Apoptose
Os inibidores da apoptose são compostos que previnem ou retardam o processo de morte celular programada, conhecido como apoptose. Esses inibidores são vitais no estudo dos mecanismos de sobrevivência celular e são usados para investigar doenças onde a apoptose é desregulada, como câncer, distúrbios neurodegenerativos e doenças autoimunes. Ao modular a apoptose, esses inibidores podem ajudar no desenvolvimento de terapias destinadas a controlar a morte celular. Na CymitQuimica, oferecemos uma ampla seleção de inibidores da apoptose de alta qualidade para apoiar sua pesquisa em biologia celular, oncologia e áreas relacionadas.
Subcategorias de "Apoptose"
- ASK(6 produtos)
- BCL(11 produtos)
- Caspase(125 produtos)
- FOXO1(3 produtos)
- IAP(66 produtos)
- Mdm2(12 produtos)
- PD-1/PD-L1(125 produtos)
- PDK(9 produtos)
- PERK(25 produtos)
- Serina/treonina quinase(15 produtos)
- Survivina(13 produtos)
- TNF(92 produtos)
- c-RET(51 produtos)
- p53(62 produtos)
Exibir 6 mais subcategorias
Foram encontrados 5599 produtos de "Apoptose"
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CNDAC
CAS:<p>CNDAC, a nucleoside analog, is a major metabolite of oral drug sapacitabine.</p>Fórmula:C10H12N4O4Pureza:98%Cor e Forma:SolidPeso molecular:252.23SAFit1
CAS:<p>SAFit1 is an inhibitor of FK506 binding protein 51 (FKBP51)-specific (Ki: 4±0.3 nM).</p>Fórmula:C42H53NO11Pureza:98%Cor e Forma:SolidPeso molecular:747.87Tylvalosin
CAS:<p>Tylvalosin (Acetylisovaleryltylosin) is a broad-spectrum macrolide antibiotic with antibacterial and antiviral properties, effective against PRRSV infection.</p>Fórmula:C53H87NO19Pureza:98%Cor e Forma:SolidPeso molecular:1042.25BQZ-485
CAS:<p>BQZ-485, a potent GDI2 inhibitor, interacts with Tyr245 to disrupt the native GDI2-Rab1A interaction.</p>Fórmula:C32H39NO3Pureza:98%Cor e Forma:SolidPeso molecular:485.66EGFR kinase inhibitor 1
CAS:<p>Potent EGFR blocker; acts on WT, L858R/T790M (IC50: 1.7 nM), less on T790M/C797S; stalls cell cycle, induces apoptosis, deters metastasis.</p>Fórmula:C30H31N7O2Cor e Forma:SolidPeso molecular:521.61Anticancer agent 127
CAS:<p>Anticancer agent 127 (142D6), an IAP inhibitor, covalently binds to the BIR3 domains of XIAP, cIAP1, and cIAP2, with IC50 values of 12 nM, 14 nM, and 9 nM,</p>Fórmula:C26H37FN4O6SPureza:98%Cor e Forma:SolidPeso molecular:552.66Anticancer agent 105
CAS:<p>Anticancer agent 105, a thienopyrimidine scaffold-based compound, exhibits selective toxicity towards melanoma and induces apoptosis.</p>Fórmula:C25H24KN3O6SPureza:98%Cor e Forma:SolidPeso molecular:533.64HJC0152 free base
CAS:<p>HJC0152 (free base) is an orally active, potent STAT3 inhibitor that impedes cell cycle progression, induces apoptosis, and notably reduces MDA-MB-231 xenograft</p>Fórmula:C15H13Cl2N3O4Pureza:98%Cor e Forma:SolidPeso molecular:370.19Siremadlin (R Enantiomer)
CAS:<p>Siremadlin R Enantiomer is the R enantiomer of Siremadlin. Siremadlin is a potent and highly specific inhibitor of MDM-2/p53.</p>Fórmula:C26H24Cl2N6O4Pureza:98%Cor e Forma:SolidPeso molecular:555.41AM-8735
CAS:<p>AM-8735 is an inhibitor of MDM2 ( IC50: 25 nM).</p>Fórmula:C27H31Cl2NO6SPureza:98%Cor e Forma:SolidPeso molecular:568.51Cerivastatin
CAS:<p>Cerivastatin is an HMG-CoA reductase inhibitor with anticancer and lipid-lowering effects and can be used to study primary hyperlipidemia.</p>Fórmula:C26H34FNO5Pureza:97.80% - 99.56%Cor e Forma:SolidPeso molecular:459.55USP7-IN-3
CAS:<p>USP7-IN-3 is a potent and selective allosteric inhibitor of ubiquitin-specific protease 7 (USP7).</p>Fórmula:C29H31F3N6O3Pureza:98%Cor e Forma:SolidPeso molecular:568.59SF5
CAS:<p>SF5 is an inhibitor of the apoptosis pathway through JNK-p53-caspase apoptotic cascade.</p>Fórmula:C15H13NSPureza:99.59%Cor e Forma:SolidPeso molecular:239.34NBI-961
CAS:<p>NBI-961, a potent NEK2 inhibitor, suppresses proteasomal degradation and effectively induces G2/mitosis arrest and apoptosis within diffuse large B cell</p>Fórmula:C28H27F3N6O2SCor e Forma:SolidPeso molecular:568.61PARP-1-IN-3
CAS:<p>PARP-1-IN-3 is a potent PARP-1 inhibitor that inhibits PARP-1 and PARP-2 with IC50 values of 0.25 nM and 2.34 nM, respectively.PARP-1-IN-3 has potential anti-</p>Fórmula:C21H17BrN2O3Pureza:98.38%Cor e Forma:SolidPeso molecular:425.28Anticancer agent 128
CAS:<p>Anticancer agent 128 (compound 1) is an IAP inhibitor that covalently binds to the BIR3 domains of XIAP, cIAP1, and cIAP2, exhibiting IC50 values of 24.9 nM, 19</p>Fórmula:C26H38N4O4Pureza:98%Cor e Forma:SolidPeso molecular:470.6Cu(II)-Elesclomol
CAS:<p>Cu(II)-Elesclomol is a complex formed by the anticancer agent Elesclomol and Cu(II), which has anticancer activity and can be used in the study of leukemia.</p>Fórmula:C19H18CuN4O2S2Pureza:99.99%Cor e Forma:SolidPeso molecular:462.05IK-862
CAS:<p>IK-862 is a selective TACE inhibitor with potential anti-inflammatory and anticancer activity for the study of neuritis.</p>Fórmula:C25H27N3O4Pureza:97.75% - 98.29%Cor e Forma:SolidPeso molecular:433.5Methyl 12-methyltridecanoate
CAS:<p>Methyl 12-methyltridecanoate ((R)-betaxolol hydrochloride), a biosurfactant derived from Brevibacterium casei LS14, enhances the biocompatibility of</p>Fórmula:C15H30O2Pureza:98%Cor e Forma:SolidPeso molecular:242.4PI3K/VEGFR2-IN-1
CAS:<p>PI3K/VEGFR2-IN-1 is a potent dual inhibitor targeting both PI3K and VEGFR2 with IC50 values of 2.21 μM for PI3K and 68 μM for VEGFR2, respectively.</p>Fórmula:C17H14ClN3OSPureza:98%Cor e Forma:SolidPeso molecular:343.83WEHI-345 analog
CAS:<p>WEHI-345 analog is an Src inhibitor.</p>Fórmula:C23H25N7OPureza:98%Cor e Forma:SolidPeso molecular:415.49GSK2245035
CAS:<p>GSK2245035: selective nasal TLR7 agonist, boosts Type-1 IFN (pEC50: 9.3 IFNα, 6.5 TFNα), curbs Th2 cytokines in blood cultures.</p>Fórmula:C20H34N6O2Cor e Forma:SolidPeso molecular:390.52c-Met-IN-10
CAS:<p>c-Met-IN-10: potent kinase inhibitor (IC50=16 nM), halts cancer cell activity/movement, induces apoptosis, for anticancer research.</p>Fórmula:C26H21FN6O5Cor e Forma:SolidPeso molecular:516.48AMRI-59
CAS:<p>AMRI-59 is a potent inhibitor of PrxI with anti-tumor activity.</p>Fórmula:C25H27N3O2Pureza:99.79%Cor e Forma:SolidPeso molecular:401.5BAI1 hydrochloride
CAS:<p>BAI1 hydrochloride is a selective inhibitor of the apoptosis factor BAX, functioning through an allosteric mechanism. By binding to BAX, it allosterically inhibits its activation, showcasing potential applications in the research of diseases mediated by BAX-dependent cell death [1].</p>Fórmula:C19H23Br2Cl2N3OCor e Forma:SolidPeso molecular:540.12K145 hydrochloride
CAS:<p>K145 hydrochloride is a selective sphk2 inhibitor with substrate competitiveness and oral activity, with IC50 of 4.3 µM and Ki of 6.4 µM.</p>Fórmula:C18H25ClN2O3SPureza:99.8%Cor e Forma:SolidPeso molecular:384.92Sirt1/2-IN-2
CAS:<p>Sirt1/2-IN-2 (compound hsa55) serves as a dual inhibitor for SIRT1 with an IC50 of 1.8 μM and SIRT2 with an IC50 of 2.4 μM, respectively.</p>Fórmula:C18H14N4O3S2Pureza:98%Cor e Forma:SolidPeso molecular:398.46A-1293102
CAS:<p>A-1293102 is a potent, selective inhibitor of BCL-XL, effective in inducing apoptosis in tumor cells reliant on BCL-XL [1].</p>Fórmula:C42H40F3N7O7S5Cor e Forma:SolidPeso molecular:972.13MY-673
CAS:<p>MY-673, a colchicine binding site inhibitor (CBSI), impedes tubulin polymerization and disrupts the ERK signaling pathway, consequently modulating SMAD4 protein</p>Fórmula:C18H14N2O4Cor e Forma:SolidPeso molecular:322.31ERα antagonist 1
CAS:<p>ERα antagonist 1 is a selective, potent, covalent estrogen receptor alpha (ERα) antagonist that blocks the cell cycle of MCF-7 cells in G0/G1 phase and induces</p>Fórmula:C33H32N2O5SCor e Forma:SolidPeso molecular:568.68RUNX-IN-1
CAS:<p>RUNX-IN-1, also known as Compound Conjugate 1, covalently attaches to RUNX-binding sequences, thereby preventing RUNX proteins from associating with their</p>Fórmula:C71H88Cl2N24O11Pureza:98%Cor e Forma:SolidPeso molecular:1524.52CUR61414
CAS:<p>CUR61414 is a cell-permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM) and selectively binds to smoothened (Ki = 44 nM).</p>Fórmula:C31H42N4O5Pureza:97.34% - 98%Cor e Forma:SolidPeso molecular:550.69SD 1008
CAS:<p>SD 1008 is a JAK2/STAT3 signaling pathway inhibitor. SD 1008 inhibits activation of STAT3, JAK2, and Src.</p>Fórmula:C18H19NO5Pureza:98%Cor e Forma:SolidPeso molecular:329.35S-Adenosyl-L-methionine (1,4-butanedisulfonate)
CAS:<p>S-Adenosyl-L-methionine (SAMe) 1,4-butanedisulfonate functions as an orally active methyl group donor and serves as a dietary supplement known for its</p>Fórmula:C19H32N6O11S3Pureza:98%Cor e Forma:SolidPeso molecular:616.69MK-2206 free base
CAS:<p>MK-2206 free base is an allosteric Akt inhibitor that is both potent and selective, administered orally, exhibiting IC50 values of 8, 12, and 65 nM for Akt1,</p>Fórmula:C25H21N5OPureza:98%Cor e Forma:SolidPeso molecular:407.47Bcl-2-IN-12
CAS:<p>Bcl-2-IN-12 (Compound 1) is a potent Bcl-2 inhibitor with an IC50 value of 6 nM, utilized in cancer research [1].</p>Fórmula:C47H41ClN4O6SCor e Forma:SolidPeso molecular:825.37GNE-900
CAS:<p>GNE-900 is an ATP-competitive ChK1 inhibitor with selective and oral activity.GNE-900 inhibits ChKl and ChK2 with IC50 values of 0.0011 and 1.5 µM, respectively</p>Fórmula:C23H21N5Pureza:97.18%Cor e Forma:SolidPeso molecular:367.45eIF4A3-IN-9
CAS:<p>eIF4A3-IN-9, a silvestrol analogue, disrupts eIF4F complex assembly; EC50s: 29/450/80 nM (myc/tub-LUC, MB-231 cells); for cancer research.</p>Fórmula:C28H27NO8Cor e Forma:SolidPeso molecular:505.52Z-YVAD-CMK
CAS:<p>Z-YVAD-CMK is an inhibitor of both caspase-1 and caspase-3, as referenced in [1].</p>Fórmula:C30H37ClN4O9Pureza:98%Cor e Forma:SolidPeso molecular:633.09Ac-YVAD-pNA
CAS:<p>Ac-YVAD-pNA, a specific substrate for Caspase-1, serves to detect Caspase-1 activity, a crucial mediator of inflammatory processes [1] [2].</p>Fórmula:C29H36N6O10Cor e Forma:SolidPeso molecular:628.639NSC 689534
CAS:<p>NSC 689534 forms a chelate with copper (Cu 2+), resulting in the NSC 689534/Cu 2+ complex, which is a potent inducer of oxidative stress and exhibits antitumor activity [1].</p>Fórmula:C19H18N6SCor e Forma:SolidPeso molecular:362.45BRD4 Inhibitor-18
CAS:<p>BRD4 Inhibitor-18: potent (IC50: 110 nM), impairs MV-4-11 cell growth, disrupts G0/G1 phase, and induces apoptosis.</p>Fórmula:C26H26ClN3O3SCor e Forma:SolidPeso molecular:496.02cis-3,4',5-Trimethoxy-3'-hydroxystilbene
CAS:<p>Cis-3,4',5-Trimethoxy-3'-hydroxystilbene, a stilbene derivative, induces apoptosis through the mitochondrial release of cytochrome c and suppresses tubulin polymerization. It is also noted for its application in leukemic research [1].</p>Fórmula:C17H18O4Cor e Forma:SolidPeso molecular:286.327HDAC-IN-59
CAS:<p>HDAC-IN-59 (compound 13a), a potent histone deacetylase (HDAC) inhibitor, enhances intracellular reactive oxygen species (ROS) production, induces DNA damage,</p>Fórmula:C20H25NO7Pureza:98%Cor e Forma:SolidPeso molecular:391.42DLC-50
CAS:<p>DLC-50 is a dual inhibitor of PARP-1 and HDAC-1, exhibiting IC50 values of 1.2 nM and 31 nM respectively. It hinders the proliferation of cancer cells such as MDA-MB-436, MDA-MB-231, and MCF-7 with IC50 values of 0.3 μM, 2.7 μM, and 2.41 μM respectively. Additionally, DLC-50 induces apoptosis in MDA-MB-231 cells and causes cell cycle arrest at the G2 phase.</p>Fórmula:C28H32FN5O4S2Cor e Forma:SolidPeso molecular:585.71HDAC1/CDK7-IN-1
CAS:<p>HDAC1/CDK7-IN-1 (compound 8e) serves as a dual inhibitor targeting both CDK7 and HDAC1, with IC50 values of 893 nM and 248 nM , respectively.</p>Fórmula:C33H32ClN7O4Pureza:98%Cor e Forma:SolidPeso molecular:626.11Purinostat mesylate
CAS:<p>Purinostat mesylate, a selective HDAC inhibitor (IC50: 0.81-11.5 nM), induces apoptosis and has potent anti-leukemic effects.</p>Fórmula:C24H30N10O6SCor e Forma:SolidPeso molecular:586.63NLRP3 agonist 1
CAS:<p>Vatalanib hydrochloride (PTK787 hydrochloride) is a VEGF inhibitor that reduces the number and area of Aβ plaques in the cortex of 5xFAD mice.</p>Fórmula:C15H16N6Pureza:99.01%Cor e Forma:SolidPeso molecular:280.33NWP-0476
CAS:<p>NWP-0476 is a modified BCL-2/BCL-xL inhibitor with enhanced specificity for BCL-xL, suitable for research on relapsed T-acute lymphoblastic leukemia (T-ALL) [1</p>Fórmula:C47H53ClN8O8SCor e Forma:SolidPeso molecular:925.49WF-210
CAS:<p>WF-210 is an effective activator of procaspase-3 that acts by inducing apoptosis in cancer cells and reducing tumor growth.</p>Fórmula:C41H38FN7O7SPureza:98%Cor e Forma:SolidPeso molecular:791.85
