Apoptose
Os inibidores da apoptose são compostos que previnem ou retardam o processo de morte celular programada, conhecido como apoptose. Esses inibidores são vitais no estudo dos mecanismos de sobrevivência celular e são usados para investigar doenças onde a apoptose é desregulada, como câncer, distúrbios neurodegenerativos e doenças autoimunes. Ao modular a apoptose, esses inibidores podem ajudar no desenvolvimento de terapias destinadas a controlar a morte celular. Na CymitQuimica, oferecemos uma ampla seleção de inibidores da apoptose de alta qualidade para apoiar sua pesquisa em biologia celular, oncologia e áreas relacionadas.
Subcategorias de "Apoptose"
- ASK(6 produtos)
- BCL(11 produtos)
- Caspase(125 produtos)
- FOXO1(3 produtos)
- IAP(66 produtos)
- Mdm2(12 produtos)
- PD-1/PD-L1(125 produtos)
- PDK(9 produtos)
- PERK(25 produtos)
- Serina/treonina quinase(15 produtos)
- Survivina(13 produtos)
- TNF(92 produtos)
- c-RET(51 produtos)
- p53(62 produtos)
Exibir 6 mais subcategorias
Foram encontrados 5599 produtos de "Apoptose"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Necrocide 1
CAS:<p>Necrocide 1 is a inducer of cancer cell necrosis that is not inhibited by caspase, BCL2 , or TNFα, and acts through the mitochondrial regulatory pathway.</p>Fórmula:C23H27NO3Pureza:98%Cor e Forma:SolidPeso molecular:365.47Z-LLY-FMK
CAS:<p>Z-LLY-FMK (Calpain Inhibitor IV) serves as an inhibitor of calpain, a family of proteases implicated in the apoptosis of various cell systems.</p>Fórmula:C30H40FN3O6Pureza:98%Cor e Forma:SolidPeso molecular:557.65Cu(II)-Elesclomol
CAS:<p>Cu(II)-Elesclomol is a complex formed by the anticancer agent Elesclomol and Cu(II), which has anticancer activity and can be used in the study of leukemia.</p>Fórmula:C19H18CuN4O2S2Pureza:99.99%Cor e Forma:SolidPeso molecular:462.05A-1293102
CAS:<p>A-1293102 is a potent, selective inhibitor of BCL-XL, effective in inducing apoptosis in tumor cells reliant on BCL-XL [1].</p>Fórmula:C42H40F3N7O7S5Cor e Forma:SolidPeso molecular:972.13Anticancer agent 81
CAS:<p>Compound 37b3, an anticancer, halts tumor growth, triggers cell death, and pairs with Trastuzumab to form T-PBA, an ADC with targeted delivery.</p>Fórmula:C46H46N6O5Pureza:98%Cor e Forma:SolidPeso molecular:762.89AM-8735
CAS:<p>AM-8735 is an inhibitor of MDM2 ( IC50: 25 nM).</p>Fórmula:C27H31Cl2NO6SPureza:98%Cor e Forma:SolidPeso molecular:568.51Siremadlin (R Enantiomer)
CAS:<p>Siremadlin R Enantiomer is the R enantiomer of Siremadlin. Siremadlin is a potent and highly specific inhibitor of MDM-2/p53.</p>Fórmula:C26H24Cl2N6O4Pureza:98%Cor e Forma:SolidPeso molecular:555.41hGGPPS-IN-3
CAS:<p>13h (hGGPPS-IN-3), a strong C2-ThP-BPs hGGPPS blocker, triggers MM cell apoptosis and shows in vivo anti-myeloma effects.</p>Fórmula:C21H19BrN4O7P2SPureza:98%Cor e Forma:SolidPeso molecular:613.31S-Adenosyl-L-methionine (1,4-butanedisulfonate)
CAS:<p>S-Adenosyl-L-methionine (SAMe) 1,4-butanedisulfonate functions as an orally active methyl group donor and serves as a dietary supplement known for its</p>Fórmula:C19H32N6O11S3Pureza:98%Cor e Forma:SolidPeso molecular:616.69WEHI-345 analog
CAS:<p>WEHI-345 analog is an Src inhibitor.</p>Fórmula:C23H25N7OPureza:98%Cor e Forma:SolidPeso molecular:415.49c-Met-IN-10
CAS:<p>c-Met-IN-10: potent kinase inhibitor (IC50=16 nM), halts cancer cell activity/movement, induces apoptosis, for anticancer research.</p>Fórmula:C26H21FN6O5Cor e Forma:SolidPeso molecular:516.48PDK4-IN-1 hydrochloride
CAS:<p>PDK4-IN-1 hydrochloride is an anthraquinone derivative and a potent and orally active inhibitor of pyruvate dehydrogenase kinase 4 (PDK4, IC50 value = 84 nM).</p>Fórmula:C22H20ClN3O2Pureza:99.67%Cor e Forma:SolidPeso molecular:393.87JMJD3/HDAC-IN-1
CAS:<p>Compound A5b, also known as JMJD3/HDAC-IN-1, is a dual inhibitor that targets both JMJD3 (Jumonji domain-containing protein demethylase 3) and HADC1 (histone</p>Fórmula:C21H30N6O2Pureza:98%Cor e Forma:SolidPeso molecular:398.5RIPK1-IN-8
CAS:<p>RIPK1-IN-8 is an aminoimidazolopyridine and is a selective and potent inhibitor of RIPK1 (IC50: 4 nM).RIPK1-IN-8 has research potential in inflammatory diseases</p>Fórmula:C26H24F2N6O3Cor e Forma:SolidPeso molecular:506.5FGFR-IN-8
CAS:<p>FGFR-IN-8, potent oral FGFR inhibitor for wild-type/mutant types, induces apoptosis with anti-cancer properties.</p>Fórmula:C27H31Cl2N9O2Cor e Forma:SolidPeso molecular:584.5BAI1 hydrochloride
CAS:<p>BAI1 hydrochloride is a selective inhibitor of the apoptosis factor BAX, functioning through an allosteric mechanism. By binding to BAX, it allosterically inhibits its activation, showcasing potential applications in the research of diseases mediated by BAX-dependent cell death [1].</p>Fórmula:C19H23Br2Cl2N3OCor e Forma:SolidPeso molecular:540.12Anticancer agent 128
CAS:<p>Anticancer agent 128 (compound 1) is an IAP inhibitor that covalently binds to the BIR3 domains of XIAP, cIAP1, and cIAP2, exhibiting IC50 values of 24.9 nM, 19</p>Fórmula:C26H38N4O4Pureza:98%Cor e Forma:SolidPeso molecular:470.6AZA197
CAS:<p>AZA197 (AZA-197) is a selective Cdc42 inhibitor.</p>Fórmula:C24H36N6Pureza:98.28%Cor e Forma:SolidPeso molecular:408.58NSC697923
CAS:<p>NSC-697923 inhibits UBE2N, triggers p53-dependent and JNK-mediated apoptosis, blocks DNA damage and NF-κB signaling in neuroblastoma cells.</p>Fórmula:C11H9NO5SPureza:97% - 99.71%Cor e Forma:SolidPeso molecular:267.26ZNL 02-096
CAS:<p>ZNL 02-096 (Pomalidomide-C3-adavosertib) is a rapid and selective degrader of Wee1 (IC50=3.58 nM).ZNL 02-096 selectively degrades Wee1 at submolar</p>Fórmula:C42H45N11O6Pureza:99.02% - 99.84%Cor e Forma:SolidPeso molecular:799.88DuP-697
CAS:<p>DuP-697 is an irreversible, specific COX-2 inhibitor with IC50 values of 10 nM and 800 nM for human COX-2 and COX-1.Cost-effective and quality-assured.</p>Fórmula:C17H12BrFO2S2Pureza:99.92%Cor e Forma:SolidPeso molecular:411.31RH01386
CAS:<p>RH01386, a small molecule, prevents ER stress in β cells, inhibits proapoptotic genes, and may treat type 2 diabetes by restoring insulin secretion.</p>Fórmula:C18H15F3N4O3SPureza:99.16% - 99.67%Cor e Forma:SolidPeso molecular:424.4CDDO-3P-Im
CAS:<p>CDDO-3P-Im is an orally active inhibitor of necroptosis with chemopreventive effects. CDDO-3P-Im can be used in studies about ischemia/reperfusion.</p>Fórmula:C39H46N4O3Pureza:97.72%Cor e Forma:SolidPeso molecular:618.81Nanatinostat
CAS:<p>Nanatinostat (CHR-3996) is an HDAC inhibitor with selectivity and oral bioavailability, for HDAC1/2/3 .anti-proliferation apoptosis.</p>Fórmula:C20H19FN6O2Pureza:99.03%Cor e Forma:SolidPeso molecular:394.4Tefinostat
CAS:<p>Tefinostat (CHR-2845) is a potent monocyte/macrophage-targeted histone deacetylase (HDAC) inhibitor.</p>Fórmula:C28H37N3O5Pureza:99.83%Cor e Forma:SolidPeso molecular:495.61CDDO-2P-Im
CAS:<p>CDDO-2P-Im shows chemopreventive effect and reduces the size and severity of the lung tumors in the mouse lung cancer model.</p>Fórmula:C39H46N4O3Pureza:99.54%Cor e Forma:SolidPeso molecular:618.81LB42708
CAS:<p>LB42708 is an orally active farnesyltransferase (FTase) inhibitor (IC50: 0.8/1.2/2.0 nM toward H/N/K-ras).</p>Fórmula:C30H27BrN4O2Pureza:99.36%Cor e Forma:SolidPeso molecular:555.47GCN2-IN-7
CAS:<p>GCN2-IN-7 is an inhibitor of the environmental sensing protein GCN2 with antitumor activity for the study of melanoma.</p>Fórmula:C22H23BrN8OSPureza:99.12%Cor e Forma:SolidPeso molecular:527.44M3541
CAS:<p>M3541: an oral ATM inhibitor with antitumor effects, hinders DNA repair and promotes cancer cell death.</p>Fórmula:C23H17FN6O2Pureza:98.97%Cor e Forma:SolidPeso molecular:428.42Ac-DEVD-CHO
CAS:<p>Ac-DEVD-CHO is a specific Caspase-3 inhibitor (Ki: 230 pM).Ac-DEVD-CHO has an inhibitory effect in SLNT-induced apoptosis.</p>Fórmula:C20H30N4O11Pureza:98.69%Cor e Forma:SolidPeso molecular:502.47GP 1a
CAS:<p>GP 1a: potent CB2 receptor agonist (EC50=7.1), 30x CB2 over CB1 preference, boosts P-ERK1/2, aids skin healing, anti-inflammatory.</p>Fórmula:C23H22Cl2N4OPureza:99.79%Cor e Forma:SolidPeso molecular:441.35VU0661013
CAS:<p>VU0661013 is an effective and selective inhibitor of MCL-1.</p>Fórmula:C39H39Cl2N5O4Pureza:99.04%Cor e Forma:SolidPeso molecular:712.66JHU395
CAS:<p>JHU395, an oral prodrug of glutamine antagonist DON, shows stable antitumor effects on MPNST in vitro and vivo.</p>Fórmula:C22H29N3O7Pureza:99.15% - 99.26%Cor e Forma:SolidPeso molecular:447.48CDC801
CAS:<p>CDC801 is an inhibitor of PDE4 and TNF-α with IC50s of 1.1 μM and 2.5 μM, respectively.</p>Fórmula:C23H24N2O5Pureza:99.61%Cor e Forma:SolidPeso molecular:408.45MC4033
CAS:<p>MC4033 exhibits inhibitory concentration 50 (IC50) values of 39.4 µM in HCT116, 52.1 µM in H1299, 41 µM in A549, and 30.1 µM in U937 [1].</p>Fórmula:C16H13N3O3Pureza:98.16%Cor e Forma:SolidPeso molecular:295.29KSQ-4279
CAS:<p>KSQ-4279 (USP1-IN-1) is an inhibitor of USP1 and PARP.KSQ-4279 has anticancer activity and is used in the study of non-small cell lung cancer, osteosarcoma,</p>Fórmula:C27H25F3N8OPureza:99.76% - 99.79%Cor e Forma:SoildPeso molecular:534.54PP5-IN-1
CAS:<p>PP5-IN-1 is a serine/threonine protein phosphatase-5 (PP5) inhibitor with potential anticancer activity that induces apoptosis in cancer cells.</p>Fórmula:C18H18N2O3SPureza:99.13%Cor e Forma:SolidPeso molecular:342.41PARP1/2/TNKS1/2-IN-1
CAS:<p>PARP1/2/TNKS1/2-IN-1 is a multi-target inhibitor of PARP-1, PARP-2, TNKS1 and TNKS2.PARP1/2/TNKS1/2-IN-1 has anti-tumor activity and induces apoptosis.</p>Fórmula:C35H31FN6O5Pureza:99.63%Cor e Forma:SolidPeso molecular:634.66Elobixibat
CAS:<p>Elobixibat (A 3309) blocks IBAT in mice/humans/dogs (IC50: 0.13/0.53/5.8 nM); used for constipation research.</p>Fórmula:C36H45N3O7S2Pureza:97.43% - 98.03%Cor e Forma:SolidPeso molecular:695.89CPI-360
CAS:<p>CPI-360 is a small molecule EZH2 inhibitor (IC50: 0.002 μM, EC50: 0.080 μM) that shows antitumor activity in an EZH200-dependent tumor xenograft model.</p>Fórmula:C25H31N3O4Pureza:99.52%Cor e Forma:SolidPeso molecular:437.53Alrizomadlin
CAS:<p>Alrizomadlin is an orally active MDM2 inhibitor. APG-115 shows significant dose-dependent inhibitory effects on TP53wt AML cell lines.Cost-effective and quality-assured.</p>Fórmula:C34H38Cl2FN3O4Pureza:98.41% - 99.47%Cor e Forma:SolidPeso molecular:642.59HM43239
CAS:<p>HM43239: oral FLT3 inhibitor; IC50: FLT3 WT 1.1nM, ITD 1.8nM, D835Y 1.0nM; blocks p-STAT5/p-ERK; affects SYK, JAK1/2, TAK1; halts leukemia cell growth.</p>Fórmula:C29H33ClN6Pureza:99.7%Cor e Forma:SolidPeso molecular:501.07GA001
CAS:<p>GA001 is a potent G9a antagonist with an IC50 of 1.32 μM. It can induce autophagy and apoptosis, and is applicable in the treatment of breast cancer.</p>Fórmula:C29H24BrN3OCor e Forma:SolidPeso molecular:510.42YLL545
CAS:<p>YLL545 is an inhibitor of Vascular Endothelial Growth Factor Receptor 2 (VEGFR2). It inhibits VEGF-induced phosphorylation of VEGFR2 and the activation of downstream signaling mediators (such as phosphorylated STAT3 and phosphorylated ERK1/2) in human umbilical vein endothelial cells (HUVEC). Additionally, YLL545 suppresses HUVEC proliferation, migration, invasion, and angiogenesis. It also induces apoptosis and inhibits tumor growth in a mouse model of breast cancer.</p>Fórmula:C19H13F3N6O2Cor e Forma:SolidPeso molecular:414.34BMI-135
CAS:<p>BMI-135, a selective estrogen mimic, demonstrates agonist activity for the estrogen receptor and induces a rapid endoplasmic reticulum stress response (UPR) alongside apoptosis in breast cancer cells.</p>Fórmula:C23H13FO2SCor e Forma:SolidPeso molecular:372.41Urease-IN-20
CAS:<p>Urease-IN-20 (compound XBP2) is an inhibitor of Helicobacter pylori (H. pylori), with an IC50 of 0.14 μM for H. pylori inhibition. It effectively decreases apoptosis in GES-1 cells infected with H. pylori and reduces levels of ROS and γH2AX. Urease-IN-20 also demonstrates significant gastric mucosal protective effects, making it suitable for H. pylori research.</p>Fórmula:C14H8FNO2SeCor e Forma:SolidPeso molecular:320.18ASCT2-IN-1
CAS:ASCT2-IN-1 (compound 20k) is an inhibitor of ASCT2, demonstrating IC50 values of 5.6 μM in A549 cells and 3.5 μM in HEK293 cells. It induces apoptosis and inhibits tumor growth.Fórmula:C36H32Cl2N2O4Peso molecular:627.56NLRP3-IN-72
CAS:<p>NLRP3-IN-72 (Compound 2) is a benzimidazole derivative. It exhibits anti-inflammatory and antioxidant properties, with an IC50 of 0.3 μM for NLRP3 IL-1β, a PD50 of 0.4 μM for protection against cell pyroptosis, and an EC50 of 0.6 μM for inducing HO-1.</p>Fórmula:C19H20FN5OCor e Forma:SolidPeso molecular:353.393Apoptosis inducer 25
CAS:<p>Apoptosisinducer 25 (Compound 4H) demonstrates potent anticancer capabilities by inhibiting the proliferation of BGC-823 cancer cells with an IC50 of 0.37 μM. It induces apoptosis in BGC-823 cells, causes mitochondrial dysfunction, and arrests the cell cycle at the G2/M phase. Additionally, Apoptosisinducer 25 exhibits favorable pharmacokinetic properties in rats.</p>Fórmula:C42H53NO7Cor e Forma:SolidPeso molecular:683.8717-Demethoxy-reblastatin
CAS:<p>17-Demethoxy-reblastatin (17-DR) acts as an inhibitor of heat shock protein 90 (Hsp90). It suppresses the proliferation of HepG2 and SMMC7721 cancer cells, diminishes colony formation, and triggers apoptosis via a mitochondria and caspase-mediated pathway.</p>Fórmula:C28H42N2O7Cor e Forma:SolidPeso molecular:518.64
