Apoptose
Os inibidores da apoptose são compostos que previnem ou retardam o processo de morte celular programada, conhecido como apoptose. Esses inibidores são vitais no estudo dos mecanismos de sobrevivência celular e são usados para investigar doenças onde a apoptose é desregulada, como câncer, distúrbios neurodegenerativos e doenças autoimunes. Ao modular a apoptose, esses inibidores podem ajudar no desenvolvimento de terapias destinadas a controlar a morte celular. Na CymitQuimica, oferecemos uma ampla seleção de inibidores da apoptose de alta qualidade para apoiar sua pesquisa em biologia celular, oncologia e áreas relacionadas.
Subcategorias de "Apoptose"
- ASK(9 produtos)
- BCL(11 produtos)
- Caspase(143 produtos)
- FOXO1(3 produtos)
- IAP(67 produtos)
- Mdm2(12 produtos)
- PD-1/PD-L1(139 produtos)
- PDK(9 produtos)
- PERK(25 produtos)
- Serina/treonina quinase(18 produtos)
- Survivina(14 produtos)
- TNF(89 produtos)
- c-RET(58 produtos)
- p53(63 produtos)
Exibir 6 mais subcategorias
Foram encontrados 5966 produtos de "Apoptose"
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Antagonist G
CAS:Antagonist G is an anticancer peptide and is also a broad spectrum neuropeptide growth factor antagonist.Fórmula:C49H66N12O6SPureza:98%Cor e Forma:SolidPeso molecular:951.1927-O-(tert-Butyldimethylsilyl)withaferin A
CAS:Compound 9a, a withanolide, induces apoptosis and has anti-cancer properties.Fórmula:C34H52O6SiCor e Forma:SolidPeso molecular:584.86iNOs-IN-5
<p>iNOs-IN-5 (Compound BN-4) is an inhibitor of iNOS with an IC50 value of 0.1707 μM, effectively reducing NO expression in RAW264.7 cells stimulated by LPS (HT-D1056). It further diminishes the expression of ROS and lactate dehydrogenase induced by hypoxic injury, displaying anti-necrotic and anti-apoptotic properties. In an SD rat model, iNOs-IN-5 exhibits neuroprotective effects against cerebral ischemia and is capable of crossing the blood-brain barrier.</p>Cor e Forma:Odour SolidLIB3S0280
LIB3S0280 is a potent inhibitor of TBK1, with an IC50 of 493.9 nM. It suppresses TBK1 downstream signaling by reducing the phosphorylation of IκBα and AKT. LIB3S0280 causes G2/M phase arrest and induces apoptosis in pancreatic cancer cells. Notably, it exhibits significant inhibitory effects on pancreatic cancer cell lines with high TBK1 expression, with a 96-hour IC50 value ranging from 6.64-10.98 μM. LIB3S0280 shows potential for research in pancreatic ductal adenocarcinoma (PDAC).Cor e Forma:Odour Solid4-N-Nonyloxyphenol
CAS:<p>4-N-Nonyloxyphenol, kaolinite nanotube photosensitizer, degrades phenolic pesticides, and disrupts endocrine.</p>Fórmula:C15H24O2Pureza:99.94%Cor e Forma:SoildPeso molecular:236.35hCAIX-IN-23
<p>hCAIX-IN-23 (Compound 27) is a human carbonic anhydrase (hCA) inhibitor with Ki values of 10.4 nM for hCA IX and 8.5 nM for hCA XII. It not only inhibits hCA activity but also releases NO, exerting dual anti-tumor effects. By reducing the expression of hCA IX and iron regulatory proteins, hCAIX-IN-23 regulates mitochondrial caspase activity and the ferroptosis pathway, thereby inducing apoptosis. This compound is utilized in research focused on renal cancer.</p>Cor e Forma:Odour Solid1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE
CAS:<p>Phospholipid with stearic acid and 15(S)-HpETE boosts ferroptosis in MEFs upon GPX4 inhibition.</p>Fórmula:C43H78NO10PCor e Forma:SolidPeso molecular:800.068PD0166285 dihydrochloride
CAS:PD-166285 is an effective and broadly active inhibitor of protein tyrosine kinase.Fórmula:C26H29Cl4N5O2Cor e Forma:SolidPeso molecular:585.353-Methoxy-9H-Carbazole
CAS:3-methoxy-9H-carbazole: photosensitizer, anti-breast cancer, from Klauseneria spp., induces apoptosis.Fórmula:C13H11NOPureza:99.24%Cor e Forma:SolidPeso molecular:197.23Ferumoxytol
CAS:<p>Ferumoxytol is an iron oxide nanoparticle with anti-leukemia properties, specifically against acute myeloid leukemia (AML) cells with low ferroportin (FPN) expression. By increasing intracellular iron levels, Ferumoxytol induces the Fenton reaction to produce reactive oxygen species (ROS), resulting in oxidative stress and ferroptosis. It selectively kills leukemia cells with low FPN expression while sparing normal cells, making it useful for studying leukemia targeting iron metabolism abnormalities.</p>Cor e Forma:SolidKB02-SLF
KB02-SLF, a molecular glue, degrades nuclear FKBP12 by modifying E3 ligase DCAF16 and extends protein degradation.Fórmula:C50H65ClN4O12Pureza:98%Cor e Forma:SolidPeso molecular:949.52CSF1R-IN-26
CAS:CSF1R-IN-26 (Compound III-1) is an inhibitor of CSF-1R with an IC50 of 20.07 nM. It promotes the polarization of M2 macrophages to M1 macrophages, inducing apoptosis in MC-38 cancer cells. CSF1R-IN-26 inhibits the activation of the AKT/ERK/STAT3 signaling pathways, remodels the tumor immune microenvironment, and exhibits antitumor activity in mouse models. In SD rats, CSF1R-IN-26 demonstrates favorable pharmacokinetic properties, with a half-life of 1.86 hours and an oral bioavailability of 79.22%.Fórmula:C20H22ClN5O3Cor e Forma:Odour SolidPeso molecular:415.87dTAGV-1-NEG TFA
dTAGV-1-NEG TFA, a diastereomer, serves as the heterobifunctional negative control for dTAGV-1. It acts specifically as an FKBP12 F36V-selective degrader [1].Fórmula:C70H91F3N6O16SCor e Forma:SolidPeso molecular:1361.56RA-XII
CAS:RA-XII is a useful organic compound for research related to life sciences. The catalog number is T125868 and the CAS number is 143343-98-0.Fórmula:C46H58N6O14Cor e Forma:SolidPeso molecular:918.998Lisaftoclax
CAS:Lisaftoclax, an oral Bcl-2/Bcl-xl inhibitor (IC50: 2 nM & 5.9 nM), treats CLL by promoting leukemia cell death.Fórmula:C45H48ClN7O8SPureza:97.14% - 99.66%Cor e Forma:SolidPeso molecular:882.42Nerelimomab
CAS:Nerelimomab (BAYX1351), an anti-TNF-α antibody, is utilized in sepsis research [1] [2].Cor e Forma:LiquidFLT3-IN-29
<p>FLT3-IN-29 (Compound MY-10) is an FLT3 inhibitor with IC50 values of 6.5 nM and 10.3 nM for FLT3-ITD and FLT3-D835Y mutants, respectively. It induces cell cycle arrest at the G0/G1 phase and effectively triggers apoptosis (Apoptosis). Additionally, FLT3-IN-29 reduces reactive oxygen species (ROS) and mitochondrial membrane potential (MMP), displaying anti-leukemic properties.</p>Fórmula:C25H30N6O2Cor e Forma:SolidPeso molecular:446.545Peginterferon β-1a
CAS:Peginterferon beta-1a: first pegylated interferon for cancer, RMS research; induces tumor cell apoptosis.Cor e Forma:SolidPROTAC Mcl1 degrader-1
CAS:<p>PROTAC Mcl1 degrader-1 is a Cereblon ligand-based targeted chimeric protein degrader (PROTAC) and an Mcl-1 inhibitor, useful in cancer research.</p>Fórmula:C45H45BrN6O8SPureza:98.74%Cor e Forma:SolidPeso molecular:909.84(R)-JAK2/STAT3-IN-10a
CAS:<p>(R)-JAK2/STAT3-IN-10a is the R-isomer of JAK2/STAT3-IN-1.JAK2/STAT3-IN-1 is a structural domain inhibitor of GP130 D1 with antitumor activity.</p>Fórmula:C34H35BrF3N5O2Pureza:97.99%Cor e Forma:SoildPeso molecular:682.57
