Apoptose
Os inibidores da apoptose são compostos que previnem ou retardam o processo de morte celular programada, conhecido como apoptose. Esses inibidores são vitais no estudo dos mecanismos de sobrevivência celular e são usados para investigar doenças onde a apoptose é desregulada, como câncer, distúrbios neurodegenerativos e doenças autoimunes. Ao modular a apoptose, esses inibidores podem ajudar no desenvolvimento de terapias destinadas a controlar a morte celular. Na CymitQuimica, oferecemos uma ampla seleção de inibidores da apoptose de alta qualidade para apoiar sua pesquisa em biologia celular, oncologia e áreas relacionadas.
Subcategorias de "Apoptose"
- ASK(9 produtos)
- BCL(8 produtos)
- Caspase(147 produtos)
- FOXO1(3 produtos)
- IAP(67 produtos)
- Mdm2(12 produtos)
- PD-1/PD-L1(140 produtos)
- PDK(9 produtos)
- PERK(26 produtos)
- Serina/treonina quinase(19 produtos)
- Survivina(14 produtos)
- TNF(91 produtos)
- c-RET(61 produtos)
- p53(63 produtos)
Exibir 6 mais subcategorias
Foram encontrados 6114 produtos de "Apoptose"
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RIP3 activator 1
CAS:RIP3 Activator 1 (compound C8) is an effective RIP3 activator that inhibits cell growth and induces necroptotic cell death (necroptosis) and autophagy through the RIP3/p62/Keap1 signaling pathway. Additionally, this compound enhances the expression of p-MLKL and promotes the accumulation of LC3-II and p62 proteins.Fórmula:C26H50N4O3Cor e Forma:SolidPeso molecular:466.7Neral
CAS:Neral, a monoterpenoid compound, exhibits anti-inflammatory and anticancer activities. It inhibits TNF-α and IL-6, along with inflammatory mediators such as pro-IL-1β, iNOS, COX-2, and NLRP-3.Fórmula:C10H16OCor e Forma:SolidPeso molecular:152.23CRI9
CRI9 effectively inhibits the c-MET/PI3K/Akt/mTOR axis, suppressing the proliferation of hepatocellular carcinoma (HCC) cells. This compound exhibits potent cytotoxicity against HCC cells and induces apoptosis.Fórmula:C26H18N6O4Cor e Forma:SolidPeso molecular:478.46Hdm2 E3 ligase inhibitor 1
CAS:Hdm2 E3ligaseinhibitor 1 (Compound 1) is a reversible inhibitor of Hdm2-mediated p53 protein ubiquitination, with an IC50 of 12.7 μM. It binds to Hdm2, blocking the transfer of ubiquitin catalyzed by Hdm2 from pre-linked Ub-Ubc4 to p53, thereby inhibiting p53 ubiquitination, stabilizing p53 protein in tumor cells, and exerting antitumor activity.Fórmula:C10H8F6N2O3SPeso molecular:350.24Anticancer agent 44
Anticancer agent 44 induces apoptosis, is selective, cytotoxic to cancer cells, and minimally toxic to human lymphocytes.Fórmula:C22H13Cl2N3O5S2Cor e Forma:SolidPeso molecular:534.39Anticancer agent 17
Anticancer agent 17 was effective against HeLa cells (IC50: 0.19 μM) and A2780 cells (IC50: 0.09 μM).Fórmula:C27H34BrN3OCor e Forma:SolidPeso molecular:496.48Minnelide free acid
CAS:Minnelide treats pancreatic cancer, hinders androgen-related prostate growth, shrinks tumors, and improves survival.Fórmula:C21H27O10PCor e Forma:SolidPeso molecular:470.41Kahweol Acetate
CAS:Kahweol Acetate, a semi-synthetic coffee bean derivative, inhibits osteoclasts, cancer cells, DNA damage, and oxidative stress.Fórmula:C22H28O4Cor e Forma:SolidPeso molecular:356.46BRD1991
CAS:BRD1991 is a chemical compound that specifically disrupts the interaction between Beclin 1 and Bcl-2, thereby inducing autophagy.Fórmula:C33H35Cl2N3O4Cor e Forma:SolidPeso molecular:608.55ASCT2-IN-1
CAS:ASCT2-IN-1 (compound 20k) is an inhibitor of ASCT2, demonstrating IC50 values of 5.6 μM in A549 cells and 3.5 μM in HEK293 cells. It induces apoptosis and inhibits tumor growth.Fórmula:C36H32Cl2N2O4Peso molecular:627.56HDAC6/HSP90-IN-2
HDAC6/HSP90-IN-2, a cancer research chemical, inhibits HDAC6 & Hsp90 with IC50s of 105.7 & 61 nM.Fórmula:C19H22N2O5Cor e Forma:SolidPeso molecular:358.39UR-AK49
CAS:UR-AK49 (compound 11) is an agonist for the human histamine H1 and H2 receptors. It exhibits an EC50 of 23 nM in the GTPase assay involving hH2R-Gsalpha fusion protein expressed in Sf9 insect cells. UR-AK49 is applicable in neurologically related research.Fórmula:C16H27N5OCor e Forma:SolidPeso molecular:305.42Apoptosis inducer 42
CAS:Apoptosis inducer42 is an apoptosis inducer that triggers late-stage apoptosis and inhibits the secretion of IL-6. It exhibits high cytotoxicity toward cancer cells and is applicable in cancer research, including studies on colon cancer.Fórmula:C11H13OPSCor e Forma:SolidPeso molecular:224.26CDK4/6-IN-10
CDK4/6-IN-10: Oral CDK4 (IC50: 22 nM) & CDK6 (IC50: 10 nM) inhibitor with anti-cancer potential for MM research.Cor e Forma:SolidPD-1/PD-L1-IN-30
CAS:PD-1/PD-L1-IN-30: Cancer research inhibitor with 0.018 μM IC50.Fórmula:C29H28F3NO5Cor e Forma:SolidPeso molecular:527.53LLW-018
CAS:LLW-018 is a potent PD-1/PD-L1 inhibitor with an IC50 value of 2.61 nM. It can disrupt the PD-1/PD-L1 interaction, with a cell-based PD-1/PD-L1 blocking bioassay IC50 value of 0.88 μM. LLW-018 holds potential for research in immune-related diseases.Fórmula:C35H38Cl2N4O5SPeso molecular:697.67Zharp1-211
CAS:Zharp1-211 is a RIPK3 inhibitor，reduces JAK/ stat1-mediated chemokines and MHC class II molecules in IECs, (GVHD) for gastrointestinal inflammation.Fórmula:C24H25N5O4Pureza:99.71%Cor e Forma:SolidPeso molecular:447.49Ref: TM-T87664
1mg87,00€5mg183,00€10mg283,00€25mg562,00€50mg873,00€100mg1.311,00€200mg1.768,00€1mL*10mM (DMSO)202,00€Zotatifin
CAS:Zotatifin (eFT226) is a selective eIF4A inhibitor with antiviral and antitumor properties, inhibiting Sox4 translation and inducing apoptosis.Fórmula:C28H29N3O5Pureza:98.85%Cor e Forma:SolidPeso molecular:487.55Darizmetinib
CAS:Darizmetinib (HRX215) is an MKK4 inhibitor.Fórmula:C21H17F2N5O3SPureza:98.03% - 99.57%Cor e Forma:SolidPeso molecular:457.45Ref: TM-T72956
1mg69,00€2mg89,00€5mg147,00€10mg224,00€25mg324,00€50mg400,00€100mg587,00€1mL*10mM (DMSO)148,00€Milademetan
CAS:Milademetan (DS-3032), an MDM2 inhibitor, exhibits antitumor activity, induces G1 cell cycle arrest and apoptosis, and can be used to study solid tumors.Fórmula:C30H34Cl2FN5O4Pureza:>99.99%Cor e Forma:SolidPeso molecular:618.53Ref: TM-T12040
1mg87,00€5mg170,00€10mg274,00€25mg518,00€50mg847,00€100mg1.454,00€1mL*10mM (DMSO)234,00€
