Apoptose
Os inibidores da apoptose são compostos que previnem ou retardam o processo de morte celular programada, conhecido como apoptose. Esses inibidores são vitais no estudo dos mecanismos de sobrevivência celular e são usados para investigar doenças onde a apoptose é desregulada, como câncer, distúrbios neurodegenerativos e doenças autoimunes. Ao modular a apoptose, esses inibidores podem ajudar no desenvolvimento de terapias destinadas a controlar a morte celular. Na CymitQuimica, oferecemos uma ampla seleção de inibidores da apoptose de alta qualidade para apoiar sua pesquisa em biologia celular, oncologia e áreas relacionadas.
Subcategorias de "Apoptose"
- ASK(9 produtos)
- BCL(8 produtos)
- Caspase(144 produtos)
- FOXO1(3 produtos)
- IAP(67 produtos)
- Mdm2(12 produtos)
- PD-1/PD-L1(139 produtos)
- PDK(9 produtos)
- PERK(26 produtos)
- Serina/treonina quinase(18 produtos)
- Survivina(14 produtos)
- TNF(93 produtos)
- c-RET(61 produtos)
- p53(63 produtos)
Exibir 6 mais subcategorias
Foram encontrados 6084 produtos de "Apoptose"
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EGFR-IN-62
EGFR-IN-62: IC50 of 10-242 nM for various EGFR mutations, blocks A549/H1975 cell cycle, induces apoptosis, and inhibits cell motility and proliferation.Fórmula:C30H33N9O2Cor e Forma:SolidPeso molecular:551.64Ganoderic acid R
CAS:Ganoderic acid R: potent anticancer, induces apoptosis, cytotoxic to MDR and sensitive tumor cells.Fórmula:C34H50O6Cor e Forma:SolidPeso molecular:554.76RWJ-56110
CAS:protease-activated receptor-1 (PAR1) antagonistFórmula:C41H43Cl2F2N7O3Pureza:98%Cor e Forma:SolidPeso molecular:790.73Anticancer agent 53
CAS:Anticancer agent 53 exhibits potent in vitro cytotoxicity, triggers apoptosis, halts S/G2/M cycle, and has antitumor effects without toxicity.Fórmula:C31H25FN4O6SCor e Forma:SolidPeso molecular:600.62D-Cl-amidine hydrochloride
D-Cl-amidine hydrochloride is a potent and highly selective inhibitor of PAD1. It exhibits excellent tolerance and does not induce significant toxicity [1].Fórmula:C14H20Cl2N4O2Cor e Forma:SolidPeso molecular:347.24MLKL-IN-6
<p>MLKL-IN-6 (compound P28) is a mixed lineage kinase inhibitor that specifically targets the Mixed Lineage Kinase domain-like (MLKL) protein.</p>Fórmula:C20H18N4O5Pureza:98%Cor e Forma:SolidPeso molecular:394.38hCAIX/XII-IN-5
Coumarin 9a: Selective inhibitor of hCA IX/XII (Ki 93.3/85.7 nM), blocks cancer cell growth, and induces apoptosis.Fórmula:C18H13NO3Cor e Forma:SolidPeso molecular:291.3Ferroptosis-IN-15
CAS:Ferroptosis-IN-15 (compound 12) serves as an effective inhibitor of ferroptosis, exhibiting EC50 values of 0.76 μM and 0.67 μM in A375 cells and 786-O cells, respectively. It acts as a potential iron chelator and radical-scavenging antioxidant.Fórmula:C17H14O5Cor e Forma:SolidPeso molecular:298.29Multi-kinase-IN-1
CAS:Multi-kinase-IN-1, a powerful kinase inhibitor, exhibits antitumor properties by inducing cell apoptosis.Fórmula:C35H36F2N6O6SCor e Forma:SolidPeso molecular:706.76Anticancer agent 14
Anticancer agent 14: a potent breast cancer inhibitor; induces cell death, disrupts mito. membrane potential (IC50: 0.20-0.65 μM).Fórmula:C29H34N2O3Cor e Forma:SolidPeso molecular:458.59MA242 free base
CAS:MA242 free base is a dual MDM2/NFAT1 inhibitor that triggers apoptosis in pancreatic cancer cells.Fórmula:C24H20ClN3O3SCor e Forma:SolidPeso molecular:465.95PD-1/PD-L1-IN-15
PD-1/PD-L1-IN-15 is a potent inhibitor of PD-1/PD-L1 (IC50: 60.1 nM) and has shown investigational potential for tumor immunotherapy.Fórmula:C32H30N4O3Cor e Forma:SolidPeso molecular:518.61HDAC-IN-27 dihydrochloride
CAS:HDAC-IN-27 dihydrochloride (Compound 11h) is a potent, orally active, HDACI class-selective inhibitor, with IC50 values ranging from 0.43 to 3.01 nM for HDAC1-3. This compound exhibits both in vivo and in vitro anticancer activity. HDAC-IN-27 shows significant antiproliferative effects against acute myeloid leukemia (AML) cell lines by inducing apoptosis and histone acetylation (AcHH3 and AcHH4). It is useful for research on acute myeloid leukemia (AML).Fórmula:C20H24Cl2N4O2Cor e Forma:SolidPeso molecular:423.336FKBP12 PROTAC dTAG-13
CAS:FKBP12 PROTAC dTAG-13 is a PROTAC and selective degrader for target validation by splicing FKBP12 F36V with CRBN and thereby degrading FKBP12 F36V.Fórmula:C57H68N4O15Pureza:97.31%Cor e Forma:SolidPeso molecular:1049.17RIP1 kinase inhibitor 1
CAS:RIP1 kinase inhibitor 1 is an orally available and brain-penetrating inhibitor of RIP1 kinase with pKi of 9.04.Fórmula:C24H20ClN5O3Pureza:98%Cor e Forma:SolidPeso molecular:461.9WK88-1
CAS:WK88-1, an inhibitor of Hsp90, effectively induces the degradation of various oncogenic signaling molecules, including EGFR, ErbB2, and ErbB3, in the gefitinib-resistant H1975 cell line. This leads to subsequent growth arrest and apoptosis.Fórmula:C28H42N2O6Cor e Forma:SolidPeso molecular:502.64Antitumor agent-100
CAS:Antitumor Agent-100 (compound A6) is a molecular gel and apoptosis inducer targeting PDE3A-SLFN12 with an IC50 of 0.3 μM, demonstrating potent antitumor activity. This orally available agent binds to the PDE3A enzyme pocket, recruiting and stabilizing SLFN12 which disrupts protein translation and induces apoptosis [1].Fórmula:C17H14ClN3OPeso molecular:311.77CRT0066101
CAS:CRT0066101 is a potent, orally active PKD inhibitor with IC 50 values of 1 nM, 2.5 nM, and 2 nM for PKD1, PKD2, and PKD3, respectively [1]. Additionally, it inhibits PIM2 with an IC 50 of approximately 135.7 nM and demonstrates anticancer effects [2].Fórmula:C18H22N6OCor e Forma:SolidPeso molecular:338.41ZNU-IMB-Z15
CAS:Compound Z15 (ZNU-IMB-Z15) acts as an antagonist and degrader of the androgen receptor (AR). It inhibits the proliferation of castration-resistant prostate cancer (CRPC) cell lines that are AR-positive and induces apoptosis. Compound Z15 exhibits anticancer activity both in vivo and in vitro.Fórmula:C20H17N3O3S2Cor e Forma:SolidPeso molecular:411.5GP130-IN-1
CAS:GP130-IN-1 (compound 49) is an effective inhibitor of GP130, demonstrating significant in vitro anti-tumor activity and higher selectivity compared to Bazedoxifene. It induces ultrastructural changes in cells, leading to a time-dependent arrest of the cell cycle at the G0/G1 phase, and triggers both apoptosis and autophagy. GP130-IN-1 is useful for research on triple-negative breast cancer.Fórmula:C21H10F5NO3Cor e Forma:SolidPeso molecular:419.30
