Apoptose
Os inibidores da apoptose são compostos que previnem ou retardam o processo de morte celular programada, conhecido como apoptose. Esses inibidores são vitais no estudo dos mecanismos de sobrevivência celular e são usados para investigar doenças onde a apoptose é desregulada, como câncer, distúrbios neurodegenerativos e doenças autoimunes. Ao modular a apoptose, esses inibidores podem ajudar no desenvolvimento de terapias destinadas a controlar a morte celular. Na CymitQuimica, oferecemos uma ampla seleção de inibidores da apoptose de alta qualidade para apoiar sua pesquisa em biologia celular, oncologia e áreas relacionadas.
Subcategorias de "Apoptose"
- ASK(6 produtos)
- BCL(11 produtos)
- Caspase(127 produtos)
- FOXO1(3 produtos)
- IAP(66 produtos)
- Mdm2(12 produtos)
- PD-1/PD-L1(126 produtos)
- PDK(9 produtos)
- PERK(23 produtos)
- Serina/treonina quinase(15 produtos)
- Survivina(13 produtos)
- TNF(91 produtos)
- c-RET(51 produtos)
- p53(62 produtos)
Exibir 6 mais subcategorias
Foram encontrados 5618 produtos de "Apoptose"
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RET-IN-4
CAS:<p>RET-IN-4: Oral RET inhibitor, IC50 ~1 nM for variants. Selective over JAK2/FLT3. Potent anticancer use.</p>Fórmula:C27H31FN10O2Cor e Forma:SolidPeso molecular:546.611Thalidomide-NH-PEG7
Thalidomide-NH-PEG7, a chemical for creating PROTAC iRucaparib-AP6, selectively degrades PARP1 and is used in ADCs.Fórmula:C27H39N3O11Pureza:98%Cor e Forma:SolidPeso molecular:581.61Maceneolignan A
CAS:<p>Maceneolignan A, a natural product isolated from the aril of Myristica fragrans (Myristicaceae), inhibits β-hexosaminidase release in RBL-2H3 cells, exhibiting</p>Fórmula:C21H24O5Cor e Forma:SolidPeso molecular:356.41RIP2 Kinase Inhibitor 4
CAS:<p>RIP2 Kinase Inhibitor 4, a selective RIPK2 PROTAC, degrades RIPK2 (pIC50=8), inhibits TNF-α release.</p>Fórmula:C50H66F2N14O7SCor e Forma:SolidPeso molecular:1045.23NFh-NMe-2
<p>NFh-NMe-2 is a photosensitizer that interacts with nitroreductase (nitroreductase) to generate singlet oxygen in tumor cells, exhibiting cytotoxicity in cancer cells and inducing apoptosis (apoptosis). In mouse models, NFh-NMe-2 demonstrates antitumor activity.</p>Fórmula:C32H33IN2OCor e Forma:SolidPeso molecular:588.522Anagrelide hydrochloride monohydrate
CAS:<p>Anagrelide HCl monohydrate is a platelet-reducing imidazoquinazoline for ET and PV research.</p>Fórmula:C10H10Cl3N3O2Cor e Forma:SolidPeso molecular:310.56Milademetan tosylate hydrate
CAS:<p>Milademetan tosylate hydrate, an oral MDM2 inhibitor targeting AML and solid tumors, induces G1 arrest and apoptosis.</p>Fórmula:C37H44Cl2FN5O8SCor e Forma:SolidPeso molecular:808.74eIF4E-IN-3
CAS:<p>eIF4E-IN-3: potent eIF4e inhibitor with promise for cancer study.</p>Fórmula:C34H30ClF3N6O4SCor e Forma:SolidPeso molecular:711.16OICR12694 TFA
CAS:<p>OICR12694 (JNJ-65234637) TFA, an orally active B cell lymphoma 6 (BCL6) inhibitor [1], demonstrates effectiveness in targeting BCL6 pathways.</p>Fórmula:C29H28ClF3N8O4·xC2HF3O2Cor e Forma:SolidChloranthalactone B
CAS:<p>Chloranthalactone B, a sesquiterpenoid from Sarcandra glabra, inhibits inflammation via AP-1 & p38 MAPK.</p>Fórmula:C15H16O3Cor e Forma:SolidPeso molecular:244.29p53 and MDM2 proteins-interaction-inhibitor dihydrochloride
<p>p53 and MDM2 proteins-interaction-inhibitor dihydrochloride is a interaction inhibitor between p53 and MDM2 proteins.</p>Fórmula:C40H51Cl4N5O4Pureza:98%Cor e Forma:SolidPeso molecular:807.68VTP50469 fumarate
CAS:<p>VTP50469 fumarate is a highly selective and orally active inhibitor of Menin-MLL interaction (Ki: 104 pM), and has potently anti-leukemia activity.</p>Fórmula:C76H106F2N12O20S2Pureza:98%Cor e Forma:SolidPeso molecular:1609.86CDK-IN-14
<p>CDK-IN-14 (B34) is a CDK2 inhibitor (IC50=0.097 μM) that exhibits anti-hepatocellular carcinoma activity. It inhibits the cell cycle in HepG-2 cancer cells and induces apoptosis (apoptosis) through a caspase-mediated mechanism.</p>Cor e Forma:Odour SolidCDK/HDAC-IN-4
<p>CDK/HDAC-IN-4 is a highly selective dual inhibitor of cyclin-dependent kinase (CDK) and histone deacetylase (HDAC), with IC50 values of 88.4 nM and 168.9 nM, respectively. This compound exhibits antiproliferative effects in both hematologic and solid tumor cells. Additionally, CDK/HDAC-IN-4 induces apoptosis and S-phase cell cycle arrest in MV-4-11 cells. It has also demonstrated significant antitumor efficacy in an MV-4-11 xenograft model.</p>Cor e Forma:Odour SolidNrf2 activator-9
<p>Nrf2 activator-9 (compound D-36) is an agent that mitigates oxidative stress by inhibiting the apoptosis of HUVEC cells induced by oxidized low-density</p>Fórmula:C26H27N5O4Cor e Forma:SolidPeso molecular:473.52Mcl1-IN-26
CAS:<p>Mcl1-IN-26 is an effective and selective myeloid cell leukemia 1 inhibitor.</p>Fórmula:C45H52ClN5O6SCor e Forma:SolidPeso molecular:826.44GPLGIAGQ acetate
<p>GPLGIAGQ acetate: MMP2-cleavable peptide; stimulus-sensitive linker for MMP2-targeted liposomal/micellar carriers in photodynamic therapy.</p>Fórmula:C33H57N9O12Pureza:97.85%Cor e Forma:SolidPeso molecular:771.86CV-4-26
<p>CV-4-26 (Compound 22) acts as a covalent inhibitor of TEAD. By inhibiting YAP/TEAD-driven transcription, it diminishes the expression of CTGF and CYR61. Furthermore, CV-4-26 impedes colony formation in Huh7 and HepG2 cells, inducing cell cycle arrest and apoptosis (apoptosis). This compound demonstrates anti-tumoral activity against hepatocellular carcinoma (HCC) and hepatoblastoma (HB).</p>Cor e Forma:Odour SolidRIPK1-IN-30
<p>RIPK1-IN-30 (compound 24) is a potent RIPK1 inhibitor with an IC50 of 2.01 μM. It demonstrates a protective effect in the HT-29 cell model of TSZ-induced necroptosis, with an EC50 of 6.77 μM.</p>Fórmula:C27H25FN2O4Cor e Forma:SolidPeso molecular:460.17984F1324
F1324: potent BCL6 inhibitor, IC50=1nM, binding t1/2=441s, strongly inhibits BCL6 PPI.Fórmula:C83H121N21O20SPureza:98%Cor e Forma:SolidPeso molecular:1765.04
