Apoptose
Os inibidores da apoptose são compostos que previnem ou retardam o processo de morte celular programada, conhecido como apoptose. Esses inibidores são vitais no estudo dos mecanismos de sobrevivência celular e são usados para investigar doenças onde a apoptose é desregulada, como câncer, distúrbios neurodegenerativos e doenças autoimunes. Ao modular a apoptose, esses inibidores podem ajudar no desenvolvimento de terapias destinadas a controlar a morte celular. Na CymitQuimica, oferecemos uma ampla seleção de inibidores da apoptose de alta qualidade para apoiar sua pesquisa em biologia celular, oncologia e áreas relacionadas.
Subcategorias de "Apoptose"
- ASK(6 produtos)
- BCL(11 produtos)
- Caspase(125 produtos)
- FOXO1(3 produtos)
- IAP(66 produtos)
- Mdm2(12 produtos)
- PD-1/PD-L1(125 produtos)
- PDK(9 produtos)
- PERK(25 produtos)
- Serina/treonina quinase(15 produtos)
- Survivina(13 produtos)
- TNF(92 produtos)
- c-RET(51 produtos)
- p53(62 produtos)
Exibir 6 mais subcategorias
Foram encontrados 5593 produtos de "Apoptose"
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Antiproliferative agent-23
<p>Antiproliferative agent-23: destabilizes microtubules, induces apoptosis in cancer cells via mitochondrial path, and triggers ER stress.</p>Fórmula:C23H28Cl3N3O6PtCor e Forma:SolidPeso molecular:743.93Ganoderic acid T1
<p>Ganoderic acid T1, a derivative of Ganoderic acid T, triggers cancer cell apoptosis by boosting ROS and activating caspases.</p>Fórmula:C34H50O7Cor e Forma:SolidPeso molecular:570.76Lodapolimab
CAS:<p>Lodapolimab (LY3300054) is an IgGλ anti- PD-1 monoclonal antibody [1] .</p>Cor e Forma:LiquidASR-488
CAS:<p>ASR-488, an activator of the mRNA-binding protein CPEB1, promotes apoptosis and suppresses the growth of bladder cancer [1].</p>Fórmula:C33H40O7SCor e Forma:SolidPeso molecular:580.73Zeluvalimab
CAS:<p>Zeluvalimab (AMG-404) is a monoclonal antibody designed to target the PD-1 receptor, and is utilized in cancer research [1].</p>Cor e Forma:LiquidDehydrobruceine B
CAS:<p>Dehydrobruceine B, from Brucea javanica, enhances Cisplatin-induced apoptosis by affecting AIF, Bax, and Keap1-Nrf2.</p>Fórmula:C23H26O11Cor e Forma:SolidPeso molecular:478.45PROTAC FLT3/CDK9 degrader-1
<p>Potent PROTAC degrader for FLT3/CDK9, induces apoptosis, and shows promise for FLT3-ITD mutated AML research.</p>Fórmula:C48H62N12O7Cor e Forma:SolidPeso molecular:919.08Betifisolimab
CAS:<p>Betifisolimab (MSB-2311) is a humanized antibody targeting PD-L1 for solid tumors and blood cancer research.</p>Cor e Forma:LiquidNSC90616
<p>NSC90616 is a mutant p53 rescue compound [1] .</p>Fórmula:C23H30FNa2O9PCor e Forma:SolidPeso molecular:546.43sEH inhibitor-19
<p>sEH inhibitor-19 (Compound (R)-14i) is an orally active soluble epoxide hydrolase (sEH) inhibitor with an IC50 of 1.2 nM. This compound suppresses the expression of TNF-α and IL-6 and exhibits anti-inflammatory effects in mouse models of acute pancreatitis and Carrageenan-induced edema.</p>Fórmula:C28H28F3N3O4Cor e Forma:SolidPeso molecular:527.535Milademetan tosylate hydrate
CAS:<p>Milademetan tosylate hydrate, an oral MDM2 inhibitor targeting AML and solid tumors, induces G1 arrest and apoptosis.</p>Fórmula:C37H44Cl2FN5O8SCor e Forma:SolidPeso molecular:808.74Chloranthalactone B
CAS:<p>Chloranthalactone B, a sesquiterpenoid from Sarcandra glabra, inhibits inflammation via AP-1 & p38 MAPK.</p>Fórmula:C15H16O3Cor e Forma:SolidPeso molecular:244.29Anagrelide hydrochloride monohydrate
CAS:<p>Anagrelide HCl monohydrate is a platelet-reducing imidazoquinazoline for ET and PV research.</p>Fórmula:C10H10Cl3N3O2Cor e Forma:SolidPeso molecular:310.56Ganglioside GD3 disodium salt
CAS:<p>Ganglioside GD3 disodium salt is a melanoma-associated antigen often targeted in immune therapy for melanomas.</p>Fórmula:C70H123N3Na2O29Cor e Forma:SolidPeso molecular:1516.71ERK-IN-6
<p>ERK-IN-6, a potent agent, inhibits ESCC growth and induces apoptosis through the ERK pathway.</p>Fórmula:C19H18BrN3O3SCor e Forma:SolidPeso molecular:448.33Thalidomide-NH-PEG2-COOH
CAS:<p>Thalidomide-NH-PEG2-COOH: a synthesized E3 ligase ligand-linker with cereblon ligand and PROTAC linker.</p>Fórmula:C20H23N3O8Cor e Forma:SolidPeso molecular:433.417(Rac)-BIO8898
CAS:<p>(Rac)-BIO8898 is a chemical compound that serves as an inhibitor of the co-stimulatory interaction between CD40 and CD154.</p>Fórmula:C53H64N8O6Cor e Forma:SolidPeso molecular:909.13Lenercept
CAS:<p>Lenercept (Ro 45-2081) is a recombinant fusion protein combining the soluble TNF-receptor (p55) with the Fc portion of human IgG1 [1].</p>Cor e Forma:LiquidAntitumor agent-64
CAS:<p>Antitumor Agent-64 (Compound 8d), a diosgenin derivative, exhibits potent cytotoxic activity against the A549 cell line and induces apoptosis in A549 cells</p>Fórmula:C35H47N3O3SCor e Forma:SolidPeso molecular:589.83Odoroside A
CAS:<p>Odoroside A, from Nerium oleander leaves, induces cancer cell death via ROS/p53, causing apoptosis and cell cycle arrest.</p>Fórmula:C30H46O7Cor e Forma:SolidPeso molecular:518.68MEDI-7352
<p>MEDI-7352 is a human bispecific antibody targeting NGF/bNGF and TNF. It can be utilized in research focused on osteoarthritis (OA) pain.</p>Cor e Forma:Odour LiquidMRIA9
CAS:<p>MRIA9 inhibits SIK1/2/3 & PAK2/3 with IC50: SIK1 (516 nM), SIK2 (180 nM), SIK3 (127 nM); ATP-competitive.</p>Fórmula:C24H22ClFN6O3Cor e Forma:SolidPeso molecular:496.92Bim BH3, Peptide IV
CAS:<p>This Bim peptide belongs to the pro-apoptotic group of the Bcl-2 family of proteins.</p>Fórmula:C145H222N44O41SPureza:98%Cor e Forma:SolidPeso molecular:3269.65Pimivalimab
CAS:<p>Pimivalimab (JTX-4014), a PD-1 inhibitor, is utilized in solid tumor research [1].</p>Cor e Forma:Liquidcis-Clovamide
CAS:<p>cis-Clovamide is a naturally occurring phenolic compound with noteworthy antioxidant, anti-inflammatory, and antiapoptotic properties.</p>Fórmula:C18H17NO7Cor e Forma:SolidPeso molecular:359.334Bcl-2-IN-4
CAS:<p>Bcl-2-IN-4: potent, selective, oral Bcl-2 inhibitor with 1.5 nM IC50, >200x selectivity over Bcl-xL.</p>Fórmula:C46H50ClN9O7SCor e Forma:SolidPeso molecular:908.46PDE4D inhibitor 1
<p>PDE4-IN-1 is a PDE4 inhibitor characterized by high potency (IC50: 8.6 nM) and superior selectivity over other PDE subtypes. This compound inhibits the release of inflammatory cytokines and chemokines. Additionally, PDE4-IN-1 significantly restores the damaged cAMP-CREB signaling pathway, inhibits proliferation, and promotes differentiation to reverse psoriasis formation.</p>Cor e Forma:Odour SolidTRP-601
CAS:<p>TRP-601 is a caspase inhibitor.</p>Fórmula:C40H48F2N6O11Pureza:98%Cor e Forma:SolidPeso molecular:826.852LZ-07
<p>LZ-07 is an IRAK4 PROTAC degrader (DC50 = 1.14 nM), that, upon degradation of IRAK4, significantly inhibits the expression of cytokines such as IL-6, IL-1β, TNF-α, and IL-10. It is applicable in research related to autoimmune diseases.</p>Cor e Forma:Odour SolidSSE1806
<p>SSE1806, a podophyllotoxin derivative (a natural antimitotic agent), functions as a microtubule/tubulin inhibitor, exhibiting potent anticancer and</p>Fórmula:C21H18N2O5Cor e Forma:SolidPeso molecular:378.38hCAIX-IN-13
CAS:<p>hCAIX-IN-13 (Pt2) inhibits CAIX with 6.57 μM IC50, curbs cancer cell growth, and induces apoptosis for cancer research.</p>Fórmula:C37H33F3N6O7PtS2Cor e Forma:SolidPeso molecular:989.9ARI-1
<p>ARI-1 is a receptor tyrosine kinase-like orphan receptor 1 (ROR1) inhibitor that binds to ROR1's extracellular Frizzled domain, effectively inhibiting aberrant</p>Cor e Forma:Odour SolidTNF-α-IN-11
<p>TNF-α-IN-11 (Compound 10) is a TNF-α inhibitor exhibiting a dissociation constant (K D) of 12.06 μM.</p>Fórmula:C24H26N2O5Cor e Forma:SolidPeso molecular:422.47Petromurin C
CAS:<p>Petromurin C, a bis-indolyl benzenoid from P. muricatus, is cytotoxic to NS-1 cells (IC50=33μg/ml) and active against T. foetus (IC50=100μg/ml).</p>Fórmula:C26H24N2O5Cor e Forma:SolidPeso molecular:444.487Diprovocim-1
CAS:<p>Diprovocim-1: TLR1/2 agonist; triggers TNF-α in THP-1 cells; boosts ovalbumin IgG1 & CTLs against tumors with anti-PD-L1 in mice.</p>Fórmula:C56H56N6O6Cor e Forma:SolidPeso molecular:909.1Pipermethystine
<p>Pipermethystine is a useful organic compound for research related to life sciences and the catalog number is T124340.</p>Fórmula:C16H17NO4Cor e Forma:SolidPeso molecular:287.315Antiproliferative agent-42
<p>Antiproliferative Agent-42 (Compound 7m), a dihydrodipyrrolo compound, exhibits antiproliferative activity against the Panc-1 cell line, with an IC 50 of 12.54</p>Cor e Forma:Odour SolidTerrein
CAS:<p>Terrain (NSC 291308), a fungal metabolite, reduces age-related inflammation via Nrf2/ERK1/2/HO-1 and inhibits IL-6 in human fibroblasts.</p>Fórmula:C8H10O3Cor e Forma:SolidPeso molecular:154.16Anticancer agent 39
CAS:<p>Compound B12, a JOA derivative, collapses MMP to induce apoptosis, inhibits cloning/migration, and has an IC50 of 0.39 μM against HGC-27 cells.</p>Fórmula:C50H65N5O10Cor e Forma:SolidPeso molecular:896.08HSP70-IN-6
<p>HSP70-IN-6 (Compound JL-15) acts as an inhibitor of the Hsp70-Bim protein-protein interactions (PPI) with an IC50 value of 70 nM. It induces apoptosis in chronic myeloid leukemia (CML) cells with EC50 values of 0.43 μM (BV173), 0.88 μM (K562), and 0.19 μM (K562-R3).</p>Cor e Forma:Odour SolidBcI-2/BcI-xI ligand 1
CAS:<p>BcI-2/BcI-xI ligand 1, functioning as a BcI-2/BcI-xI ligand, is utilized in the synthesis of PROTAC BcI-2/BcI-xI Degrader-1 .</p>Fórmula:C53H64ClF3N6O8S3Cor e Forma:SolidPeso molecular:1101.75Necroptosis-IN-4
<p>Necroptosis-IN-4 is an effective inhibitor of necroptosis, specifically targeting RIP kinase 1 (RIPK1) without inhibitory activity against RIPK3. It exhibits weak inhibitory effects on VEGFR1/2 and PDGFR-α.</p>Cor e Forma:Odour Solid5-Fluorouracil-13C,15N2
CAS:<p>5-Fluorouracil-13C,15N2 is a standard for quantifying 5-fluorouracil via GC/LC-MS and blocks DNA synthesis, causing cell apoptosis.</p>Fórmula:C4H3FN2O2Cor e Forma:SolidPeso molecular:133.057RET Ligand-Linker Conjugate-1
<p>RET Ligand-Linker Conjugate-1 consists of a complex formed by a RET ligand and a linker, which can be utilized in the synthesis of QZ2135.</p>Fórmula:C40H44N10OCor e Forma:SolidPeso molecular:680.84Necroptosis-IN-5
<p>Necroptosis-IN-5 (Compound 26) is an orally active inhibitor of necroptotic cell death (necroptosis). This compound also exhibits potent inhibitory activity against receptor-interacting protein kinase 1 (RIPK1). It can be utilized in research related to inflammatory diseases, neurodegenerative disorders, and cancer associated with necroptosis.</p>Cor e Forma:Odour SolidCDC20-IN-2
<p>CDC20-IN-2 (14c) is an inhibitor of Cdc20 with a KD of 7.65 μM, inducing G2/M phase arrest, promoting DNA damage accumulation, and stabilizing key substrates such as Cyclin B1 and Bim. This leads to enhanced apoptosis, as well as inhibition of tumor cell proliferation and migration.</p>Cor e Forma:Odour SolidZamzetoclax
CAS:<p>Zamzetoclax (compound 1) acts as a potential inhibitor of Mcl-1.</p>Fórmula:C38H46ClN5O6SCor e Forma:SolidPeso molecular:736.32Antagonist G TFA
<p>Potent vasopressin blocker, Antagonist G TFA also mildly inhibits GRP & Bradykinin, triggers AP-1, enhances chemo response.</p>Fórmula:C51H67F3N12O8SCor e Forma:SolidPeso molecular:1065.21(E/Z)-Eltrombopag 13C4
CAS:<p>(E/Z)-Eltrombopag 13C4 is a mix of E/Z isotopologues, both 13C-labeled TPO receptor agonists for thrombocytopenia.</p>Fórmula:C25H22N4O4Cor e Forma:SolidPeso molecular:446.444Solasodine hydrochloride
CAS:<p>Solasodine hydrochloride (90 μM; 2 days) treatment induced significant budding in P19 cells. This compound strongly stimulated the expression of various neuronal markers, including βIII-tubulin, synaptophysin, MAP2, ChAT, and the neural progenitor marker doublecortin. Predominantly, Solasodine hydrochloride directed the differentiation of P19 cells towards neuronal pathways.</p>Fórmula:C27H44ClNO2Cor e Forma:SolidPeso molecular:450.1RLX HCl
CAS:<p>RLX HCl is anticancer, inhibits tumour proliferation by suppressing the PI3K/Akt/FoxO3a in experimental colon cancer, antiproliferative.</p>Fórmula:C13H15ClN2OPureza:99.43%Cor e Forma:SoildPeso molecular:250.72Reproxalap
CAS:<p>Reproxalap (NS-2) is a dry eye treatment that neutralizes aldehydes like malondialdehyde.</p>Fórmula:C12H13ClN2OPureza:99.4% - 99.97%Cor e Forma:SolidPeso molecular:236.7FL118
CAS:<p>FL118 is a novel survivin inhibitor that inhibits cancer stem cell-like properties.FL118 is a novel camptothecin analog with anticancer activity that inhibits</p>Fórmula:C21H16N2O6Pureza:98.99%Cor e Forma:SoildPeso molecular:392.36Carbonic anhydrase inhibitor 33
<p>Carbonic anhydrase inhibitor33 (11D) is a dual inhibitor that targets both CA (carbonic anhydrase) IX/XII and CDK6. It exhibits Ki values of 19.7 nM for hCA IX and 26.1 nM for hCA XII. Additionally, Carbonic anhydrase inhibitor33 (11D) can induce G1 phase cell cycle arrest and apoptosis, making it relevant for research in non-small cell lung cancer (NSCLC).</p>Fórmula:C19H15FN6O2SCor e Forma:SolidPeso molecular:410.09612TRAP1-IN-1
CAS:<p>TRAP1-IN-1 is a selective TRAP1 inhibitor, induces degradation of TRAP1 downstream proteins, inhibits OXPHOS, and disrupts mitochondrial membrane potential.</p>Fórmula:C45H39F7N2O4P2Pureza:98%Cor e Forma:SolidPeso molecular:866.74CDK2-IN-45
<p>CDK2-IN-45 is a CDK2 inhibitor with an IC50 value of 0.64 μM. It effectively inhibits the proliferation of DU-145 and PC-3 cell lines, with IC50 values of 2.20 μM and 4.17 μM, respectively. Additionally, CDK2-IN-45 induces G0/G1 phase cell cycle arrest and apoptosis. It is utilized in prostate cancer research.</p>Fórmula:C25H16ClN5SCor e Forma:SolidPeso molecular:453.95YX0798
<p>YX0798 is a selective, orally active CDK9 inhibitor (Kd: 0.28 nM). It downregulates the oncogenic protein c-MYC and the pro-survival protein MCL-1. YX0798 disrupts the cell cycle and causes transcriptome reprogramming, ultimately leading to apoptosis. The compound exhibits antitumor activity.</p>Fórmula:C21H19ClF3N5O2Cor e Forma:SolidPeso molecular:465.86FAK-IN-25
<p>FAK-IN-25 (4c) is an inhibitor of FAK with an IC50 value of 50.98 nM. It induces apoptosis and causes cell cycle arrest in the G1 phase, making it relevant for cancer research.</p>Fórmula:C22H13ClN4OS2Cor e Forma:SolidPeso molecular:448.95Cot inhibitor-1 hydrochloride
<p>Cot inhibitor-1 hydrochloride blocks TPL-2 kinase (IC50=28nM) and TNF-α synthesis (IC50=5.7nM) in human blood.</p>Fórmula:C27H28Cl3FN8Pureza:98.26%Cor e Forma:SoildPeso molecular:589.92Pep19-2.5
CAS:<p>Pep19-2.5: Synthetic antitoxin peptide inhibits LP/LPS signals via PRRs, preventing inflammation and pyroptosis.</p>Fórmula:C135H187N37O22SCor e Forma:SolidPeso molecular:2712.23Boc-Asp(OBzl)-CMK
CAS:<p>Boc-Asp(OBzl)-CMK, an inhibitor of IL-1 converting enzyme (ICE, caspase1), prevents the death of CHP100 neuroblastoma cells and inhibits IL-1β release induced by the viral coat protein [1].</p>Fórmula:C17H22ClNO5Cor e Forma:SolidPeso molecular:355.81Trilexium
CAS:<p>Trilexium (TRX-E-009-1), a third-generation benzopyran structurally related to TRX-E-002-1, increases p21 protein expression, induces apoptosis, depolymerizes microtubules, and demonstrates broad anti-cancer activity [1] [2].</p>Fórmula:C24H23FO6Cor e Forma:SolidPeso molecular:426.43Ac-LEVD-CHO
CAS:<p>Ac-LEVD-CHO, a caspase-4 inhibitor, is a peptide with the sequence Ac-Leu-Glu-Val-Asp-al [1].</p>Fórmula:C22H36N4O9Cor e Forma:SolidPeso molecular:500.54Ac-FEID-CMK
<p>Ac-FEID-CMK: Potent inhibitor for zebrafish GSDMEb, reduces pyroptosis, and lessens septic AKI.</p>Fórmula:C27H37ClN4O9Cor e Forma:SolidPeso molecular:597.06Volrustomig
CAS:<p>Volrustomig is a bi-engineered fragment crystallizable (Fc) domain, a monovalent bispecific IgG1 monoclonal antibody targeting the key immune checkpoint receptors PD-1 and CTLA-4. It boosts T-cell activation and antitumor immunity, making it a promising immunotherapy for various cancers. Molecular weight: 146.77 kDa.</p>Cor e Forma:LiquidUNC10245380
<p>UNC10245380 is a CIB1 inhibitor with an IC50 of 8 μM. It also inhibits the phosphorylation of AKT and ERK while upregulating the expression of TRAIL-R1/D5. UNC10245380 specifically kills cancer cells that are dependent on CIB1, demonstrating its potential value in the development of CIB1 probes and cancer research.</p>Cor e Forma:Odour SolidBIIB023
<p>BIIB023 is a human monoclonal antibody (mAb) that targets TNFRSF12A/TWEAKR/CD266. It is applicable for research in lupus nephritis and rheumatoid arthritis.</p>Cor e Forma:Odour LiquidVinepidine sulfate
CAS:<p>Vinepidine (LY-119863) sulfate, a derivative of vincristine, exhibits antitumor activity .</p>Fórmula:C46H58N4O13SCor e Forma:SolidPeso molecular:907.04Human PD-L1 inhibitor IV
CAS:<p>PD-L1 inhibitor IV, a polypeptide, competitively blocks hPD-1 with a Kd of 1.38 μM, preventing hPD-1/hPD-L1 interaction.</p>Fórmula:C80H113N25O27Cor e Forma:SolidPeso molecular:1856.932MS105
CAS:<p>MS105 is an orally active, selective protein tyrosine kinase 6 (PTK6) PROTAC degrader. It recruits the VHL E3 ligase through a VHL ligand fragment, facilitating ubiquitination and proteasomal degradation of PTK6, thereby inhibiting the proliferation and migration of breast cancer cells and inducing apoptosis (apoptosis). MS105 is a promising compound for breast cancer research.</p>Fórmula:C56H70FN13O6SCor e Forma:SolidPeso molecular:1072.30FR900359
CAS:<p>FR900359 is a macrocyclic Gq protein inhibitor that inhibits melanoma cell proliferation and can be used to study asthma, inflammation and cancer.</p>Fórmula:C49H75N7O15Pureza:98%Cor e Forma:SolidPeso molecular:1002.16PROTAC GPX4 degrader-4
CAS:<p>PROTACGPX4 degrader-4 is a GPX4 PROTAC degrader with a DC50 of 5.32 nM. It inhibits the activity of cancer cell lines RT4, T24, and J82 with IC50 values of 0.09, 2.97, and 7.58 μM, respectively. This compound elevates lipid ROS levels and induces ferroptosis in T24 and RT4 cells. In T24 tumor-bearing BALB/c nude mouse models, PROTACGPX4 degrader-4 demonstrates antitumor activity. It is applicable to bladder cancer research.</p>Fórmula:C43H58N2O13Cor e Forma:SolidPeso molecular:810.93C-Peptide 1 (rat)
CAS:<p>C-Peptide 1 (rat) is a polypeptide isolated from proinsulin. C-Peptide acts as a β-catenin/GSK-3β activator, influences Na/K-ATPase, regulates apoptosis.</p>Fórmula:C140H228N38O51Pureza:99.788%Cor e Forma:SolidPeso molecular:3259.58Sandalore
CAS:<p>Sandalore boosts hair growth, reduces cell death, and raises IGF-1, acting on olfactory receptor OR2AT4.</p>Fórmula:C14H26OPureza:97.96%Cor e Forma:Light Yellow Viscous LiquidPeso molecular:210.36YX-02-030
CAS:<p>YX-02-030M is a PROTACMDM2 degrader. It inhibits the binding of MDM2 to p53 and VHL to HIF1α, with IC50 values of 63 nM and 1.35 μM, respectively. YX-02-030M binds to MDM2 and recruits the VHL E3 ubiquitin ligase to initiate MDM2 degradation, effectively killing p53 mutant or deficient triple-negative breast cancer (TNBC) cells.</p>Fórmula:C66H85Cl2N9O10SPeso molecular:1267.41PRMT5-IN-33
<p>PRMT5-IN-33 (compound A8) is a selective inhibitor of PRMT5 that competes with SAM, exhibiting an IC50 of 10.9 nM. It induces apoptosis and inhibits the proliferation of Z-138 and MOLM-13 cells, demonstrating antitumor activity.</p>Fórmula:C25H24BrN5O3SPeso molecular:553.07832PD-L1-IN-5
<p>PD-L1-IN-5 (X22) is an orally active PD-L1 inhibitor with an IC50 of 785.6 nM, demonstrating antitumor activity in vivo.</p>CBI1
<p>CBI1 is a covalent BAX inhibitor. It selectively derivatizes BAX at C126 and inhibits BAX activation by triggering a ligand or through point mutations. CBI1 prevents the lipidation and oligomerization of BAX by t-2-hex. It also inhibits BAX activation induced by BH3 ligands, F116A mutation, or t-2-hex.</p>Fórmula:C15H19BrN4OS2Peso molecular:414.01837NAE-IN-1
<p>NAE-IN-1 (compound X-10) is a potent inhibitor of NAE1. It induces apoptosis and causes cell cycle arrest in the G2/M phase. Furthermore, NAE-IN-1 increases ROS levels and inhibits cell migration, demonstrating antiproliferative activity.</p>Fórmula:C29H30N4O2SPeso molecular:498.20895Ru-Poma
<p>Ru-Poma is an Ru(II)-based photosensitizer designed to enhance the efficacy of photodynamic therapy (PDT) against tumors resistant to Cisplatin. It targets Pomalidomide to partially degrade CRBN, inducing ferroptosis by increasing lipid peroxides and downregulating GPX4 and GAPDH expression. In A549 cells, Ru-Poma exhibits cytotoxicity with IC50 values of 18.46 μM in the dark and 0.37 μM under illumination.</p>Fórmula:C89H75Cl2N11O11Ru·7H2OS2/IAPinh
<p>S2/IAPinh is a conjugate composed of an inhibitor of apoptosis proteins inhibitor (IAPinh) and a ligand of sigma 2 SW43. It demonstrates anti-proliferative and apoptosis-inducing activity by degrading inhibitor of apoptosis proteins (clAP-1).</p>Fórmula:C52H75Cl2FN6O6SPeso molecular:1000.48299Topoisomerase II inhibitor 17
<p>TopoisomeraseII inhibitor 17 (compound 4c) is a thiazolopyrimidine-based inhibitor of Topoisomerase II with an IC50 of 0.23 μM. This compound significantly disrupts the cell cycle and induces apoptosis.</p>Fórmula:C25H22Cl3N3O5SPeso molecular:581.03458WEE1-IN-7
<p>WEE1-IN-7 (compound 12h) is a potent, orally active WEE1 inhibitor with an IC50 value of 2.1 nM. This compound induces apoptosis and causes cell cycle arrest in the S phase, demonstrating antitumor activity.</p>PROTAC GPX4 degrader-2
<p>PROTACGPX4 degrader-2 (compound 18a) is a proteolysis-targeting chimera (PROTAC) that targets the degradation of glutathione peroxidase 4 (GPX4), with a DC50, 48h value of 1.68 μM. It induces the accumulation of lipid peroxides and mitochondrial depolarization, subsequently triggering ferroptosis. Additionally, PROTACGPX4 degrader-2 exhibits antiproliferative activity.</p>Fórmula:C50H61ClN8O9Peso molecular:952.425LZFPN-90
LZFPN-90 (LZ90) is a dual-target compound aimed at NAMPT and PD-L1. It inhibits the interaction between PD-1/PD-L1 and NAMPT activity. LZFPN-90 suppresses cell growth in a NAMPT-dependent manner, blocking the cell cycle and subsequently inducing apoptosis. Additionally, LZFPN-90 exhibits target-dependent antitumor activity, impacting metabolic processes and the immune system.Fórmula:C33H36N8O2SPeso molecular:608.26819WD6305
<p>WD6305 is an effective and selective METTL3-METTL14 PROTAC degrader, with DC50 values of 140 nM and 194 nM for METTL3 and METTL14, respectively. It inhibits m6A modification and the proliferation of acute myeloid leukemia cells while inducing apoptosis. WD6305 also exhibits antitumor activity.</p>Fórmula:C61H75F2N11O5SPeso molecular:1111.56414Anticancer agent 204
<p>Anticanceragent 204 (Compound 6) is a fluorinated derivative of cinnamamides with anticancer activity. It can arrest the cell cycle of HepG2 cells in the G1 phase and induces apoptosis by reducing mitochondrial membrane polarization (MMP) levels.</p>Fórmula:C26H18FN5O3SPeso molecular:499.11144DA5-HTL
<p>DA5-HTL is a compound that combines dasatinib with the HaloTag system, effectively inhibiting the growth of tumor cells, with a GI50 of 1.923 nM.</p>Fórmula:C39H58Cl2N8O8SPeso molecular:868.34754Antitumor agent-170
<p>Antitumor agent-170 (Compound C6) inhibits PD-1/PD-L1 interaction and PARP7 with IC50 values of 0.342 μM and 7.05 nM, respectively. It shows high affinity for human PD-L1, with a Ki of 9.31 nM, and can restore T cell function while increasing IFN-γ secretion. In mouse models, Antitumor agent-170 exhibits antitumor effects against melanoma and demonstrates favorable pharmacokinetic properties.</p>Fórmula:C59H69ClF3N11O9Peso molecular:1167.49204PRDX1-IN-2
<p>PRDX1-IN-2 (compound 15) is a selective inhibitor of the antioxidant enzyme Peroxiredoxin 1 (PRDX1) with an IC50 of 0.35 μM. It reduces mitochondrial membrane potential in SW620 cells, potentially due to increased ROS resulting from PRDX1 inhibition, leading to apoptosis. PRDX1-IN-2 is applicable in colorectal cancer research.</p>HDAC6-IN-28
<p>HDAC6-IN-28 (compound 10C) is a potent inhibitor of HDAC6 with an IC50 of 261 nM. It significantly induces apoptosis in B16-F10 cells and causes S phase arrest. Additionally, HDAC6-IN-28 effectively increases the expression of acetylated-α-tubulin both in vitro and in vivo.</p>Fórmula:C23H16FN3O2Peso molecular:385.12265Chlopynostat
<p>Chlopynostat (Compound 6c) is an HDAC1 inhibitor with an IC50 value of 67 nM. It induces apoptosis by inhibiting HDAC1, thereby reversing STAT4/p66Shc defects.</p>Fórmula:C22H17ClN4O2Peso molecular:404.104EGFR-IN-107
<p>EGFR-IN-107 (compound 3r) is an orally active EGFR inhibitor with IC50 values of 0.4333 μM for EGFRWT and 0.0438 μM for EGFRL858R/T790M. It exhibits antiproliferative activity, effectively inhibiting the proliferation of H1975 cells and inducing apoptosis (apoptosis). EGFR-IN-107 is applicable in cancer research.</p>Fórmula:C34H36FN7O2Peso molecular:593.29145Thalidomide-NH-amido-C6-NH2 hydrochloride
<p>Thalidomide-NH-amido-C6-NH2 hydrochloride is a synthetic E3 ligase ligand-linker conjugate that includes a thalidomide-based cereblon ligand and a linker, designed for the synthesis of PROTAC.</p>Fórmula:C21H28ClN5O5Peso molecular:465.1779Camrelizumab
CAS:<p>Camrelizumab (SHR-1210) is a human IgG4-κ monoclonal antibody with high affinity and directed against PD-1.Camrelizumab binds PD-1 with a binding affinity of up</p>Pureza:95% - 98.6%Cor e Forma:LiquidPeso molecular:143.7 kDaLw13
<p>Lw13 is a PROTAC targeting Hsp90, exhibiting maximal degradation efficacy at a concentration of 0.05 μM in Siha cells. Lw13 induces apoptosis and demonstrates potent antitumor activity both in vitro and in vivo.</p>Fórmula:C46H55F3N8O8Peso molecular:904.4095Pidilizumab
CAS:<p>Pidilizumab (CT-011), a humanized IgG1κ anti-PD-1 monoclonal antibody, serves as a DLL1 antagonist with potential applications in researching hematologic</p>Pureza:98%Cor e Forma:LiquidFeladilimab
CAS:<p>Feladilimab (GSK3359609) is an IgG4 monoclonal antibody that is an ICOS agonist.</p>Pureza:SDS-PAGE:95% SEC-HPLC:98%Cor e Forma:LiquidPeso molecular:145.24 kDaAcrixolimab
CAS:<p>Acrixolimab is a humanized IgG4-κ monoclonal antibody that selectively targets PD-1 [1] [2].</p>Pureza:98%Cor e Forma:LiquidProlgolimab
CAS:<p>Prolgolimab (BCD-100) is an anti-PD-1 antibody used in melanoma research.</p>Pureza:>95%Cor e Forma:LiquidPoly (I:C):Kanamycin (1:1)
<p>Poly (I:C):Kanamycin (1:1) is an equimolar mixture of Poly(I:C) and kanamycin. TLR3 agonist commonly used as a vaccine adjuvant; enhanced Poly(I:C) stability.</p>Cor e Forma:SolidDanburstotug
CAS:<p>Danburstotug (IMC-001), an immunostimulant and antineoplastic [1], is a humanized IgG1-lambda monoclonal antibody targeting CD274 (PDL1, B7 homologue 1, B7H1).</p>Pureza:98%Cor e Forma:Liquid4-Nitro-3-cresol
CAS:<p>4-Nitro-3-cresol exhibits ciliate toxicity against Tetrahymena pyriformis and is widely used in biochemical experiments and drug synthesis research.</p>Fórmula:C7H7NO3Pureza:99.87%Cor e Forma:Beige PowderPeso molecular:153.14WF 10129
CAS:<p>WF 10129 is a new angiotensin converting enzyme inhibitor generated by a fungus, Doratomyces putredinis.</p>Fórmula:C20H28N2O8Pureza:98%Cor e Forma:SolidPeso molecular:424.45Pro-GA
CAS:<p>Pro-GA is a cell-permeable γ-glutamylcyclotransferase (γ-GGCT) inhibitor that inhibit proliferation in multiple bladder cancer cell lines. antitumour.</p>Fórmula:C12H19NO7Cor e Forma:SolidPeso molecular:289.28MBC-11 triethylamine
<p>MBC-11 triethylamine, a first-in-class etidronate-araC conjugate, may treat TIBD.</p>Fórmula:C17H35N4O14P3Pureza:98%Cor e Forma:SolidPeso molecular:612.4Sasanlimab
CAS:<p>Sasanlimab (PF-06801591), a humanized IgG4-κ antibody, selectively targets PD-1 and is primarily produced in Chinese Hamster Ovary (CHO) cells [1].</p>Pureza:98%Cor e Forma:LiquidRo 48-8071
CAS:<p>Oxidosqualene cyclase inhibitor</p>Fórmula:C23H27BrFNO2Pureza:98%Cor e Forma:SolidPeso molecular:448.37Anti-Mouse PD-1 Antibody (RMP1-14)
<p>Anti-Mouse PD-1 Antibody (RMP1-14) is an IgG2a antibody inhibitor against mouse PD-1 and can block PD-1/PD-L1 signaling. High-Quality, Low-Cost!</p>Pureza:14.68mg/ml - >95%Cor e Forma:Odour LiquidSolanidine
CAS:<p>Solanidine is a cholestane alkaloid isolated from potato species with antitumor effects. Solanidine inhibits proliferation.</p>Fórmula:C27H43NOPureza:96.83%Cor e Forma:SolidPeso molecular:397.64Trimebutine
CAS:<p>Trimebutine (Mebutin) is a spasmolytic agent that regulates intestinal and colonic motility and relieves abdominal pain with antimuscarinic and weak mu-opioid</p>Fórmula:C22H29NO5Pureza:98.13% - 99.49%Cor e Forma:SolidPeso molecular:387.47(E/Z)-LAQ824
CAS:<p>(E/Z)-LAQ824 is an inhibitor of histone deacetylase.</p>Fórmula:C22H25N3O3Pureza:98%Cor e Forma:SolidPeso molecular:379.46Isomahanine
<p>Isomahanine is a useful organic compound for research related to life sciences and the catalog number is T125848.</p>Fórmula:C23H25NO2Cor e Forma:SolidPeso molecular:347.458Isorhamnetin 3-glucuronide
<p>Isorhamnetin 3-glucuronide is a useful organic compound for research related to life sciences and the catalog number is T124938.</p>Fórmula:C22H20O13Cor e Forma:SolidPeso molecular:492.389BDK-IN-1
<p>BDK-IN-1 (compound (-)-43) is a BDK inhibitor with an IC50 of 0.23 μM and a maximum inhibition rate of 90%. It reduces phosphorylated-E1 levels and is useful in the study of cardiac metabolic diseases.</p>Fórmula:C18H14F2N2O3SCor e Forma:SolidPeso molecular:376.38Apoptosis inducer 29
Apoptosis Inducer 29 (compound Y9) demonstrates anticancer efficacy in non-small cell lung cancer by inducing lysosomal dysfunction and apoptosis, and exhibits superior performance to Gboixn both in vitro and in vivo.Fórmula:C33H46ClN3O3Cor e Forma:SolidPeso molecular:568.192-Chloronaphthalene
CAS:<p>2-Chloronaphthalene is an organochlorine chemical compound and is a chlorinated derivative of naphthalene. The compound is an isomer for 1-chloronaphthalene.</p>Fórmula:C10H7ClPureza:98%Cor e Forma:SolidPeso molecular:162.62Lambertianic acid
CAS:<p>Lambertianic acid is a bioactive chemical that has anti-allergic and antibacterial effects.</p>Fórmula:C20H28O3Pureza:98%Cor e Forma:SolidPeso molecular:316.441Fludioxonil
CAS:<p>Fludioxonil (CGA 173506), a phenylpyrrole fungicide, inhibits the growth of B. cinerea from strawberry and blackberry crops.</p>Fórmula:C12H6F2N2O2Pureza:99.971%Cor e Forma:SolidPeso molecular:248.18Aspochalasin D
CAS:<p>Aspochalasin D, isolated from A. microcysticus, shows antibacterial properties and cytotoxicity affecting Ba/F3-V12 cells, with IC50s of 0.49 and 1.9 μg/ml.</p>Fórmula:C24H35NO4Cor e Forma:SolidPeso molecular:401.54Linearol
CAS:<p>Linearol: diterpene from Sideritis L. with antioxidant, anti-inflammatory, anti-apoptotic effects.</p>Fórmula:C22H34O4Pureza:98%Cor e Forma:SolidPeso molecular:362.50spisulosine
CAS:<p>spisulosine is a natural product for research related to life sciences. The catalog number is T9664 and the CAS number is 196497-48-0.</p>Fórmula:C18H39NOCor e Forma:SolidPeso molecular:285.5161-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE
CAS:<p>Phospholipid with stearic acid and 15(S)-HpETE boosts ferroptosis in MEFs upon GPX4 inhibition.</p>Fórmula:C43H78NO10PCor e Forma:SolidPeso molecular:800.068Albicanol
CAS:<p>Albicanol is a biochemical.</p>Fórmula:C15H26OCor e Forma:SolidPeso molecular:222.372Ceftiofur hydrochloride
CAS:<p>Ceftiofur hydrochloride (U-67279A) is a stable, broad-spectrum 3rd-gen cephalosporin with antibacterial properties.</p>Fórmula:C19H17N5O7S3·HClPureza:99.51%Cor e Forma:Off-White SolidPeso molecular:560.02NQO2-IN-1
CAS:<p>NQO2-IN-1, a resveratrol analog, is a potent NQO2 inhibito,antitumor,generation of ROS and up-regulation of DR5 (death receptor 5) to promote apoptosis.</p>Fórmula:C18H18N2O3Pureza:99.83%Cor e Forma:SoildPeso molecular:310.35(E/Z)-10-Hydroxy-2-decenoic acid
CAS:<p>(E/Z)-10-Hydroxy-2-decenoic acid is a useful organic compound for research related to life sciences.</p>Fórmula:C10H18O3Cor e Forma:SolidPeso molecular:186.251Streptonigrin
CAS:<p>Streptonigrin, from Streptomyces flocculus, has anti-tumor and anti-bacterial properties, inhibiting PAD1-4.</p>Fórmula:C25H22N4O8Pureza:98%Cor e Forma:SolidPeso molecular:506.46HTR2A antagonist 1
<p>HTR2A antagonist 1 (Compound 15f) is an HTR2A antagonist with an IC50 of 42.79 nM. It induces sub-G1 cell cycle arrest and apoptosis in colorectal cancer cells by activating the p53/p21/caspase 3 signaling pathway. HTR2A antagonist 1 exhibits good liver microsomal stability and is useful for colorectal cancer research.</p>Fórmula:C35H43Cl2F2N5O4Cor e Forma:SolidPeso molecular:706.65Verdinexor
CAS:<p>Verdinexor (KPT-335) (KPT-335), a specific XPO1/CRM1 inhibitor, are orally bioavailable.</p>Fórmula:C18H12F6N6OPureza:98% - 99.68%Cor e Forma:SolidPeso molecular:442.32Rozanolixizumab
CAS:<p>Rozanolixizumab (RYSTIGGO) is a humanized IgG4 monoclonal antibody that targets FcRn in newborns for autoimmune research.</p>Pureza:SDS-PAGE:97.2%;SEC-HPLC:95.9%Cor e Forma:LiquidPeso molecular:145.19 kDaFerroptosis-IN-14
<p>Ferroptosis-IN-14 (compund 36) exhibits the most potent anti-ferroptotic activity with an EC50 value of 0.58 ± 0.02 μM, demonstrating excellent anti-ferroptotic efficacy, as well as stability in microsomes and plasma.</p>Cor e Forma:Odour SolidKB03-SLF
CAS:<p>KB03-SLF is a protease with the capability to target specific proteins and regulate intracellular protein levels by inducing protein degradation. This mechanism renders KB03-SLF potentially valuable in the suppression of related diseases.</p>Fórmula:C50H63ClF3N5O12Cor e Forma:SolidPeso molecular:1018.51Ianalumab
CAS:<p>Ianalumab (VAY-736) is a decarboxylated humanized antibody against BAFF-R.</p>Pureza:100% (SEC-HPLC) - > 95%Cor e Forma:LiquidPeso molecular:146.44 kDaOxatomide
CAS:<p>Oxatomide: Dual H1/P2X7 antagonist, antihistamine, anti-allergic, treats immune diseases, IC50: 0.95 μM (P2X7), 0.43 μM (5-HT).</p>Fórmula:C27H30N4OPureza:98.82% - 99.72%Cor e Forma:White PowderPeso molecular:426.552-Acetamidophenol
CAS:<p>2-Acetamidophenol (Orthocetamol) has analgesic and antipyretic effects. 2-Acetamidophenol is an isomer of Paracetamol (4-acetamidophenol).</p>Fórmula:C8H9NO2Pureza:>99.99%Cor e Forma:Light Brown PowderPeso molecular:151.16Spexin TFA
<p>Spexin TFA: GAL2/GAL3 agonist (EC50: 45.7/112.2 nM), no activity at GAL1, reduces appetite, fatty acid uptake, and LH secretion; anxiolytic.</p>Fórmula:C76H115F3N20O21SCor e Forma:SolidPeso molecular:1733.9Z-Ala-Ala-Asp-CMK
CAS:<p>Z-Ala-Ala-Asp-CMK (Z-AAD-CMK) is a selective granzyme B inhibitor that blocks granzyme B protease activity, for inflammatory diseases and tumours.</p>Fórmula:C19H24ClN3O7Pureza:99.967%Cor e Forma:SolidPeso molecular:441.86RMC-9805
CAS:<p>RMC-9805(Zoldonrasib) is a KRAS G12D inhibitor with anti-tumor and anti-proliferative activity for the study of pancreatic cancer.</p>Fórmula:C63H88F3N11O7Pureza:98.10% - 99.51%Cor e Forma:SolidPeso molecular:1168.44ChoKα inhibitor-4
<p>ChoKα Inhibitor-4 is a bioisosteric agent that effectively inhibits human choline kinase α1 (HChoK α1) with an IC50 of 0.66 μM.</p>Cor e Forma:Odour SolidTralokinumab
CAS:<p>Tralokinumab: human IgG4 monoclonal antibody, blocks IL-13, may treat atopic dermatitis.</p>Pureza:SDS-PAGE:95% SEC-HPLC:99.99%Cor e Forma:LiquidPeso molecular:144.14 kDa5α-dihydro Levonorgestrel
CAS:<p>5α-dihydro Levonorgestrel is a metabolite of the synthetic progestin levonorgestrel .</p>Fórmula:C21H30O2Cor e Forma:SolidPeso molecular:314.469S-Adenosyl-L-methionine iodide
CAS:<p>S-(5'-Adenosyl)-L-methionine iodide, also known as S-Adenosyl-L-methionine iodide, is a vital methyl donor present in all living organisms [1].</p>Fórmula:C15H23IN6O5SCor e Forma:SolidPeso molecular:526.35BLU-222
CAS:<p>BLU-222 is a potent, selective and orally active CDK2 inhibitor. BLU-222 shows robust antitumor activity.</p>Fórmula:C15H17F2N7O2Pureza:99.17% - 99.92%Cor e Forma:SoildPeso molecular:365.34Syringolin A
CAS:<p>Syringolin A is a useful organic compound for research related to life sciences. The catalog number is T125354 and the CAS number is 212115-96-3.</p>Fórmula:C24H39N5O6Cor e Forma:SolidPeso molecular:493.605HKB99
CAS:<p>HKB99 suppresses NSCLC growth, metastasis, and overcomes erlotinib resistance.</p>Fórmula:C23H18N2O6SPureza:97.35% - 97.35%Cor e Forma:SolidPeso molecular:450.46Urelumab
CAS:<p>"Urelumab (BMS-66513), a humanized IgG4 mAb CD137 agonist, boosts T-cell/NK cell-mediated cytotoxicity and anti-tumor activity."</p>Pureza:97.70%Cor e Forma:LiquidPeso molecular:145.90 kDaChloranil
CAS:<p>Chloranil (tetrachloro-p-benzoquinone) induces inflammation and neurological dysfunction and can be used to model inflammation in mice.</p>Fórmula:C6Cl4O2Pureza:99.38%Cor e Forma:SolidPeso molecular:245.88Z-DQMD-FMK
CAS:<p>Caspase-3 inhibitor. Inhibits MG 132-induced small cell lung cancer cell death in vitro.</p>Fórmula:C29H40FN5O11SPureza:98%Cor e Forma:SolidPeso molecular:685.72Spexin
CAS:<p>Potent GAL2/GAL3 agonist (EC50 = 45.7, 112.2 nM), inactive at GAL1. Reduces appetite, fatty acid uptake in adipocytes, and LH in goldfish; anxiolytic in vivo.</p>Fórmula:C74H114N20O19SPureza:98%Cor e Forma:SolidPeso molecular:1619.9Giloralimab
CAS:<p>Giloralimab (ABBV-927) is a antibody targeting CD40 with anticancer activity for the study of triple-negative breast cancer and non-small cell lung cancer.</p>Pureza:95.6% (SDS-PAGE); 95.1% (SEC-HPLC) - 95.6% (SDS-PAGE); 95.1% (SEC-HPLC)Cor e Forma:LiquidHPOB
CAS:<p>HPOB is an effective and specific HDAC6 inhibitor (IC50: 56 nM), >30-fold selectivity over other HDACs.</p>Fórmula:C17H18N2O4Pureza:99.91%Cor e Forma:SolidPeso molecular:314.34Z-LEHD-fmk
CAS:<p>Z-LEHD-FMK is a selective and potent caspase-9 inhibitor that protects against reperfusion injury and slows apoptosis.Z-LEHD-FMK exhibits antitumor and</p>Fórmula:C32H43FN6O10Pureza:96.13%Cor e Forma:SolidPeso molecular:690.72Human membrane-bound PD-L1 polypeptide
CAS:<p>Human membrane-bound PD-L1 polypeptide serves as an antigen for inducing the production of PD-L1 antibodies [1].</p>Fórmula:C85H140N26O36SPureza:98%Cor e Forma:SolidPeso molecular:2134.24(Iso)-Z-VAD(OMe)-FMK
CAS:<p>(Iso)-Z-VAD(OMe)-FMK is an isomer of Z-VAD(OMe)-FMK, which is a pan-caspase inhibitor with irreversible properties. Z-VAD(OMe)-FMK is also an inhibitor UCHL1.</p>Fórmula:C22H30FN3O7Pureza:97.10%Cor e Forma:SoildPeso molecular:467.49Thevetiaflavone
CAS:<p>Thevetiaflavone, a natural flavonoid from W. indica, blocks LDH leakage, boosting cell survival.</p>Fórmula:C16H12O5Pureza:98%Cor e Forma:SolidPeso molecular:284.26YTHDF2-IN-1
<p>YTHDF2-IN-1 (Compound CK-75) is an inhibitor of YT521-B homology domain family 2 (YTHDF2) with a dissociation constant (Kd) of 26.2 μM, and it effectively blocks the interaction between YTHDF2 and m6A RNA. It suppresses colony formation in JAR cells and exhibits antiproliferative activity in various cancer cell lines, with an IC50 in the micromolar range. Additionally, YTHDF2-IN-1 induces apoptosis in K562 cells and causes cell cycle arrest at the G0/G1 phase.</p>Fórmula:C21H14N2O4Cor e Forma:SolidPeso molecular:358.35ERK1/2 inhibitor 13
<p>ERK1/2 inhibitor 13 (Compound 21y) is an orally bioavailable ERK inhibitor that targets ERK1 and ERK2, with IC50 values of 91.71 nM and 97.87 nM, respectively. It effectively suppresses the proliferation of cancer cell lines MCF-7, 4T1, MDA-MB-468, and HCC1970 with IC50 values of 0.67 μM, 2.76 μM, 2.15 μM, and 1.68 μM, respectively. Additionally, it inhibits cancer cell migration, induces apoptosis and autophagy in MCF-7 cells, and demonstrates anti-tumor and anti-metastatic effects in a 4T1 xenograft mouse model.</p>Fórmula:C36H29BrF6N4OCor e Forma:SolidPeso molecular:727.54Anticancer agent 267
<p>Anticanceragent 267 (Compound 5q) serves as an activator of RIPK3 and MLKL. It effectively inhibits the proliferation of several cancer cell lines, with IC50 values of 9.79, 10.77, and 5.94 μM for MDA-MB-231, MDA-MB-486, and MCF-7, respectively. The compound induces cell cycle arrest at the subG1 phase and triggers necroptosis in MDA-MB-231 cells. Additionally, Anticanceragent 267 demonstrates antitumor activity in mouse xenograft models.</p>Fórmula:C13H11N5O4SCor e Forma:SolidPeso molecular:333.32WR-S-462
<p>WR-S-462 is a STAT3 inhibitor. It effectively blocks the phosphorylation and biological functions of STAT3 in vitro. The IC50 of WR-S-462 for inhibiting MDA-MB-231 cells is 0.03 μM, and it exhibits a strong binding affinity for STAT3 protein with a Kd of 58 nM. WR-S-462 prevents the nuclear translocation of p-STAT3 and selectively inhibits the expression of p-STAT3Tyr705 in MDA-MB-231 cells, as well as the expression of downstream target genes regulated by STAT3, such as Cyclin D1, Bcl-2, and Bcl-xl. This compound inhibits the growth and metastasis of triple-negative breast cancer (TNBC).</p>Fórmula:C24H22N4O4SCor e Forma:SolidPeso molecular:462.52EMB-02
<p>EMB-02 is a bispecific antibody targeting both PD-1 and LAG-3. It inhibits the downregulation of T cell activation and proliferation mediated by PD-1 and LAG-3, showing potent anti-cancer properties.</p>Cor e Forma:Odour LiquidDual Galectin-3/EGFR-IN-1
<p>Dual Galectin-3/EGFR-IN-1 (Compound 29) is a dual inhibitor targeting Galectin-3 and EGFR, with dissociation constants (KD) of 52.29 μM and 3.31 μM, respectively. It inhibits TGF-β-induced hepatic stellate cell (HSC) activation, induces apoptosis in LX-2 cells, and shows antifibrotic activity in the liver.</p>Fórmula:C32H41N7O10Cor e Forma:SolidPeso molecular:683.709TrxR1-IN-2
<p>TrxR1-IN-2 (Compound 6a) acts as a TrxR1 inhibitor that covalently bonds with the Cys475 and Sec498 sites of TrxR1. This interaction hampers TrxR1 activity, resulting in a redox homeostasis disruption and inducing apoptosis and ferroptosis.</p>Fórmula:C19H23NO6Cor e Forma:SolidPeso molecular:361.389JAK-IN-40
<p>JAK-IN-40 (Compound 46) is an inhibitor of JAK, effectively targeting JAK1, JAK2, and JAK3 with IC50 values of 0.022, 0.759, and 1.601 μM, respectively. It reduces the phosphorylation of STAT3 and inhibits the proliferation of cancer cells Ba/F3 and JAK1-TEL Ba/F3 with GI50 values of 0.614 μM and 0.193 μM. JAK-IN-40 arrests cell cycle progression at the G2/M phase in H1975 and H2087 cells, leading to apoptosis. Additionally, JAK-IN-40 exhibits a synergistic anti-tumor effect when used in combination with Osimertinib.</p>Fórmula:C26H32N8O3SCor e Forma:SolidPeso molecular:536.65XY221
<p>XY221 (Compound 16o) selectively inhibits BRD4 BD2 with an IC50 of 5.8 nM. It demonstrates high selectivity for pan-BD2 and BRD4 BD2 domains, being 667 times more selective than for BRD4 BD1, and 9-32 times more selective than for BRD2/3/T BD2. XY221 can induce apoptosis in MV4-11 cells and exhibits anti-cancer activity.</p>Fórmula:C32H34FN3O5Cor e Forma:SolidPeso molecular:559.628STEP-IN-1
<p>STEP-IN-1 (Compound 14b) is a potent and selective inhibitor of STEP, with an IC50 of 5.27 μM. It offers neuroprotective effects by safeguarding neuronal cells from glutamate-induced toxicity, reducing intracellular reactive oxygen species (ROS) accumulation, and inhibiting apoptosis. STEP-IN-1 is applicable in research related to neurodegenerative diseases.</p>Fórmula:C21H10ClNO7Cor e Forma:SolidPeso molecular:423.76PROTAC XPO1 degrader-1
<p>PROTAC XPO1 degrader-1 (Compound 2c) is an XPO1 degrader. It exhibits anti-proliferative effects, induces apoptosis, inhibits NF-κB activity, and causes cell cycle arrest at the G1 phase. PROTAC XPO1 degrader-1 is applicable to research on hematological malignancies.</p>Fórmula:C33H35ClF3N7O7Cor e Forma:SolidPeso molecular:734.122DP-15
CAS:<p>DP-15 acts as a degrader of GSPT1 and BRD4, with DC50 values of 5.25 nM and 0.48 nM, respectively. This compound exhibits antiproliferative activity in AML and NHL cells, showing IC50 values in the nanomolar range, induces G1 phase cell cycle arrest, and triggers apoptosis in MOLM13 cells. Additionally, DP-15 demonstrates anti-leukemic properties in the MOLM-13 xenograft mouse model. [Pink: ligand for target protein JQ-1 carboxylic acid; Black: linker; Blue: ligand for E3 ligaseCereblonThalidomide-5-OH]</p>Fórmula:C42H44ClN9O5SCor e Forma:SolidPeso molecular:822.374BC13
<p>BC13 is a CDK6/BRD4 inhibitor with IC50 values of 234 nM for CDK6 and 36 nM for BRD4. It exhibits antiproliferative properties, induces apoptosis (cell death) and DNA damage, and elevates ROS levels.</p>Fórmula:C37H39N7O5Cor e Forma:SolidPeso molecular:661.75(+)-Mcl-1 inhibitor 21
CAS:<p>(+)-Mcl-1 inhibitor 21 (Example 1-37) is a chemical compound that acts as an Mcl-1 inhibitor with an IC50 value of 172 nM. It demonstrates pro-apoptotic and antiproliferative activities in SUDHL5 and SUDHL10 cell lines, making it useful for cancer research.</p>Fórmula:C32H33N3O4Cor e Forma:SolidPeso molecular:523.622CDK4/6/HDAC-IN-1
<p>CDK4/6/HDAC-IN-1 (Compound N14) is a dual-target inhibitor of CDK4/6 and HDAC, with IC50 values of 7.23 nM for CDK4, 13.20 nM for CDK6, 55.66 nM for HDAC1, and 48.38 nM for HDAC6. It induces apoptosis and G0/G1 phase arrest through the HDAC-p21-CDK signaling pathway and can inhibit hepatocellular carcinoma.</p>Fórmula:C35H39N9O5Cor e Forma:SolidPeso molecular:665.742TRF2-IN-1
<p>TRF2-IN-1 (compound F2) is a potent inhibitor of telomere repeat-binding factor 2 (TRF2). It exhibits antiproliferative activity and induces apoptosis. TRF2-IN-1 binds directly to the TRF2TRFH domain, selectively inhibiting TRF2 protein expression and telomere localization. Additionally, TRF2-IN-1 possesses anticancer properties and shows potential for osteosarcoma research.</p>Fórmula:C18H17BrO4Cor e Forma:SolidPeso molecular:377.229TRK-IN-30
<p>TRK-IN-30 (Compound C11) is an inhibitor of tropomyosin receptor kinases (TRK), effectively inhibiting TRKA, TRKB, TRKC, and the resistant mutant TRKAG595R, with IC50 values of 1.8, 0.98, 3.8, and 54 nM, respectively. It also suppresses the activation of downstream PI3K/AKT and MEK/ERK signaling pathways. TRK-IN-30 hinders colony formation and cell migration of Km-12, induces cell cycle arrest at the G0/G1 phase, and triggers apoptosis in Km-12 cells.</p>Fórmula:C24H21N5O3Cor e Forma:SolidPeso molecular:427.455PROTAC LZK-IN-1
CAS:<p>PROTAC LZK-IN-1 (Compound 21A) is a PROTAC molecule that targets the degradation of LZK (leucine zipper kinase, encoded by MAP3K13). At a concentration of 10 μM, PROTAC LZK-IN-1 facilitates the degradation of LZK and inhibits the expression of p53 and c-MYC, leading to reduced viability of global head and neck squamous cell carcinoma (HNSCC) cell lines. This compound is applicable in anticancer research.</p>Fórmula:C51H64F2N10O5SCor e Forma:SolidPeso molecular:967.18Antioxidant agent-20
<p>Antioxidant agent-20 (Compound 3d) exhibits potent anti-inflammatory and antioxidant activities. It reduces reactive oxygen species (ROS) and apoptosis in a dose-dependent manner. Antioxidant agent-20 demonstrates photoprotective effects on UVB-exposed human skin keratinocytes (HaCaT) (IC50=5.13 µM) by activating Nrf2/HO-1 signaling and inhibiting the NF-κB pathway.</p>Fórmula:C18H24O4Cor e Forma:SolidPeso molecular:304.381Mitochondria modulator-2
<p>Mitochondria modulator-2 (Compound Ir1) induces depolarization of the mitochondrial membrane potential, generates reactive oxygen species (ROS), inhibits the migration of A549 cells, causes cell cycle arrest at the G2/M phase, and triggers apoptosis in A549 cells.</p>Fórmula:C63H50F12IrN6OP3Cor e Forma:SolidPeso molecular:1420.23EGFR-IN-143
<p>EGFR-IN-143 (Compound 5f) is a potent EGFR inhibitor with an IC50 value of 0.15 μM. It induces apoptosis by arresting the cell cycle at the G2/M phase and exhibits antitumor activity.</p>Fórmula:C20H21ClN6O3Cor e Forma:SolidPeso molecular:428.872MDM2 ligand 4
<p>MDM2ligand 4 is a ligand of MDM2 and can be used in the synthesis of the PROTAC degrader [KT-253].</p>Fórmula:C31H33Cl2FN2O4Cor e Forma:SolidPeso molecular:587.509NFh-NMe-2
<p>NFh-NMe-2 is a photosensitizer that interacts with nitroreductase (nitroreductase) to generate singlet oxygen in tumor cells, exhibiting cytotoxicity in cancer cells and inducing apoptosis (apoptosis). In mouse models, NFh-NMe-2 demonstrates antitumor activity.</p>Fórmula:C32H33IN2OCor e Forma:SolidPeso molecular:588.522Diethyl phthalate
CAS:<p>Diethyl phthalate disrupts endocrine and induces apoptosis in PC12 cells; common in plastics, personal care items.</p>Fórmula:C12H14O4Pureza:99.68% - 99.8%Cor e Forma:SolidPeso molecular:222.24ARV-393 HCl
<p>ARV-393 HCl is an orally active and potent PROTAC targeting BCL6 with antitumor activity for the study of non-Hodgkin's lymphoma.</p>Fórmula:C46H54Cl2FN9O7Pureza:99.79%Cor e Forma:SolidPeso molecular:934.88Sarglaroids F
<p>Sarglaroids F (compound 6), an anti-inflammatory agent extracted from the roots of Grass Coral, suppresses LPS/ATP-induced IL-1β secretion by modulating K+</p>Fórmula:C38H44O12Pureza:98%Cor e Forma:SolidPeso molecular:692.7515-Acetoxyscirpenol
CAS:<p>15-acetoxyscirpenol: ASM that induces apoptosis, inhibits Jurkat T cell growth dose-dependently, and activates caspases other than caspase-3.</p>Fórmula:C17H24O6Pureza:98%Cor e Forma:SolidPeso molecular:324.373PLD-IN-1
<p>PLD-IN-1 (Compound 3r) is an orally effective inhibitor of phospholipase D (phospholipaseD) with an IC50 of 1.97 μM. It reduces the expression of CD24, CD47, and PD-L1 while enhancing the expression of calreticulin, thereby modulating the immune evasion mechanisms of lung cancer cells by promoting the phagocytosis of cancer cells by macrophages. PLD-IN-1 inhibits the viability of lung cancer cell lines A549, HCC44, H460, and HCC15 with IC50 values of 18.44, 22.31, 24.85, and 21.45 μM, respectively. It induces apoptosis (apoptosis) in A549 cells and inhibits cell migration. Additionally, PLD-IN-1 increases pro-inflammatory M1 macrophage levels and decreases anti-inflammatory M2 macrophage levels, exhibiting anti-tumor activity in mouse models.</p>Fórmula:C19H14F6N2OCor e Forma:SolidPeso molecular:400.32Asaretoclax
CAS:<p>Asaretoclax is an effective inhibitor of B-cell lymphoma 2 (Bcl-2), demonstrating potential for use in cancer research.</p>Fórmula:C47H57F2N7O7SCor e Forma:SolidPeso molecular:902.06EGFR-IN-131
<p>EGFR-IN-131 (compound 3a) is an efficacious EGFR inhibitor capable of crossing the blood-brain barrier, with an IC50 value of 272.9 nM. This compound exhibits anti-proliferative activity, induces cellular apoptosis (apoptosis), and causes cell cycle arrest in the G0/G1 phase. Additionally, EGFR-IN-131 reduces the protein expression of p-EGFR.</p>Fórmula:C26H23FN4O2SCor e Forma:SolidPeso molecular:474.55PRMT5-IN-45
<p>PRMT5-IN-45 (compound 36) is a potent and selective inhibitor of PRMT5, exhibiting an IC50 value of 3 nM. This compound effectively reduces the levels of symmetrical dimethylarginine (sDMA) and inhibits the proliferation of the MOLM-13 cell line by inducing apoptosis and causing cell cycle arrest.</p>Fórmula:C26H31N7O2Cor e Forma:SolidPeso molecular:473.57CQ-ER
<p>CQ-ER is a Coumarin-quinazolinone-based photosensitizer targeting the endoplasmic reticulum (ER). It induces ferroptosis, thereby enhancing photodynamic therapy (PDT).</p>Fórmula:C33H33N7O6SCor e Forma:SolidPeso molecular:655.72ROS inducer 5
<p>ROS inducer 5 (compound 6e) induces intracellular ROS accumulation and subsequent nuclear fragmentation. It can provoke apoptosis in MCF-7 cells with an IC50 of 3.85 μM. ROS inducer 5 is useful for cancer research applications.</p>Fórmula:C20H15ClN4O2S3Cor e Forma:SolidPeso molecular:475.01FGFR1/VEGFR2-IN-3
<p>FGFR1/VEGFR2-IN-3 (Compound 8m) acts as a dual inhibitor of FGFR1 and VEGFR2. This compound exhibits both anti-cancer cell proliferation and anti-migration activities, and it also has the capability to induce cell apoptosis (apoptosis).</p>Fórmula:C27H18N4O4Cor e Forma:SolidPeso molecular:462.46PROTAC EZH2 Degrader-3
<p>PROTAC EZH2 Degrader-3 (compound ZJ-20) is a potent EZH2 degrader that exhibits strong inhibitory effects not only on EZH2 protein expression but also on the levels of other PRC2 subunits and H3k27me3 protein. Additionally, PROTAC EZH2 Degrader-3 demonstrates antiproliferative activity by blocking the cell cycle at the G0-G1 phase and inducing apoptosis (cell death). At a concentration of 5 μM and over a period of 24 hours, it effectively suppresses the expression of these critical proteins involved in cell regulation and growth.</p>Fórmula:C56H68N8O8Cor e Forma:SolidPeso molecular:981.19DH-18
<p>DH-18 is an inhibitor of matrix metalloproteinase-2 (MMP-2), exhibiting IC50 values of 139.45 nM for MMP-2, 518.11 nM for MMP-9, and 833.34 nM for MMP-8. The compound promotes cell apoptosis and causes cell cycle arrest in the G0/G1 phase. DH-18 also inhibits cell growth, making it potential for research in chronic myeloid leukemia.</p>Fórmula:C26H23F6N3O5SCor e Forma:SolidPeso molecular:603.53CDK-TCIP1
CAS:<p>CDK-TCIP1 is a bivalent molecule that links the CDK9 inhibitor SNS-032 with the BCL6 ligand BI3812. It effectively and specifically kills cells overexpressing BCL6, with an EC50 of 7.7 nM for SUDHL5 cells.</p>Fórmula:C48H62ClN11O8S2Cor e Forma:SolidPeso molecular:1020.66GGTI298 Trifluoroacetate
CAS:<p>GGTI298 trifluoroacetate (GGTI298TFA salt) is a geranylgeranyltransferase I inhibitor that causes cell cycle arrest and induces apoptosis.</p>Fórmula:C27H33N3O3S·C2HF3O2Pureza:98.07% - >99.99%Cor e Forma:SolidPeso molecular:593.66COG-1410 acetate
<p>COG-1410 acetate is an apolipoprotein E-derived peptide and can be used in studies about neurological diseases.</p>Fórmula:C66H125N21O16Pureza:99.61%Cor e Forma:SolidPeso molecular:1468.83AFMK
CAS:<p>AFMK (Formyl-N-acetyl-5-methoxykynurenamine) is an active metabolite of Melatonin with antioxidant and free radical scavenging activity.</p>Fórmula:C13H16N2O4Pureza:98.34% - 99.81%Cor e Forma:SolidPeso molecular:264.281,2-Naphthoquinone
CAS:<p>1,2-Naphthoquinone inhibits urease, induces apoptosis in PBMC cells, inhibitory activity against hiCE, hCE1, hAChE, and hBChE.</p>Fórmula:C10H6O2Pureza:98.01%Cor e Forma:Golden Yellow Needles Color On Standing (Ntp 1992)Peso molecular:158.15Diethanolamine hydrochloride
CAS:<p>Diethanolamine hydrochloride is HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4) and pregnane X receptor (PXR), p53 Estrogen receptor.</p>Fórmula:C4H12ClNO2Pureza:99.69%Cor e Forma:SolidPeso molecular:141.6Rasagiline
CAS:<p>Rasagiline (AGN1135) is an inhibitor of monamine oxidase used as adjunctive therapy in combination with levodopa and carbidopa in the management of Parkinsons</p>Fórmula:C12H13NPureza:98% - 99.87%Cor e Forma:SolidPeso molecular:171.24Cyanoacetamide
CAS:<p>Cyanoacetamide has inhibitory activity against the myeloid leukaemia cell differentiation protein Mcl-1</p>Fórmula:C3H4N2OPureza:97.04%Cor e Forma:Needles From Alcohol White To Light Cream Crystalline PowderPeso molecular:84.08
