Apoptose
Os inibidores da apoptose são compostos que previnem ou retardam o processo de morte celular programada, conhecido como apoptose. Esses inibidores são vitais no estudo dos mecanismos de sobrevivência celular e são usados para investigar doenças onde a apoptose é desregulada, como câncer, distúrbios neurodegenerativos e doenças autoimunes. Ao modular a apoptose, esses inibidores podem ajudar no desenvolvimento de terapias destinadas a controlar a morte celular. Na CymitQuimica, oferecemos uma ampla seleção de inibidores da apoptose de alta qualidade para apoiar sua pesquisa em biologia celular, oncologia e áreas relacionadas.
Subcategorias de "Apoptose"
- ASK(9 produtos)
- BCL(11 produtos)
- Caspase(141 produtos)
- FOXO1(3 produtos)
- IAP(66 produtos)
- Mdm2(12 produtos)
- PD-1/PD-L1(138 produtos)
- PDK(9 produtos)
- PERK(25 produtos)
- Serina/treonina quinase(14 produtos)
- Survivina(14 produtos)
- TNF(92 produtos)
- c-RET(55 produtos)
- p53(63 produtos)
Exibir 6 mais subcategorias
Foram encontrados 5865 produtos de "Apoptose"
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YN14-H
<p>YN14-H is a PROTAC degrader that targets KRASG12C. It effectively inhibits the growth of NCI-H358 and MIA PaCa-2 cells, with IC50 values of 0.042 μM and 0.021 μM, respectively, and DC50 values of 28.9 nM and 18.1 nM. YN14-H significantly induces apoptosis and suppresses cell migration. It demonstrates favorable pharmacokinetics and excellent in vivo antitumor activity.</p>Cor e Forma:Odour SolidAlbanol B
CAS:<p>Albanol B, from mulberries, combats Alzheimer's, bacteria, and oxidation, hinders cancer growth, and triggers cell arrest and apoptosis.</p>Fórmula:C34H22O8Cor e Forma:SolidPeso molecular:558.53dTAG-47
CAS:dTAG-47 targets FKBP12 F36V for protein degradation, useful in basal-like breast cancer research.Fórmula:C59H73N5O14Cor e Forma:SolidPeso molecular:1076.24BMf-BH3
<p>BMf-BH3 is a Bcl-2 family peptide, key in HDAC inhibition affecting acetylation balance.</p>Fórmula:C131H214N45O35SPureza:98%Cor e Forma:SolidPeso molecular:3012.5Thalidomide-NH-C5-NH2 hydrochloride
CAS:<p>Functionalized cereblon ligand with E3 ligase and alkylC5 linker for PROTAC R&D; ready for protein conjugation. Formerly Pomalidomide-linker 4.</p>Fórmula:C18H23ClN4O4Cor e Forma:SolidPeso molecular:394.85FB49
<p>FB49 is a selective Bcl-2-associated athanogene 3 (BAG3) inhibitor with a Ki of 45 μM.</p>Fórmula:C17H18N2O6SPureza:98%Cor e Forma:SolidPeso molecular:378.4Anticancer agent 154
<p>Anticancer agent 154 (Compound 8h) enhances reactive oxygen species production, causing mitochondrial damage, and promotes cell apoptosis and DNA damage.</p>Fórmula:C22H23N5O2Pureza:98%Cor e Forma:SolidPeso molecular:389.45SM-164 Hydrochloride (957135-43-2 free base)
SM-164 Hydrochloride: cell-permeable, binds to XIAP (BIR2/3 domains), IC50 of 1.39 nM, potent XIAP antagonist.Fórmula:C62H85ClN14O6Pureza:98%Cor e Forma:SolidPeso molecular:1157.88Etanercept
CAS:<p>Etanercept is a fusion protein consisting of the soluble portion of the p75-tumor necrosis factor receptor (TNFR) and the Fc fragment of human IgG1 and is commonly used to treat patients with rheumatoid arthritis.Cost-effective and quality-assured.</p>Pureza:98%Cor e Forma:LiquidFerroptosis-IN-3
Ferroptosis-IN-3 (Compound 25), a ferroptosis inhibitor, demonstrates potent activity by inhibiting RSL3-induced ferroptosis in HT-1080 cells (EC50: 8.6 nM).Pureza:98%Cor e Forma:Odour SolidAcetyl coenzyme A
CAS:<p>Acetyl coenzyme A (Acetyl-CoA) is a pivotal molecule connecting multiple cellular metabolic pathways in the tricarboxylic acid cycle, fatty acid synthesis</p>Fórmula:C23H38N7O17P3SCor e Forma:SolidPeso molecular:809.57PROTAC SMARCA2/4 degrader-38
<p>PROTACSMARCA2/4 degrader-38 is a SMARCA2/4 PROTAC degrader with DC50 values of 3.0 nM and 4.0 nM, respectively. It facilitates the ubiquitination and degradation of SMARCA2/4 and can block the G0/G1 phase of the cell cycle, leading to the induction of apoptosis. PROTACSMARCA2/4 degrader-38 is applicable in acute myeloid leukemia (AML) research.</p>Cor e Forma:Odour SolidGPLGIAGQ acetate
<p>GPLGIAGQ acetate: MMP2-cleavable peptide; stimulus-sensitive linker for MMP2-targeted liposomal/micellar carriers in photodynamic therapy.</p>Fórmula:C33H57N9O12Pureza:97.85%Cor e Forma:SolidPeso molecular:771.86BRD4 Inhibitor-38
<p>BRD4 Inhibitor-38 (Compound 25) is an orally active BRD4 inhibitor, exhibiting IC50 values of 3.64 μM for BRD4 BD1 and 0.12 μM for BRD4 BD2. It also demonstrates anti-inflammatory properties, with an IC50 value of 1.98 μM for nitric oxide (NO) production.</p>Fórmula:C19H18N2O4Cor e Forma:SolidPeso molecular:338.357ATWLPPRAANLLMAAS
CAS:ATWLPPRAANLLMAAS is a chimeric peptide with anti-angiogenic and potent antitumor capabilities. It effectively inhibits the proliferation, viability, migration, and invasion of human hepatocellular carcinoma cells, and induces apoptosis (apoptosis).Fórmula:C76H123N21O20SPeso molecular:1682.98Polyphyllin G
CAS:<p>Polyphyllin G (Polyphyllin VII), the the main member of polyphyllin family, shows strong anticancer activity against several carcinomas.</p>Fórmula:C51H84O22Pureza:98%Cor e Forma:SolidPeso molecular:1049.21α-Tubulin polymerization-IN-1
<p>α-Tubulin polymerization-IN-1 (Compound 8l) functions as an inhibitor of α-tubulin polymerization. This compound modulates the NRF2/KEAP-1 signaling pathway and induces ROS production in PC-3 cells, leading to apoptosis. It inhibits the proliferation of PC-3 cells with a GI50 of 0.17 µM, causing cell cycle arrest in the G2/M phase. Additionally, α-Tubulin polymerization-IN-1 demonstrates antitumor activity in mouse models.</p>Cor e Forma:Odour SolidNSC 295642
CAS:<p>NSC 295642: phosphatase inhibitor, boosts phospho-Erk in cells, aids cancer research.</p>Fórmula:C15H14ClCuN3S2Cor e Forma:SolidPeso molecular:399.42PROTAC AR-NTD degrader 1
<p>PROTAC AR-NTD antagonist 1 (compound 18) is a small molecule belonging to the protein-targeting chimeras (PROTACs) that selectively targets the N-terminal</p>Fórmula:C41H47ClN6O7Pureza:98%Cor e Forma:SolidPeso molecular:771.3POV-PC
CAS:<p>POV-PC is an oxidized phospholipid that inhibits VSMC growth under high serum conditions and induces cell apoptosis under low serum conditions.</p>Fórmula:C29H56NO9PCor e Forma:SolidPeso molecular:593.73
