Apoptose

<p>NU 9056 is an effective and selective inhibitor of KAT5 histone acetyltransferase with an IC50 of 2 µM.</p>

<p>Lestaurtinib (CEP 701) is a FLT3 inhibitor that inhibits the phosphorylation of RPTKs and can be used to study leukemia.</p>

<p>Momelotinib sulfate is an ATP-competitive JAK1/JAK2 inhibitor (IC50: 11 nM/18 nM). It has 10-fold selectivity versus JAK3.</p>

<p>Isoscabertopin has anticancer activity.</p>

<p>Cerivastatin sodium (BAY W 6228 sodium) is an HMG-CoA reductase inhibitor with lipid-lowering activity that reduces LDL cholesterol levels.</p>

AZD5582 is an inhibitor of IAPs, which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. It induces apoptosis.

<p>ODN 1826 is a TLR9 agonist and immunostimulant, which has antitumor effects and promotes cell apoptosis.</p>

<p>GSK778 selectively inhibits BD1 bromodomains (BRD2, BRD3, BRD4, BRDT) and impedes cell growth, causing arrest and apoptosis.</p>

<p>Gum Arabic, from A. Senegal, is an antioxidant that defends against hepatic, renal, and cardiac toxicities and aids in immunohistochemistry.</p>

<p>6-Formylpterin (Pterin-6-aldehyde) is an inhibitor of Xanthine Oxidase, which induces ROS generation and apoptosis in HL-60 cells.</p>

<p>Methopterin shows the activation and bone resorption function of murine osteoclasts.</p>

<p>Hydroxy-PP-Me is a CBR1 inhibitor that inhibits apoptosis induced by serum withdrawal.Hydroxy-PP-Me is used in the study of leukemia.</p>

<p>MM-401 (TFA), an MLL1 H3K4 methylation inhibitor (IC50 = 0.32 µM), blocks MLL1-WDR5, causing cell cycle arrest and apoptosis, for MLL leukemia studies.</p>

<p>Cu/Zn-SOD1 enzyme scavenges radicals; mutations cause ALS. Cu-ATSM, crossing blood-brain barrier, targets hypoxic tissue, may aid ALS mice.</p>

<p>(-)-Apomorphine hydrochloride hydrate is a broad-spectrum dopamine agonist and ferroptosis inhibitor.</p>

<p>MRT00033659 inhibits CK1 (IC50=0.9 μM), CHK1 (IC50=0.23 μM), activates p53, and destabilizes E2F-1; it's a pyrazolo-pyridine.</p>

<p>CLZ-8 (Mcl1-IN-8) is a Mcl-1-PUMA inhibitor with radioprotective activity and inhibits radiation-induced overexpression of PUMA.</p>

<p>N-3-oxo-dodecanoyl-L-Homoserine lactone (3-oxo-C12-HSL), a quorum-sensing signaling molecule synthesized by P. aeruginosa and specific B. cepacia complex strains [1][2], facilitates bacterial gene expression modulation in response to cell density escalation and triggers IL-8 production in 16HBE human bronchial epithelial cells [3].</p>

PDK1-IN-RS2, a PIFtide mimic, selectively inhibits PDK1, blocking S6K1 activation (Kd: 9 μM).

<p>Almorexant hydrochloride (ACT 078573 hydrochloride) is a dual orexin receptor antagonist that induces apoptosis and can be used to study sleep disorders.</p>

Tubulin inhibitor 1 blocks tubulin polymerization, with strong anti-tumor effects, induces apoptosis and G2/M mitotic arrest.

<p>Chlorhexidine digluconate is a disinfectant with antibacterial activity that induces apoptosis and can be used to study bacterial infections.</p>

<p>(Rac)-Apremilast D5 is a deuterium-labeled version of the enantiomer (R)-Apremilast, also known as (R)-CC-10004, which itself is one specific form of Apremilast</p>

<p>DCVC inhibits pathogen-stimulated TNF-α in human extra placental membranes in vitro.</p>

<p>L-Cystine, hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T124989 and the CAS number is 34760-60-6.</p>

<p>TMI-1 (WAY-171318), a novel orally active inhibitor of ADAM17 (TACE) and MMP, induces tumor apoptosis in a breast cancer.</p>

<p>Fluorizoline is a PHB-binding compound with anticancer and antiproliferative activity and induces apoptosis.</p>

<p>AZD-5991, an antitumor compound, is a highly selective, potent and direct MCL-1 inhibitor, rapid apoptosis by Bak-dependent mitochondrial apoptotic pathway.</p>

<p>EPZ020411 is a specific and effective inhibitor of PRMT6 (IC50=10 nM).</p>

<p>Fmoc-D-Cha-OH (FDCO) is an apoptotic DNase γ inhibitor that inhibits the release of HMGB1.</p>

<p>Gemcitabine elaidate (CP-4126), is a lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, with</p>

<p>Acyclovir sodium is an antimetabolite. Acyclovir sodium inhibits HSV-specified DNA polymerases and prevents further viral DNA synthesis.</p>

<p>Capecitabine-d11 is a deuterated compound of Capecitabine. Capecitabine has a CAS number of 154361-50-9. Capecitabine is a fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively activated by tumor cells to its cytotoxic moiety, 5-fluorouracil (5-FU); subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells. FdUMP inhibits DNA synthesis and cell division by reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate for incorporation into the RNA strand.</p>

Octreotide (SMS 201-995) is a potent inhibitor of growth hormone, glucagon, and insulin.

<p>Hematoporphyrin monomethyl ether is a porphyrin photosensitizer that can be used in studies of port wine stains.</p>

<p>Celosin K (compound 8), isolated from Semen Celosiae seeds, effectively inhibits t-BHP-induced neuronal injury.</p>

<p>3,4,5-Trihydroxycinnamic acid decyl ester is an anti-obesity agent that inhibits lipid absorption and pancreatic lipase (EC50 ≈ 0.9μM).</p>

<p>Prexasertib dimesylate is a selective CHK1 inhibitor with K i 0.9 nM, blocks CHK2 &amp; RSK1, induces DNA breakage, and has potent anti-tumor effects.</p>

<p>Asiatic acid (Dammarolic acid) is the aglycone of asiaticoside used in wound healing with antioxidant, anti-inflammatory, and neuroprotective properties.</p>

<p>Crebanine mitigates arrhythmias, increases aconitine tolerance in rats, lacks effect on ouabain-induce arrhythmias, and shows anti-cancer properties.</p>