Apoptose
Os inibidores da apoptose são compostos que previnem ou retardam o processo de morte celular programada, conhecido como apoptose. Esses inibidores são vitais no estudo dos mecanismos de sobrevivência celular e são usados para investigar doenças onde a apoptose é desregulada, como câncer, distúrbios neurodegenerativos e doenças autoimunes. Ao modular a apoptose, esses inibidores podem ajudar no desenvolvimento de terapias destinadas a controlar a morte celular. Na CymitQuimica, oferecemos uma ampla seleção de inibidores da apoptose de alta qualidade para apoiar sua pesquisa em biologia celular, oncologia e áreas relacionadas.
Subcategorias de "Apoptose"
- ASK(6 produtos)
- BCL(11 produtos)
- Caspase(125 produtos)
- FOXO1(3 produtos)
- IAP(66 produtos)
- Mdm2(12 produtos)
- PD-1/PD-L1(125 produtos)
- PDK(9 produtos)
- PERK(25 produtos)
- Serina/treonina quinase(15 produtos)
- Survivina(13 produtos)
- TNF(92 produtos)
- c-RET(51 produtos)
- p53(62 produtos)
Exibir 6 mais subcategorias
Foram encontrados 5598 produtos de "Apoptose"
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Thalidomide-NH-C8-NH2
CAS:<p>Thalidomide-NH-C8-NH2 is a synthetic E3 ligase ligand-linker for PROTAC, combining cereblon ligand and a specific linker.</p>Fórmula:C21H28N4O4Cor e Forma:SolidPeso molecular:400.479Linsidomine hydrochloride
CAS:<p>SIN-1 chloride is a moxidomine metabolite with vasodilatory, anti-platelet, and antianginal effects, reducing myocardial ischemia-related damage.</p>Fórmula:C6H11ClN4O2Pureza:99.27% - 99.67%Cor e Forma:White Solid CrystallinePeso molecular:206.63Antitumor photosensitizer-7
<p>Antitumor photosensitizer-7 (compound 15), a photosensitizer possessing anti-cancer properties, demonstrates substantial cytotoxic effects on the G361 melanoma cell line when exposed to 414 nm blue light irradiation.</p>Fórmula:C23H20N2O3Cor e Forma:SolidPeso molecular:372.42HEMTAC CDK4/6 degrader 1
CAS:<p>HEMTAC CDK4/6 degrader 1, a PROTAC targeting HSP90/CDK4/6, Kd of 35.7 μM, disrupts B16F10 melanoma cell cycle, and induces apoptosis.</p>Fórmula:C48H53ClN16O4Cor e Forma:SolidPeso molecular:953.49AZT triphosphate TEA
<p>AZT triphosphate TFA, a Zidovudine metabolite, inhibits HIV & HBV replication and triggers mitochondrial apoptosis.</p>Cor e Forma:SolidIsorhamnetin 3-glucuronide
<p>Isorhamnetin 3-glucuronide is a useful organic compound for research related to life sciences and the catalog number is T124938.</p>Fórmula:C22H20O13Cor e Forma:SolidPeso molecular:492.3892-Chloronaphthalene
CAS:<p>2-Chloronaphthalene is an organochlorine chemical compound and is a chlorinated derivative of naphthalene. The compound is an isomer for 1-chloronaphthalene.</p>Fórmula:C10H7ClPureza:98%Cor e Forma:SolidPeso molecular:162.62Furazolidone
CAS:<p>Furazolidone (Furoxone), a nitrofuran derivative, inhibits AML1-ETO transformed cells with IC50 value of 12.7 μM.</p>Fórmula:C8H7N3O5Pureza:99.96%Cor e Forma:Yellow Crystals From Dmf (N N-Dimethylformamide) SolidPeso molecular:225.16Sterigmatocystine
CAS:<p>Sterigmatocystine, a G1 phase and DNA synthesis inhibitor, curbs p21 and is a mycotoxin precursor from Aspergillus versicolor.</p>Fórmula:C18H12O6Pureza:98%Cor e Forma:Pale-Yellow Crystals Pale Yellow SolidPeso molecular:324.28HDAC-IN-77
<p>HDAC-IN-77 (HL-5s), an HDAC inhibitor, has the capability to induce ferroptosis and suppress the Nrf2/HO-1 signaling pathway. This compound is utilized in cancer research.</p>Fórmula:C22H26N4O2SCor e Forma:SolidPeso molecular:410.53Amorfrutin A
CAS:<p>Amorfrutin A is a useful organic compound for research related to life sciences. The catalog number is T124190 and the CAS number is 80489-90-3.</p>Fórmula:C21H24O4Cor e Forma:SolidPeso molecular:340.419PROTAC LZK-IN-1
CAS:<p>PROTAC LZK-IN-1 (Compound 21A) is a PROTAC molecule that targets the degradation of LZK (leucine zipper kinase, encoded by MAP3K13). At a concentration of 10 μM, PROTAC LZK-IN-1 facilitates the degradation of LZK and inhibits the expression of p53 and c-MYC, leading to reduced viability of global head and neck squamous cell carcinoma (HNSCC) cell lines. This compound is applicable in anticancer research.</p>Fórmula:C51H64F2N10O5SCor e Forma:SolidPeso molecular:967.18EGFR/HER2/DHFR-IN-3
<p>EGFR/HER2/DHFR-IN-3 (compound 4c) serves as an efficacious dual inhibitor specifically targeting EGFR/HER2, exhibiting IC50 values of 0.138 μM for EGFR and 0.</p>Pureza:98%Cor e Forma:Odour SolidSorafenib-d4
CAS:<p>Sorafenib D4 is deuterium-labeled Sorafenib, a multi-kinase inhibitor (Raf-1, B-Raf, VEGFR-3) with IC50s: 6, 20, 22 nM.</p>Fórmula:C21H16ClF3N4O3Pureza:98%Cor e Forma:SolidPeso molecular:468.85SA-VA
<p>SA-VA, an intracellular self-assembled PROTAC featuring azide and alkyne groups, selectively degrades VEGFR-2 and EphB4 proteins within U87 cells.</p>Fórmula:C50H53ClF3N11O7SPureza:98%Cor e Forma:SolidPeso molecular:1044.54WAY-118959-A
CAS:<p>WAY-118959-A is a potential microtubule acetylation inhibitor.</p>Fórmula:C16H14N4OS2Pureza:99.92%Cor e Forma:SolidPeso molecular:342.44PARP1-IN-17
<p>PARP1-IN-17 is an inhibitor that targets PARP-1 (IC50=19.24 nM ) with a slightly reduced affinity for PARP-2 (IC50=32.58 nM ) and induces apoptosis.</p>Pureza:98%Cor e Forma:Odour SolidKRAS inhibitor-40
CAS:<p>KRAS inhibitor-40 (Compound 41) is an inhibitor of KRAS, disrupting the KRAS G12C-BRAF complex and suppressing the phosphorylation of the downstream ERK signaling pathway. This compound also inhibits the proliferation of tumor cells with various KRAS mutations, exhibiting antitumor activity.</p>Fórmula:C53H66ClF4N9O8SCor e Forma:SolidPeso molecular:1100.66NFh-NMe-2
<p>NFh-NMe-2 is a photosensitizer that interacts with nitroreductase (nitroreductase) to generate singlet oxygen in tumor cells, exhibiting cytotoxicity in cancer cells and inducing apoptosis (apoptosis). In mouse models, NFh-NMe-2 demonstrates antitumor activity.</p>Fórmula:C32H33IN2OCor e Forma:SolidPeso molecular:588.522G-Glu-Val
CAS:<p>G-Glu-Val (γ-glutamyl-L-valine, H-Glu-Val -OH), a flavour-regulating dipeptide, is a major contributor to "mellow".</p>Fórmula:C10H18N2O5Cor e Forma:SolidPeso molecular:246.26ROS inducer 4
<p>Compound TE3, also known as ROS inducer 4, serves as a mitochondrial inhibitor. This compound induces a variety of mitochondria-related physiological alterations in tumors, including mitochondrial fragmentation, intense generation and accumulation of ROS, reduced mitochondrial membrane potential, and lower ATP content. Additionally, it activates ROS-mediated apoptotic signaling within mitochondria.</p>Fórmula:C49H62BrO4PCor e Forma:SolidPeso molecular:825.89TD1092
<p>TD1092, a pan-IAP degrader, activates caspase 3/7, induces apoptosis in cancer cells, inhibits NF-κB, and is used in cancer research.</p>Fórmula:C55H70N8O9Cor e Forma:SolidPeso molecular:987.19Ch282-5
CAS:<p>Ch282-5, an orally active inhibitor targeting the Bcl-2 protein, promotes mitochondria-dependent apoptosis (Apoptosis) by disrupting mitophagy and the mTOR pathway. It demonstrates antiproliferative effects on colorectal cancer cells, effective both in vitro and in vivo, while also inhibiting metastasis. Further, Ch282-5 augments Oxaliplatin-induced autophagy (Autophagy) by downregulating Mcl-1 protein and raising platelet count, which helps mitigate the adverse effects of Navitoclax.</p>Fórmula:C34H34N2Na2O14S2Cor e Forma:SolidPeso molecular:804.75Chol-CTPP
<p>Chol-CTPP targets the BBB and glioma cells; when combined with Chol-TPP, forms Lip-CTPP, enhancing anti-glioma drug efficacy.</p>Fórmula:C144H263N3O53Cor e Forma:SolidPeso molecular:2884.62Enniatin A1
CAS:<p>Enniatin A1, a cyclic hexadepsipeptide from Fusarium, induces apoptosis and disrupts ERK, inhibiting ACAT (IC50: 49 μM).</p>Fórmula:C35H61N3O9Pureza:98%Cor e Forma:SolidPeso molecular:667.885Iparomlimab
CAS:<p>Iparomlimab: anti-PD-1 IgG4κ antibody, targets PSB103 γ4/κ-chains, forms dimers, used in cancer research.</p>Cor e Forma:LiquidFPR1 antagonist 2
<p>Compound 25b, an FPR1 antagonist, exhibits potent inhibition of the formyl peptide receptor 1 with an IC50 of 70 nM.</p>Fórmula:C25H25F3O5Cor e Forma:SolidPeso molecular:462.46PRMT5-IN-33
<p>PRMT5-IN-33 (compound A8) is a selective inhibitor of PRMT5 that competes with SAM, exhibiting an IC50 of 10.9 nM. It induces apoptosis and inhibits the proliferation of Z-138 and MOLM-13 cells, demonstrating antitumor activity.</p>Fórmula:C25H24BrN5O3SPeso molecular:553.07832Ferroptosis-IN-13
<p>Ferroptosis-IN-13 (compound NY-26) is an inhibitor of ferroptosis. It effectively suppresses RSL3-induced ferroptosis in 786-O cells, with an EC50 value of 62 nM.</p>Fórmula:C32H30F2N4O3Cor e Forma:SolidPeso molecular:556.602Enniatin complex
CAS:<p>Enniatin complex: fungal cyclohexadepsipeptides inhibit enzymes, induce cancer cell apoptosis, and have ionophoric, antibiotic, and hypolipidemic effects.</p>Pureza:98%Cor e Forma:SolidAc-FEID-CMK
<p>Ac-FEID-CMK: Potent inhibitor for zebrafish GSDMEb, reduces pyroptosis, and lessens septic AKI.</p>Fórmula:C27H37ClN4O9Cor e Forma:SolidPeso molecular:597.06AMG-7209
CAS:<p>AMG-7209 is an effective and selective MDM2-p53 interaction inhibitor.</p>Fórmula:C37H41Cl2FN2O7SCor e Forma:SolidPeso molecular:747.7Satratoxin G
CAS:<p>Satratoxin G, from Stachybotrys chartarum, triggers apoptosis in nasal and brain OSNs.</p>Fórmula:C29H36O10Cor e Forma:SolidPeso molecular:544.597PAA5
<p>PAA5, a polynuclear Au(I) cluster, triggers ferroptosis and has anticancer effects by increasing pH2AX over time.</p>Fórmula:C14H8Au5B2F8N2Cor e Forma:SolidPeso molecular:1348.66PRMT5-IN-45
<p>PRMT5-IN-45 (compound 36) is a potent and selective inhibitor of PRMT5, exhibiting an IC50 value of 3 nM. This compound effectively reduces the levels of symmetrical dimethylarginine (sDMA) and inhibits the proliferation of the MOLM-13 cell line by inducing apoptosis and causing cell cycle arrest.</p>Fórmula:C26H31N7O2Cor e Forma:SolidPeso molecular:473.57TS-24
CAS:<p>TS-24 is a cysteine protease histone S (CTSS) inhibitor that promotes BRCA1-mediated apoptosis.</p>Fórmula:C20H15NO2Pureza:99.41%Cor e Forma:SoildPeso molecular:301.34CDK2-IN-32
<p>CDK2-IN-32 (Compound 5g) is a selective CDK2 inhibitor with an IC50 of 0.21 μM. It exhibits cytotoxicity towards Vero cells with an IC50 of 28.52 μM.</p>Fórmula:C18H13Cl2N5O2Cor e Forma:SolidPeso molecular:402.23A-1248767
CAS:<p>A-1248767, a derivative of A-1210477, is an MCL-1 inhibitor (IC50=23.9 nM; Ki=0.41 nM) known for its anticancer properties. It binds to MCL-1 with high affinity, induces an increase in MCL-1 protein levels inside cells, and promotes apoptosis in tumor cells.</p>Fórmula:C47H55N7O6Cor e Forma:SolidPeso molecular:813.98Ru-Poma
<p>Ru-Poma is an Ru(II)-based photosensitizer designed to enhance the efficacy of photodynamic therapy (PDT) against tumors resistant to Cisplatin. It targets Pomalidomide to partially degrade CRBN, inducing ferroptosis by increasing lipid peroxides and downregulating GPX4 and GAPDH expression. In A549 cells, Ru-Poma exhibits cytotoxicity with IC50 values of 18.46 μM in the dark and 0.37 μM under illumination.</p>Fórmula:C89H75Cl2N11O11Ru·7H2OMS1943
CAS:<p>MS1943 is a orally bioavailable EZH2 selective degrader(IC50 of 120 nM).</p>Fórmula:C42H54N8O3Pureza:95.41% - 95.82%Cor e Forma:SolidPeso molecular:718.93Antitumor agent-116
<p>Antitumor Agent-116 (Compound 6C) is an anti-tumor agent that exhibits anti-proliferative properties and induces apoptosis.</p>Fórmula:C31H23BrN4O4SPureza:98%Cor e Forma:SolidPeso molecular:627.51SRE-II
<p>SRE-II, an amide derivative, serves as an activatable photosensitizer tailored for photodynamic cancer research, exhibiting diminished fluorescence and</p>Fórmula:C15H9ClINO2Pureza:98%Cor e Forma:SolidPeso molecular:397.59Tubulin/HDAC-IN-2
<p>Tubulin/HDAC-IN-2 (Compound II-19k) is a dual inhibitor targeting Tubulin and HDAC, exhibiting IC50 values of 0.403 μM for HDAC1, 0.591 μM for HDAC2, 3.552 μM</p>Fórmula:C21H19FN2O4Cor e Forma:SolidPeso molecular:382.38Waltonitone
CAS:<p>Waltonitone is a natural ursane-type pentacyclic triterpene isolated from Gentian waltonii Burkill.</p>Fórmula:C30H48O2Pureza:98%Cor e Forma:SolidPeso molecular:440.7NAE-IN-1
<p>NAE-IN-1 (compound X-10) is a potent inhibitor of NAE1. It induces apoptosis and causes cell cycle arrest in the G2/M phase. Furthermore, NAE-IN-1 increases ROS levels and inhibits cell migration, demonstrating antiproliferative activity.</p>Fórmula:C29H30N4O2SPeso molecular:498.20895Ropeginterferon alfa-2b
CAS:<p>Ropeginterferon alfa-2b (Ropeginterferon alfa-2b-njft), a monopegylated interferon-alpha (IFN-α), is utilized in the study of myeloproliferative neoplasms [1].</p>Cor e Forma:LiquidAntitumor agent-41
<p>Antitumor Agent-41 (Compound N-12) exhibits potent antitumor properties, demonstrating significant antimigration and anti-invasion activities.</p>Fórmula:C64H109IN2O21Cor e Forma:SolidPeso molecular:1369.46Mofarotene
CAS:<p>Mofarotene (Ro-40-8757) is a small molecule compound that shows considerable antitumor activity in many cancer cell lines and can be used for the treatment of</p>Fórmula:C29H39NO2Pureza:99.96%Cor e Forma:SolidPeso molecular:433.63Humulone
<p>Humulone is a natural product and has a wide range of applications in life science related research.</p>Fórmula:C21H30O5Cor e Forma:SolidPeso molecular:362.47(±)-Enterodiol
CAS:<p>"(±)-Enterodiol, the racemate of Enterodiol, is metabolized from lignans found in whole-grain cereals, nuts, legumes, flaxseed, and vegetables by human intestinal bacteria. This compound exhibits apoptotic effects in colorectal cancer (CRC) cells and has been identified to possess anti-cancer activities [1] [2]."</p>Fórmula:C18H22O4Cor e Forma:SolidPeso molecular:302.36
