Apoptose
Os inibidores da apoptose são compostos que previnem ou retardam o processo de morte celular programada, conhecido como apoptose. Esses inibidores são vitais no estudo dos mecanismos de sobrevivência celular e são usados para investigar doenças onde a apoptose é desregulada, como câncer, distúrbios neurodegenerativos e doenças autoimunes. Ao modular a apoptose, esses inibidores podem ajudar no desenvolvimento de terapias destinadas a controlar a morte celular. Na CymitQuimica, oferecemos uma ampla seleção de inibidores da apoptose de alta qualidade para apoiar sua pesquisa em biologia celular, oncologia e áreas relacionadas.
Subcategorias de "Apoptose"
- ASK(6 produtos)
- BCL(11 produtos)
- Caspase(125 produtos)
- FOXO1(3 produtos)
- IAP(66 produtos)
- Mdm2(12 produtos)
- PD-1/PD-L1(125 produtos)
- PDK(9 produtos)
- PERK(25 produtos)
- Serina/treonina quinase(15 produtos)
- Survivina(13 produtos)
- TNF(92 produtos)
- c-RET(51 produtos)
- p53(62 produtos)
Exibir 6 mais subcategorias
Foram encontrados 5598 produtos de "Apoptose"
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NSD-IN-4
<p>NSD-IN-4 (Compound A8) is a potent and orally active inhibitor of NSD3, inducing apoptosis in a dose-dependent manner. It demonstrates significant antitumor activity against lung squamous cell carcinoma.</p>Fórmula:C17H12ClFN2O2Cor e Forma:SolidPeso molecular:330.741(±)-Enterodiol
CAS:<p>"(±)-Enterodiol, the racemate of Enterodiol, is metabolized from lignans found in whole-grain cereals, nuts, legumes, flaxseed, and vegetables by human intestinal bacteria. This compound exhibits apoptotic effects in colorectal cancer (CRC) cells and has been identified to possess anti-cancer activities [1] [2]."</p>Fórmula:C18H22O4Cor e Forma:SolidPeso molecular:302.36Anticancer agent 267
<p>Anticanceragent 267 (Compound 5q) serves as an activator of RIPK3 and MLKL. It effectively inhibits the proliferation of several cancer cell lines, with IC50 values of 9.79, 10.77, and 5.94 μM for MDA-MB-231, MDA-MB-486, and MCF-7, respectively. The compound induces cell cycle arrest at the subG1 phase and triggers necroptosis in MDA-MB-231 cells. Additionally, Anticanceragent 267 demonstrates antitumor activity in mouse xenograft models.</p>Fórmula:C13H11N5O4SCor e Forma:SolidPeso molecular:333.32Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride
CAS:<p>Thalidomide-based E3 ligase ligand with PEG2-C2 linker; used as an immunomodulatory cancer treatment.</p>Fórmula:C21H27ClN4O8Pureza:98.09%Cor e Forma:SolidPeso molecular:498.914MSU-42011
CAS:<p>MSU-42011: oral RXR-like agonist, inhibits iNOS & p-ERK, antitumor in lung cancer model, effective preclinical treatment.</p>Fórmula:C24H34N2O2Pureza:99.52%Cor e Forma:SoildPeso molecular:382.54MAO-B-IN-30
CAS:<p>MAO-B-IN-30 is a selective and potent MAO-B inhibitor that crosses the blood-brain barrier with antiproliferative activity and inhibits both MAO-A and MAO-B.MAO-B-IN-30 reduces the levels of TNF-alpha, IL-6, and NF-kB in organisms, and can be used to study Parkinson's-type neurological disorders.</p>Fórmula:C15H10BrN3O2Pureza:98.31%Cor e Forma:SoildPeso molecular:344.16G-Glu-Val
CAS:<p>G-Glu-Val (γ-glutamyl-L-valine, H-Glu-Val -OH), a flavour-regulating dipeptide, is a major contributor to "mellow".</p>Fórmula:C10H18N2O5Cor e Forma:SolidPeso molecular:246.26CYP51/PD-L1-IN-4
<p>CYP51/PD-L1-IN-4 (compound 14a-2) is a potent dual-target inhibitor of CYP51/PD-L1, displaying IC50 values of 0.17 and 0.021 μM, respectively.</p>Fórmula:C27H28N4O3Cor e Forma:SolidPeso molecular:456.54Cardanol (C15:1)
CAS:<p>Cardanol (C15:1), found in cashew nut shell liquid, induces mitochondria-associated apoptosis in human melanoma cells.</p>Fórmula:C21H34OPureza:98.48% - 99.77%Cor e Forma:SolidPeso molecular:302.49IC 86621
CAS:<p>IC 86621: DNA-PK ATP-competitive inhibitor, IC50 120 nM, enhances DSB antitumor effects, EC50 68 µM for repair.</p>Fórmula:C12H15NO3Pureza:99.68%Cor e Forma:SolidPeso molecular:221.25β-Apopicropodophyllin
CAS:<p>β-Apopicropodophyllin, a natural product isolated from Hyptis wticillata, promotes apoptosis through mechanisms including microtubule disruption, DNA damage,</p>Fórmula:C22H20O7Cor e Forma:SolidPeso molecular:396.39H-20
CAS:<p>H-20 is a PD-1 agonist that reduces the required dosage of morphine for analgesia. It can be used in studies related to chronic pain.</p>Fórmula:C44H64N10O15Cor e Forma:SolidPeso molecular:973.037ChoKα inhibitor-5
<p>ChoKα Inhibitor-5, a sulfur-containing choline kinase inhibitor, effectively inhibits HChoKα1 with an IC50 value of 0.64 μM and induces apoptosis.</p>Fórmula:C54H68Br2N4S4Cor e Forma:SolidPeso molecular:1061.21Thevetiaflavone
CAS:<p>Thevetiaflavone, a natural flavonoid from W. indica, blocks LDH leakage, boosting cell survival.</p>Fórmula:C16H12O5Pureza:98%Cor e Forma:SolidPeso molecular:284.26Pim-1 kinase inhibitor 4
<p>Pim-1 kinase inhibitor 4 is a potent Pim-1 kinase inhibitor with an IC50 value of 17.01 nM.Pim-1 kinase inhibitor 4 also possesses antioxidant activity and</p>Fórmula:C19H12ClN3OPureza:97.72%Cor e Forma:SolidPeso molecular:333.77Mechercharmycin A
CAS:<p>Mechercharmycin A, a cytotoxic compound, was isolated from Thermoactinomyces sp. YM3-251, a marine source. It demonstrates potent antitumor activity.</p>Fórmula:C35H32N8O7SCor e Forma:SolidPeso molecular:708.75Garivulimab
CAS:<p>Garivulimab (BGB-A333), a humanized IgG1 monoclonal antibody, binds to PD-L1, blocking PD-1 interaction and exhibiting antitumor activity.</p>Cor e Forma:Liquid(D)-PPA 1 TFA
<p>(D)-PPA 1 TFA is a hydrolysis-resistant D-peptide antagonist and a potent PD-1/PD-L1 inhibitor, exhibiting an affinity for PD-1 of 0.51 μM and demonstrating</p>Fórmula:C72H99F3N20O23Pureza:98%Cor e Forma:SolidPeso molecular:1669.67AS-99 free base
CAS:<p>AS-99 is a first-in-class, potent and selective ASH1L histone methyltransferase inhibitor (IC50= 0.79 μM, Kd= 0.89 μM) with anti-leukemic activity.</p>Fórmula:C27H30F3N5O3S2Cor e Forma:SolidPeso molecular:593.687,3′,5′-Trihydroxyflavanone
CAS:<p>7,3′,5′-Trihydroxyflavanone, a flavanoid derivative, promotes apoptotic cell death in MCF-7 cells by augmenting Bax expression.</p>Fórmula:C15H12O5Cor e Forma:SolidPeso molecular:272.25Inuviscolide
CAS:<p>Inuviscolide induces apoptosis, G2/M arrest in melanoma, and has anti-cancer, anti-inflammatory effects.</p>Fórmula:C15H20O3Cor e Forma:SolidPeso molecular:248.32HLDA-212
CAS:HLDA-212 (Compound 43) is a bifunctional small molecule designed to target HaloTag-tagged protein (target protein, TP) and Aurora kinase A/B (AURKA/B, effector protein, EP). By binding TP and EP, it forms a stable ternary complex (TP:RIPTAC:EP) that inhibits the cell survival functions of EP, inducing apoptosis in cancer cells expressing TP. In 293_HFL cells, HLDA-212 demonstrates antiproliferative activity with a GI50 of 0.011 μM. This compound holds promise for treating cancers with high TP expression, such as prostate cancer and hematological malignancies.Fórmula:C70H90BrFN8O19SPeso molecular:1478.47CTP-347
CAS:CTP-347, a deuterated version of paroxetine, is potentially the best non-hormonal drug in its class for the treatment of hot flashes.Fórmula:C19H20FNO3Peso molecular:331.38Chol-CTPP
<p>Chol-CTPP targets the BBB and glioma cells; when combined with Chol-TPP, forms Lip-CTPP, enhancing anti-glioma drug efficacy.</p>Fórmula:C144H263N3O53Cor e Forma:SolidPeso molecular:2884.62Iparomlimab
CAS:<p>Iparomlimab: anti-PD-1 IgG4κ antibody, targets PSB103 γ4/κ-chains, forms dimers, used in cancer research.</p>Cor e Forma:LiquidRopeginterferon alfa-2b
CAS:<p>Ropeginterferon alfa-2b (Ropeginterferon alfa-2b-njft), a monopegylated interferon-alpha (IFN-α), is utilized in the study of myeloproliferative neoplasms [1].</p>Cor e Forma:LiquidTanfanercept
CAS:<p>Tanfanercept (HL036337) is an anti-TNF-α antibody, improving corneal erosions in dry eye mice.</p>Cor e Forma:LiquidMetronidazole hydrochloride
CAS:<p>Oral nitroimidazole antibiotic; treats anaerobic infections; may cause inflammation and muscle contractions with long-term use.</p>Fórmula:C6H10ClN3O3Cor e Forma:SolidPeso molecular:207.62BOC-D-FMK
CAS:<p>Boc-D-FMK is an irreversible, cell-permeable, and broad-spectrum caspase inhibitor and inhibits apoptosis stimulated by TNF-α (IC50: 39 μM).</p>Fórmula:C11H18FNO5Pureza:97.02%Cor e Forma:SolidPeso molecular:263.26Echitamine chloride
CAS:<p>Echitamine chloride, an alkaloid in Alstonia scholaris, has anti-cancer properties and inhibits pancreatic lipase (IC50: 10.92 µM).</p>Fórmula:C22H29ClN2O4Cor e Forma:SolidPeso molecular:420.93TD52 dihydrochloride
<p>TD52 dihydrochloride, an Erlotinib derivative, inhibits protein phosphatase 2A and induces apoptosis in TNBC by disrupting CIP2A/PP2A/p-Akt signaling.</p>Fórmula:C24H18Cl2N4Pureza:97.23%Cor e Forma:SoildPeso molecular:433.33Ac-YVAD-CHO acetate
<p>Ac-YVAD-CHO acetate, potent reversible ICE and caspase-1 inhibitor; K_i: 3.0 nM (mouse), 0.76 nM (human); blocks IL-lβ production.</p>Fórmula:C25H36N4O10Cor e Forma:SolidPeso molecular:552.57Sotigalimab
CAS:<p>Sotigalimab (APX 005) is a monoclonal antibody targeting CD40 with anticancer activity for the study of metastatic pancreatic cancer.</p>Pureza:98.50% - 98.50%Cor e Forma:LiquidThalidomide-O-amido-C3-COOH
CAS:<p>Thalidomide-O-amido-C3-COOH is a cereblon ligand-linker for PROTACs, melding Thalidomide with a standard linker.</p>Fórmula:C19H19N3O8Pureza:98%Cor e Forma:SolidPeso molecular:417.37Epoprostenol sodium
CAS:<p>Epoprostenol sodium (Prostaglandin I2 sodium salt) is a vasodilator and a synthetic prostacyclin that can be used to study pulmonary hypertension.</p>Fórmula:C20H31NaO5Pureza:98%Cor e Forma:White Crystalline PowderPeso molecular:374.45Thalidomide-NH-PEG8-Ts
CAS:<p>Thalidomide-NH-PEG8-Ts: a synthesized Thalidomide-PEG8 E3 ligase linker for PROTAC-mediated IDO1 degradation.</p>Fórmula:C36H49N3O14SCor e Forma:SolidPeso molecular:779.86Ganoderic acid Mf
CAS:<p>Ganoderic acid Mf: antitumor triterpenoid, arrests G1 cell cycle, selective for cancer cells, triggers apoptosis via mitochondria.</p>Fórmula:C32H48O5Cor e Forma:SolidPeso molecular:512.72Malformin A
CAS:<p>Malformin A, from A. niger, is a plant growth regulator and has anti-TMV and cancer cell cytotoxic properties. Intraperitoneal LD50 in mice is 3.1 mg/kg.</p>Fórmula:C23H39N5O5S2Cor e Forma:SolidPeso molecular:529.72SZUH280
CAS:<p>SZUH280 is a potent, selective PROTAC (proteolysis targeting chimera) HDAC8 (histone deacetylase 8) degrader, demonstrating a DC50 of 0.58 μM in A549 cells.</p>Fórmula:C36H34N8O8Cor e Forma:SolidPeso molecular:706.7MDM2/4-p53-IN-2
<p>MDM2/4-p53-IN-2 (2q) is a dual MDM2/MDM4 inhibitor, p53 activator; IC50: 70.7 nM(MDM2), 81.4 nM(MDM4); tumor suppressor.</p>Fórmula:C25H17Cl3FN3O3Cor e Forma:SolidPeso molecular:532.78RBN013209
CAS:<p>RBN013209 is a potent CD38 inhibitor. RBN013209 is useful in the treatment of cancer.</p>Fórmula:C19H24N6O3Pureza:99.84%Cor e Forma:SoildPeso molecular:384.43eIF4A3-IN-5
CAS:<p>eIF4A3-IN-5 potently inhibits eIF4AI/II, promising for cancer research.</p>Fórmula:C26H22N2O7Cor e Forma:SolidPeso molecular:474.469EAD1
CAS:<p>EAD1 is a useful organic compound for research related to life sciences. The catalog number is T35329 and the CAS number is 1644388-26-0.</p>Fórmula:C24H27Cl2N7Pureza:98%Cor e Forma:SolidPeso molecular:484.42Urelumab
CAS:<p>"Urelumab (BMS-66513), a humanized IgG4 mAb CD137 agonist, boosts T-cell/NK cell-mediated cytotoxicity and anti-tumor activity."</p>Pureza:97.70%Cor e Forma:LiquidPeso molecular:145.90 kDaHKB99
CAS:<p>HKB99 suppresses NSCLC growth, metastasis, and overcomes erlotinib resistance.</p>Fórmula:C23H18N2O6SPureza:97.35% - 97.35%Cor e Forma:SolidPeso molecular:450.46AM-8553
CAS:<p>AM-8553 is potent and selective piperidine the MDM2-p53 interaction inhibitor.</p>Fórmula:C25H29Cl2NO4Cor e Forma:SolidPeso molecular:478.41MI-1061 TFA
CAS:<p>MI-1061 TFA: potent MDM2 inhibitor, orally bioavailable, stable (IC50=4.4 nM, Ki=0.16 nM), activates p53, induces apoptosis in mice tumors.</p>Fórmula:C32H27Cl2F4N3O6Cor e Forma:SolidPeso molecular:696.47CYP51/PD-L1-IN-1
<p>CYP51/PD-L1-IN-1 (compound L11), a quinazoline with antifungal properties, simultaneously inhibits CYP51 (IC50: 0.884 μM) and PD-L1 (IC50: 0.083 μM).</p>Fórmula:C20H15N5O2Cor e Forma:SolidPeso molecular:357.37HJC0416 hydrochloride
CAS:<p>HJC0416 hydrochloride: potent oral STAT3 inhibitor, better anticancer effects than Stattic, promising for breast cancer research.</p>Fórmula:C18H18Cl2N2O4SCor e Forma:SolidPeso molecular:429.31Vorsetuzumab
CAS:<p>Vorsetuzumab (Anti-Human CD70 Recombinant Antibody) is a monoclonal antibody targeting the CD70 antibody.</p>Pureza:SDS-PAGE:95% SEC-HPLC:99.29%Cor e Forma:LiquidPeso molecular:146.1 kDa
