.53TLBC
CAS:<p>TLBC, a borane-chalcone derivative, exhibits dose-dependent inhibitory effects across various glioma cell lines with IC50 values ranging from 5.5 to 25.5 μM. TLBC induces apoptosis independently of alterations in the tumor suppressor factor p53.</p>Fórmula:C15H12BIO3Cor e Forma:SolidPeso molecular:377.97Antiproliferative agent-63
CAS:<p>Antiproliferative agent-63 (compound 4d) is a cyclic analog of cannabidiol that acts as an anticancer agent. It demonstrates favorable activity against breast and colorectal cancer. Moreover, this compound can arrest the cell cycle in the G1 phase and induce apoptosis through the mitochondrial pathway in breast cancer cell lines.</p>Fórmula:C27H41NO2Cor e Forma:SolidPeso molecular:411.62Nitrovin
CAS:<p>Nitrovin is an antimicrobial growth promoter that induces ROS-mediated non-apoptotic and quasi-apoptotic cell death by targeting TrxR1. It exhibits anticancer activity with IC50 values ranging from 1.31 to 6.60 μM for both tumor and normal cells.</p>Fórmula:C14H12N6O6Cor e Forma:SolidPeso molecular:360.28
