Apoptose
Os inibidores da apoptose são compostos que previnem ou retardam o processo de morte celular programada, conhecido como apoptose. Esses inibidores são vitais no estudo dos mecanismos de sobrevivência celular e são usados para investigar doenças onde a apoptose é desregulada, como câncer, distúrbios neurodegenerativos e doenças autoimunes. Ao modular a apoptose, esses inibidores podem ajudar no desenvolvimento de terapias destinadas a controlar a morte celular. Na CymitQuimica, oferecemos uma ampla seleção de inibidores da apoptose de alta qualidade para apoiar sua pesquisa em biologia celular, oncologia e áreas relacionadas.
Subcategorias de "Apoptose"
- ASK(6 produtos)
- BCL(11 produtos)
- Caspase(127 produtos)
- FOXO1(3 produtos)
- IAP(65 produtos)
- Mdm2(12 produtos)
- PD-1/PD-L1(126 produtos)
- PDK(9 produtos)
- PERK(24 produtos)
- Serina/treonina quinase(15 produtos)
- Survivina(13 produtos)
- TNF(91 produtos)
- c-RET(51 produtos)
- p53(62 produtos)
Exibir 6 mais subcategorias
Foram encontrados 5622 produtos de "Apoptose"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
PROTAC HIF-1α degrader-1
<p>PROTAC HIF-1α degrader-1 (compound V2) is an effective proteolysis-targeting chimeric (PROTAC) degrader of hypoxia-inducible factor-1α (HIF-1α), with an IC50 value of 7.54 µM. This compound exhibits anti-proliferative activity, reduces HIF-1α protein expression, and induces apoptosis.</p>Fórmula:C51H72N6O7SCor e Forma:SolidPeso molecular:913.22NDI-Lyso
CAS:<p>NDI-Lyso is an anticancer agent targeting lysosomes, functioning through an enzyme-induced self-assembly (EISA) mechanism catalyzed by Cathepsin B. In cancer cell lysosomes, it forms rigid long fibers, promoting lysosomal swelling, lysosomal membrane permeabilization (LMP), and membrane disruption. This leads to non-classical caspase-independent apoptosis (Apoptosis). NDI-Lyso demonstrates significant selective anticancer activity across various cancer cell lines and drug-resistant cancer cells (IC50 approximately 10 μM), while exhibiting low toxicity to normal cells (IC50 > 60 μM).</p>Fórmula:C71H100N22O13Cor e Forma:SolidPeso molecular:1469.69Pipermethystine
<p>Pipermethystine is a useful organic compound for research related to life sciences and the catalog number is T124340.</p>Fórmula:C16H17NO4Cor e Forma:SolidPeso molecular:287.315MG-277
<p>MG-277 is a molecular glue compound transformed from PROTAC degradation agent, MG-277 potently inhibits tumor cell growth in a p53-independent manner.</p>Fórmula:C41H42Cl2FN5O5Pureza:98%Cor e Forma:SolidPeso molecular:774.71Methyl-4-oxoretinoate
CAS:<p>Methyl-4-oxoretinoate is a synthetic retinoid with anticancer properties, used for skin conditions and potential ocular treatments.</p>Fórmula:C21H28O3Pureza:98.07%Cor e Forma:SolidPeso molecular:328.454-N-Nonyloxyphenol
CAS:<p>4-N-Nonyloxyphenol, kaolinite nanotube photosensitizer, degrades phenolic pesticides, and disrupts endocrine.</p>Fórmula:C15H24O2Pureza:99.94%Cor e Forma:SoildPeso molecular:236.35SCR7
CAS:<p>SCR7, a specific DNA Ligase IV inhibitor, blocks nonhomologous end-joining (NHEJ).</p>Fórmula:C18H14N4OSPureza:98%Cor e Forma:SolidPeso molecular:334.4DAPK-IN-2
CAS:<p>DAPK-IN-2: DAPK inhibitor with anticancer potential. Used in cerebral infarction and ischemia research.</p>Fórmula:C17H14N2O4Pureza:98.26%Cor e Forma:SolidPeso molecular:310.3XM-U-14
<p>XM-U-14 is a selective PROTAC USP7 degrader that induces the degradation of USP7 in the RS4;11 cell line with a DC50 of 0.74 nM. This compound elevates the levels of p53 and p21, and significantly inhibits the growth of acute lymphoblastic leukemia (ALL) cells, with IC50 values of 0.5 nM in RS4;11 cells and 8.3 nM in Reh cells. Moreover, XM-U-14 induces apoptosis and cell cycle arrest, and effectively inhibits tumor growth.</p>Cor e Forma:Odour SolidXIAP BIR2/BIR2-3 inhibitor-1
CAS:<p>XIAP BIR2/BIR2-3 inhibitor-1 (compound 3) serves as a potent dual inhibitor targeting BIR2 and BIR2-3 domains, with IC50 values of 1.9 nM and 0.8 nM, respectively. This compound is utilized in cancer research studies [1].</p>Fórmula:C72H96N16O14Cor e Forma:SolidPeso molecular:1409.63Azurin p28 peptide
CAS:<p>Azurin p28 peptide, a tumor-penetrating antitumor agent, stabilizes p53 by reducing its proteasomal degradation via the formation of a p28:p53 complex.</p>Fórmula:C122H197N31O47S2Cor e Forma:SolidPeso molecular:2914.18PD-1/PD-L1-IN-48
<p>PD-1/PD-L1-IN-48 (compound HD10) is an effective inhibitor of the PD-1/PD-L1 interaction, exhibiting an IC50 of 3.1 nM. It plays a vital role in cancer research.</p>Cor e Forma:Odour SolidPROTAC NCOA4 degrader-1
<p>PROTACNCOA4 degrader-1 (Compound V3) is a PROTAC-based degrader of NCOA4, exhibiting a DC50 of 3 nM in HeLa cells. Besides acting as a ferroptosis inhibitor, this compound effectively reduces the levels of NCOA4 and decreases intracellular ferrous (Fe2+) levels. Moreover, PROTACNCOA4 degrader-1 ameliorates liver damage in a CCl4-induced acute liver injury model.</p>Cor e Forma:Odour SolidBcl-xL antagonist 2
CAS:<p>Bcl-xL antagonist 2 is an effective and selective antagonist of Bcl-xL with an IC50 of 91 nM and a Ki of 65 nM.</p>Fórmula:C21H16N4O3S2Pureza:99.81%Cor e Forma:SolidPeso molecular:436.51icFSP1
CAS:<p>icFSP1 is a mitochondria-associated apoptosis-inducing factor regulator with antitumor activity for the study and treatment of tumor diseases.</p>Fórmula:C26H25N3O5Pureza:99.87% - 99.93%Cor e Forma:SoildPeso molecular:459.49BMSpep-57
CAS:<p>BMSpep-57: Macrocyclic peptide, inhibits PD-1/PD-L1, IC50=7.68 nM, binds PD-L1 (Kd=19 nM/MST, 19.88 nM/SPR), boosts T cell IL-2 in PBMCs.</p>Fórmula:C89H126N24O19SCor e Forma:SolidPeso molecular:1868.2Human PD-L1 inhibitor II
CAS:<p>Human PD-L1 inhibitor II is a potent PD-L1 inhibitor with anti-cancer activity.</p>Fórmula:C103H151N25O30Cor e Forma:SolidPeso molecular:2219.486Human PD-L1 inhibitor I
CAS:<p>Human PD-L1 inhibitor I, a peptide, blocks PD-L1/PD-1 interaction with 3.39 μM affinity.</p>Fórmula:C110H152N26O32Cor e Forma:SolidPeso molecular:2350.576RPS6-IN-1
<p>RPS6-IN-1 (Compound 22o) inhibits cell migration and induces apoptosis (increasing the expression of Bax, p53, cleaved-caspase 3, and cleaved-PARP). It reduces mitochondrial membrane potential and activates autophagy (Autophagy) through the PI3K-Akt-mTOR signaling pathway, damaging mitochondria and lysosomes within the cell and causing endoplasmic reticulum stress. RPS6-IN-1 also inhibits the phosphorylation of RPS6. Notably, RPS6-IN-1 is a low systemic toxicity anticancer agent.</p>Cor e Forma:Odour SolidPROTAC CDK4/6 degrader 1
CAS:<p>PROTAC CDK4/6 degrader 1 (Compound 7f) is a dual degrader of CDK4 and CDK6, with DC50 values of 10.5 nM and 2.5 nM, respectively. This compound effectively inhibits proliferation in Jurkat cells (IC50 of 0.18 μM), induces cell cycle arrest during the G1 phase, and triggers cell apoptosis (apoptosis).</p>Fórmula:C41H47N11O6Cor e Forma:SolidPeso molecular:789.88
