Apoptose
Os inibidores da apoptose são compostos que previnem ou retardam o processo de morte celular programada, conhecido como apoptose. Esses inibidores são vitais no estudo dos mecanismos de sobrevivência celular e são usados para investigar doenças onde a apoptose é desregulada, como câncer, distúrbios neurodegenerativos e doenças autoimunes. Ao modular a apoptose, esses inibidores podem ajudar no desenvolvimento de terapias destinadas a controlar a morte celular. Na CymitQuimica, oferecemos uma ampla seleção de inibidores da apoptose de alta qualidade para apoiar sua pesquisa em biologia celular, oncologia e áreas relacionadas.
Subcategorias de "Apoptose"
- ASK(9 produtos)
- BCL(1 produtos)
- Caspase(154 produtos)
- FOXO1(2 produtos)
- IAP(67 produtos)
- Mdm2(12 produtos)
- PD-1/PD-L1(135 produtos)
- PDK(9 produtos)
- PERK(23 produtos)
- Serina/treonina quinase(17 produtos)
- Survivina(14 produtos)
- TNF(93 produtos)
- c-RET(61 produtos)
- p53(63 produtos)
Exibir 6 mais subcategorias
Foram encontrados 6225 produtos de "Apoptose"
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LP23
LP23, a non-arylmethylamine PD-1/PD-L1 inhibitor (IC 50: 16.7 nM), exhibits anti-tumor activity through the restoration of immune cell function in HepG2/JurkatFórmula:C27H27N3O5SPureza:98%Cor e Forma:SolidPeso molecular:505.59Compound TPX-0046
CAS:Compound TPX-0046 is an inhibitor of RET. Compound TPX-0046 can inhibit the RET autophosphorylation. Compound TPX-0046 can be used for the research of cancer.Fórmula:C21H21FN6O3Pureza:99.94%Cor e Forma:SoildPeso molecular:424.43IRF1-IN-1
CAS:IRF1-IN-1 (Compound I-2) is an IRF1 inhibitor , inhibiting the cleavage of Caspase 1, GSDMD, IL-1, and PARP1,protecting against skin inflammatory damage.Fórmula:C22H24N4O4SPureza:99.88%Cor e Forma:SolidPeso molecular:440.52PROTAC TRIB2 degrader-1
PROTAC TRIB2 degrader-1 (Compound 5k) is a potent TRIB2 degrader that selectively induces TRIB2 degradation via the CRBN-dependent ubiquitin-proteasome pathway. It effectively inhibits cell proliferation and induces cell apoptosis (apoptosis), making it useful in cancer research.Fórmula:C45H45FN8O6Cor e Forma:SolidPeso molecular:812.89SM-164 Hydrochloride (957135-43-2 free base)
SM-164 Hydrochloride: cell-permeable, binds to XIAP (BIR2/3 domains), IC50 of 1.39 nM, potent XIAP antagonist.Fórmula:C62H85ClN14O6Pureza:98%Cor e Forma:SolidPeso molecular:1157.88hMcl-1-IN-1
hMcl-1-IN-1 (Compound 9) is an hMcl-1 inhibitor based on a His224 arylsulfonyl fluoride, displaying an IC50 value of 5.8 nM.Fórmula:C69H113FN20O19SCor e Forma:SolidPeso molecular:1577.82TPP-resveratrol
TPP-resveratrol is a conjugate of Resveratrol and triphenylphosphine (TPP), noted for its anticancer activity. This compound enhances the efficacy of Resveratrol by facilitating its targeted delivery to mitochondria, thus inducing mitochondrial-mediated cell apoptosis (apoptosis).Fórmula:C36H32BrO4PCor e Forma:SolidPeso molecular:639.51SCR7
CAS:SCR7, a specific DNA Ligase IV inhibitor, blocks nonhomologous end-joining (NHEJ).Fórmula:C18H14N4OSPureza:98%Cor e Forma:SolidPeso molecular:334.4FA4-Cu
FA4-Cu is a compound formed from the effective pancreatic cancer inhibitor FA4 and Cu(II), which can induce apoptosis by triggering ER and mitochondrial stress.Fórmula:C27H33Cl2CuN5O2SCor e Forma:SolidPeso molecular:626.1UM4118
CAS:UM4118 (N-quinolin-8-ylpyridine-2-carboxamide) is a copper ion carrier used in the study of acute myeloid leukemia.Fórmula:C15H11N3OPureza:99.76%Cor e Forma:SolidPeso molecular:249.27Sandacanol
CAS:Sandacanol (Sandranol) is an olfactory receptor (OR10H1) agonist.Sandacanol induces cell cycle arrest and partial apoptosis in bladder cancer cells.Fórmula:C14H24OPureza:99.59%Cor e Forma:SolidPeso molecular:208.34BMS-986156
BMS-986156 is a fully humanized IgG1 agonist monoclonal antibody that targets the glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR). It binds to GITR and enhances the activation of T effector cells while deactivating T regulatory cells. BMS-986156 is applicable for research in advanced solid tumors.Giloralimab
CAS:Giloralimab (ABBV-927) is a antibody targeting CD40 with anticancer activity for the study of triple-negative breast cancer and non-small cell lung cancer.Pureza:95.6% (SDS-PAGE); 95.1% (SEC-HPLC) - 95.6% (SDS-PAGE); 95.1% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:146.34 kDaBCL-XL-IN-1
BCL-XL-IN-1 (Compound 11) is a selective inhibitor of BCL-XL, exhibiting a Ki of less than 0.01 nM against BCL-XLTR-FERT. It is primarily used in cancer research.Fórmula:C46H55N7O6SCor e Forma:SolidPeso molecular:834.04BMH-7 HCl
BMH-7 HCl is a p53 activator, showing anti-cancer activity by activating the p53 pathway.Fórmula:C20H22ClN5OPureza:99.62%Cor e Forma:SolidPeso molecular:383.88Pantoprazole Sodium Hydrate
CAS:Pantoprazole Sodium Hydrate (BY1023 (sodium hydrate)) is a proton pump inhibitor drug, used for short-term treatment of erosion and ulceration of the esophagusFórmula:C16H14F2N3NaO4SH2OPureza:98.32%Cor e Forma:SolidPeso molecular:432.37Sarglaroids F
Sarglaroids F (compound 6), an anti-inflammatory agent extracted from the roots of Grass Coral, suppresses LPS/ATP-induced IL-1β secretion by modulating K+Fórmula:C38H44O12Pureza:98%Cor e Forma:SolidPeso molecular:692.75Antitumor agent-103
Antitumor Agent-103 (compound 24l) induces apoptosis and possesses antiproliferative and anti-colony formation properties.Fórmula:C36H36N8O9S2Pureza:98%Cor e Forma:SolidPeso molecular:788.85Anticancer agent 132
Compound Rh1 (Anticancer agent 132) acts as an inducer of apoptosis and autophagy, exhibiting both antitumor and antimetastatic activities.Fórmula:C24H16Cl3F3N5ORhPureza:98%Cor e Forma:SolidPeso molecular:656.68SACLAC
CAS:SACLAC is a cysteine asparaginase activation inhibitor with antitumor activity used in the study of acute myeloid leukemia and cancer.Fórmula:C20H40ClNO3Pureza:97.03%Cor e Forma:SoildPeso molecular:377.99IMMH 010 maleate
CAS:IMMH 010 maleate (YPD-30 maleate) is a programmed cell death ligand 1 inhibitor used in the study of neurological disorders and advanced malignant solid tumors.Fórmula:C36H36BrClN2O9Cor e Forma:SoildPeso molecular:756.04PROTAC PD-1/PD-L1 degrader-1
CAS:PROTAC PD-1/PD-L1 degrader-1, a Cereblon-based inhibitor, blocks PD-1/PD-L1 with 39.2 nM IC50, boosting immune response and reducing PD-L1 via lysosomes.Fórmula:C59H58ClN7O11Pureza:99.07%Cor e Forma:SolidPeso molecular:1076.59Ac-FEID-CMK TFA
Ac-FEID-CMK TFA is a zebrafish GSDMEb-derived peptide inhibitor that acts by inhibiting the caspy2-mediated atypical inflammatory vesicle pathway.Fórmula:C29H38ClF3N4O11Pureza:95%Cor e Forma:SolidPeso molecular:711.08Antitumor agent-113
Antitumor Agent-113 exhibits cytotoxicity in A549 cells, with an IC50 of 46.60 μM, and induces apoptosis, making it applicable for research in non-small cellFórmula:C21H22ClN5O2SPureza:98%Cor e Forma:SolidPeso molecular:443.95PIM-1/CK2-IN-2
PIM-1/CK2-IN-2 (compound 3aA) is an inhibitor of the PIM-1/CK2 enzymes. This compound can induce the mitochondrial apoptosis pathway in CCRF-CEM cells and is utilized in cancer research.Fórmula:C15H8Br4N2OCor e Forma:SolidPeso molecular:551.85TP4 (Nile tilapia piscidin)
CAS:TP4 (Nile tilapia piscidin) is an orally active piscidin-like antimicrobial peptide that exhibits inhibition of various gram-positive and negative bacterialFórmula:C135H226N50O27Pureza:98%Cor e Forma:SolidPeso molecular:2981.56[Au(L4)(CyJohnPhos)]SbF6
[Au(L4)(CyJohnPhos)]SbF6 is a gold-containing compound that exhibits inhibitory effects on cyclooxygenase-1/2 (COX-1/2), suppresses the proliferation of colon cancer cells Caco2-/TC7 with an IC50 of 0.98 μM, and induces cell apoptosis (apoptosis). Additionally, [Au(L4)(CyJohnPhos)]SbF6 acts as an inhibitor of thioredoxin reductase (TrxR) and demonstrates antioxidative activity by modulating ROS levels.Fórmula:C44H56AuF6NO4PSSbCor e Forma:SolidPeso molecular:1158.68TRAP-1
TRAP-1 (XJZ-06-462) is a p53 transcription activator that effectively activates mutant p53 and triggers the transcription of p53 target genes. In the p53Y220C pancreatic cell line, TRAP-1 rapidly upregulates p21 and other p53 target genes. TRAP-1 also inhibits cell proliferation, exhibiting IC50 values of 3.94 μM and 0.531 μM in BxPC-3 and A549 cell lines, respectively. Additionally, TRAP-1 modulates autophagy in lung cancer cells and provides protection against oxidative stress and apoptosis.Fórmula:C57H66ClF3N11O3PSCor e Forma:SolidPeso molecular:1108.69CQ-Mito
CQ-Mito, a derivative of CQ, demonstrates excellent phototherapeutic efficacy with a PI value of 167. This compound induces cell death through mechanisms such as apoptosis and ferroptosis. It mediates mitochondrial dysfunction, characterized by alterations in mitochondrial morphology and loss of MMP. Additionally, CQ-Mito effectively inhibits tumor growth in 3D multicellular tumor spheroid models.Fórmula:C45H42BrN6O4PCor e Forma:SolidPeso molecular:841.73XY221
XY221 (Compound 16o) selectively inhibits BRD4 BD2 with an IC50 of 5.8 nM. It demonstrates high selectivity for pan-BD2 and BRD4 BD2 domains, being 667 times more selective than for BRD4 BD1, and 9-32 times more selective than for BRD2/3/T BD2. XY221 can induce apoptosis in MV4-11 cells and exhibits anti-cancer activity.Fórmula:C32H34FN3O5Cor e Forma:SolidPeso molecular:559.628CPD-10
CAS:CPD-10 is a potent bifunctional PROTAC degrader targeting CCND1 and CDK4 and exhibits antiproliferative effects. It induces apoptosis and reduces the protein expression of Cyclin D1, Cyclin D3, CDK4, and P-Rb(5807/811) in a dose-dependent manner.Fórmula:C46H61N15O4Cor e Forma:SolidPeso molecular:888.08PROTAC HIF-1α degrader-1
PROTAC HIF-1α degrader-1 (compound V2) is an effective proteolysis-targeting chimeric (PROTAC) degrader of hypoxia-inducible factor-1α (HIF-1α), with an IC50 value of 7.54 µM. This compound exhibits anti-proliferative activity, reduces HIF-1α protein expression, and induces apoptosis.Fórmula:C51H72N6O7SCor e Forma:SolidPeso molecular:913.22NDI-Lyso
CAS:NDI-Lyso is an anticancer agent targeting lysosomes, functioning through an enzyme-induced self-assembly (EISA) mechanism catalyzed by Cathepsin B. In cancer cell lysosomes, it forms rigid long fibers, promoting lysosomal swelling, lysosomal membrane permeabilization (LMP), and membrane disruption. This leads to non-classical caspase-independent apoptosis (Apoptosis). NDI-Lyso demonstrates significant selective anticancer activity across various cancer cell lines and drug-resistant cancer cells (IC50 approximately 10 μM), while exhibiting low toxicity to normal cells (IC50 > 60 μM).Fórmula:C71H100N22O13Cor e Forma:SolidPeso molecular:1469.69RIPK2/3-IN-1
RIPK2/3-IN-1 is a potent inhibitor of both RIPK2 and RIPK3 kinases, exhibiting IC50 values of 3 nM for RIPK2 and 117 nM for RIPK3.Fórmula:C24H16N4O2S2Pureza:98%Cor e Forma:SolidPeso molecular:456.54MG-277
MG-277 is a molecular glue compound transformed from PROTAC degradation agent, MG-277 potently inhibits tumor cell growth in a p53-independent manner.Fórmula:C41H42Cl2FN5O5Pureza:98%Cor e Forma:SolidPeso molecular:774.71VEGFR-2-IN-61
VEGFR-2-IN-61 (Compound 7b) is an inhibitor of VEGFR-2 with an IC50 of 2.83 µM. It effectively inhibits the proliferation of various cancer cells, including MCF-7 cells, with an IC50 of 2.12 µM. Additionally, VEGFR-2-IN-61 suppresses cell migration and induces oxidative stress and apoptosis in MCF-7 cells.Fórmula:C27H25N5OCor e Forma:SolidPeso molecular:435.52CGP-74514
CAS:CGP-74514,CDK1 inhibitor (IC50=25 nM). Induces G2/M arrest, apoptosis. Used in bladder cancer research.Fórmula:C19H24ClN7Pureza:98.54%Cor e Forma:SoildPeso molecular:385.89ALK/ROS1 inhibitor 2e HCL
(R)-1-(2-((2-MeO-4-(piperazin-1-yl)phenyl)amino)pyridin-4-yl)-N-(4-(CF3O)benzyl)piperidine-3-carboxamide HCl is anti-apoptotic and anti-cancer.Fórmula:C30H36ClF3N6O3Pureza:98.66%Cor e Forma:SoildPeso molecular:621.09GJ19
GJ19 is a PD-L1 inhibitor with an IC50 of 32.06 nM. It binds effectively to human and mouse PD-L1 proteins, exhibiting KD values of 171 nM and 290 nM, respectively. In a co-culture model of HepG2/hPD-L1 and Jurkat T/hPD-1 cells, GJ19 promotes HepG2 cell death in a concentration-dependent manner. In the B16-F10 melanoma mouse model, GJ19 demonstrates significant tumor growth inhibition. GJ19 is applicable in tumor immunotherapy research.Cor e Forma:Odour SolidBcl-xL antagonist 2
CAS:Bcl-xL antagonist 2 is an effective and selective antagonist of Bcl-xL with an IC50 of 91 nM and a Ki of 65 nM.Fórmula:C21H16N4O3S2Pureza:99.81%Cor e Forma:SolidPeso molecular:436.51Ref: TM-T38622
1mg77,00€5mg166,00€1mL*10mM (DMSO)182,00€10mg248,00€25mg447,00€50mg622,00€100mg800,00€200mg1.071,00€Pegsunercept
CAS:Pegsunercept (PEG sTNF-RI), a pegylated monoclonal antibody, selectively binds to TNFA, incorporating a polyethylene glycol (pegol) moiety [1].Cor e Forma:LiquidCitatuzumab bogatox
CAS:Citatuzumab bogatox is a recombinant immunotoxin targeting EpCAM with the toxin bouganin, inducing apoptosis in EpCAM-positive tumors.Cor e Forma:LiquidTilogotamab
CAS:Tilogotamab (GEN-1029) is an agonistic hexameric complex targeting two independent epitopes on DR5, used for studying multiple myeloma (MM).Pureza:95%Cor e Forma:LiquidPeso molecular:144.88 kDaRopeginterferon alfa-2b
CAS:Ropeginterferon alfa-2b (Ropeginterferon alfa-2b-njft), a monopegylated interferon-alpha (IFN-α), is utilized in the study of myeloproliferative neoplasms [1].Cor e Forma:LiquidTibulizumab
CAS:Tibulizumab (LY 3090106) is a bispecific antibody for BAFF & IL-17A; Kds: 60 & 14 pM; for autoimmune research.Cor e Forma:LiquidRetifanlimab
CAS:Retifanlimab (MGA-012) is a monoclonal antibody targeting programmed cell death protein 1 (PD-1). Retifanlimab is used in studies of Merkel cell carcinoma.Pureza:98.56% (SEC-HPLC) - >95.0% (SDS-PAGE); 100% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:148.28 kDaDaporinad hydrochloride
CAS:Daporinad hydrochloride (FK 866 hydrochloride) is a NAMPT inhibitor with antitumor and antiangiogenic activity that induces apoptosis in tumor cells.Fórmula:C24H30ClN3O2Pureza:98.99%Cor e Forma:SolidPeso molecular:427.97Spiroplatin
CAS:Spiroplatin (TNO-6) is a novel platinum-containing analogue with antitumor activity that is commonly used in the study of solid tumors.Fórmula:C8H18N2O4PtSPureza:≥98%Cor e Forma:SolidPeso molecular:433.39Garivulimab
CAS:Garivulimab (BGB-A333), a humanized IgG1 monoclonal antibody, binds to PD-L1, blocking PD-1 interaction and exhibiting antitumor activity.Cor e Forma:Liquid
