Apoptose
Os inibidores da apoptose são compostos que previnem ou retardam o processo de morte celular programada, conhecido como apoptose. Esses inibidores são vitais no estudo dos mecanismos de sobrevivência celular e são usados para investigar doenças onde a apoptose é desregulada, como câncer, distúrbios neurodegenerativos e doenças autoimunes. Ao modular a apoptose, esses inibidores podem ajudar no desenvolvimento de terapias destinadas a controlar a morte celular. Na CymitQuimica, oferecemos uma ampla seleção de inibidores da apoptose de alta qualidade para apoiar sua pesquisa em biologia celular, oncologia e áreas relacionadas.
Subcategorias de "Apoptose"
- ASK(6 produtos)
- BCL(11 produtos)
- Caspase(125 produtos)
- FOXO1(3 produtos)
- IAP(66 produtos)
- Mdm2(12 produtos)
- PD-1/PD-L1(125 produtos)
- PDK(9 produtos)
- PERK(25 produtos)
- Serina/treonina quinase(15 produtos)
- Survivina(13 produtos)
- TNF(92 produtos)
- c-RET(51 produtos)
- p53(62 produtos)
Exibir 6 mais subcategorias
Foram encontrados 5592 produtos de "Apoptose"
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CYP51/PD-L1-IN-3
<p>CYP51/PD-L1-IN-3 (compound L21), a quinazoline with antifungal properties, serves as a dual inhibitor targeting CYP51 (IC50: 0.205 μM) and PD-L1 (IC50: 0.039 μM</p>Fórmula:C27H28N6O2Cor e Forma:SolidPeso molecular:468.55Distamycin A
CAS:<p>Distamycin A (NSC-82150), oligopeptide antibiotic, binds A/T rich DNA, affects cleavage sites, enhances apoptosis.</p>Fórmula:C22H27N9O4Cor e Forma:SolidPeso molecular:481.51Nauclefine
CAS:<p>Nauclefine, a plant alkaloid, triggers cancer cell death through PDE3A-SLFN12, binding but not inhibiting PDE3A.</p>Fórmula:C18H13N3OPureza:99.92%Cor e Forma:SolidPeso molecular:287.32MD-222
CAS:<p>MD-222: a first-in-class, highly potent PROTAC that degrades MDM2, activates p53, and exhibits anticancer properties.</p>Fórmula:C48H47Cl2FN6O6Cor e Forma:SolidPeso molecular:893.84TG101209 analog 1
<p>TG101209 analog 1 (Compound 8h) serves as an inhibitor of BUB1B, exhibiting an IC50 of 10.36 μM. It also possesses cytotoxic properties, demonstrated by an IC50 of 1.347 μM against Caki-1 cells, and can induce necrosis and apoptosis.</p>Fórmula:C24H31N5O5SCor e Forma:SolidPeso molecular:501.598XM-U-14
<p>XM-U-14 is a selective PROTAC USP7 degrader that induces the degradation of USP7 in the RS4;11 cell line with a DC50 of 0.74 nM. This compound elevates the levels of p53 and p21, and significantly inhibits the growth of acute lymphoblastic leukemia (ALL) cells, with IC50 values of 0.5 nM in RS4;11 cells and 8.3 nM in Reh cells. Moreover, XM-U-14 induces apoptosis and cell cycle arrest, and effectively inhibits tumor growth.</p>Cor e Forma:Odour SolidHematein
CAS:<p>Hematein blocks Akt/PKB, Wnt signaling, promotes apoptosis in lung cancer, is a dye from hematoxylin, and inhibits casein kinase II (IC50: 0.74 μM).</p>Fórmula:C16H12O6Pureza:98%Cor e Forma:Dark Brown Crystalline PowderPeso molecular:300.26RIPK2-IN-2
CAS:<p>RIPK2-IN-2, a RIP2 kinase PROTAC inhibitor, blocks proinflammatory signaling in autoinflammatory diseases.</p>Fórmula:C53H65FN14O7S2Cor e Forma:SolidPeso molecular:1093.3CAY10726
CAS:<p>CAY10726, an arylurea fatty acid, cuts ATP by 28% and promotes apoptosis in breast cancer cells by depleting mitochondrial lipids.</p>Fórmula:C24H36ClF3N2O3Cor e Forma:SolidPeso molecular:493JAK05
<p>JAK05 exhibits inhibitory activity against Helicobacter pylori, effectively suppressing strains J63, J196, and J107, with a MIC of 3-5 µg/mL. It shows affinity for binding to H+/K+-ATPase, COX-1/2, TNF-α, and PGE2, and possesses antioxidant and anti-inflammatory properties. In a rat model of ethanol-induced gastric ulcers, JAK05 demonstrates anti-ulcer activity.</p>Fórmula:C27H27ClN4O9SCor e Forma:SolidPeso molecular:619.043Human PD-L1 inhibitor II
CAS:<p>Human PD-L1 inhibitor II is a potent PD-L1 inhibitor with anti-cancer activity.</p>Fórmula:C103H151N25O30Cor e Forma:SolidPeso molecular:2219.486Albanol B
CAS:<p>Albanol B, from mulberries, combats Alzheimer's, bacteria, and oxidation, hinders cancer growth, and triggers cell arrest and apoptosis.</p>Fórmula:C34H22O8Cor e Forma:SolidPeso molecular:558.53Pipernonaline
CAS:<p>Pipernonaline is a useful organic compound for research related to life sciences. The catalog number is T124000 and the CAS number is 88660-10-0.</p>Fórmula:C21H27NO3Cor e Forma:SolidPeso molecular:341.451VEGFR/PARP-IN-1
<p>VEGFR/PARP-IN-1 (Compound 14b) is a dual inhibitor of VEGFR and PARP with IC50 values of 191 nM and 60.9 nM, respectively.</p>Fórmula:C29H27N9OPureza:98%Cor e Forma:SolidPeso molecular:517.58DB2115 tertahydrochloride
CAS:<p>DB2115 (tertahydrochloride) inhibits PU.1, key in leukemia; potential for cancer research.</p>Fórmula:C32H34Cl4N8O2Cor e Forma:SolidPeso molecular:704.48Beclin1-Bcl-2 interaction inhibitor 1
<p>Beclin1-Bcl-2 Interaction Inhibitor 1 effectively disrupts the binding of Beclin 1 to Bcl-2, and is utilized in cancer and neurodegeneration research [1].</p>Cor e Forma:Odour SolidFB49
<p>FB49 is a selective Bcl-2-associated athanogene 3 (BAG3) inhibitor with a Ki of 45 μM.</p>Fórmula:C17H18N2O6SPureza:98%Cor e Forma:SolidPeso molecular:378.4Anticancer agent 39
CAS:<p>Compound B12, a JOA derivative, collapses MMP to induce apoptosis, inhibits cloning/migration, and has an IC50 of 0.39 μM against HGC-27 cells.</p>Fórmula:C50H65N5O10Cor e Forma:SolidPeso molecular:896.08PROTAC RIPK degrader-6
CAS:<p>PROTAC RIPK degrader-6 (example 1) is a PROTAC designed for the targeted degradation of RIP Kinase, featuring a RIP2 kinase inhibitor connected through a linker</p>Fórmula:C43H48N6O11S2Cor e Forma:SolidPeso molecular:889.01c-JUN peptide
CAS:<p>Peptide from c-Jun (33-57) blocks JNK binding, inhibits phosphorylation, upregulates p21, and induces HeLa cell apoptosis.</p>Fórmula:C121H210N36O34SPureza:98%Cor e Forma:SolidPeso molecular:2743.55Poly(I:C):Kanamycin (1:1) sodium
<p>Poly(I:C):Kanamycin (1:1) sodium is a complex.Poly(I:C) is a TLR3 and RIG-I/MDA5 agonist.Kanamycin is an antimicrobial,Gram-negative and positive bacteria.</p>Pureza:99%Cor e Forma:SolidCytostatin
CAS:<p>Cytostatin: Natural antitumor, inhibits cell adhesion, blocks B16 melanoma, induces apoptosis, selectively targets PP2A (IC50 = 29 nM).</p>Fórmula:C21H33O7PCor e Forma:SolidPeso molecular:428.462p38α inhibitor 6
<p>p38α inhibitor6 (compound 19) is a p38α inhibitor with an IC50 value of 0.68 μM. It induces apoptosis, arrests the cell cycle in the G0 and G2/M phases, reduces TNF-α concentration, upregulates the expression of the tumor suppressor gene p53, increases the Bax/BCL-2 ratio, and activates caspase3/7.</p>Cor e Forma:Odour Solid(Rac)-AMXT-1501 4HCl
CAS:<p>AMXT-1501 tetrahydrochloride is an inhibitor of polyamine transport.</p>Fórmula:C32H72Cl4N6O2Pureza:98.31%Cor e Forma:SolidPeso molecular:714.77Mcl-1 inhibitor 14
<p>Compound (Ra)-10, also known as Mcl-1 inhibitor 14, is a potent inhibitor of myeloid cell leukemia-1 (MCL-1), exhibiting a K_i of 0.018 nM, and holds potential</p>Fórmula:C39H41ClFN5O5SCor e Forma:SolidPeso molecular:746.29Petromurin C
CAS:<p>Petromurin C, a bis-indolyl benzenoid from P. muricatus, is cytotoxic to NS-1 cells (IC50=33μg/ml) and active against T. foetus (IC50=100μg/ml).</p>Fórmula:C26H24N2O5Cor e Forma:SolidPeso molecular:444.487EGFR-IN-153
<p>EGFR-IN-153 (Compound 5l) is an EGFR inhibitor that suppresses the proliferation of MDA-MB-231 cells with an IC50 of 0.73 μM and induces apoptosis. It is applicable for research in breast cancer.</p>Cor e Forma:Odour SolidMY-943
<p>MY-943, a potent inhibitor of tubulin polymerization and LSD1, exhibits anticancer properties by inducing G2/M phase arrest, promoting apoptosis, and</p>Fórmula:C30H36N4O6S2Cor e Forma:SolidPeso molecular:612.76WEHI-3773
<p>WEHI-3773 is an inhibitor of the interaction between VDAC2 and either BAK or BAX. It prevents BAX-mediated apoptosis (Apoptosis) by blocking the recruitment of BAX to the mitochondria through VDAC2. Conversely, WEHI-3773 promotes BAK-mediated apoptosis (Apoptosis) by limiting VDAC2's inhibitory sequestration of BAK. This compound shows promise for research in the field of cancer therapy.</p>Cor e Forma:Odour Solid3-Hydroxyterphenyllin
CAS:<p>3-Hydroxyterphenyllin from A. candidus is a fungal compound with antioxidant, anticancer, antibacterial, and antiviral effects.</p>Fórmula:C20H18O6Cor e Forma:SolidPeso molecular:354.35YB-0158 ammonium
<p>YB-0158 ammonium (Wnt pathway inhibitor 2 ammonium) is a reverse-rotation peptidomimetic with translation-enhancing potential and anticancer activity.</p>Fórmula:C32H40N9O7PPureza:99.14% - 99.18%Cor e Forma:SolidPeso molecular:693.69PROTAC AR-NTD degrader 1
<p>PROTAC AR-NTD antagonist 1 (compound 18) is a small molecule belonging to the protein-targeting chimeras (PROTACs) that selectively targets the N-terminal</p>Fórmula:C41H47ClN6O7Pureza:98%Cor e Forma:SolidPeso molecular:771.3Mcl-1 inhibitor 15
<p>Mcl-1 Inhibitor 15 (Compound (Ra)-15), with a K i of 0.02 nM, is utilized in cancer research [1].</p>Fórmula:C40H42ClFN6O4SCor e Forma:SolidPeso molecular:757.32Thalidomide-NH-C5-NH2 hydrochloride
CAS:<p>Functionalized cereblon ligand with E3 ligase and alkylC5 linker for PROTAC R&D; ready for protein conjugation. Formerly Pomalidomide-linker 4.</p>Fórmula:C18H23ClN4O4Cor e Forma:SolidPeso molecular:394.85SSE1806
<p>SSE1806, a podophyllotoxin derivative (a natural antimitotic agent), functions as a microtubule/tubulin inhibitor, exhibiting potent anticancer and</p>Fórmula:C21H18N2O5Cor e Forma:SolidPeso molecular:378.38SLF TFA
CAS:<p>SLF TFA, a synthetic FKBP ligand, binds FKBP51 (3.1 μM) and inhibits FKBP12 (IC50 2.6 μM); used in PROTAC synthesis.</p>Fórmula:C32H41F3N2O8Cor e Forma:SolidPeso molecular:638.67hCAIX-IN-13
CAS:<p>hCAIX-IN-13 (Pt2) inhibits CAIX with 6.57 μM IC50, curbs cancer cell growth, and induces apoptosis for cancer research.</p>Fórmula:C37H33F3N6O7PtS2Cor e Forma:SolidPeso molecular:989.9Lactoferrin (17-41)
CAS:<p>Amino acids 17-41 of lactoferrin, lactoferricin B, enhance anti-fungal effects, targeting Candida Albicans.</p>Fórmula:C141H224N46O29S3Pureza:98%Cor e Forma:SolidPeso molecular:3123.77NSC 295642
CAS:<p>NSC 295642: phosphatase inhibitor, boosts phospho-Erk in cells, aids cancer research.</p>Fórmula:C15H14ClCuN3S2Cor e Forma:SolidPeso molecular:399.42UCM-1336
CAS:<p>UCM-1336 (3,3′-(Octylimino)bis[N-phenylpropanamide]) is a potent ICMT inhibitor with an IC50 of 2 μM which is selective against the other enzymes involved in</p>Fórmula:C26H37N3O2Pureza:98.86%Cor e Forma:SolidPeso molecular:423.59Aspidin BB
CAS:<p>Aspidin BB, a phloroglucinol from Dryopteris, inhibits cancer by causing cell cycle arrest and apoptosis in HO-8910 cells.</p>Fórmula:C25H32O8Cor e Forma:SolidPeso molecular:460.52Angiogenesis inhibitor 3
CAS:<p>Angiogenesis Inhibitor 3 (compound 8) is a potent anti-cancer agent, blocking HUVEC/HCT-15 cell growth and inducing apoptosis.</p>Fórmula:C44H42BrN3O9Cor e Forma:SolidPeso molecular:836.72ARI-1
<p>ARI-1 is a receptor tyrosine kinase-like orphan receptor 1 (ROR1) inhibitor that binds to ROR1's extracellular Frizzled domain, effectively inhibiting aberrant</p>Cor e Forma:Odour SolidYCH3124
<p>YCH3124 (compound Z33) is an inhibitor of USP7, exhibiting anti-tumor activity with an IC50 value of 41.9 nM. This compound demonstrates substantial in vitro anti-proliferative effects on various tumor cells, including LNCaP (IC50= 3.6 nM) and CHP-212 (IC50=9.9 nM). Moreover, YCH3124 induces apoptosis in CHP-212 cells by disrupting the cell cycle process during the G1 phase.</p>Fórmula:C30H34N4O5Cor e Forma:SolidPeso molecular:530.61RO7567132
<p>RO7567132 is a bispecific antibody that binds and agonizes LTBR bivalently while binds and antagonizes FAP monovalently, inducing the formation of local TLS.</p>Cor e Forma:Odour Liquidcis-Clovamide
CAS:<p>cis-Clovamide is a naturally occurring phenolic compound with noteworthy antioxidant, anti-inflammatory, and antiapoptotic properties.</p>Fórmula:C18H17NO7Cor e Forma:SolidPeso molecular:359.334KB02-SLF
<p>KB02-SLF, a molecular glue, degrades nuclear FKBP12 by modifying E3 ligase DCAF16 and extends protein degradation.</p>Fórmula:C50H65ClN4O12Pureza:98%Cor e Forma:SolidPeso molecular:949.52Ascochlorin
CAS:<p>Ascochlorin, an isoprenoid antibiotic, inhibits STAT3 to combat tumors, induces apoptosis, and reduces inflammation.</p>Fórmula:C23H29ClO4Pureza:98%Cor e Forma:SolidPeso molecular:404.93DCZ3301
CAS:<p>DCZ3301 is a novel aryl-guanidino inhibitor.</p>Fórmula:C20H16ClF3N6O2Pureza:99.89%Cor e Forma:SolidPeso molecular:464.83TRP-601
CAS:<p>TRP-601 is a caspase inhibitor.</p>Fórmula:C40H48F2N6O11Pureza:98%Cor e Forma:SolidPeso molecular:826.852
