Apoptose
Os inibidores da apoptose são compostos que previnem ou retardam o processo de morte celular programada, conhecido como apoptose. Esses inibidores são vitais no estudo dos mecanismos de sobrevivência celular e são usados para investigar doenças onde a apoptose é desregulada, como câncer, distúrbios neurodegenerativos e doenças autoimunes. Ao modular a apoptose, esses inibidores podem ajudar no desenvolvimento de terapias destinadas a controlar a morte celular. Na CymitQuimica, oferecemos uma ampla seleção de inibidores da apoptose de alta qualidade para apoiar sua pesquisa em biologia celular, oncologia e áreas relacionadas.
Subcategorias de "Apoptose"
- ASK(6 produtos)
- BCL(11 produtos)
- Caspase(125 produtos)
- FOXO1(3 produtos)
- IAP(66 produtos)
- Mdm2(12 produtos)
- PD-1/PD-L1(125 produtos)
- PDK(9 produtos)
- PERK(25 produtos)
- Serina/treonina quinase(15 produtos)
- Survivina(13 produtos)
- TNF(92 produtos)
- c-RET(51 produtos)
- p53(62 produtos)
Exibir 6 mais subcategorias
Foram encontrados 5598 produtos de "Apoptose"
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HDAC3-IN-6
<p>HDAC3-IN-6 (Compound SC26) is a selective HDAC3 inhibitor with an IC50 of 53 nM. It induces PD-L1 expression in a dose-dependent manner and leads to significant apoptosis and reactive oxygen species (ROS) production. HDAC3-IN-6 exhibits strong antitumor efficacy against colorectal cancer.</p>Fórmula:C23H23N5O3Cor e Forma:SolidPeso molecular:417.46Human membrane-bound PD-L1 polypeptide
CAS:<p>Human membrane-bound PD-L1 polypeptide serves as an antigen for inducing the production of PD-L1 antibodies [1].</p>Fórmula:C85H140N26O36SPureza:98%Cor e Forma:SolidPeso molecular:2134.24Enpp/Carbonic anhydrase-IN-1
CAS:<p>Enpp/Carbonic anhydrase-IN-1 (compound 1e) is a potent inhibitor of Enpp and carbonic anhydrase.</p>Fórmula:C23H25NO4SPureza:99.96%Cor e Forma:SoildPeso molecular:411.51Pim-1 kinase inhibitor 4
<p>Pim-1 kinase inhibitor 4 is a potent Pim-1 kinase inhibitor with an IC50 value of 17.01 nM.Pim-1 kinase inhibitor 4 also possesses antioxidant activity and</p>Fórmula:C19H12ClN3OPureza:97.72%Cor e Forma:SolidPeso molecular:333.77Euphornin
CAS:<p>Euphornin is a natural product that can be used as a reference standard. The CAS number of Euphornin is 80454-47-3.</p>Fórmula:C33H44O9Cor e Forma:SolidPeso molecular:584.706Ganoderic acid Mk
CAS:<p>GA-Mk is a triterpenoid from Ganoderma lucidum mycelia, inhibits HeLa cell growth, and induces apoptosis via mitochondria; used in cervical cancer studies.</p>Fórmula:C34H50O7Cor e Forma:SolidPeso molecular:570.76YW-N-7 TFA
<p>YW-N-7 (TFA) is a PROTAC designed to target, inhibit, and degrade RET kinase, demonstrating a DC50 of 88 nM. It exhibits antitumor activity in xenograft mouse models driven by KIF5B-RET, making it a valuable compound for cancer research.</p>Fórmula:C58H63F3N12O9Cor e Forma:SolidPeso molecular:1129.19PROTAC RIPK degrader-6
CAS:<p>PROTAC RIPK degrader-6 (example 1) is a PROTAC designed for the targeted degradation of RIP Kinase, featuring a RIP2 kinase inhibitor connected through a linker</p>Fórmula:C43H48N6O11S2Cor e Forma:SolidPeso molecular:889.01Rosamultic acid
<p>Rosamultic acid is a useful organic compound for research related to life sciences and the catalog number is T125342.</p>Fórmula:C30H46O5Cor e Forma:SolidPeso molecular:486.693(D)-PPA 1 TFA
<p>(D)-PPA 1 TFA is a hydrolysis-resistant D-peptide antagonist and a potent PD-1/PD-L1 inhibitor, exhibiting an affinity for PD-1 of 0.51 μM and demonstrating</p>Fórmula:C72H99F3N20O23Pureza:98%Cor e Forma:SolidPeso molecular:1669.67Hematein
CAS:<p>Hematein blocks Akt/PKB, Wnt signaling, promotes apoptosis in lung cancer, is a dye from hematoxylin, and inhibits casein kinase II (IC50: 0.74 μM).</p>Fórmula:C16H12O6Pureza:98%Cor e Forma:Dark Brown Crystalline PowderPeso molecular:300.26PROTAC Bcl-xL degrader-3
CAS:<p>PROTAC Bcl-xL degrader-3 is a potent ROTAC Bcl-xL degrader.</p>Fórmula:C82H105ClF3N11O11S4Cor e Forma:SolidPeso molecular:1641.49MD-222
CAS:<p>MD-222: a first-in-class, highly potent PROTAC that degrades MDM2, activates p53, and exhibits anticancer properties.</p>Fórmula:C48H47Cl2FN6O6Cor e Forma:SolidPeso molecular:893.84HLDA-212
CAS:HLDA-212 (Compound 43) is a bifunctional small molecule designed to target HaloTag-tagged protein (target protein, TP) and Aurora kinase A/B (AURKA/B, effector protein, EP). By binding TP and EP, it forms a stable ternary complex (TP:RIPTAC:EP) that inhibits the cell survival functions of EP, inducing apoptosis in cancer cells expressing TP. In 293_HFL cells, HLDA-212 demonstrates antiproliferative activity with a GI50 of 0.011 μM. This compound holds promise for treating cancers with high TP expression, such as prostate cancer and hematological malignancies.Fórmula:C70H90BrFN8O19SPeso molecular:1478.47Se-Aspirin
CAS:<p>Se-Aspirin (Se-NSAID-8) has anticancer activity and gastroprotective effects, inhibits activation of proinflammatory and pro-survival NF-ĸB pathways, and inhibits the expression of anti-apoptotic targets downstream of NF-ĸB (e.g., Bcl-xL, Mcl-1, and survivin).Se-Aspirin induces Cell cycle arrest and activation of apoptosis accelerates ulcer healing and can be used to study pancreatic and colorectal cancer.</p>Fórmula:C12H12N2O3SePureza:98.07%Cor e Forma:SolidPeso molecular:311.2CTP-347
CAS:CTP-347, a deuterated version of paroxetine, is potentially the best non-hormonal drug in its class for the treatment of hot flashes.Fórmula:C19H20FNO3Peso molecular:331.38UBX1325
CAS:<p>UBX1325, a potent Bcl-xL inhibitor, induces cell death in aging cells, useful for age-related eye disease research.</p>Fórmula:C53H59ClF3N6O10PS3Cor e Forma:SolidPeso molecular:1159.69PROTAC EGFR degrader 7
<p>Compound 13b, a potent EGFR degrader, inhibits and induces apoptosis in NSCLC cells with a DC50 of 13.2 nM.</p>Fórmula:C46H48N10O6Cor e Forma:SolidPeso molecular:836.94Bak BH3
<p>Flu-BakBH3 peptide, derived from Bak's BH3 domain, binds tightly to a crucial pocket of Bcl-XL, essential for its anti-death role.</p>Fórmula:C72H125N25O24Pureza:98%Cor e Forma:SolidPeso molecular:1724.9Ecdysone
CAS:<p>Ecdysone is a major steroid hormone in insects and herbs.</p>Fórmula:C27H44O6Pureza:99.22%Cor e Forma:PowderPeso molecular:464.638-Aminoadenosine
CAS:<p>8-Aminoadenosine reduces ATP, blocks mRNA synthesis, and Akt/mTOR signaling, triggering autophagy and apoptosis independently of p53, with antitumor effects.</p>Fórmula:C10H14N6O4Cor e Forma:SolidPeso molecular:282.26PB28
CAS:<p>PB28: A potent σ2 agonist (Ki 0.68 nM), σ1 antagonist (Ki 0.38 nM), with anti-tumor properties and inhibits SARS-CoV-2 interactions.</p>Fórmula:C24H38N2OCor e Forma:SolidPeso molecular:370.581BOC-D-FMK
CAS:<p>Boc-D-FMK is an irreversible, cell-permeable, and broad-spectrum caspase inhibitor and inhibits apoptosis stimulated by TNF-α (IC50: 39 μM).</p>Fórmula:C11H18FNO5Pureza:97.02%Cor e Forma:SolidPeso molecular:263.26S-Adenosyl-L-methionine
CAS:<p>S-Adenosyl-L-methionine (Ademetionine) is an intermediate metabolite of methionine,for treatment of primary biliary cirrhosis and major depressive disorder.</p>Fórmula:C15H22N6O5SPureza:99.08%Cor e Forma:SolidPeso molecular:398.44Oxybenzone-d3
<p>Oxybenzone-d3 (Benzophenone 3-d3) is a deuterium-labeled form of Oxybenzone. Commonly used as a UV filter in tanning and skin protection products, Oxybenzone (Benzophenone 3) acts as an endocrine-disrupting chemical (EDC) that can cross both the placental and blood-brain barriers. It impairs autophagy, alters epigenetic states, and disrupts retinoid X receptor signaling in apoptotic neuronal cells.</p>Fórmula:C14H9D3O3Cor e Forma:SolidPeso molecular:231.26Giloralimab
CAS:<p>Giloralimab (ABBV-927) is a antibody targeting CD40 with anticancer activity for the study of triple-negative breast cancer and non-small cell lung cancer.</p>Pureza:95.6% (SDS-PAGE); 95.1% (SEC-HPLC) - 95.6% (SDS-PAGE); 95.1% (SEC-HPLC)Cor e Forma:LiquidABBV-167
CAS:<p>ABBV-167 is a phosphate prodrug of the BCL-2 inhibitor venetoclax.</p>Fórmula:C46H53ClN7O11PSCor e Forma:SolidPeso molecular:978.45Spexin
CAS:<p>Potent GAL2/GAL3 agonist (EC50 = 45.7, 112.2 nM), inactive at GAL1. Reduces appetite, fatty acid uptake in adipocytes, and LH in goldfish; anxiolytic in vivo.</p>Fórmula:C74H114N20O19SPureza:98%Cor e Forma:SolidPeso molecular:1619.9Z-DQMD-FMK
CAS:<p>Caspase-3 inhibitor. Inhibits MG 132-induced small cell lung cancer cell death in vitro.</p>Fórmula:C29H40FN5O11SPureza:98%Cor e Forma:SolidPeso molecular:685.72Enniatin A1
CAS:<p>Enniatin A1, a cyclic hexadepsipeptide from Fusarium, induces apoptosis and disrupts ERK, inhibiting ACAT (IC50: 49 μM).</p>Fórmula:C35H61N3O9Pureza:98%Cor e Forma:SolidPeso molecular:667.885Chloranil
CAS:<p>Chloranil (tetrachloro-p-benzoquinone) induces inflammation and neurological dysfunction and can be used to model inflammation in mice.</p>Fórmula:C6Cl4O2Pureza:99.38%Cor e Forma:SolidPeso molecular:245.88Urelumab
CAS:<p>"Urelumab (BMS-66513), a humanized IgG4 mAb CD137 agonist, boosts T-cell/NK cell-mediated cytotoxicity and anti-tumor activity."</p>Pureza:97.70%Cor e Forma:LiquidPeso molecular:145.90 kDaPAA5
<p>PAA5, a polynuclear Au(I) cluster, triggers ferroptosis and has anticancer effects by increasing pH2AX over time.</p>Fórmula:C14H8Au5B2F8N2Cor e Forma:SolidPeso molecular:1348.66Multi-kinase-IN-4
<p>Multi-kinase-IN-4 (compound 5d) is a multi-targeted kinase inhibitor active against VEGFR2, EGFR, HER2, and CDK2, with respective IC50 values of 0.33, 0.22, 0.</p>Fórmula:C21H20ClFN2OSPureza:98%Cor e Forma:SolidPeso molecular:402.91HDAC6 degrader-5
<p>HDAC6degrader-5 (Compound 6) exhibits inhibitory and degradative activity against HDAC6, with an IC50 of 4.95 nM and a DC50 of 0.96 nM. It suppresses the release of TNF-α, IL-1β, and IL-6, and prevents apoptosis in liver cells. Additionally, HDAC6degrader-5 demonstrates anti-inflammatory properties in a mouse model of APAP-induced liver injury.</p>Fórmula:C21H22N4O3Cor e Forma:SolidPeso molecular:378.424HKB99
CAS:<p>HKB99 suppresses NSCLC growth, metastasis, and overcomes erlotinib resistance.</p>Fórmula:C23H18N2O6SPureza:97.35% - 97.35%Cor e Forma:SolidPeso molecular:450.46Thalidomide-NH-PEG7
<p>Thalidomide-NH-PEG7, a chemical for creating PROTAC iRucaparib-AP6, selectively degrades PARP1 and is used in ADCs.</p>Fórmula:C27H39N3O11Pureza:98%Cor e Forma:SolidPeso molecular:581.61Syringolin A
CAS:<p>Syringolin A is a useful organic compound for research related to life sciences. The catalog number is T125354 and the CAS number is 212115-96-3.</p>Fórmula:C24H39N5O6Cor e Forma:SolidPeso molecular:493.605S-Adenosyl-L-methionine iodide
CAS:<p>S-(5'-Adenosyl)-L-methionine iodide, also known as S-Adenosyl-L-methionine iodide, is a vital methyl donor present in all living organisms [1].</p>Fórmula:C15H23IN6O5SCor e Forma:SolidPeso molecular:526.35HDAC6-IN-16
<p>HDAC6-IN-16 (compound 5c), a quinazolin-4(3H)-one-based inhibitor of histone deacetylase 6 (HDAC6), demonstrates an anticancer effect by inhibiting colony</p>Fórmula:C23H19N3O3SPureza:98%Cor e Forma:SolidPeso molecular:417.48ChoKα inhibitor-4
<p>ChoKα Inhibitor-4 is a bioisosteric agent that effectively inhibits human choline kinase α1 (HChoK α1) with an IC50 of 0.66 μM.</p>Cor e Forma:Odour SolidRMC-9805
CAS:<p>RMC-9805(Zoldonrasib) is a KRAS G12D inhibitor with anti-tumor and anti-proliferative activity for the study of pancreatic cancer.</p>Fórmula:C63H88F3N11O7Pureza:98.10% - 99.51%Cor e Forma:SolidPeso molecular:1168.44PROTAC-O4I2
CAS:PROTAC-O4I2, a PROTAC ligand targeting splicing factor 3B1 (SF3B1), induced FLAG-SF3B1 degradation in K562 cells with an IC50 value of 0.244 μM.Fórmula:C29H29ClN6O5SPureza:97.45%Cor e Forma:SolidPeso molecular:609.1Z-Ala-Ala-Asp-CMK
CAS:<p>Z-Ala-Ala-Asp-CMK (Z-AAD-CMK) is a selective granzyme B inhibitor that blocks granzyme B protease activity, for inflammatory diseases and tumours.</p>Fórmula:C19H24ClN3O7Pureza:99.967%Cor e Forma:SolidPeso molecular:441.86Spexin TFA
<p>Spexin TFA: GAL2/GAL3 agonist (EC50: 45.7/112.2 nM), no activity at GAL1, reduces appetite, fatty acid uptake, and LH secretion; anxiolytic.</p>Fórmula:C76H115F3N20O21SCor e Forma:SolidPeso molecular:1733.9KC01
CAS:<p>KC01 selectively inhibits ABHD16A (IC50: 0.2-0.5 μM), much more potent than KC02 (>10 μM); human ABHD16A IC50: 90±20 nM.</p>Fórmula:C22H39NO3Pureza:98%Cor e Forma:SolidPeso molecular:365.558PD0166285 dihydrochloride
CAS:<p>PD-166285 is an effective and broadly active inhibitor of protein tyrosine kinase.</p>Fórmula:C26H29Cl4N5O2Cor e Forma:SolidPeso molecular:585.352-Acetamidophenol
CAS:<p>2-Acetamidophenol (Orthocetamol) has analgesic and antipyretic effects. 2-Acetamidophenol is an isomer of Paracetamol (4-acetamidophenol).</p>Fórmula:C8H9NO2Pureza:>99.99%Cor e Forma:Light Brown PowderPeso molecular:151.16GPLGIAGQ acetate
<p>GPLGIAGQ acetate: MMP2-cleavable peptide; stimulus-sensitive linker for MMP2-targeted liposomal/micellar carriers in photodynamic therapy.</p>Fórmula:C33H57N9O12Pureza:97.85%Cor e Forma:SolidPeso molecular:771.86Thalidomide 4'-oxyacetamide-alkyl-C2-amine HCl
CAS:<p>Thalidomide 4'-oxyacetamide-alkyl-C2-amine HCl is an E3 ligase ligand-linker conjugate containing the E3 ubiquitin ligase cereblon (CRBN) and linker.</p>Fórmula:C17H19ClN4O6Pureza:99.78%Cor e Forma:SolidPeso molecular:410.81
