Apoptose
Os inibidores da apoptose são compostos que previnem ou retardam o processo de morte celular programada, conhecido como apoptose. Esses inibidores são vitais no estudo dos mecanismos de sobrevivência celular e são usados para investigar doenças onde a apoptose é desregulada, como câncer, distúrbios neurodegenerativos e doenças autoimunes. Ao modular a apoptose, esses inibidores podem ajudar no desenvolvimento de terapias destinadas a controlar a morte celular. Na CymitQuimica, oferecemos uma ampla seleção de inibidores da apoptose de alta qualidade para apoiar sua pesquisa em biologia celular, oncologia e áreas relacionadas.
Subcategorias de "Apoptose"
- ASK(6 produtos)
- BCL(11 produtos)
- Caspase(125 produtos)
- FOXO1(3 produtos)
- IAP(66 produtos)
- Mdm2(12 produtos)
- PD-1/PD-L1(125 produtos)
- PDK(9 produtos)
- PERK(25 produtos)
- Serina/treonina quinase(15 produtos)
- Survivina(13 produtos)
- TNF(92 produtos)
- c-RET(51 produtos)
- p53(62 produtos)
Exibir 6 mais subcategorias
Foram encontrados 5592 produtos de "Apoptose"
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Prodigiosin hydrochloride
CAS:<p>Prodigiosin hydrochloride is a bioactive red pigment from bacteria with antibacterial, antifungal, anticancer properties, and inhibits Wnt/β-catenin.</p>Fórmula:C20H26ClN3OCor e Forma:SolidPeso molecular:359.9JC2-11
CAS:<p>JC2-11 is an anti-inflammatory agent blocking NLRC 4, AIM 2, ROS production, caspase-1 activity, and reducing GSDMD, IL-1β, and LDH in vesicles.</p>Fórmula:C17H15FO4Pureza:98.6%Cor e Forma:SoildPeso molecular:302.3MDM2/4-p53-IN-2
<p>MDM2/4-p53-IN-2 (2q) is a dual MDM2/MDM4 inhibitor, p53 activator; IC50: 70.7 nM(MDM2), 81.4 nM(MDM4); tumor suppressor.</p>Fórmula:C25H17Cl3FN3O3Cor e Forma:SolidPeso molecular:532.78β-Amyloid (1-40) (rat)
CAS:<p>Rat form of the beta-Amyloid (1-40) peptide</p>Fórmula:C190H291N51O57SPureza:98%Cor e Forma:SolidPeso molecular:4233.76WEHI-3773
<p>WEHI-3773 is an inhibitor of the interaction between VDAC2 and either BAK or BAX. It prevents BAX-mediated apoptosis (Apoptosis) by blocking the recruitment of BAX to the mitochondria through VDAC2. Conversely, WEHI-3773 promotes BAK-mediated apoptosis (Apoptosis) by limiting VDAC2's inhibitory sequestration of BAK. This compound shows promise for research in the field of cancer therapy.</p>Cor e Forma:Odour Solid9,11-Dehydroergosterol peroxide
CAS:<p>9,11-Dehydroergosterol peroxide is a useful organic compound for research related to life sciences.</p>Fórmula:C28H42O3Cor e Forma:SolidPeso molecular:426.641CDK9-Cyclin T1 PPI-IN-1
<p>CDK9-Cyclin T1 PPI-IN-1 (Compound B19) is a selective inhibitor of the CDK9-Cyclin T1 protein-protein interaction (PPI), suppressing cell proliferation in TNBC</p>Pureza:98%Cor e Forma:Odour SolidGanoderic acid Mf
CAS:<p>Ganoderic acid Mf: antitumor triterpenoid, arrests G1 cell cycle, selective for cancer cells, triggers apoptosis via mitochondria.</p>Fórmula:C32H48O5Cor e Forma:SolidPeso molecular:512.72Narasin (sodium salt)
CAS:<p>Narasin (sodium salt) (HainanMycin) induces tumor necrosis factor-related apoptosis-induced ligand (TRAIL)-mediated apoptosis by ER stress in glioma cells and</p>Fórmula:C43H71NaO11Pureza:98%Cor e Forma:SolidPeso molecular:787.01Bifenthrin
CAS:<p>Bifenthrin is a synthetic pyrethroid insecticide.Bifenthrin induces cell death in bovine mammary epithelial cells through ROS generation, disruption of calcium homeostasis, and alteration of the MAPK signaling cascade.Bifenthrin induces apoptosis by inducing cell-cycle arrest.</p>Fórmula:C23H22ClF3O2Pureza:99.25%Cor e Forma:SolidPeso molecular:422.87Nargenicin
CAS:<p>Nargenicin: a macrolide antibiotic effective against S. aureus, MRSA, M. luteus; inhibits bacterial DnaE and reduces inflammation and leukemia cell growth.</p>Fórmula:C28H37NO8Cor e Forma:SolidPeso molecular:515.6Ferroptosis-IN-12
<p>Ferroptosis-IN-12 (Cpd-A1) is an inhibitor of ferroptosis. It effectively suppresses ferroptosis in mouse renal tubular epithelial cells (mTECs) treated with Erastin and improves renal function in dose-dependent manners in mouse models of acute kidney injury (AKI) induced by ischemia/reperfusion (I/R) or cecal ligation and puncture (CLP). This compound also reduces renal tubular damage and eliminates inflammation. Exhibiting good plasma stability and high distribution in renal tissues during pharmacokinetic studies in mice, Ferroptosis-IN-12 shows promising potential for research in the field of AKI.</p>Cor e Forma:Odour SolidApoptosis inducer 12
CAS:<p>Apoptosis Inducer 12 (Compound 3z) is a compound that promotes cell death via the mitochondrial pathway and is utilized in cancer research [1].</p>Fórmula:C26H27N3O5Cor e Forma:SolidPeso molecular:461.51Thalidomide-NH-C5-NH2 hydrochloride
CAS:<p>Functionalized cereblon ligand with E3 ligase and alkylC5 linker for PROTAC R&D; ready for protein conjugation. Formerly Pomalidomide-linker 4.</p>Fórmula:C18H23ClN4O4Cor e Forma:SolidPeso molecular:394.85Manelimab
CAS:<p>Manelimab is a monoclonal antibody that inhibits programmed death-ligand 1 ( PD-L1 ) [1] .</p>Cor e Forma:LiquidHDAC-IN-57
CAS:<p>HDAC-IN-57 is an orally active pan-inhibitor of histone deacetylase (HDAC), inhibiting HDAC1, HDAC2, HDAC6, and HDAC8 with IC50 values of 2.07 nM, 4.71 nM, 2.4</p>Fórmula:C21H19N3O4Pureza:98.38%Cor e Forma:SoildPeso molecular:377.39Thalidomide-NH-PEG8-Ts
CAS:<p>Thalidomide-NH-PEG8-Ts: a synthesized Thalidomide-PEG8 E3 ligase linker for PROTAC-mediated IDO1 degradation.</p>Fórmula:C36H49N3O14SCor e Forma:SolidPeso molecular:779.86AZD5582 dihydrochloride
CAS:<p>Dimeric Smac mimetic inhibits XIAP, cIAP1/2 (IC50: 15/15/21 nM); binds BIR3 domain; degrades cIAPs; induces apoptosis in cancer cells; shrinks tumors in mice.</p>Fórmula:C58H80Cl2N8O8Cor e Forma:SolidPeso molecular:1088.23HDAC-IN-77
<p>HDAC-IN-77 (HL-5s), an HDAC inhibitor, has the capability to induce ferroptosis and suppress the Nrf2/HO-1 signaling pathway. This compound is utilized in cancer research.</p>Fórmula:C22H26N4O2SCor e Forma:SolidPeso molecular:410.53ROS inducer 4
<p>Compound TE3, also known as ROS inducer 4, serves as a mitochondrial inhibitor. This compound induces a variety of mitochondria-related physiological alterations in tumors, including mitochondrial fragmentation, intense generation and accumulation of ROS, reduced mitochondrial membrane potential, and lower ATP content. Additionally, it activates ROS-mediated apoptotic signaling within mitochondria.</p>Fórmula:C49H62BrO4PCor e Forma:SolidPeso molecular:825.89TCF4/β-catenin-IN-1
<p>TCF4/β-catenin-IN-1 (Compound 8b) is an inhibitor of TCF4/β-catenin that induces apoptosis. This compound enhances the expression of p53, caspase-3, caspase-8, caspase-9, and Bax proteins, while reducing Bcl-2 protein levels. TCF4/β-catenin-IN-1 also inhibits CYP3A4, CYP1A2, and CYP2C19, demonstrating significant cytotoxic activity in cancer cells.</p>Fórmula:C23H15N7O3Cor e Forma:SolidPeso molecular:437.41Antitumor photosensitizer-6
CAS:<p>Compound Ru2 (Antitumor photosensitizer-6) exhibits synergistic type I/II photosensitization and photocatalytic activities under illumination at 595 nm. It causes oxidative redox imbalance within cells, affecting biosynthesis and metabolic processes, leading to cell apoptosis (Apoptosis). Compound Ru2 is applicable in studies of photodynamic therapy (PDT).</p>Fórmula:C74H46F26N14P4Ru2S3Cor e Forma:SolidPeso molecular:2047.44iNOS/TopoI-IN-1
<p>Compound AuL9, also known as iNOS/TopoI-IN-1, is a multi-target hybrid molecule possessing anti-tumor, anti-inflammatory, and antioxidant properties. This compound effectively inhibits the growth of MCF-7 and MDA MB-231 breast cancer cells in vitro, exhibiting IC50 values of 3.5 μM and 6.3 μM respectively. It also prompts DNA damage and apoptosis in these cells by inhibiting human topoisomerase I (TopoI) with a K_i of 2.72 μM. Additionally, iNOS/TopoI-IN-1 reduces the expression of iNOS by suppressing the activation of NF-kB, with a K_i of 1.49 μM.</p>Fórmula:C34H40AuBrCl2N3OSCor e Forma:SolidPeso molecular:886.541,8-Cineole
CAS:<p>Eucalyptol, a natural monoterpenoid and cyclic ether found in eucalyptus species, effectively controls excessive airway mucus secretion and asthma by inhibiting pro-inflammatory cytokines. It serves as an efficacious treatment for non-purulent sinusitis, reducing inflammation and pain when applied topically, and demonstrating leukemic cell-killing capabilities in vitro.</p>Fórmula:C10H18OPureza:97.44% - 97.44%Cor e Forma:SolidPeso molecular:154.25Polyphyllin G
CAS:<p>Polyphyllin G (Polyphyllin VII), the the main member of polyphyllin family, shows strong anticancer activity against several carcinomas.</p>Fórmula:C51H84O22Pureza:98%Cor e Forma:SolidPeso molecular:1049.21Neocarzinostatin
CAS:<p>Neocarzinostatin is an effective DNA-damaging, anti-tumor antibiotic.</p>Pureza:98%Cor e Forma:SolidPeso molecular:N/ACitreoviridin
CAS:<p>Citreoviridin from Penicillium citreoviride blocks brain Na+/K+-ATPase; boosts Na+/K+- and Mg2+-ATPase in microsomes dose-dependently.</p>Fórmula:C23H30O6Pureza:98%Cor e Forma:SolidPeso molecular:402.48Iparomlimab
CAS:<p>Iparomlimab: anti-PD-1 IgG4κ antibody, targets PSB103 γ4/κ-chains, forms dimers, used in cancer research.</p>Cor e Forma:LiquidFW-1
<p>FW-1 is a type I inhibitor of FLT3, with an IC50 of approximately 1 μM. It exhibits cytotoxic effects in FLT3-mutant AML cells, causes cell cycle arrest at the G0/G1 phase, and induces apoptosis in MV4-11 and MOLM-13 cells.</p>Fórmula:C24H27N7OCor e Forma:SolidPeso molecular:429.517TOFA-Plasmalogen
<p>TOFA-Plasmalogen (compound 1), a derivative of glyceraldehyde, exhibits ferroptosis-inducing properties. This compound promotes lipid peroxidation in cell membranes, leading to cytotoxic effects with an inhibition concentration (IC 50 = 32.87 μM).</p>Fórmula:C33H62NO7PCor e Forma:SolidPeso molecular:615.82Antiproliferative agent-27
<p>Antiproliferative Agent-27 (Compound 11) is a notable antiproliferative agent that markedly diminishes tumor cell colony formation and induces apoptosis,</p>Fórmula:C26H40FNO6SPureza:98%Cor e Forma:SolidPeso molecular:513.66Apoptosis inducer 11
<p>Apoptosis Inducer 11 (compound 3u) promotes apoptosis via the mitochondrial pathway and elicits a G2/M block alongside a marked reduction in the S phase within</p>Fórmula:C27H28N2O5Pureza:98%Cor e Forma:SolidPeso molecular:460.52Anticancer agent 106
<p>Compound 106 (compound 10ic) induces apoptosis in B16-F10 melanoma cells and potently inhibits metastatic nodules in mouse models of lung metastatic melanoma,</p>Fórmula:C26H25N3O4SPureza:98%Cor e Forma:SolidPeso molecular:475.56MTX-23
CAS:<p>MTX-23, an AR-targeted Proteolysis Targeting Chimera (PROTAC), effectively degrades both AR-V7 and AR-FL, inhibiting the proliferation of CaP cells and inducing</p>Fórmula:C43H53F2N7O7S2Cor e Forma:SolidPeso molecular:882.05Thalidomide-PEG2-NH2
CAS:<p>Thalidomide-PEG2-NH2: synthetic E3 ligase ligand-linker, combines Thalidomide-based cereblon and PROTAC linker.</p>Fórmula:C17H19N3O6Cor e Forma:SolidPeso molecular:361.354Ac-Pro-Gly-Pro-OH
CAS:<p>Ac-Pro-Gly-Pro-OH can be used as a CXCR2 agonist with bactericidal and anti-inflammatory activity for the study of sepsis and lung inflammation.</p>Fórmula:C14H21N3O5Pureza:98.32%Cor e Forma:SolidPeso molecular:311.33Antitumor agent-96
<p>"Antitumor agent-96 (Compound D34) is a potent MRE11 inhibitor that down-regulates the homologous recombination (HR) pathway by binding to and suppressing the</p>Fórmula:C27H32N2O2Pureza:98%Cor e Forma:SolidPeso molecular:416.56Uvarigrin
CAS:<p>Uvarigrin induces tumor multidrug resistance cell apoptosis and triggers Caspase-9 activation. Uvarigrin is isolated from the roots of Uvaria calamistrata.</p>Fórmula:C37H68O6Pureza:98%Cor e Forma:SolidPeso molecular:608.93Thalidomide-5-PEG2-Cl
CAS:<p>Thalidomide-5-PEG2-Cl is a cereblon ligand that recruits CRBN protein and forms PROTACs through linker conjugation.</p>Fórmula:C17H17ClN2O6Cor e Forma:SolidPeso molecular:380.78FKBP12 Ligand-Linker Conjugate 1
CAS:<p>FKBP12 Ligand-Linker Conjugate 1 is a complex comprising a target protein ligand for FKBP12 and a linker, which is utilized in the synthesis of the PROTAC degrader MC-25B.</p>Fórmula:C42H63N3O11Cor e Forma:SolidPeso molecular:785.963Targaprimir-96
CAS:<p>Targaprimir-96 is a potent microRNA-96 (miR-96) processing inhibitor.</p>Fórmula:C77H102N18O7Pureza:98%Cor e Forma:SolidPeso molecular:1391.75CWI1-2 HCL
CAS:<p>CWI1-2 HCL: Potent IGF2BP2 inhibitor, induces apoptosis/differentiation, targets leukemia therapy.</p>Fórmula:C22H18Cl4N6O3Pureza:98.09%Cor e Forma:SolidPeso molecular:556.23Flaccidoside II
CAS:<p>Flaccidoside II, an active triterpenoid saponin from Anemone flaccida rhizome, both inhibits proliferation and induces apoptosis in Malignant Peripheral Nerve</p>Fórmula:C59H96O25Pureza:98%Cor e Forma:SolidPeso molecular:1205.38EGFR-IN-151
<p>EGFR-IN-151 (Compound 10) inhibits EGFR and its downstream signaling pathways ERK/STAT3. It effectively suppresses the proliferation of various lung cancer cells, with IC50 values of 11.7, 5.19, 7.32, and 1.53 μM for NCI-H1781, HCC827, NCI-H3255, and NCI-H1975, respectively. Additionally, EGFR-IN-151 hinders colony formation and cell migration in H1975, induces G1 phase cell cycle arrest, and triggers apoptosis in H1975 cells.</p>Cor e Forma:Odour SolidGPX4-IN-14
<p>GPX4-IN-14 (compound 2c) acts as a GPX4 inhibitor, exhibiting both free radical scavenging activity (with a maximum scavenging rate of 72.52%) and anti-tumor proliferation activity in vitro. This compound targets GPX4 protein, elevating lipid peroxide and intracellular Reactive Oxygen Species (ROS) levels, which induces ferroptosis and contributes to its anti-tumor proliferation effects.</p>Fórmula:C26H39NO8SeCor e Forma:SolidPeso molecular:572.55Ac-YVAD-CHO acetate
<p>Ac-YVAD-CHO acetate, potent reversible ICE and caspase-1 inhibitor; K_i: 3.0 nM (mouse), 0.76 nM (human); blocks IL-lβ production.</p>Fórmula:C25H36N4O10Cor e Forma:SolidPeso molecular:552.572'-epi-2'-O-Acetylthevetin B
CAS:<p>2'-Epi-2'-O-Acetylthevetin B (GHSC-74), a cardiac glycoside extractable from Cerbera manghas L.</p>Fórmula:C44H68O19Pureza:98%Cor e Forma:SolidPeso molecular:901EGFR-IN-78
<p>EGFR-IN-78 (compound A5), a 2-aminopyrimidine derivative, serves as a reversible EGFR C797S-TK inhibitor and an apoptosis inducer.</p>Fórmula:C23H32BrN7O2SPureza:98%Cor e Forma:SolidPeso molecular:550.51Ferroptosis-IN-1
<p>Ferroptosis-IN-1, a diterpene derived from A.</p>Fórmula:C22H34O5Pureza:98%Cor e Forma:SolidPeso molecular:378.5DB818 dihydrochloride
<p>DB818 dihydrochloride is the dihydrochloride salt form of DB818. It acts as an inhibitor of Homeobox A9 (HOXA9). By reducing the formation of the HOXA9-DNA complex, DB818 dihydrochloride inhibits the growth of AML cell lines OCI/AML3, MV4-11, and THP-1 and induces cell apoptosis (apoptosis).</p>Cor e Forma:Odour Solid
