Apoptose
Os inibidores da apoptose são compostos que previnem ou retardam o processo de morte celular programada, conhecido como apoptose. Esses inibidores são vitais no estudo dos mecanismos de sobrevivência celular e são usados para investigar doenças onde a apoptose é desregulada, como câncer, distúrbios neurodegenerativos e doenças autoimunes. Ao modular a apoptose, esses inibidores podem ajudar no desenvolvimento de terapias destinadas a controlar a morte celular. Na CymitQuimica, oferecemos uma ampla seleção de inibidores da apoptose de alta qualidade para apoiar sua pesquisa em biologia celular, oncologia e áreas relacionadas.
Subcategorias de "Apoptose"
- ASK(6 produtos)
- BCL(11 produtos)
- Caspase(127 produtos)
- FOXO1(3 produtos)
- IAP(65 produtos)
- Mdm2(12 produtos)
- PD-1/PD-L1(126 produtos)
- PDK(9 produtos)
- PERK(24 produtos)
- Serina/treonina quinase(15 produtos)
- Survivina(13 produtos)
- TNF(91 produtos)
- c-RET(51 produtos)
- p53(62 produtos)
Exibir 6 mais subcategorias
Foram encontrados 5622 produtos de "Apoptose"
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Mepacrine
CAS:Mepacrine (Erion) is an acridine derivative formerly widely used as an antimalarial.Fórmula:C23H30ClN3OPureza:98.78%Cor e Forma:Bright Yellow CrystalsPeso molecular:399.96PAK4-IN-3
<p>PAK4-IN-3 (compound 27e) is a PAK4 inhibitor exhibiting an IC50 of 10 nM and demonstrates antiproliferative effects on A549 cells with an IC50 of 0.61μM.</p>Pureza:98%Cor e Forma:Odour SolidGGTI298 Trifluoroacetate
CAS:<p>GGTI298 trifluoroacetate (GGTI298TFA salt) is a geranylgeranyltransferase I inhibitor that causes cell cycle arrest and induces apoptosis.</p>Fórmula:C27H33N3O3S·C2HF3O2Pureza:98.07% - >99.99%Cor e Forma:SolidPeso molecular:593.66Salinomycin sodium salt
CAS:<p>Salinomycin sodium salt (Sodium salinomycin), an antibiotic potassium ionophore, is an effective inhibitor of Wnt/β-catenin signaling.</p>Fórmula:C42H69NaO11Pureza:98.76% - 99.11%Cor e Forma:White Or Light Yellow Crystalline Powder With Special SmelPeso molecular:772.98Barakol
CAS:<p>Barakol, a primary compound found in Cassia siamea, inhibits MMP-3 activity and enhances the anti-metastatic effects of doxorubicin. Additionally, Barakol induces apoptosis (Apoptosis), generates reactive oxygen species, increases the Bax/Bcl-2 expression ratio, and activates caspase-9. This compound also exhibits laxative, anti-anxiety, central nervous system depressant, antioxidant, and anticancer properties.</p>Fórmula:C13H12O4Cor e Forma:SolidPeso molecular:232.23HSP90-IN-33
HSP90-IN-33 (compound 24e) is an effective Hsp90 inhibitor, demonstrating dissociation constants (Kd) of ≥200 µM for Hsp90α and 7.3 µM for Hsp90β. This compound induces cellular apoptosis (apoptosis) and arrests the cell cycle at the G0/G1 phase. Additionally, HSP90-IN-33 reduces the protein expression of ERα, CDK4, and Akt.Fórmula:C21H25Cl2N5O2Cor e Forma:SolidPeso molecular:450.36TOPOI/PARP-1-IN-2
<p>TOPOI/PARP-1-IN-2 (compound 6c) serves as a dual inhibitor targeting both PARP-1 and topoisomerase 1 (TOPO-1), with IC50 values of 32.2 nM and 46.2 nM, respectively. This compound exhibits greater selectivity for PARP-1 over PARP-2. Additionally, TOPOI/PARP-1-IN-2 disrupts the S phase of the cell cycle and induces apoptosis in the NCI-60 cancer cell lines.</p>Fórmula:C16H11ClN4O2SCor e Forma:SolidPeso molecular:358.80Vonlerizumab
<p>Vonlerizumab (Anti-TNFRSF4/OX40/CD134 Antibody) is a humanized monoclonal antibody targeting OX40, used in tumor research.</p>Pureza:>95%Cor e Forma:LiquidPeso molecular:145.5 kDaDesmethyl-WEHI-345 analog
CAS:<p>Desmethyl-WEHI-345 analog, a protein kinase inhibitor, holds potential for colon cancer research.</p>Fórmula:C22H23N7OCor e Forma:SolidPeso molecular:401.474Os30
<p>Os30 is a potent fourth-generation EGFR inhibitor, specifically targeting the EGFRC797S-TK mutation with IC50 values of 18 nM for EGFRDel19/T790M/C797S TK and</p>Pureza:98%Cor e Forma:Odour Solid[Au(L4)(CyJohnPhos)]SbF6
[Au(L4)(CyJohnPhos)]SbF6 is a gold-containing compound that exhibits inhibitory effects on cyclooxygenase-1/2 (COX-1/2), suppresses the proliferation of colon cancer cells Caco2-/TC7 with an IC50 of 0.98 μM, and induces cell apoptosis (apoptosis). Additionally, [Au(L4)(CyJohnPhos)]SbF6 acts as an inhibitor of thioredoxin reductase (TrxR) and demonstrates antioxidative activity by modulating ROS levels.Fórmula:C44H56AuF6NO4PSSbCor e Forma:SolidPeso molecular:1158.68ECDD-S18
<p>ECDD-S18 (compound ECDD-S18) induces apoptosis in a dose-dependent manner, effectively targeting the vacuolar ATPase (V-ATPase) and impairing lysosomal acidification.</p>Fórmula:C35H31BrO12Cor e Forma:SolidPeso molecular:723.52Tubulin polymerization-IN-70
<p>Tubulin polymerization-IN-70 (compound Q19) is an effective inhibitor of tubulin polymerization. This compound exerts antiproliferative properties by targeting the colchicine binding site on tubulin, thereby inhibiting its polymerization. Tubulin polymerization-IN-70 also induces apoptosis and cell cycle arrest at the G2/M phase. Additionally, it triggers a decrease in mitochondrial membrane potential and elevates levels of reactive oxygen species (ROS). Moreover, Tubulin polymerization-IN-70 possesses anti-angiogenic and anticancer activities.</p>Fórmula:C25H23N3O2Cor e Forma:SolidPeso molecular:397.47Thalidomide-O-PEG4-amine
CAS:<p>Thalidomide-O-PEG4-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].</p>Fórmula:C23H31N3O9Pureza:98%Cor e Forma:SolidPeso molecular:493.51Platycoside G3
CAS:<p>Platycoside G3 is a useful organic compound for research related to life sciences. The catalog number is T124100 and the CAS number is 849758-44-7.</p>Fórmula:C63H102O32Cor e Forma:SolidPeso molecular:1371.48Apoptosis inducer 30
<p>Apoptosisinducer 30 (Compound 15a) acts as an anticancer agent. It induces apoptosis in MCF-7 cells through the mitochondrial pathway. This compound elevates intracellular levels of reactive oxygen species (ROS), decreases mitochondrial membrane potential, and arrests the cell cycle at the G0/G1 phase. Apoptosisinducer 30 inhibits cell growth, with an IC50 value of 0.32 μM against MCF-7 cells, and suppresses tumor growth in a mouse breast cancer model.</p>Fórmula:C52H69BrNO4PCor e Forma:SolidPeso molecular:882.99Polyinosinic-polycytidylic acid potassium
CAS:Poly(I:C) potassium is a synthetic RNA analog, activates TLR3/RIG-I, used as a vaccine adjuvant, and induces apoptosis in cancer cells.Fórmula:(C10H13N4O8P)x·(C9H14N3O8P)x·xKCor e Forma:SolidQuercetin-d3
<p>Quercetin-d3 hydrate, a deuterated form of Quercetin hydrate, acts as a flavonoid that stimulates recombinant SIRT1 and serves as a PI3K inhibitor. The compound specifically exhibits IC50 values of 2.4 μM, 3.0 μM, and 5.4 μM against PI3Kγ, PI3Kδ, and PI3Kβ, respectively.</p>Fórmula:C15H9D3O8Cor e Forma:SolidPeso molecular:323.27PTD-p65-P1 Peptide TFA
<p>Ptd-p65-p1 Peptide TFA inhibits NF-kappaB, has a cell-penetrating antennapedia sequence, and selectively blocks NF-kappaB activation.</p>Fórmula:C170H276F3N57O46SPureza:98%Cor e Forma:SolidPeso molecular:3943.52Tubulin inhibitor 34
<p>Tubulin Inhibitor 34 (compound b5), a potent anticancer agent, inhibits tubulin polymerization and induces G2/M arrest and apoptosis.</p>Fórmula:C21H22N4O3SCor e Forma:SolidPeso molecular:410.49
