Apoptose
Os inibidores da apoptose são compostos que previnem ou retardam o processo de morte celular programada, conhecido como apoptose. Esses inibidores são vitais no estudo dos mecanismos de sobrevivência celular e são usados para investigar doenças onde a apoptose é desregulada, como câncer, distúrbios neurodegenerativos e doenças autoimunes. Ao modular a apoptose, esses inibidores podem ajudar no desenvolvimento de terapias destinadas a controlar a morte celular. Na CymitQuimica, oferecemos uma ampla seleção de inibidores da apoptose de alta qualidade para apoiar sua pesquisa em biologia celular, oncologia e áreas relacionadas.
Subcategorias de "Apoptose"
- ASK(6 produtos)
- BCL(11 produtos)
- Caspase(125 produtos)
- FOXO1(3 produtos)
- IAP(66 produtos)
- Mdm2(12 produtos)
- PD-1/PD-L1(125 produtos)
- PDK(9 produtos)
- PERK(25 produtos)
- Serina/treonina quinase(15 produtos)
- Survivina(13 produtos)
- TNF(92 produtos)
- c-RET(51 produtos)
- p53(62 produtos)
Exibir 6 mais subcategorias
Foram encontrados 5598 produtos de "Apoptose"
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LD4172
CAS:<p>LD4172 is a PROTAC degrader capable of degrading RIP kinase (RIPK1) with a DC50 in the nanomolar range. When used in combination with TNF-α, LD4172 can induce apoptosis in B16F10 cells. In mouse models, it demonstrates antitumor activity. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligase VHL)</p>Fórmula:C61H75F3N10O7SCor e Forma:SolidPeso molecular:1149.37QN523
CAS:<p>QN523 has drug-like traits, kills cancer cells in vitro, effective in vivo against pancreatic cancer, works via autophagy.</p>Fórmula:C14H10N4OPureza:99.83%Cor e Forma:SolidPeso molecular:250.26Chalcones A-N-5
CAS:<p>Chalcones A-N-5, a non-cytotoxic trihydroxy chalcone, aids cell growth & neuroprotection, inhibits ferroptosis, and targets AD research.</p>Fórmula:C21H20N4O4Cor e Forma:SolidPeso molecular:392.41Sanggenon G
CAS:<p>Sanggenon G inhibits XIAP by binding its BIR3 domain; affinity is 34.26 μM, boosting caspase activation.</p>Fórmula:C40H38O11Cor e Forma:SolidPeso molecular:694.72AMG-7209
CAS:<p>AMG-7209 is an effective and selective MDM2-p53 interaction inhibitor.</p>Fórmula:C37H41Cl2FN2O7SCor e Forma:SolidPeso molecular:747.7Onfekafusp alfa
CAS:<p>Onfekafusp alfa (L19TNF), a trimeric fusion of L19 scFv and human TNF, targets malignant glioma.</p>Cor e Forma:LiquidIzuralimab
CAS:<p>Izuralimab is a bispecific IgG1 antibody that targets both the inducible T-cell costimulator (ICOS/CD278) and PD-1 [1].</p>Cor e Forma:LiquidPexelizumab
CAS:<p>Pexelizumab is a humanized antibody targeting C5 to inhibit apoptosis and treat cerebral IR injury and myocardial infarction.</p>Cor e Forma:LiquidThalidomide-PEG2-C2-NH2
CAS:<p>Thalidomide-O-amido-PEG3-C2-NH2 is a cereblon ligand-linked E3 ligase used in PROTAC with a 2-unit PEG.</p>Fórmula:C19H24N4O6Pureza:98%Cor e Forma:SolidPeso molecular:404.42ZLDI-8
CAS:<p>ZLDI-8 is an inhibitor of Notch activating/cleaving enzyme ADAM-17 and inhibits the cleavage of Notch protein.</p>Fórmula:C24H23N3O3SPureza:98.09%Cor e Forma:SolidPeso molecular:433.52Sudubrilimab
<p>Sudubrilimab (HS636) is an IgG1-κ monoclonal antibody targeting PDL1, fused with TGFBR2-ECD to block PD-1/PDL1 and TGF-β in tumors.</p>Cor e Forma:Odour LiquidTopoisomerase IIα-IN-10
<p>TopoisomeraseIIα-IN-10 (Compound 13r) is a topoisomerase IIα inhibitor that binds to the active site of DNA when complexed with topoisomerase IIα. This binding is stabilized through interactions with DNA base pairs and amino acid residues. By intercalating into DNA, TopoisomeraseIIα-IN-10 induces apoptosis and disrupts the mitochondrial membrane potential in HCT116 cells, effectively inhibiting their growth with an IC50 of 4.37 μM. It is applicable for cancer research studies.</p>Fórmula:C32H27N3O3Cor e Forma:SolidPeso molecular:501.575Nrf2 activator-9
<p>Nrf2 activator-9 (compound D-36) is an agent that mitigates oxidative stress by inhibiting the apoptosis of HUVEC cells induced by oxidized low-density</p>Fórmula:C26H27N5O4Cor e Forma:SolidPeso molecular:473.52TTQ-SA
<p>TTQ-SA is a near-infrared spiraling aggregation-induced emitter capable of converting near-infrared light (NIR) into thermal energy, resulting in thermal damage and death of tumor cells. In cancer cells MF-7, TTQ-SA shows cell uptake and targeting capabilities. TTQ-SA binds with DNAzyme to inhibit the expression of the survivin gene, enhancing the sensitivity of tumor cells to photothermal therapy.</p>Fórmula:C78H53N7SCor e Forma:SolidPeso molecular:1120.37PROTAC XPO1 degrader-1
<p>PROTAC XPO1 degrader-1 (Compound 2c) is an XPO1 degrader. It exhibits anti-proliferative effects, induces apoptosis, inhibits NF-κB activity, and causes cell cycle arrest at the G1 phase. PROTAC XPO1 degrader-1 is applicable to research on hematological malignancies.</p>Fórmula:C33H35ClF3N7O7Cor e Forma:SolidPeso molecular:734.122STEP-IN-1
<p>STEP-IN-1 (Compound 14b) is a potent and selective inhibitor of STEP, with an IC50 of 5.27 μM. It offers neuroprotective effects by safeguarding neuronal cells from glutamate-induced toxicity, reducing intracellular reactive oxygen species (ROS) accumulation, and inhibiting apoptosis. STEP-IN-1 is applicable in research related to neurodegenerative diseases.</p>Fórmula:C21H10ClNO7Cor e Forma:SolidPeso molecular:423.76CPT2
CAS:<p>Carnitine palmitoyltransferase 2 (CPT2), an enzyme involved in fatty acid oxidation, serves as a prognostic biomarker for colorectal cancer (CRC).</p>Pureza:98%Cor e Forma:SolidPROTAC ROR1 degrader-1
<p>PROTACROR1degrader-1 (Compound 11d) serves as a PROTAC degrader targeting the pseudokinase ROR1, with the capability of degrading ROR1 in NSCLC cells at a DC50 of 40-80 nM. It induces PARP cleavage and apoptosis in NCI-H23 cells. [Pink: ligand for target protein ROR1 ligand-1; Black: linker; Blue: ligand for VHL E3 ligase (S,R,S)-AHPC]</p>Fórmula:C55H74BrN11O5SCor e Forma:SolidPeso molecular:1081.22MitoEbselen-2 chloride
CAS:<p>MitoEbselen-2 mitigates radiation, cuts lipid hydroperoxides, blocks cell death, and boosts survival in irradiated mice.</p>Fórmula:C35H30ClN2O2PSeCor e Forma:SolidPeso molecular:656.01DS-5272
CAS:<p>DS-5272 is a potent and orally active inhibitor of p53-MDM2 interaction.</p>Fórmula:C34H38Cl2F2N6O2SCor e Forma:SolidPeso molecular:703.67
