Apoptose
Os inibidores da apoptose são compostos que previnem ou retardam o processo de morte celular programada, conhecido como apoptose. Esses inibidores são vitais no estudo dos mecanismos de sobrevivência celular e são usados para investigar doenças onde a apoptose é desregulada, como câncer, distúrbios neurodegenerativos e doenças autoimunes. Ao modular a apoptose, esses inibidores podem ajudar no desenvolvimento de terapias destinadas a controlar a morte celular. Na CymitQuimica, oferecemos uma ampla seleção de inibidores da apoptose de alta qualidade para apoiar sua pesquisa em biologia celular, oncologia e áreas relacionadas.
Subcategorias de "Apoptose"
- ASK(6 produtos)
- BCL(11 produtos)
- Caspase(125 produtos)
- FOXO1(3 produtos)
- IAP(66 produtos)
- Mdm2(12 produtos)
- PD-1/PD-L1(125 produtos)
- PDK(9 produtos)
- PERK(25 produtos)
- Serina/treonina quinase(15 produtos)
- Survivina(13 produtos)
- TNF(92 produtos)
- c-RET(51 produtos)
- p53(62 produtos)
Exibir 6 mais subcategorias
Foram encontrados 5592 produtos de "Apoptose"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Thalidomide-5-PEG2-Cl
CAS:<p>Thalidomide-5-PEG2-Cl is a cereblon ligand that recruits CRBN protein and forms PROTACs through linker conjugation.</p>Fórmula:C17H17ClN2O6Cor e Forma:SolidPeso molecular:380.78FAK-IN-24
CAS:<p>FAK-IN-24 (Compound 9f) is a potent FAK inhibitor with an IC50 of 0.815 nM. It induces DNA damage and apoptosis, and exhibits activity against glioblastoma. FAK-IN-24 effectively inhibits proliferation of glioblastoma cell lines U87-MG (IC50= 15 nM) and U251 (IC50= 20 nM), and suppresses tumor growth in U87-MG xenograft models.</p>Fórmula:C39H45Cl2F3N8O3Cor e Forma:SolidPeso molecular:801.728TCF4/β-catenin-IN-1
<p>TCF4/β-catenin-IN-1 (Compound 8b) is an inhibitor of TCF4/β-catenin that induces apoptosis. This compound enhances the expression of p53, caspase-3, caspase-8, caspase-9, and Bax proteins, while reducing Bcl-2 protein levels. TCF4/β-catenin-IN-1 also inhibits CYP3A4, CYP1A2, and CYP2C19, demonstrating significant cytotoxic activity in cancer cells.</p>Fórmula:C23H15N7O3Cor e Forma:SolidPeso molecular:437.41GD3 Ganglioside sodium
<p>GD3 Ganglioside sodium is a crucial ganglioside in human melanoma and functions as an inducer of mitochondrial permeability. It targets mitochondria directly in a manner controlled by bcl-2. Following the aggregation of death-inducing receptors, ceramide accumulates rapidly, synthesizes GD3 ganglioside, and triggers apoptosis.</p>Cor e Forma:SolidHYS-072
<p>HYS-072 is an orally active derivative of chrysin with antitumor properties. It induces apoptosis (Apoptosis) and autophagy (Autophagy) by inhibiting the PI3K/AKT/mTOR signaling pathway, and suppresses tumor growth in xenograft models in vivo by modulating autophagy-related pathways. HYS-072 is applicable for research in treating triple-negative breast cancer.</p>Fórmula:C27H26N2O5Cor e Forma:SolidPeso molecular:458.51Multi-kinase-IN-4
<p>Multi-kinase-IN-4 (compound 5d) is a multi-targeted kinase inhibitor active against VEGFR2, EGFR, HER2, and CDK2, with respective IC50 values of 0.33, 0.22, 0.</p>Fórmula:C21H20ClFN2OSPureza:98%Cor e Forma:SolidPeso molecular:402.91AZT triphosphate TEA
<p>AZT triphosphate TFA, a Zidovudine metabolite, inhibits HIV & HBV replication and triggers mitochondrial apoptosis.</p>Cor e Forma:SolidFKBP12 Ligand-Linker Conjugate 1
CAS:<p>FKBP12 Ligand-Linker Conjugate 1 is a complex comprising a target protein ligand for FKBP12 and a linker, which is utilized in the synthesis of the PROTAC degrader MC-25B.</p>Fórmula:C42H63N3O11Cor e Forma:SolidPeso molecular:785.963AXL/Angiokinase-IN-1
<p>AXL/Angiokinase-IN-1 (compound 11b) is an inhibitor of AXL/triple angiokinase, with an IC50 of 3.75 nM for AXL expression. This compound suppresses epithelial-mesenchymal transition (EMT) in Bxpc-3 cells and prevents metastasis in lung cancer cells. Additionally, AXL/Angiokinase-IN-1 impairs the functions of vascular and fibroblast cells and induces apoptosis in both cancer and fibroblast cells. It is characterized by low toxicity and favorable metabolic stability.</p>Fórmula:C31H34ClN5O2Cor e Forma:SolidPeso molecular:544.09Siomycin A
CAS:<p>Siomycin A: thiopeptide antibiotic, selectively inhibits FOXM1, anti-tumor, induces apoptosis.</p>Fórmula:C71H81N19O18S5Pureza:98%Cor e Forma:SolidPeso molecular:1648.84IPH10
<p>IPH10 is an anticancer agent with strong antitumor effects in vivo and exhibits no liver or kidney toxicity. It significantly increases the reactive oxygen species (ROS) levels in tumor cells, decreases mitochondrial membrane potential, and induces apoptosis (apoptosis) in these cells.</p>Fórmula:C32H33NO4Cor e Forma:SolidPeso molecular:495.61Betamethasone
CAS:<p>Betamethasone (NSC-39470), a glucocorticoid steroid, has immunosuppressive and anti-inflammatory properties.</p>Fórmula:C22H29FO5Pureza:98% - 99.71%Cor e Forma:White Or Almost White Powder Solid CrystallinePeso molecular:392.46Resolvin D2 n-3 DPA
CAS:<p>RvD2 n-3 DPA is an SPM made from docosapentaenoic acid in human leukocytes, inhibiting neutrophil chemotaxis and adhesion.</p>Fórmula:C22H34O5Cor e Forma:SolidPeso molecular:378.509Carubicin
CAS:<p>Carubicin, an anthracycline antibiotic from Actinomadura carminata, disrupts DNA replication and repair by intercalating DNA and inhibiting topoisomerase II.</p>Fórmula:C26H27NO10Pureza:98%Cor e Forma:SolidPeso molecular:513.49KRASG12C IN-16
<p>KRASG12C IN-16 (Compound SK-17) is a selective, covalent, and orally active KRASG12C inhibitor. It can induce apoptosis and effectively prevent the activation of the MAPK and PI3K/mTOR signaling pathways. Additionally, KRASG12C IN-16 exhibits antitumor activity against pancreatic cancer.</p>Fórmula:C28H35ClN8O2Cor e Forma:SolidPeso molecular:551.08AChE-IN-81
<p>AChE-IN-81 (compound 22) is a reversible, selective inhibitor of AChE with an 80.0% inhibition rate and an IC50 of 3.7 μM. It binds to AChE with an affinity (Kd) of 5.37 μM. AChE-IN-81 effectively reduces apoptosis in zebrafish brain cells and shows potential neuroprotective activity in an H2O2-induced SH-SY5Y cell damage model.</p>Fórmula:C37H54ClNO5Cor e Forma:SolidPeso molecular:628.28Fluorescein-diisobutyrate-6-amide
CAS:<p>Fluorescein-diisobutyrate-6-amide, a powerful inducer of ferroptosis, shows promise for cancer research applications [1].</p>Fórmula:C62H61ClN6O16Cor e Forma:SolidPeso molecular:1181.63PKM2 modulator 1
<p>PKM2 modulator 1 (compound C998) is an effective PKM2 inhibitor with antiproliferative activity. It induces apoptosis and holds potential for research in glioblastoma studies.</p>Fórmula:C26H25N3O3Cor e Forma:SolidPeso molecular:427.5TD52 dihydrochloride
<p>TD52 dihydrochloride, an Erlotinib derivative, inhibits protein phosphatase 2A and induces apoptosis in TNBC by disrupting CIP2A/PP2A/p-Akt signaling.</p>Fórmula:C24H18Cl2N4Pureza:97.23%Cor e Forma:SoildPeso molecular:433.33Thalidomide-PEG3-NH2
CAS:<p>Thalidomide-PEG3-NH2: a cereblon-based E3 ligase ligand-linker for PROTAC tech.</p>Fórmula:C19H23N3O7Cor e Forma:SolidPeso molecular:405.407GPLGIAGQ
CAS:<p>GPLGIAGQ, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting.</p>Fórmula:C31H53N9O10Pureza:98%Cor e Forma:SolidPeso molecular:711.81HG-7-85-01
CAS:<p>HG-7-85-01 is a novel ATP-competitive and type II tyrosine kinase inhibitor targeting both wild-type and watchman mutant BCR-ABL, PDGFRα, Kit, and Src kinases.</p>Fórmula:C31H31F3N6O2SPureza:98.08%Cor e Forma:SolidPeso molecular:608.68Humulone
<p>Humulone is a natural product and has a wide range of applications in life science related research.</p>Fórmula:C21H30O5Cor e Forma:SolidPeso molecular:362.47KWCN-41
CAS:<p>KWCN-41, a RIPK1 inhibitor with 88 nM IC50, blocks necrosis, spares apoptosis, and is anti-inflammatory.</p>Fórmula:C18H17N3O2Cor e Forma:SolidPeso molecular:307.35Thalidomide-O-PEG4-Boc
CAS:<p>Thalidomide-O-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].</p>Fórmula:C28H38N2O11Pureza:98%Cor e Forma:SolidPeso molecular:578.61ZZM-1220
<p>ZZM-1220, a covalent inhibitor of histone lysine methyltransferase G9a/GLP, exhibits IC50 values of 458 nM for G9a and 924 nM for GLP.</p>Fórmula:C25H29N5O3Pureza:98%Cor e Forma:SolidPeso molecular:447.53Topoisomerase I/II inhibitor 6
<p>TopoisomeraseI/II inhibitor 6 (compound 3i) acts as an effective inhibitor of topoisomerase I and II, with IC50 values of 4.77 µM and 15 µM, respectively. Additionally, it exhibits antiproliferative activity against the human melanoma cell line LOX IMVI, demonstrating IC50 values of 26.7 µM and 25.4 µM.</p>Fórmula:C31H28F2N4O6SCor e Forma:SolidPeso molecular:622.64Calcimycin hemicalcium salt
CAS:<p>Calcimycin (A-23187) is an antibiotic calcium ionophore that raises intracellular Ca2+ to induce cell death.</p>Fórmula:C58H72CaN6O12Pureza:98%Cor e Forma:SolidPeso molecular:1085.322p53 (17-26)
CAS:<p>Peptide is p53's amino acids 17-26, contacts Mdm-2 binding domain, also called p53N.</p>Fórmula:C60H90N12O17Pureza:98%Cor e Forma:SolidPeso molecular:1251.433MB-PP1
CAS:<p>3MB-PP1 is a bulky purine analog and a Polo-like kinase 1 (Plk1) inhibitor.</p>Fórmula:C17H21N5Pureza:99.96%Cor e Forma:White SolidPeso molecular:295.38Tubulin/MMP-IN-3
<p>Tubulin/MMP-IN-3 (Compound 15j) is a dual inhibitor of tubulin polymerization and MMP, effectively inhibiting MMP-2 and MMP-9 with IC50 values of 21.13 μM and 19.24 μM, respectively. It disrupts the NF-κB signaling pathway, leading to mitochondrial dysfunction and mitochondrial-dependent apoptosis. Tubulin/MMP-IN-3 shows antiproliferative activity in various cancer cells by causing cell cycle arrest at the G2/M phase and demonstrates antitumor effects in mouse models.</p>Fórmula:C38H41N2O12PCor e Forma:SolidPeso molecular:748.712Anticancer agent 268
<p>Anticanceragent 268 (Compound 4k) is a potential antitumor agent. It exhibits antiproliferative effects on HepG2 cells, with an IC50 value of 6.08 μM. Additionally, Anticanceragent 268 induces apoptosis and inhibits colony formation and migration of HepG2 cells.</p>Cor e Forma:Odour SolidDelmitide
CAS:<p>Delmitide, a TNF-alpha production inhibitor, is used potentially for the treatment of Crohn's disease and ulcerative colitis.</p>Fórmula:C59H105N17O11Pureza:98%Cor e Forma:SolidPeso molecular:1228.57Zalypsis
CAS:<p>Zalypsis, a transcription factor inhibitor, is used potentially for the treatment of lymphoma, and cervical carcinoma.</p>Fórmula:C37H38F3N3O8Cor e Forma:SolidPeso molecular:709.71dTAGV-1-NEG
CAS:<p>Negative control for dTAGV-1.</p>Fórmula:C68H90N6O14SCor e Forma:SolidPeso molecular:1247.56VEGFR/PARP-IN-1
<p>VEGFR/PARP-IN-1 (Compound 14b) is a dual inhibitor of VEGFR and PARP with IC50 values of 191 nM and 60.9 nM, respectively.</p>Fórmula:C29H27N9OPureza:98%Cor e Forma:SolidPeso molecular:517.58Echitamine chloride
CAS:<p>Echitamine chloride, an alkaloid in Alstonia scholaris, has anti-cancer properties and inhibits pancreatic lipase (IC50: 10.92 µM).</p>Fórmula:C22H29ClN2O4Cor e Forma:SolidPeso molecular:420.93Ac-YVAD-CHO acetate
<p>Ac-YVAD-CHO acetate, potent reversible ICE and caspase-1 inhibitor; K_i: 3.0 nM (mouse), 0.76 nM (human); blocks IL-lβ production.</p>Fórmula:C25H36N4O10Cor e Forma:SolidPeso molecular:552.57Azadirone
CAS:<p>Azadirone, a limonoid, sensitizes cancer cells to TRAIL by modulating DR4/DR5, survival, and apoptotic proteins.</p>Fórmula:C9H15N3O5Cor e Forma:SolidPeso molecular:245.23VEGFR-2-IN-36
<p>VEGFR-2-IN-36 (compound 15) serves as a potent VEGFR-2 inhibitor, exhibiting an IC50 value of 0.067 μM, and acts as an apoptosis inducer with demonstrated</p>Fórmula:C24H23N7O5Pureza:98%Cor e Forma:SolidPeso molecular:489.48HTR2A antagonist 1
<p>HTR2A antagonist 1 (Compound 15f) is an HTR2A antagonist with an IC50 of 42.79 nM. It induces sub-G1 cell cycle arrest and apoptosis in colorectal cancer cells by activating the p53/p21/caspase 3 signaling pathway. HTR2A antagonist 1 exhibits good liver microsomal stability and is useful for colorectal cancer research.</p>Fórmula:C35H43Cl2F2N5O4Cor e Forma:SolidPeso molecular:706.65Anticancer agent 157
<p>Anticancer Agent 157 (compound 15) is a nitric oxide (NO) inhibitor with IC50 values of 0.62 μg/mL, exhibiting both anti-inflammatory and anticancer effects.</p>Fórmula:C14H20O2Pureza:98%Cor e Forma:SolidPeso molecular:220.31Ropeginterferon alfa-2b
CAS:<p>Ropeginterferon alfa-2b (Ropeginterferon alfa-2b-njft), a monopegylated interferon-alpha (IFN-α), is utilized in the study of myeloproliferative neoplasms [1].</p>Cor e Forma:LiquidKRN 5500
CAS:<p>KRN 5500, a derivative of the nucleoside antibiotic spicamycin, has a wide range of antitumor activity against human cancer cell lines.</p>Fórmula:C28H43N7O7Pureza:98%Cor e Forma:SolidPeso molecular:589.68PARP-1/2-IN-2
<p>PARP-1/2-IN-2-IN-1 (Compound 12e) effectively inhibits PARP1/2 and CDK12 with IC 50 values of 34 nM, 30 nM, and 285 nM respectively, impairing DNA damage repair</p>Fórmula:C25H23IN8O3Pureza:98%Cor e Forma:SolidPeso molecular:610.41Thalidomide-O-amido-C8-NH2
CAS:<p>Thalidomide-O-amido-C8-NH2 is a thalidomide-based ligand-linker for PROTAC synthesis.</p>Fórmula:C23H30N4O6Pureza:98%Cor e Forma:SolidPeso molecular:458.51(Rac)-AMXT-1501 4HCl
CAS:<p>AMXT-1501 tetrahydrochloride is an inhibitor of polyamine transport.</p>Fórmula:C32H72Cl4N6O2Pureza:98.31%Cor e Forma:SolidPeso molecular:714.77Tanfanercept
CAS:<p>Tanfanercept (HL036337) is an anti-TNF-α antibody, improving corneal erosions in dry eye mice.</p>Cor e Forma:LiquidKinamycin C
CAS:<p>Kinamycin C is a bacterial metabolite used as an anticancer agent.</p>Fórmula:C24H20N2O10Cor e Forma:SolidPeso molecular:496.428Vonlerizumab
<p>Vonlerizumab (Anti-TNFRSF4/OX40/CD134 Antibody) is a humanized monoclonal antibody targeting OX40, used in tumor research.</p>Pureza:>95%Cor e Forma:LiquidPeso molecular:145.5 kDa
