Apoptose
Os inibidores da apoptose são compostos que previnem ou retardam o processo de morte celular programada, conhecido como apoptose. Esses inibidores são vitais no estudo dos mecanismos de sobrevivência celular e são usados para investigar doenças onde a apoptose é desregulada, como câncer, distúrbios neurodegenerativos e doenças autoimunes. Ao modular a apoptose, esses inibidores podem ajudar no desenvolvimento de terapias destinadas a controlar a morte celular. Na CymitQuimica, oferecemos uma ampla seleção de inibidores da apoptose de alta qualidade para apoiar sua pesquisa em biologia celular, oncologia e áreas relacionadas.
Subcategorias de "Apoptose"
- ASK(9 produtos)
- BCL(11 produtos)
- Caspase(143 produtos)
- FOXO1(3 produtos)
- IAP(67 produtos)
- Mdm2(12 produtos)
- PD-1/PD-L1(139 produtos)
- PDK(9 produtos)
- PERK(25 produtos)
- Serina/treonina quinase(18 produtos)
- Survivina(14 produtos)
- TNF(89 produtos)
- c-RET(58 produtos)
- p53(63 produtos)
Exibir 6 mais subcategorias
Foram encontrados 5966 produtos de "Apoptose"
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JAK05
JAK05 exhibits inhibitory activity against Helicobacter pylori, effectively suppressing strains J63, J196, and J107, with a MIC of 3-5 µg/mL. It shows affinity for binding to H+/K+-ATPase, COX-1/2, TNF-α, and PGE2, and possesses antioxidant and anti-inflammatory properties. In a rat model of ethanol-induced gastric ulcers, JAK05 demonstrates anti-ulcer activity.Fórmula:C27H27ClN4O9SCor e Forma:SolidPeso molecular:619.043WEHI-3773
WEHI-3773 is an inhibitor of the interaction between VDAC2 and either BAK or BAX. It prevents BAX-mediated apoptosis (Apoptosis) by blocking the recruitment of BAX to the mitochondria through VDAC2. Conversely, WEHI-3773 promotes BAK-mediated apoptosis (Apoptosis) by limiting VDAC2's inhibitory sequestration of BAK. This compound shows promise for research in the field of cancer therapy.Cor e Forma:Odour SolidGal-ARV-771
Gal-ARV-771 is a PROTAC prodrug, modified with galactose, based on ARV-771. It is activated in senescent cancer cells that express SA-β-Gal, thereby releasing ARV-771. Through the ubiquitin-proteasome pathway, Gal-ARV-771 induces selective degradation of the BRD4 protein in senescent cells and promotes apoptosis (apoptosis) of these cancer cells.Fórmula:C71H84ClN9O19S2Peso molecular:1465.50134Thalidomide-NH-(CH2)2-NH2 TFA
CAS:Thalidomide-NH-(CH2)2-NH2 TFA is an alkyl-modified derivative of Thalidomide serving as a Cereblon ligand to recruit CRBN proteins and a pivotal intermediate inFórmula:C17H17F3N4O6Cor e Forma:SolidPeso molecular:430.34CDK9-IN-24
CDK9-IN-24 (compound 21a) is a potent and selective inhibitor of CDK9 that exhibits a pronounced inhibitory impact on tumor proliferation.Fórmula:C27H31N3O4Pureza:98%Cor e Forma:SolidPeso molecular:461.55PD1-PDL1-IN 1 TFA
PD1-PDL1-IN 1 TFA (compound 16) is a potent inhibitor of programmed cell death 1 (PD-1), functioning as an immune modulator [1].Fórmula:C16H24F3N7O8Cor e Forma:SolidPeso molecular:499.4Thalidomide-O-PEG4-NHS ester
CAS:Thalidomide-O-PEG4-NHS ester is a polyethylene glycol (PEG)-based linker, commonly employed for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].Fórmula:C28H33N3O13Pureza:98%Cor e Forma:SolidPeso molecular:619.57HMGB1-IN-1
HMGB1-IN-1 (compound 6) exhibits potent inhibition of NO production in RAW264.7 cells, with an IC50 of 15.9 ± 0.6 μM, and effectively disrupts the HMGB1/NF-κB/Fórmula:C57H75N3O15Cor e Forma:SolidPeso molecular:1042.22Zeluvalimab
CAS:Zeluvalimab (AMG-404) is a monoclonal antibody designed to target the PD-1 receptor, and is utilized in cancer research [1].Cor e Forma:LiquidMoracin N
CAS:Moracin N, a ferroptosis inhibitor derived from mulberry leaves, exhibits neuroprotective activity by mitigating oxidative stress [1].Fórmula:C19H18O4Pureza:98%Cor e Forma:SolidPeso molecular:310.34Uvarigrin
CAS:<p>Uvarigrin induces tumor multidrug resistance cell apoptosis and triggers Caspase-9 activation. Uvarigrin is isolated from the roots of Uvaria calamistrata.</p>Fórmula:C37H68O6Pureza:98%Cor e Forma:SolidPeso molecular:608.93Tubulin polymerization-IN-72
Tubulin polymerization-IN-72 (Compound 4a4) is a microtubule synthesis inhibitor with anticancer properties. By binding to the colchicine site, it disrupts the polymerization of tubulin, resulting in the arrest of cancer cells at the G2/M phase and inducing apoptosis (Apoptosis). The IC50 for its activity against cancer cells is 0.4-2.7 nM.Fórmula:C19H19FN4OCor e Forma:SolidPeso molecular:338.379Episilvestrol
CAS:<p>Episilvestrol is a derivative of silvestrol with eIF4A-targeted antitumor properties, found in Aglaia silvestris fruits and twigs.</p>Fórmula:C34H38O13Pureza:98%Cor e Forma:SolidPeso molecular:654.66USP7-IN-9
USP7-IN-9 is a potent USP7 inhibitor (IC50 = 40.8 nM), induces apoptosis, arrests RS4;11 cells, and modulates key oncoproteins.Fórmula:C32H33ClF6N6O8Cor e Forma:SolidPeso molecular:779.08β-Amyloid (1-40) (rat)
CAS:<p>Rat form of the beta-Amyloid (1-40) peptide</p>Fórmula:C190H291N51O57SPureza:98%Cor e Forma:SolidPeso molecular:4233.76MS41
CAS:MS41 is a selective eleven-nineteen leukemia (ENL) PROTAC degrader, with DC50s values of 3.50 nM (MV4;11), 2.84 nM (SEMK2), 3.03 nM (Jurkat), and 26.58 nM (KASUMI1). This compound effectively inhibits the growth of ENL-dependent leukemia cells, induces G1 cell cycle arrest, and increases cellular apoptosis (Apoptosis). Additionally, MS41 reduces chromatin occupancy related to ENL-mediated transcription elongation mechanisms and suppresses the expression of oncogenes and the progression of leukemia.Fórmula:C56H70N8O9SCor e Forma:SolidPeso molecular:1031.27p53 and MDM2 proteins-interaction-inhibitor (racemic)
CAS:p53 and MDM2 proteins-interaction-inhibitor (racemic) is an inhibitor of the interaction between p53 and MDM2 proteins.Fórmula:C40H49Cl2N5O4Pureza:98%Cor e Forma:SolidPeso molecular:734.75Triphenyl phosphate
CAS:Triphenyl phosphate is an flame retardant and endocrine disruptor that activates MAO-A/ROS/NF-κB pathways, disrupting placental tryptophan metabolism.Fórmula:C18H15O4PPureza:99.94%Peso molecular:326.288p53 (17-26)
CAS:Peptide is p53's amino acids 17-26, contacts Mdm-2 binding domain, also called p53N.Fórmula:C60H90N12O17Pureza:98%Cor e Forma:SolidPeso molecular:1251.43Osajin
CAS:<p>Osajin is the major bioactive iso avone present in the fruit of Maclura pomifera. It has antitumor, antioxidant, and anti-inflammatory activities.</p>Fórmula:C25H24O5Pureza:98%Cor e Forma:SolidPeso molecular:404.46
