Apoptose
Os inibidores da apoptose são compostos que previnem ou retardam o processo de morte celular programada, conhecido como apoptose. Esses inibidores são vitais no estudo dos mecanismos de sobrevivência celular e são usados para investigar doenças onde a apoptose é desregulada, como câncer, distúrbios neurodegenerativos e doenças autoimunes. Ao modular a apoptose, esses inibidores podem ajudar no desenvolvimento de terapias destinadas a controlar a morte celular. Na CymitQuimica, oferecemos uma ampla seleção de inibidores da apoptose de alta qualidade para apoiar sua pesquisa em biologia celular, oncologia e áreas relacionadas.
Subcategorias de "Apoptose"
- ASK(9 produtos)
- BCL(1 produtos)
- Caspase(154 produtos)
- FOXO1(2 produtos)
- IAP(67 produtos)
- Mdm2(12 produtos)
- PD-1/PD-L1(134 produtos)
- PDK(9 produtos)
- PERK(23 produtos)
- Serina/treonina quinase(17 produtos)
- Survivina(14 produtos)
- TNF(93 produtos)
- c-RET(61 produtos)
- p53(63 produtos)
Exibir 6 mais subcategorias
Foram encontrados 6222 produtos de "Apoptose"
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Stavudine sodium
CAS:Stavudine sodium, an oral HIV-1/2 inhibitor, also hinders mtDNA replication, NLRP3 inflammasome, and Amyloid-β autophagy, prompting apoptosis.Fórmula:C10H11N2NaO4Cor e Forma:SolidPeso molecular:246.198Urolithin C
CAS:Urolithin C is a gut metabolite of ellagic acid. Urolithin C induces apoptosis in PC12 cells through a mitochondria-mediated pathway.Fórmula:C13H8O5Pureza:98.01% - 99.53%Cor e Forma:SolidPeso molecular:244.2Ref: TM-TN7108
5mg50,00€1mL*10mM (DMSO)56,00€10mg84,00€25mg136,00€50mg222,00€100mg334,00€200mg495,00€500mg782,00€Musk ketone
CAS:Musk ketone may suppress cancer cell growth, induce apoptosis, and boost glutathione S-transferase, potentially aiding cancer protection.Fórmula:C14H18N2O5Pureza:99.85%Cor e Forma:Yellow Crystals Physical Description Light Yellow Crystalline Solid Insoluble In Water (Ntp 1992)Peso molecular:294.30PRIMA-1
CAS:PRIMA-1 (NSC-281668) is a mutant p53 reactivator. It induces apoptosis and inhibits growth of human tumors with mutant p53.Fórmula:C9H15NO3Pureza:99.22%Cor e Forma:SolidPeso molecular:185.22Ref: TM-T6954
5mg49,00€1mL*10mM (DMSO)54,00€10mg70,00€25mg133,00€50mg195,00€100mg349,00€200mg518,00€500mg830,00€GSK2656157
CAS:GSK2656157 is a highly specific and ATP-competitive PERK inhibitor (IC50: 0.9 nM) in a cell-free assay.Fórmula:C23H21FN6OPureza:98.59% - >99.99%Cor e Forma:SolidPeso molecular:416.45Ref: TM-T2654
2mg34,00€5mg52,00€1mL*10mM (DMSO)52,00€10mg77,00€25mg135,00€50mg245,00€100mg442,00€200mg598,00€KRAS inhibitor-9
CAS:KRAS inhibitor-9 (DUN09716) hinders GTP-KRAS formation, with a Kd of 92 μM, causes G2/M arrest, and induces apoptosis in mutated NSC-LC cells.Fórmula:C13H9ClN2S2Pureza:99.66%Cor e Forma:SolidPeso molecular:292.81Ref: TM-T8756
1mg57,00€2mg81,00€5mg113,00€1mL*10mM (DMSO)136,00€10mg178,00€25mg334,00€50mg485,00€100mg622,00€Aristolactam I
CAS:Aristolactam I (Aristololactum) has cytotoxic potency, mediated through the induction of apoptosis in a caspase 3-dependent pathway.Fórmula:C17H11NO4Pureza:98.98% - 99.96%Cor e Forma:SolidPeso molecular:293.27Ref: TM-T3S1227
1mg57,00€5mg133,00€1mL*10mM (DMSO)172,00€10mg205,00€25mg350,00€50mg515,00€100mg735,00€Nimustine Hydrochloride
CAS:Nimustine Hydrochloride (Nidran hydrochloride) has been used in trials studying the treatment of Glioblastoma.Fórmula:C9H14Cl2N6O2Pureza:98.80%Cor e Forma:SolidPeso molecular:309.15Ref: TM-T5017
2mg34,00€5mg49,00€1mL*10mM (DMSO)50,00€10mg71,00€25mg92,00€50mg152,00€100mg268,00€200mg398,00€Cabozantinib hydrochloride
CAS:Cabozantinib hydrochloride (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt4 (IC50s: 0.035, 1.3, 4.6, 7 and 6Fórmula:C28H25ClFN3O5Pureza:99.97%Cor e Forma:SolidPeso molecular:537.96Ref: TM-T5164
1mg42,00€2mg52,00€5mg65,00€10mg92,00€25mg160,00€50mg235,00€100mg330,00€200mg538,00€500mg860,00€Malachite green oxalate
CAS:Malachite green oxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions.Fórmula:C23H25N2·C2HO4C2H2O4Cor e Forma:Dark Green Crystals With A Metallic LusterPeso molecular:463.51HYPOCRELLIN B
CAS:HYPOCRELLIN B, from Hypocrella bambusae, breaks DNA, triggers apoptosis in ovarian cells, and stops Staphylococcus growth via ROS.Fórmula:C30H24O9Pureza:98% - 98.87%Cor e Forma:SolidPeso molecular:528.51Madecassoside
CAS:Madecassoside (Asiaticoside A) is a pentacyclic triterpene extracted from Centella asitica (L.) with anti-inflammatory, anti-oxidative and anti-aging activitiesFórmula:C48H78O20Pureza:99.46% - 99.85%Cor e Forma:White PowderPeso molecular:975.12Ref: TM-T2813
10mg49,00€1mL*10mM (DMSO)49,00€25mg84,00€50mg120,00€100mg178,00€200mg289,00€500mg485,00€O6-Benzylguanine
CAS:O6-Benzylguanine is a guanine analog with antineoplastic activity,and is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.Fórmula:C12H11N5OPureza:98.9%Cor e Forma:Solid CrystallinePeso molecular:241.25BMS-1
CAS:BMS-1 is a PD-1/PD-L1 inhibitor and immunomodulator; it targets the CD274 gene product, PD-L1, linked to tumor evasion and higher mortality.
Fórmula:C29H33NO5Pureza:99.40% - 99.81%Cor e Forma:SolidPeso molecular:475.58GSK1324726A
CAS:GSK1324726A (I-BET726) is a greatly specific inhibitor of BET family proteins for BRD2(IC50=41 nM), BRD3(IC50=31 nM), and BRD4 (IC50=22 nM).
Fórmula:C25H23ClN2O3Pureza:98.34% - 99.85%Cor e Forma:SolidPeso molecular:434.91Milademetan free base
CAS:Milademetan (DS-3032b) is a potent MDM2 inhibitor, potentially blocking cancer growth by targeting p53 protein.Fórmula:C37H42Cl2FN5O7SPureza:98%Cor e Forma:SolidPeso molecular:790.73MK-2206
CAS:MK-2206: selective Akt inhibitor, oral, targets Akt1, Akt2, Akt3; effective in breast cancer, PIK3CA mutants, PTEN-deficient cells.Fórmula:C25H22ClN5OCor e Forma:SolidPeso molecular:443.94Glycitein
CAS:1. Gycitein has weak estrogenic activity. 2. Glycitein (Glycetein) inhibits glioma cell invasion through down-regulation of MMP-3 and MMP-9 gene expression.Fórmula:C16H12O5Pureza:99.23% - 99.94%Cor e Forma:White PowderPeso molecular:284.26Ref: TM-T6S0325
2mg34,00€5mg52,00€1mL*10mM (DMSO)52,00€10mg65,00€25mg92,00€50mg137,00€100mg193,00€200mg286,00€Radotinib
CAS:Radotinib (IY-5511), and sometimes referred to by its investigational name IY5511, is a drug for the treatment of different types of Y, most notably
Fórmula:C27H21F3N8OPureza:99.13% - 99.97%Cor e Forma:SolidPeso molecular:530.5Isoliensinine
CAS:Isoliensinine (Isoliensinin) is a natural product, a bisbenzylisoquinoline alkaloid. Isoliensinine has antitumor and antioxidant effects. Cost effective and quality assured.Fórmula:C37H42N2O6Pureza:98.53% - 99.79%Cor e Forma:SolidPeso molecular:610.74Ref: TM-T5S1103
1mg34,00€5mg65,00€10mg94,00€1mL*10mM (DMSO)94,00€25mg137,00€50mg193,00€100mg286,00€500mg695,00€Macitentan
CAS:Macitentan (ACT-064992) is an endothelin receptor antagonist that is used in the therapy of pulmonary arterial hypertension (PAH).Fórmula:C19H20Br2N6O4SPureza:98% - >99.99%Cor e Forma:SolidPeso molecular:588.27BDA-366
CAS:BDA-366, a potent Bcl2 antagonist, selectively binds the Bcl2-BH4 domain with high affinity (Ki = 3.3 nM), inducing a conformational change that nullifies itsFórmula:C24H29N3O4Pureza:98.61%Cor e Forma:SoildPeso molecular:423.53BDO
CAS:3BDO is a new mTOR activator. 3BDO inhibits autophagy.Fórmula:C18H17NO5Pureza:97.76%Cor e Forma:SolidPeso molecular:327.33Ref: TM-T14033
1mg34,00€2mg44,00€5mg64,00€1mL*10mM (DMSO)71,00€10mg92,00€25mg195,00€50mg313,00€100mg467,00€Sodium dichloroacetate
CAS:Sodium dichloroacetate (BCA) inhibits PDK (IC50: 183 μM PDK2, 80 μM PDK4), triggers cancer cell apoptosis, and impedes tumor growth.Fórmula:C2HCl2NaO2Pureza:99.32% - 99.87%Cor e Forma:White PowderPeso molecular:150.92AES-350
CAS:AES-350, an HDAC6 inhibitor (IC50: 0.0244 μM), also targets HDAC-3, -8, -11, induces AML cell apoptosis, and aids AML research.Fórmula:C18H20N2O3Pureza:98.82%Cor e Forma:SolidPeso molecular:312.36Medicarpin
CAS:Medicarpin, an ER agonist, stimulates osteoblasts, enhances peak bone mass, has no uterine effects, and is orally bioavailable.Fórmula:C16H14O4Pureza:99.32% - 99.86%Cor e Forma:SolidPeso molecular:270.28Ref: TM-TN1918
1mg109,00€1mL*10mM (DMSO)235,00€5mg260,00€10mg385,00€25mg628,00€50mg872,00€100mg1.153,00€200mg1.584,00€Fenobam hydrate
CAS:Fenobam hydrate blocks mGluR5, preventing calcium mobilization, and may reduce stress, anxiety, and pain.Fórmula:C11H13ClN4O3Cor e Forma:SolidPeso molecular:284.7FLLL32
CAS:FLLL32 is an effective JAK2/STAT3 inhibitor (IC50 of <5 μM).Fórmula:C28H32O6Pureza:97% - 97.90%Cor e Forma:SolidPeso molecular:464.55Ref: TM-T6838
2mg43,00€5mg63,00€1mL*10mM (DMSO)69,00€10mg88,00€25mg117,00€50mg187,00€100mg333,00€500mg797,00€Sulindac sodium
CAS:Sulindac (sodium) (MK-231) is an NSAID used for arthritis pain, swelling, gout, and as an immunomodulator in CRC therapy.Fórmula:C20H16FNaO3SCor e Forma:SolidPeso molecular:378.39TPCA-1
CAS:TPCA-1 (TPCA1) is an effective and specific IKK-2 inhibitor (IC50: 17.9 nM); shows >22-fold selectivity over IKK-1 and >550-fold selectivity over others kinasesFórmula:C12H10FN3O2SPureza:95.03% - 97.86%Cor e Forma:SolidPeso molecular:279.29Nodinitib-1
CAS:Nodinitib-1 (CID-1088438) is a potent and selective NOD1 inhibitor with an IC50 of 0.56 μM.Fórmula:C14H13N3O2SPureza:99.97% - >99.99%Cor e Forma:SolidPeso molecular:287.34Vandetanib trifluoroacetate
CAS:Vandetanib trifluoroacetate: oral VEGFR2/KDR inhibitor, IC50=40nM, also blocks VEGFR3/FLT4 (110nM) and EGFR/HER1 (500nM).Fórmula:C24H25BrF4N4O4Cor e Forma:SolidPeso molecular:589.386Epoxomicin
CAS:Epoxomicin, a selective proteasome inhibitor, chiefly blocks CH-L activity, mildly affecting T-L and PGPH at lower rates.Fórmula:C28H50N4O7Pureza:98.65% - 98.86%Cor e Forma:White To Off-White SolidPeso molecular:554.72Ref: TM-T6830
1mg125,00€5mg311,00€1mL*10mM (DMSO)375,00€10mg502,00€25mg817,00€50mg1.130,00€100mg1.501,00€500mg3.022,00€Flavokawain B
CAS:Flavokawain B inhibits NO and PGE2, causes oxidative stress, and induces apoptosis, with potential for treating prostate cancer.Fórmula:C17H16O4Pureza:99.94% - >99.99%Cor e Forma:SolidPeso molecular:284.31Ligustrazine
CAS:Ligustrazine (Tetramethylpyrazine), a natural compound isolated from Chuan Xiong shows anti-inflammation, antioxidant, antiplatelet, and antiapoptosis effects.Fórmula:C8H12N2Pureza:99.91% - >99.99%Cor e Forma:White Crystals Or PowderPeso molecular:136.19Navtemadlin
CAS:Navtemadlin (AMG232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction (IC50: 0.6 nM).Cost-effective and quality-assured.Fórmula:C28H35Cl2NO5SPureza:95.55% - 99.08%Cor e Forma:SolidPeso molecular:568.55(20S)-Protopanaxatriol
CAS:(20S)-Protopanaxatriol (g-PPT)(g-PPT), a metabolite of ginsenoside, could regulate endothelial cell functions through the estrogen receptor and glucocorticoidFórmula:C30H52O4Pureza:95% - 99%Cor e Forma:SolidPeso molecular:476.73Ref: TM-T2810
2mg34,00€5mg50,00€1mL*10mM (DMSO)55,00€10mg66,00€25mg114,00€50mg178,00€100mg295,00€200mg442,00€(Rac)-Idroxioleic acid
CAS:(Rac)-Idroxioleic acid (2-Hydroxyoleic acid) is a fatty acid amide hydrolase inhibitor with anti-tumor effect.Fórmula:C18H34O3Pureza:≥98%Cor e Forma:SolidPeso molecular:298.46NVP-TAE 226
CAS:NVP-TAE 226: Potent FAK inhibitor, IC50=5.5nM, stronger vs Pyk2, IC50=3.5nM, weaker against IGF-1R, InsR, c-Met, ALK.Fórmula:C23H25ClN6O3Pureza:98.07% - 98.78%Cor e Forma:SolidPeso molecular:468.94Ref: TM-T1918
1mg46,00€2mg59,00€5mg96,00€1mL*10mM (DMSO)96,00€10mg155,00€25mg250,00€50mg358,00€100mg537,00€Ospemifene
CAS:Ospemifene (FC-1271a) is a new selective non-hormonal estrogen receptor modulator (SERM) that is used for the treatment of moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause. FDA approved on February 26, 2013.Fórmula:C24H23ClO2Pureza:99.95%Cor e Forma:SolidPeso molecular:378.89TW-37
CAS:TW-37 is an nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 (Ki: 0.29/1.11/0.26 μM).Fórmula:C33H35NO6SPureza:97.06% - ≥95%Cor e Forma:SolidPeso molecular:573.7Ref: TM-T6281
1mg38,00€2mg50,00€5mg65,00€1mL*10mM (DMSO)90,00€10mg107,00€25mg202,00€50mg334,00€100mg495,00€Eltrombopag
CAS:Eltrombopag (SB-497115-GR), an orally active thrombopoietin receptor agonist with megakaryopoiesis stimulating activity, binds to and stimulates the plateletFórmula:C25H22N4O4Pureza:99.27%Cor e Forma:Orange To Red SolidPeso molecular:442.47Bomedemstat
CAS:Bomedemstat (IMG-7289),Irreversible LSD1 inhibitor. Active in MPN models. Antineoplastic effects. Used in AML and myelofibrosis research.Fórmula:C28H34FN7O2Pureza:98.23% - 99.00%Cor e Forma:SolidPeso molecular:519.61Luminespib
CAS:Luminespib (VER-52296) is an HSP90 inhibitor that inhibits HSP90α and HSP90β. Luminespib has antitumor activity. Cost-effective and quality-assured.Fórmula:C26H31N3O5Pureza:98% - 99.25%Cor e Forma:SolidPeso molecular:465.54Ref: TM-T1989
5mg54,00€1mL*10mM (DMSO)59,00€10mg77,00€25mg138,00€50mg210,00€100mg344,00€200mg512,00€500mg825,00€DC260126
CAS:DC260126 is a small-molecule antagonist of FFA1 (GPR40)Fórmula:C16H18FNO2SPureza:99.77%Cor e Forma:SolidPeso molecular:307.38Rimiducid
CAS:Rimiducid, a tacrolimus analogue, dimerizes FKBP domains to activate Caspase 9 and induce apoptosis; binds FKBP12 weakly.Fórmula:C78H98N4O20Pureza:99.54%Cor e Forma:SolidPeso molecular:1411.63Ref: TM-T14298
1mg129,00€2mg177,00€5mg285,00€10mg420,00€25mg692,00€50mg973,00€100mg1.305,00€500mg2.602,00€Licofelone
CAS:Licofelone (ML-3000) is a dual COX/LOX inhibitor potentially for the treatment of osteoarthritis.Fórmula:C23H22ClNO2Pureza:99.25%Cor e Forma:Yellowish SolidPeso molecular:379.88Ref: TM-T6568
5mg44,00€1mL*10mM (DMSO)48,00€10mg66,00€25mg119,00€50mg177,00€100mg264,00€200mg394,00€500mg623,00€Staurosporine
CAS:Staurosporine (AM-2282) is a protein kinase inhibitor with ATP-competitive and non-selective inhibitory activity (IC50=6/15/2/3/3000 nM) against PKC, PKA, c-FgrFórmula:C28H26N4O3Pureza:99.24% - 99.82%Cor e Forma:Off-White PowderPeso molecular:466.53Ref: TM-T6680
1mg58,00€2mg82,00€5mg92,00€1mL*10mM (DMSO)103,00€10mg138,00€25mg234,00€50mg380,00€100mg565,00€500mg1.215,00€3-O-Methylgallic acid
CAS:3-O-Methylgallic acid (3,4-Dihydroxy-5-methoxybenzoic acid) reduces cell proliferation in Caco-2 cells(IC50 = 24.1 μM) more effectively than anthocyanins andFórmula:C8H8O5Pureza:99.56%Cor e Forma:SolidPeso molecular:184.15Astaxanthin
CAS:Astaxanthin, a keto-carotenoid and xanthophyll, offers antioxidant benefits, present in red aquatic species, and used as a colorant in animal feed.Fórmula:C40H52O4Pureza:95.10% - 99.79%Cor e Forma:Needles From Acetone/Light Petroleum SolidPeso molecular:596.84
