Apoptose
Os inibidores da apoptose são compostos que previnem ou retardam o processo de morte celular programada, conhecido como apoptose. Esses inibidores são vitais no estudo dos mecanismos de sobrevivência celular e são usados para investigar doenças onde a apoptose é desregulada, como câncer, distúrbios neurodegenerativos e doenças autoimunes. Ao modular a apoptose, esses inibidores podem ajudar no desenvolvimento de terapias destinadas a controlar a morte celular. Na CymitQuimica, oferecemos uma ampla seleção de inibidores da apoptose de alta qualidade para apoiar sua pesquisa em biologia celular, oncologia e áreas relacionadas.
Subcategorias de "Apoptose"
- ASK(6 produtos)
- BCL(11 produtos)
- Caspase(125 produtos)
- FOXO1(3 produtos)
- IAP(66 produtos)
- Mdm2(12 produtos)
- PD-1/PD-L1(125 produtos)
- PDK(9 produtos)
- PERK(25 produtos)
- Serina/treonina quinase(15 produtos)
- Survivina(13 produtos)
- TNF(92 produtos)
- c-RET(51 produtos)
- p53(62 produtos)
Exibir 6 mais subcategorias
Foram encontrados 5598 produtos de "Apoptose"
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Tubulin polymerization-IN-70
<p>Tubulin polymerization-IN-70 (compound Q19) is an effective inhibitor of tubulin polymerization. This compound exerts antiproliferative properties by targeting the colchicine binding site on tubulin, thereby inhibiting its polymerization. Tubulin polymerization-IN-70 also induces apoptosis and cell cycle arrest at the G2/M phase. Additionally, it triggers a decrease in mitochondrial membrane potential and elevates levels of reactive oxygen species (ROS). Moreover, Tubulin polymerization-IN-70 possesses anti-angiogenic and anticancer activities.</p>Fórmula:C25H23N3O2Cor e Forma:SolidPeso molecular:397.47Thalidomide-Piperazine-PEG2-NH2
CAS:<p>Thalidomide-Piperazine-PEG2-NH2 is a synthetic E3 ligase ligand-linker for PROTAC, combining cereblon ligand with a PEG2 linker.</p>Fórmula:C23H31N5O6Cor e Forma:SolidPeso molecular:473.53Bcl-2-IN-2
CAS:<p>Bcl-2-IN-2 is a highly potent and selective inhibitor targeting Bcl-2 and Bcl-xL.</p>Fórmula:C48H57N7O7SCor e Forma:SolidPeso molecular:876.09Apoptosis inducer 30
<p>Apoptosisinducer 30 (Compound 15a) acts as an anticancer agent. It induces apoptosis in MCF-7 cells through the mitochondrial pathway. This compound elevates intracellular levels of reactive oxygen species (ROS), decreases mitochondrial membrane potential, and arrests the cell cycle at the G0/G1 phase. Apoptosisinducer 30 inhibits cell growth, with an IC50 value of 0.32 μM against MCF-7 cells, and suppresses tumor growth in a mouse breast cancer model.</p>Fórmula:C52H69BrNO4PCor e Forma:SolidPeso molecular:882.99Quercetin-d3
<p>Quercetin-d3 hydrate, a deuterated form of Quercetin hydrate, acts as a flavonoid that stimulates recombinant SIRT1 and serves as a PI3K inhibitor. The compound specifically exhibits IC50 values of 2.4 μM, 3.0 μM, and 5.4 μM against PI3Kγ, PI3Kδ, and PI3Kβ, respectively.</p>Fórmula:C15H9D3O8Cor e Forma:SolidPeso molecular:323.27Mcl-1 inhibitor 15
<p>Mcl-1 Inhibitor 15 (Compound (Ra)-15), with a K i of 0.02 nM, is utilized in cancer research [1].</p>Fórmula:C40H42ClFN6O4SCor e Forma:SolidPeso molecular:757.32Thalidomide-N-C3-O-C4-O-C3-OH
<p>Thalidomide-N-C3-O-C4-O-C3-OH is a conjugate of an E3 ligase ligand and a linker, used in the synthesis of the Aster-APROTAC degrader.</p>Fórmula:C23H31N3O7Peso molecular:461.2162DA5-HTL
<p>DA5-HTL is a compound that combines dasatinib with the HaloTag system, effectively inhibiting the growth of tumor cells, with a GI50 of 1.923 nM.</p>Fórmula:C39H58Cl2N8O8SPeso molecular:868.34754HSP70-IN-6
<p>HSP70-IN-6 (Compound JL-15) acts as an inhibitor of the Hsp70-Bim protein-protein interactions (PPI) with an IC50 value of 70 nM. It induces apoptosis in chronic myeloid leukemia (CML) cells with EC50 values of 0.43 μM (BV173), 0.88 μM (K562), and 0.19 μM (K562-R3).</p>Cor e Forma:Odour SolidNecroptosis-IN-4
<p>Necroptosis-IN-4 is an effective inhibitor of necroptosis, specifically targeting RIP kinase 1 (RIPK1) without inhibitory activity against RIPK3. It exhibits weak inhibitory effects on VEGFR1/2 and PDGFR-α.</p>Cor e Forma:Odour Solid5-Fluorouracil-13C,15N2
CAS:<p>5-Fluorouracil-13C,15N2 is a standard for quantifying 5-fluorouracil via GC/LC-MS and blocks DNA synthesis, causing cell apoptosis.</p>Fórmula:C4H3FN2O2Cor e Forma:SolidPeso molecular:133.057155H1
155H1 (Compound 11) is a stapled peptide that covalently binds to hMcl1 (172-323) with an IC50 of 18 nM.Fórmula:C79H120FN19O23SPeso molecular:1753.85092NAE-IN-1
<p>NAE-IN-1 (compound X-10) is a potent inhibitor of NAE1. It induces apoptosis and causes cell cycle arrest in the G2/M phase. Furthermore, NAE-IN-1 increases ROS levels and inhibits cell migration, demonstrating antiproliferative activity.</p>Fórmula:C29H30N4O2SPeso molecular:498.20895EGFR/DHFR-IN-2
<p>EGFR/DHFR-IN-2 (9b) is a dual inhibitor of h-DHFR/EGFR TK, exhibiting IC50 values of 0.192 μM for h-DHFR and 0.109 μM for EGFR. It causes cell cycle arrest at the G1/S phase and induces apoptosis. Additionally, EGFR/DHFR-IN-2 (9b) is a potential inhibitor of CYP2C9 and CYP3A4. This compound can be utilized in cancer research.</p>Fórmula:C24H16N4O5Cor e Forma:SolidPeso molecular:440.11207PRMT5-IN-33
<p>PRMT5-IN-33 (compound A8) is a selective inhibitor of PRMT5 that competes with SAM, exhibiting an IC50 of 10.9 nM. It induces apoptosis and inhibits the proliferation of Z-138 and MOLM-13 cells, demonstrating antitumor activity.</p>Fórmula:C25H24BrN5O3SPeso molecular:553.07832Antitumor agent-150
<p>Antitumor agent-150 (V10) is a breast cancer treatment that functions as a PROTAC degrader of MDM2.</p>Fórmula:C70H106N8O14SPeso molecular:1314.75492TPP-1 TFA
<p>TPP-1 TFA is a high-affinity PD-L1 inhibitor (KD=95nM) that boosts T-cell function to curb tumor growth.</p>Fórmula:C109H151F3N34O34S2Cor e Forma:SolidPeso molecular:2602.69Emfizatamab
CAS:<p>Emfizatamab (GNC-038) is a tetravalent antibody that activates CD3 and 4-1BB on T cells while targeting CD19 or PD-L1 on tumor cells, resulting in T-cell-mediated cytotoxicity against human leukemia and lymphoma cells.</p>Cor e Forma:LiquidAtibuclimab
CAS:<p>Atibuclimab is a chimeric monoclonal antibody targeting CD14, consisting of a mouse variable region and a human IgG4 Fc region.</p>Pureza:> 95% - > 95%Cor e Forma:LiquidPeso molecular:145.28 kDaGSK-1070916
CAS:<p>GSK-1070916 (GSK-1070916A) is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM.</p>Fórmula:C30H33N7OPureza:99.73%Cor e Forma:SolidPeso molecular:507.634-Nitrothalidomide
CAS:<p>4-Nitrothalidomide is a modified form of thalidomide that inhibits the growth and proliferation of HUVEC cells and is commonly used in the synthesis of pomalidomide, which has anticancer potential.</p>Fórmula:C13H9N3O6Pureza:99.94%Cor e Forma:SolidPeso molecular:303.23FR900359
CAS:<p>FR900359 is a macrocyclic Gq protein inhibitor that inhibits melanoma cell proliferation and can be used to study asthma, inflammation and cancer.</p>Fórmula:C49H75N7O15Pureza:98%Cor e Forma:SolidPeso molecular:1002.16Ac-Trp-Glu-His-Asp-Aldehyde
CAS:<p>Ac-Trp-Glu-His-Asp-Aldehyde is a powerful and selective inhibitor of caspase-1, demonstrating a K_i value of 56 pM [1] [2].</p>Fórmula:C28H33N7O9Cor e Forma:SolidPeso molecular:611.6Anticancer agent 134
<p>Anticancer Agent 134 (Compound 6a), an environment-sensitive fluorescent probe, induces apoptosis and selectively differentiates between tumor and normal</p>Fórmula:C34H36ClN7O3S2Pureza:98%Cor e Forma:SolidPeso molecular:690.28TAT-NEP1-40 acetate
<p>TAT-NEP1-40 acetate, a potential therapeutic for axonal regeneration and functional recovery post-stroke, safeguards PC12 cells from oxygen and glucose</p>Fórmula:C268H438N88O77·xC2H4O2Pureza:98%Cor e Forma:SolidPeso molecular:6124.89 (free base)Reproxalap
CAS:<p>Reproxalap (NS-2) is a dry eye treatment that neutralizes aldehydes like malondialdehyde.</p>Fórmula:C12H13ClN2OPureza:99.4% - 99.97%Cor e Forma:SolidPeso molecular:236.7Mepacrine
CAS:<p>Mepacrine (Erion) is an acridine derivative formerly widely used as an antimalarial.</p>Fórmula:C23H30ClN3OPureza:98.78%Cor e Forma:Bright Yellow CrystalsPeso molecular:399.96MS105
CAS:<p>MS105 is an orally active, selective protein tyrosine kinase 6 (PTK6) PROTAC degrader. It recruits the VHL E3 ligase through a VHL ligand fragment, facilitating ubiquitination and proteasomal degradation of PTK6, thereby inhibiting the proliferation and migration of breast cancer cells and inducing apoptosis (apoptosis). MS105 is a promising compound for breast cancer research.</p>Fórmula:C56H70FN13O6SCor e Forma:SolidPeso molecular:1072.30PAK4-IN-3
<p>PAK4-IN-3 (compound 27e) is a PAK4 inhibitor exhibiting an IC50 of 10 nM and demonstrates antiproliferative effects on A549 cells with an IC50 of 0.61μM.</p>Pureza:98%Cor e Forma:Odour SolidVinepidine sulfate
CAS:<p>Vinepidine (LY-119863) sulfate, a derivative of vincristine, exhibits antitumor activity .</p>Fórmula:C46H58N4O13SCor e Forma:SolidPeso molecular:907.04Antitumor agent-113
<p>Antitumor Agent-113 exhibits cytotoxicity in A549 cells, with an IC50 of 46.60 μM, and induces apoptosis, making it applicable for research in non-small cell</p>Fórmula:C21H22ClN5O2SPureza:98%Cor e Forma:SolidPeso molecular:443.95Carbonic anhydrase inhibitor 33
<p>Carbonic anhydrase inhibitor33 (11D) is a dual inhibitor that targets both CA (carbonic anhydrase) IX/XII and CDK6. It exhibits Ki values of 19.7 nM for hCA IX and 26.1 nM for hCA XII. Additionally, Carbonic anhydrase inhibitor33 (11D) can induce G1 phase cell cycle arrest and apoptosis, making it relevant for research in non-small cell lung cancer (NSCLC).</p>Fórmula:C19H15FN6O2SCor e Forma:SolidPeso molecular:410.09612TP4 (Nile tilapia piscidin)
CAS:<p>TP4 (Nile tilapia piscidin) is an orally active piscidin-like antimicrobial peptide that exhibits inhibition of various gram-positive and negative bacterial</p>Fórmula:C135H226N50O27Pureza:98%Cor e Forma:SolidPeso molecular:2981.56Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2
<p>Thalidomide-PEG conjugate for E3 ligase in PROTACs; has cereblon ligand and 3-unit PEG linker.</p>Fórmula:C27H35F3N4O11Pureza:98%Cor e Forma:SolidPeso molecular:648.58TAT-NEP1-40 TFA
<p>TAT-NEP1-40 TFA, a blood-brain barrier-permeable peptide, safeguards PC12 cells against oxygen and glucose deprivation (OGD) and fosters neurite outgrowth.</p>Fórmula:C268H438N88O77·xC2HF3O2Pureza:98%Cor e Forma:SolidPeso molecular:6124.89 (free base)fac-[Re(CO)3(L6)(H2O)][NO3]
<p>Compound 6, fac-[Re(CO)3(L6)(H2O)][NO3], a rhenium(I) tricarbonyl aqua complex, serves as an anticancer agent by disrupting mitochondrial function.</p>Fórmula:C24H14N5O7ReSPureza:98%Cor e Forma:SolidPeso molecular:702.67Anticancer agent 133
<p>Compound Rh2 (Anticancer agent 133) is a cytotoxic and antimetastatic agent that induces cell cycle arrest, apoptosis, and autophagy.</p>Fórmula:C24H19Cl3N5ORhPureza:98%Cor e Forma:SolidPeso molecular:602.71Antimycin A2c
<p>Anticancer Agent 141 (Compound AE), an antimycin alkaloid, exhibits inhibitory potential against HPV-infected cervical cancer.</p>Fórmula:C28H40N2O9Pureza:98%Cor e Forma:SolidPeso molecular:548.63Aphidicolin
CAS:<p>Aphidicolin blocks DNA synthesis, hinders herpes virus growth, and stimulates apoptosis in leukemia cells; it's a mold-derived DNA polymerase inhibitor.</p>Fórmula:C20H34O4Pureza:>99.99%Cor e Forma:SolidPeso molecular:338.48TNF-α Antagonist
CAS:<p>TNF-α antagonist is an exocyclic peptide that mimics the critical TNF-α recognition loop on TNF receptor I complex and, thus, prevents ligand interaction with</p>Fórmula:C58H71N11O15S2Cor e Forma:SolidPeso molecular:1226.39PBE-AMF
<p>PBE-AMF is a prodrug that activates H2O2 and exhibits anticancer activity. It impedes tumor proliferation by inhibiting DNA synthesis, reducing ATP levels, inducing cell death (apoptosis), and blocking the cell cycle. PBE-AMF effectively and selectively inhibits the proliferation of MDA-MB-231 cells (IC50=6.4 μM) while sparing non-cancerous MCF-10A cells.</p>Cor e Forma:Odour SolidAnti-inflammatory agent 45
<p>Compound 2v (Anti-inflammatory agent 45) demonstrates anticancer properties with direct inhibitory impacts on the proliferation of various blood malignancies,</p>Fórmula:C25H22BrNO6Pureza:98%Cor e Forma:SolidPeso molecular:512.35Trilexium
CAS:<p>Trilexium (TRX-E-009-1), a third-generation benzopyran structurally related to TRX-E-002-1, increases p21 protein expression, induces apoptosis, depolymerizes microtubules, and demonstrates broad anti-cancer activity [1] [2].</p>Fórmula:C24H23FO6Cor e Forma:SolidPeso molecular:426.43Ac-FEID-CMK
<p>Ac-FEID-CMK: Potent inhibitor for zebrafish GSDMEb, reduces pyroptosis, and lessens septic AKI.</p>Fórmula:C27H37ClN4O9Cor e Forma:SolidPeso molecular:597.06Volrustomig
CAS:<p>Volrustomig is a bi-engineered fragment crystallizable (Fc) domain, a monovalent bispecific IgG1 monoclonal antibody targeting the key immune checkpoint receptors PD-1 and CTLA-4. It boosts T-cell activation and antitumor immunity, making it a promising immunotherapy for various cancers. Molecular weight: 146.77 kDa.</p>Cor e Forma:LiquidDJ4
CAS:<p>DJ4 induces a dose-dependent pro-apoptotic effect in the micromolar range.</p>Fórmula:C19H16N4OSPureza:≥98%Cor e Forma:SoildPeso molecular:348.424-hydroperoxy cyclophosphamide
CAS:<p>4-hydroperoxy cyclophosphamide (4-OOH-CY) induces hepatotoxicity. It increases ghrelin levels and enhances inflammatory factors and oxidative markers.</p>Fórmula:C7H15Cl2N2O4PPureza:98%Cor e Forma:SolidPeso molecular:293.09BAY 1892005
CAS:<p>BAY 1892005 is a p53 protein modulator that targets the p53 condenser for the study of diseases associated with misfolded p53 protein</p>Fórmula:C11H8ClFN2OSPureza:99.62%Cor e Forma:SoildPeso molecular:270.71ZC0109
<p>ZC0109 inhibits IDO1 (50 nM) & TrxR1 (3.0 μM), induces ROS, arrests G1/S phase, causing cancer cell apoptosis.</p>Fórmula:C22H20BrFN8O4SCor e Forma:SolidPeso molecular:591.41EGFR/BRAFV600E-IN-3
<p>EGFR/BRAFV600E-IN-3 is an inhibitor targeting EGFR, BRAFV600E, and EGFRT790M with IC50 values of 57 nM, 68 nM, and 9.70 nM, respectively.</p>Fórmula:C25H18N4O3Pureza:98%Cor e Forma:SolidPeso molecular:422.44
