Apoptose
Os inibidores da apoptose são compostos que previnem ou retardam o processo de morte celular programada, conhecido como apoptose. Esses inibidores são vitais no estudo dos mecanismos de sobrevivência celular e são usados para investigar doenças onde a apoptose é desregulada, como câncer, distúrbios neurodegenerativos e doenças autoimunes. Ao modular a apoptose, esses inibidores podem ajudar no desenvolvimento de terapias destinadas a controlar a morte celular. Na CymitQuimica, oferecemos uma ampla seleção de inibidores da apoptose de alta qualidade para apoiar sua pesquisa em biologia celular, oncologia e áreas relacionadas.
Subcategorias de "Apoptose"
- ASK(6 produtos)
- BCL(11 produtos)
- Caspase(125 produtos)
- FOXO1(3 produtos)
- IAP(66 produtos)
- Mdm2(12 produtos)
- PD-1/PD-L1(125 produtos)
- PDK(9 produtos)
- PERK(25 produtos)
- Serina/treonina quinase(15 produtos)
- Survivina(13 produtos)
- TNF(92 produtos)
- c-RET(51 produtos)
- p53(62 produtos)
Exibir 6 mais subcategorias
Foram encontrados 5600 produtos de "Apoptose"
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Bcl-2-IN-13
CAS:<p>Bcl-2-IN-13 is a potent inhibitor of Bcl-2, exhibiting an IC50 of 17 nM, and holds potential for use in cancer research [1].</p>Fórmula:C42H44ClN7O6S3Cor e Forma:SolidPeso molecular:874.49INU-152
CAS:<p>INU-152: pan-RAF inhibitor with potent anti-tumor effects on BRAFV600E cancers, inhibits MAPK in mutant cells, minimal side effects on RAS-mutant melanoma.</p>Fórmula:C20H13F2N7O3SPureza:98%Cor e Forma:SolidPeso molecular:469.42Cerivastatin
CAS:<p>Cerivastatin is an HMG-CoA reductase inhibitor with anticancer and lipid-lowering effects and can be used to study primary hyperlipidemia.</p>Fórmula:C26H34FNO5Pureza:97.80% - 99.56%Cor e Forma:SolidPeso molecular:459.55RIP2 kinase inhibitor 1
CAS:<p>Potent RIP2 kinase inhibitor with 0.03 μM IC50, selective for autoimmune disease treatment.</p>Fórmula:C17H17N5O2SPureza:98%Cor e Forma:SolidPeso molecular:355.41Mcl-1 inhibitor 13
CAS:<p>Mcl-1 Inhibitor 13 (Example 9), with a Ki of 8.2 nM, serves as an MCL-1 inhibitor suitable for cancer research [1].</p>Fórmula:C47H45ClFN7O6Cor e Forma:SolidPeso molecular:858.35Tylvalosin
CAS:<p>Tylvalosin (Acetylisovaleryltylosin) is a broad-spectrum macrolide antibiotic with antibacterial and antiviral properties, effective against PRRSV infection.</p>Fórmula:C53H87NO19Pureza:98%Cor e Forma:SolidPeso molecular:1042.25WNY1613
CAS:<p>WNY1613: Potent PI3Kδ inhibitor with anti-NHL properties, induces apoptosis in cells, affects phosphorylation in vitro/in vivo.</p>Fórmula:C29H35N9O3Cor e Forma:SolidPeso molecular:557.65Sirt1/2-IN-3
CAS:<p>Sirt1/2-IN-3 (compound PS9) serves as a dual inhibitor of SIRT1/2, exhibiting IC50 values of 1.4 μM (SIRT1) and 2.0 μM (SIRT2), respectively.</p>Fórmula:C17H14ClNO4SPureza:98%Cor e Forma:SolidPeso molecular:363.82NSC 689534
CAS:<p>NSC 689534 forms a chelate with copper (Cu 2+), resulting in the NSC 689534/Cu 2+ complex, which is a potent inducer of oxidative stress and exhibits antitumor activity [1].</p>Fórmula:C19H18N6SCor e Forma:SolidPeso molecular:362.45CHM-1
CAS:<p>CHM-1 is an inducer of apoptosis, and displays potent antitumor ability in human hepatocellular carcinoma by activation of Cdc2 kinase activity.</p>Fórmula:C16H10FNO3Pureza:99.839%Cor e Forma:SolidPeso molecular:283.25BAX-IN-1
CAS:<p>BAX-IN-1 is a potential selective inhibitor of Bcl-2-associated X protein (BAX).</p>Fórmula:C16H14N6OCor e Forma:SolidPeso molecular:306.32p-Tolylmaleimide
CAS:<p>p-Tolylmaleimide (p Tolylmaleimide) is an inhibitor of the water channel and binds to Aquaporin Z.</p>Fórmula:C11H9NO2Pureza:99.94%Cor e Forma:SolidPeso molecular:187.19BTM-3566
CAS:<p>BTM-3566 triggers ISR via OMA1, induces apoptosis in cancer cells, and is used to research DLBCL.</p>Fórmula:C24H23F4N3O2S2Pureza:99.95%Cor e Forma:SolidPeso molecular:525.58PDK4-IN-1 hydrochloride
CAS:<p>PDK4-IN-1 hydrochloride is an anthraquinone derivative and a potent and orally active inhibitor of pyruvate dehydrogenase kinase 4 (PDK4, IC50 value = 84 nM).</p>Fórmula:C22H20ClN3O2Pureza:99.67%Cor e Forma:SolidPeso molecular:393.87Nedometinib
CAS:<p>Nedometinib (NFX-179) is a MEK1 inhibitor with anticancer and antitumor activities, which can be used to study malignant tumors.</p>Fórmula:C17H16FIN4O3Pureza:99.18%Cor e Forma:SolidPeso molecular:470.24Pivanex
CAS:<p>Pivanex, an oral HDAC inhibitor, targets metastasis, angiogenesis, reduces Bcr-Abl protein, and promotes apoptosis.</p>Fórmula:C10H18O4Pureza:≥98%Cor e Forma:SolidPeso molecular:202.25(S)-Verapamil hydrochloride
CAS:(S)-Verapamil hydrochloride is an inhibitor of leukotriene C4 (LTC4) and calcein transport by MRP1,and leads to the death of potentially resistant tumor cells.Fórmula:C27H39ClN2O4Cor e Forma:SolidPeso molecular:491.06MY-673
CAS:<p>MY-673, a colchicine binding site inhibitor (CBSI), impedes tubulin polymerization and disrupts the ERK signaling pathway, consequently modulating SMAD4 protein</p>Fórmula:C18H14N2O4Cor e Forma:SolidPeso molecular:322.31Antitumor agent-92
CAS:<p>Antitumor Agent-92, a derivative of Icaritin, halts cell cycle, triggers cell death, and is promising for liver cancer study.</p>Fórmula:C33H41NO10Pureza:98%Cor e Forma:SolidPeso molecular:611.68C 87
CAS:C 87: Small-molecule TNF-α inhibitor, binds TNFα, inhibits cytotoxicity with IC50 of 8.73 μM, blocks signaling.Fórmula:C24H15ClN6O3SPureza:≥98%Cor e Forma:SolidPeso molecular:502.93Deoxynybomycin
CAS:<p>Deoxynybomycin, a selective anti-tumor agent, inhibits topoisomerase I and induces apoptosis.</p>Fórmula:C16H14N2O3Pureza:98%Cor e Forma:SolidPeso molecular:282.29SF5
CAS:<p>SF5 is an inhibitor of the apoptosis pathway through JNK-p53-caspase apoptotic cascade.</p>Fórmula:C15H13NSPureza:99.59%Cor e Forma:SolidPeso molecular:239.34Ferroptocide
CAS:<p>Ferroptocide is a thioredoxin inhibitor that induces iron death in cancer cells and can be used in breast cancer research.</p>Fórmula:C30H36ClN3O7Cor e Forma:SolidPeso molecular:586.08FGFR-IN-8
CAS:<p>FGFR-IN-8, potent oral FGFR inhibitor for wild-type/mutant types, induces apoptosis with anti-cancer properties.</p>Fórmula:C27H31Cl2N9O2Cor e Forma:SolidPeso molecular:584.5CDKI-83
CAS:<p>CDKI-83, a potent CDK9 inhibitor, inhibits tumor growth with GI50 <1μM and triggers apoptosis in A2780 cells, showing promise as an anti-cancer agent.</p>Fórmula:C21H23N7O3S2Cor e Forma:SolidPeso molecular:485.58MTP
CAS:<p>MTP, a PKM2 inhibitor, promotes apoptosis in cancer cells via caspase-3 activation while also inducing autophagy and enhancing ROS generation.</p>Fórmula:C29H23F3N4O2Pureza:98%Cor e Forma:SolidPeso molecular:516.51PD-1/PD-L1-IN-22
CAS:<p>PD-1/PD-L1-IN-22 is a small molecule inhibitor of PD-1/PD-L1 protein-protein interactions that blocks PD-1/PD-L1 interactions (IC50: 0.732 μM).</p>Fórmula:C25H26BrClN2O3Cor e Forma:SolidPeso molecular:517.84Mcl-1 inhibitor 17
CAS:<p>Mcl-1 Inhibitor 17 is a compound that functions as an inhibitor of the Mcl-1 protein, specifically designed for use in cancer and other disease research [1].</p>Fórmula:C27H25FN4O2Cor e Forma:SolidPeso molecular:456.51Boserolimab
CAS:<p>Boserolimab (MK-5890) is a chimeric, humanized IgG1κ antibody that targets the signaling regulatory protein CD27 in mice.</p>Cor e Forma:LiquidMP7
CAS:<p>MP7 (PDK1 inhibitor) is a inhibitor of phosphoinositide-dependent kinase-1 (PDK1).</p>Fórmula:C28H22F2N4O4Pureza:99.84% - 99.89%Cor e Forma:SolidPeso molecular:516.5USP7-IN-3
CAS:<p>USP7-IN-3 is a potent and selective allosteric inhibitor of ubiquitin-specific protease 7 (USP7).</p>Fórmula:C29H31F3N6O3Pureza:98%Cor e Forma:SolidPeso molecular:568.59DLC-50
CAS:<p>DLC-50 is a dual inhibitor of PARP-1 and HDAC-1, exhibiting IC50 values of 1.2 nM and 31 nM respectively. It hinders the proliferation of cancer cells such as MDA-MB-436, MDA-MB-231, and MCF-7 with IC50 values of 0.3 μM, 2.7 μM, and 2.41 μM respectively. Additionally, DLC-50 induces apoptosis in MDA-MB-231 cells and causes cell cycle arrest at the G2 phase.</p>Fórmula:C28H32FN5O4S2Cor e Forma:SolidPeso molecular:585.71CA-170
CAS:<p>PD-1-IN-1 is a programmed cell dealth-1inhibitor. PD-1-IN-1 can be used as an immune modulator.</p>Fórmula:C12H20N6O7Pureza:98%Cor e Forma:SolidPeso molecular:360.32BPR1J-340
CAS:<p>BPR1J-340, a novel potent FLT3 inhibitor, shows anticancer promise, with IC50 ~25 nM and GC50 ~5 nM, causing apoptosis in AML cells.</p>Fórmula:C29H34N8O3Cor e Forma:SolidPeso molecular:542.63HDAC-IN-63
CAS:<p>HDAC-IN-63 (Compound 63) is a dual FLT3/HDAC inhibitor with IC50 values of 0.844 nM for FLT3 and 30.0 nM for HDAC1.</p>Fórmula:C25H26Cl2N6O3Cor e Forma:SolidPeso molecular:529.42NBI-961
CAS:<p>NBI-961, a potent NEK2 inhibitor, suppresses proteasomal degradation and effectively induces G2/mitosis arrest and apoptosis within diffuse large B cell</p>Fórmula:C28H27F3N6O2SCor e Forma:SolidPeso molecular:568.61JNJ-1013
CAS:<p>JNJ-1013 is a selective IRAK1 PROTAC degrader with an IC50 of 72 nM ,antiproliferative and proapoptotic, increases cleaved-PARP expression.</p>Fórmula:C46H55N9O7SPureza:99.596%Cor e Forma:SolidPeso molecular:878.05Lepadin E
CAS:<p>Lepadin E, a notably cytotoxic compound, effectively stimulates ferroptosis via the canonical p53-SLC7A11-GPX4 pathway.</p>Fórmula:C26H47NO3Pureza:98%Cor e Forma:SolidPeso molecular:421.66PLK1/BRD4-IN-1
CAS:<p>PLK1/BRD4-IN-1 (9b) is an orally active dual inhibitor of PLK1 (IC50: 22 nM) and BRD4 (IC50: 109 nM).</p>Fórmula:C31H43N9O2Cor e Forma:SolidPeso molecular:573.73Atiprimod dimaleate
CAS:Atiprimod Dimaleate is a JAK2 inhibitor.Fórmula:C30H52N2O8Cor e Forma:SolidPeso molecular:568.74LY303511 hydrochloride
CAS:<p>LY303511, a structural analog of LY294002, selectively inhibits mTOR-dependent phosphorylation of S6K, unlike its counterpart, which acts as a phosphatidylinositol 3-kinase (PI3K) inhibitor. It effectively reduces cell proliferation in human lung epithelial adenocarcinoma cells by hindering G2/M phase progression and suppressing casein kinase 2 activity. Additionally, LY303511 enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) sensitivity in HeLa cells resistant to TRAIL-induced apoptosis and blocks voltage-gated potassium (Kv) channels.</p>Fórmula:C19H20Cl2N2O2Cor e Forma:SolidPeso molecular:379.28Cu(II)-Elesclomol
CAS:<p>Cu(II)-Elesclomol is a complex formed by the anticancer agent Elesclomol and Cu(II), which has anticancer activity and can be used in the study of leukemia.</p>Fórmula:C19H18CuN4O2S2Pureza:99.99%Cor e Forma:SolidPeso molecular:462.05S-Adenosyl-L-methionine (1,4-butanedisulfonate)
CAS:<p>S-Adenosyl-L-methionine (SAMe) 1,4-butanedisulfonate functions as an orally active methyl group donor and serves as a dietary supplement known for its</p>Fórmula:C19H32N6O11S3Pureza:98%Cor e Forma:SolidPeso molecular:616.69HS148
CAS:<p>HS148 selectively inhibits DAPK3 (Ki 119 nM), reducing gastric cancer progression via ULK1-dependent autophagy and tumor suppression pathways.</p>Fórmula:C15H14FN5O2SPureza:98.024%Cor e Forma:SolidPeso molecular:347.37Lacutoclax
CAS:<p>Lacutoclax (LP-108) is an orally active and selective Bcl-2 inhibitor with antitumor activity both in vivo and ex vivo，lymphoma and leukemia.</p>Fórmula:C48H55ClN8O7SCor e Forma:SolidPeso molecular:923.52Topoisomerase II inhibitor 15
CAS:<p>Topoisomerase II inhibitor 15 (compound 2g) serves as a potent apoptotic inducer, exhibiting heightened selectivity for head and neck tumors [1].</p>Fórmula:C15H11Cl2N5Pureza:98%Cor e Forma:SolidPeso molecular:332.19WF-210
CAS:<p>WF-210 is an effective activator of procaspase-3 that acts by inducing apoptosis in cancer cells and reducing tumor growth.</p>Fórmula:C41H38FN7O7SPureza:98%Cor e Forma:SolidPeso molecular:791.85Purinostat mesylate
CAS:<p>Purinostat mesylate, a selective HDAC inhibitor (IC50: 0.81-11.5 nM), induces apoptosis and has potent anti-leukemic effects.</p>Fórmula:C24H30N10O6SCor e Forma:SolidPeso molecular:586.63RIPK3-IN-4
CAS:<p>RIPK3-IN-4 (Compound 42) is a RIPK3 inhibitor that mitigates necroptosis, inflammatory responses, and HK-2 cell damage.</p>Fórmula:C24H18BrFN4O3SPureza:98%Cor e Forma:SolidPeso molecular:541.39PIM447
CAS:<p>PIM447 (LGH447) is a pan-PIM kinase inhibitor with anti-tumor and bone protective effects. PIM447 reduces the viability, and motility of HuH6 cell.</p>Fórmula:C24H23F3N4OPureza:98.97%Cor e Forma:SolidPeso molecular:440.46
