Apoptose
Os inibidores da apoptose são compostos que previnem ou retardam o processo de morte celular programada, conhecido como apoptose. Esses inibidores são vitais no estudo dos mecanismos de sobrevivência celular e são usados para investigar doenças onde a apoptose é desregulada, como câncer, distúrbios neurodegenerativos e doenças autoimunes. Ao modular a apoptose, esses inibidores podem ajudar no desenvolvimento de terapias destinadas a controlar a morte celular. Na CymitQuimica, oferecemos uma ampla seleção de inibidores da apoptose de alta qualidade para apoiar sua pesquisa em biologia celular, oncologia e áreas relacionadas.
Subcategorias de "Apoptose"
- ASK(6 produtos)
- BCL(11 produtos)
- Caspase(125 produtos)
- FOXO1(3 produtos)
- IAP(66 produtos)
- Mdm2(12 produtos)
- PD-1/PD-L1(125 produtos)
- PDK(9 produtos)
- PERK(25 produtos)
- Serina/treonina quinase(15 produtos)
- Survivina(13 produtos)
- TNF(92 produtos)
- c-RET(51 produtos)
- p53(62 produtos)
Exibir 6 mais subcategorias
Foram encontrados 5598 produtos de "Apoptose"
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PZ703b
CAS:<p>PZ703b is a novel BCL-XL PROTAC degrader with enhanced BCL-2 inhibition.</p>Fórmula:C80H102ClF3N10O11S4Cor e Forma:SolidPeso molecular:1600.44Shepherdin (79-87)
CAS:<p>Shepherdin 79-87: Amino acid fragment 79-87 of Hsp90/Survivin antagonist with anticancer properties.</p>Fórmula:C41H64N12O12SPureza:98%Cor e Forma:SolidPeso molecular:949.09SFI003
CAS:<p>SFI003 is a novel SRSF3 inhibitor that exerts anticancer activity against colorectal cancer by modulating the SRSF3 / DHCR24 / ROS axis and driving apoptosis in</p>Fórmula:C19H17N5OSPureza:98.92%Cor e Forma:SoildPeso molecular:363.44Sandacanol
CAS:<p>Sandacanol (Sandranol) is an olfactory receptor (OR10H1) agonist.Sandacanol induces cell cycle arrest and partial apoptosis in bladder cancer cells.</p>Fórmula:C14H24OPureza:99.59%Cor e Forma:SolidPeso molecular:208.34NecroIr2
<p>NecroIr2, an iridium(III) compound, induces necroptosis in Cisplatin-resistant A549R lung cancer cells and disrupts mitochondria.</p>Fórmula:C46H30ClIrN6O2Cor e Forma:SolidPeso molecular:926.44ZZM-1220
<p>ZZM-1220, a covalent inhibitor of histone lysine methyltransferase G9a/GLP, exhibits IC50 values of 458 nM for G9a and 924 nM for GLP.</p>Fórmula:C25H29N5O3Pureza:98%Cor e Forma:SolidPeso molecular:447.53ChoKα inhibitor-5
<p>ChoKα Inhibitor-5, a sulfur-containing choline kinase inhibitor, effectively inhibits HChoKα1 with an IC50 value of 0.64 μM and induces apoptosis.</p>Fórmula:C54H68Br2N4S4Cor e Forma:SolidPeso molecular:1061.21PEAQX tetrasodium hydrate
<p>PEAQX tetrasodium hydrate: potent/selective oral NMDA antagonist, IC50 270 nM (1A/2A), 29600 nM (1A/2B).</p>Fórmula:C17H15BrN3Na4O6PPureza:99%Cor e Forma:SolidPeso molecular:560.15PD-1-IN-20
<p>PD-1-IN-20 is the less active enantiomer of PD-1-IN-1.</p>Fórmula:C12H20N6O7Pureza:98%Cor e Forma:SolidPeso molecular:360.32Avotaciclib hydrochloride
<p>Avotaciclib hydrochloride, a CDK1 inhibitor, is the hydrochloride salt of Avotaciclib and exhibits potential therapeutic use in specific malignancies, including</p>Fórmula:C13H12ClN7OPureza:98%Cor e Forma:SolidPeso molecular:317.73MG-277
<p>MG-277 is a molecular glue compound transformed from PROTAC degradation agent, MG-277 potently inhibits tumor cell growth in a p53-independent manner.</p>Fórmula:C41H42Cl2FN5O5Pureza:98%Cor e Forma:SolidPeso molecular:774.71Nrf2 activator-9
<p>Nrf2 activator-9 (compound D-36) is an agent that mitigates oxidative stress by inhibiting the apoptosis of HUVEC cells induced by oxidized low-density</p>Fórmula:C26H27N5O4Cor e Forma:SolidPeso molecular:473.52Annonacin
CAS:<p>Annonacin is a cytotoxic acetogenin in Graviola leaf extract; it blocks mitochondrial complex and inhibits NKA/SERCA ATPase pumps.</p>Fórmula:C35H64O7Pureza:98%Cor e Forma:SolidPeso molecular:596.88Mcl1-IN-26
CAS:<p>Mcl1-IN-26 is an effective and selective myeloid cell leukemia 1 inhibitor.</p>Fórmula:C45H52ClN5O6SCor e Forma:SolidPeso molecular:826.44Thalidomide-5-propargyne-NH2 hydrochloride
CAS:<p>Thalidomide derivative for CRBN protein recruitment, used in PROTACs production for protein degradation.</p>Fórmula:C16H14ClN3O4Cor e Forma:SolidPeso molecular:347.753Kdo2-Lipid A ammonium
CAS:<p>Kdo2-Lipid A ammonium (KLA) is a selective and potent TLR4 agonist, a lipopolysaccharide.Kdo2-Lipid A ammonium induces the release of TNF and PGE2.</p>Fórmula:C110H214N6O39P2Pureza:98%Cor e Forma:SolidPeso molecular:2306.842,5-Dimethylcyclohexa-2,5-diene-1,4-dione
CAS:<p>2,5-Dimethylcyclohexa-2,5-diene-1,4-dione inhibits the viability of HL60 and K562 cells and exhibits antibacterial and anticancer properties.</p>Fórmula:C8H8O2Pureza:99.80%Cor e Forma:SolidPeso molecular:136.15Odoroside A
CAS:<p>Odoroside A, from Nerium oleander leaves, induces cancer cell death via ROS/p53, causing apoptosis and cell cycle arrest.</p>Fórmula:C30H46O7Cor e Forma:SolidPeso molecular:518.68Thalidomide-PEG2-C2-NH2 hydrochloride
CAS:<p>Thalidomide-based cereblon ligand with 2-unit PEG linker for PROTAC, in hydrochloride form.</p>Fórmula:C19H25ClN4O6Pureza:98%Cor e Forma:SolidPeso molecular:440.88Tripchlorolide
<p>Tripchlorolide is a useful organic compound for research related to life sciences and the catalog number is T126047.</p>Fórmula:C20H25ClO6Cor e Forma:SolidPeso molecular:396.86JPS014 TFA
<p>JPS014 TFA, a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC), effectively degrades class I histone deacetylase (HDAC</p>Fórmula:C48H60F3N7O9SPureza:98%Cor e Forma:SolidPeso molecular:968.09Sarglaroids F
<p>Sarglaroids F (compound 6), an anti-inflammatory agent extracted from the roots of Grass Coral, suppresses LPS/ATP-induced IL-1β secretion by modulating K+</p>Fórmula:C38H44O12Pureza:98%Cor e Forma:SolidPeso molecular:692.75WEHI-3773
<p>WEHI-3773 is an inhibitor of the interaction between VDAC2 and either BAK or BAX. It prevents BAX-mediated apoptosis (Apoptosis) by blocking the recruitment of BAX to the mitochondria through VDAC2. Conversely, WEHI-3773 promotes BAK-mediated apoptosis (Apoptosis) by limiting VDAC2's inhibitory sequestration of BAK. This compound shows promise for research in the field of cancer therapy.</p>Cor e Forma:Odour SolidAKT-IN-24
<p>AKT-IN-24 (Compound M17) is an allosteric inhibitor of AKT exhibiting antitumor activity. In combination with Trametinib, it targets the AKT/mTOR and MEK/ERK signaling pathways while inhibiting epithelial-mesenchymal transition, resulting in a synergistic suppression effect on TNBC. This combination promotes apoptosis and inhibits cell proliferation and migration.</p>Fórmula:C32H28N2O10Cor e Forma:SolidPeso molecular:600.572Indinavir
CAS:<p>Indinavir is an HIV protease inhibitor,HAART. inhibits the activation of MMP-2 in endothelial cells and exhibits affinity for α7-nAchR and SARS-CoV-2 Mpro.</p>Fórmula:C36H47N5O4Cor e Forma:SolidPeso molecular:613.79c-JUN peptide
CAS:<p>Peptide from c-Jun (33-57) blocks JNK binding, inhibits phosphorylation, upregulates p21, and induces HeLa cell apoptosis.</p>Fórmula:C121H210N36O34SPureza:98%Cor e Forma:SolidPeso molecular:2743.55Lactoferrin (17-41)
CAS:<p>Amino acids 17-41 of lactoferrin, lactoferricin B, enhance anti-fungal effects, targeting Candida Albicans.</p>Fórmula:C141H224N46O29S3Pureza:98%Cor e Forma:SolidPeso molecular:3123.77NLRP3-IN-60
<p>NLRP3-IN-60 (Compound 39) is an orally bioavailable inhibitor of NLRP3. It effectively suppresses pyroptosis in THP-1 cells with an IC50 of 13 nM and inhibits IL-1β release in human whole blood, exhibiting an IC50 of 225 nM.</p>Fórmula:C23H24F2N4O4SCor e Forma:SolidPeso molecular:490.523Aspochalasin D
CAS:<p>Aspochalasin D, isolated from A. microcysticus, shows antibacterial properties and cytotoxicity affecting Ba/F3-V12 cells, with IC50s of 0.49 and 1.9 μg/ml.</p>Fórmula:C24H35NO4Cor e Forma:SolidPeso molecular:401.54Angiogenesis inhibitor 3
CAS:<p>Angiogenesis Inhibitor 3 (compound 8) is a potent anti-cancer agent, blocking HUVEC/HCT-15 cell growth and inducing apoptosis.</p>Fórmula:C44H42BrN3O9Cor e Forma:SolidPeso molecular:836.72Pralnacasan
CAS:<p>Pralnacasan blocks IL-18, IL-1β, IFN-γ. It’s a potent oral enzyme inhibitor with use in arthritis therapy (Ki: 1.4 nM).</p>Fórmula:C26H29N5O7Pureza:98%Cor e Forma:SolidPeso molecular:523.54TrxR-IN-7
<p>TrxR-IN-7 (14f) is a potent inhibitor of thioredoxin reductase (TrxR), with an IC50 value of 3.5 µM. It exhibits antiproliferative activity and can induce apoptosis and the production of reactive oxygen species (ROS).</p>Fórmula:C22H21NO3Cor e Forma:SolidPeso molecular:347.407Fludarabine triphosphate
CAS:<p>Fludarabine triphosphate inhibits key enzymes, causing cell death.</p>Fórmula:C10H15FN5O13P3Cor e Forma:SolidPeso molecular:525.17TS-IN-5
<p>TS-IN-5 (Compound 15) is an inhibitor of thymidylate synthase (TS). It induces apoptosis by modulating the proteins Bax, BCL-2, PI3K, and STAT1. TS-IN-5 exhibits antitumor activity against liver cancer, breast cancer, and colon cancer.</p>Fórmula:C16H17N5OSCor e Forma:SolidPeso molecular:327.404MY-943
<p>MY-943, a potent inhibitor of tubulin polymerization and LSD1, exhibits anticancer properties by inducing G2/M phase arrest, promoting apoptosis, and</p>Fórmula:C30H36N4O6S2Cor e Forma:SolidPeso molecular:612.76Fludioxonil
CAS:<p>Fludioxonil (CGA 173506), a phenylpyrrole fungicide, inhibits the growth of B. cinerea from strawberry and blackberry crops.</p>Fórmula:C12H6F2N2O2Pureza:99.971%Cor e Forma:SolidPeso molecular:248.183-Hydroxyterphenyllin
CAS:<p>3-Hydroxyterphenyllin from A. candidus is a fungal compound with antioxidant, anticancer, antibacterial, and antiviral effects.</p>Fórmula:C20H18O6Cor e Forma:SolidPeso molecular:354.35LL-K9-3
CAS:<p>LL-K9-3, a selective hydrophobic tagging technology (HyT)-based degrader, specifically targets the CDK9-cyclin T1 complex, displaying DC50 values of 589 nM for</p>Fórmula:C31H49N5O6S3Cor e Forma:SolidPeso molecular:683.94BODIPY FL thalidomide
CAS:<p>BODIPY FL thalidomide is a fluorescent probe that binds human cereblon protein with high affinity, exhibiting a dissociation constant (Kd) of 3.6 nM [1].</p>Fórmula:C37H43BF2N6O7Cor e Forma:SolidPeso molecular:732.58fac-[Re(CO)3(L3)(H2O)][NO3]
<p>Fac-[Re(CO)3(L3)(H2O)][NO3] (Compound 3), a rhenium(I) tricarbonyl aqua complex, acts as an anticancer agent through the induction of mitochondrial dysfunction.</p>Fórmula:C25H17N6O8ReCor e Forma:SolidPeso molecular:715.64Thalidomide-Piperazine 5-fluoride hydrochloride
CAS:<p>Thalidomide-Piperazine 5-fluoride hydrochloride, a derivative of the cereblon (CRBN) inhibitor Thalidomide, serves as a ligand for E3 ubiquitin ligase (Ligands for E3 Ligase), facilitating the synthesis of PROTACs [1].</p>Fórmula:C17H18ClFN4O4Cor e Forma:SolidPeso molecular:396.8PERK-IN-4
CAS:<p>PERK-IN-4 is a potent and selective PERK inhibitor with an IC50 value of 0.3 nM.PERK-IN-4 can be used in the study of cancer and neurological disorders.</p>Fórmula:C24H19F4N5OPureza:98.07% - 98.95%Cor e Forma:SolidPeso molecular:469.43Antitumor agent-116
<p>Antitumor Agent-116 (Compound 6C) is an anti-tumor agent that exhibits anti-proliferative properties and induces apoptosis.</p>Fórmula:C31H23BrN4O4SPureza:98%Cor e Forma:SolidPeso molecular:627.51Lambertianic acid
CAS:<p>Lambertianic acid is a bioactive chemical that has anti-allergic and antibacterial effects.</p>Fórmula:C20H28O3Pureza:98%Cor e Forma:SolidPeso molecular:316.441Antitumor photosensitizer-4
<p>Antitumor Photosensitizer-4 (compound 10b), a conjugate of dasatinib and imatinib, serves as a potent tyrosine kinase inhibitor (TKI) targeting ABCG2.</p>Fórmula:C65H77ClN12O11SPureza:98%Cor e Forma:SolidPeso molecular:1269.9Voreloxin
CAS:<p>Voreloxin (SNS-595) is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2.</p>Fórmula:C18H19N5O4SPureza:98%Cor e Forma:SolidPeso molecular:401.44TAT-GluN2BCTM
CAS:<p>TAT-GluN2BCTM is a membrane-permeable peptide that selectively targets active DAPK1 (Death-associated protein kinase 1) for lysosomal degradation, thereby</p>Fórmula:C224H374N86O54Pureza:98%Cor e Forma:SolidPeso molecular:5135.91Mcl-1 inhibitor 15
<p>Mcl-1 Inhibitor 15 (Compound (Ra)-15), with a K i of 0.02 nM, is utilized in cancer research [1].</p>Fórmula:C40H42ClFN6O4SCor e Forma:SolidPeso molecular:757.32Thrombospondin-1 (1016-1023) (human, bovine, mouse)
CAS:<p>Thrombospondin-1 (1016-1023) (human, bovine, mouse) is part of Thrombospondin-1 (TSP-1), a peptide with CD47 agonism.</p>Fórmula:C56H81N13O10SPureza:99.23%Cor e Forma:SolidPeso molecular:1128.39HDAC-IN-84
<p>HDAC-IN-84 (compound 4a) is a potent HDAC inhibitor with IC50 values of 0.0045, 0.015, 0.013, 0.038, 5.8, and 26 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC11, respectively. It effectively inhibits the proliferation of leukemia cells without causing toxicity.</p>Fórmula:C17H21N3O5SCor e Forma:SolidPeso molecular:379.431
