Apoptose

<p>N1-Acetylspermidine HCl, an acetyl spermidine derivative, boosts polyamine oxidase levels in colorectal adenocarcinomas.</p>

<p>Applications γ-Bisabolene (Mixture of Isomers), is a sesquiterpene and can be extracted from oregano and other aromatic plants. It may be a potential anticancer agent that can induce apoptosis in A549 cancer cell line.<br>References Grosso, N. R., et al.: Argent., Pat. Appl. AR 90961 A1 20141217 (2014); Yfanti, P., et al.: Am J Plant Sci. 6, 2092 (2015)<br></p>

<p>Ionomycin is a calcium ionophore and a Ca2+ -binding antibiotic, increases intracellular Ca 2 + to induce cellular responses. High-Quality, Low-Cost!</p>

<p>Applications Bisabolene is a sesquiterpene and can be extracted from oregano and other aromatic plants. It may be a potential anticancer agent that can induce apoptosis in A549 cancer cell line.<br>References Grosso, N. R., et al.: Argent., Pat. Appl. AR 90961 A1 20141217 (2014); Yfanti, P., et al.: Am J Plant Sci. 6, 2092 (2015)<br></p>

<p>Envafolimab (ASC 22) is a humanized antibody targeting PD-L1, with anticancer activity, blocking the PD-L1 and PD-1 interaction.</p>

<p>2′,2′-Difluorodeoxyuridine has anticancer activity, and shows radiosensitization under hypoxic conditions, and can be used to study pancreatic cancer.</p>

BC-1471 is a STAMBP deubiquitinase inhibitor that blocks NALP7 inflammasome activity.

<p>Applications 25R-3α,7α,12α-Trihydroxy-5β-cholestanoic acid is an intermediate in the synthesis of (25R)-3β,7α,12α-Trihydroxy-5-cholestenoic Acid (T795130), which is an oxysterol, an oxidized derivatives of cholesterol (C432501), which may be important in many biological processes, including cholesterol homeostasis, atherosclerosis, sphingolipid metabolism, platelet aggregation, apoptosis, and protein prenylation,[1] though their roles are poorly understood.<br>References Schroepfer, G., et al.: Physiol. Rev., 80, 361 (2000); Bjorkhem, I.: J. Clin. Invest., 6, 725(2002); Bjorkhem, I., et al.: Arterio. hromb. Vascul. Biol., 22, 734 (2002)<br></p>

IACS-010759 hydrochloride is an orally potent and selective OXPHOS inhibitor that inhibits proliferation and induces apoptosis AML and solid tumours.

MitoBloCK-6 inhibits Erv1/ALR (IC50: 900/700 nM) and Erv2 (IC50: 1.4 μM), induces apoptosis in hESCs.

<p>Impurity Phenylbutyrate USP Related Compound B<br>Applications α-Tetralone (Phenylbutyrate USP Related Compound B) is a reagent used in the synthesis of amino-pyrazolopyridines with anti-NF-κB and pro-apoptotic potential.<br>References Orlikova, B., et al.: Eur. J. Med. Chem., 85, 450 (2014);<br></p>

<p>PF-543 Citrate is an SPHK1 inhibitor and also an inhibitor of S1P formation, exhibiting anticancer, antifibrotic, and anti-inflammatory activities.</p>

<p>Applications Azaserine and Acivicin are classical and irreversible inhibitors of γ-Glutamyltranspeptidase (GGT). Acivicin is a potent antitumor antibiotic that induces apoptosis in human lymphoblastoid cells.<br>References Hanigan, M., et al.: Biochemistry, 32, 6302 (1993); Suzuki, H., et al.: J. Bacteriol., 175, 6038 (1993); Suzuki, H., et al.: J. Biol. Chem., 277, 43536 (2002); Magdalena, L., et al.: Biochem. Pharma., 77, 76 (2009)<br></p>

Donafenib(Bay 43-9006 (D3)) is a deuterium-labeled Sorafenib which is a multikinase inhibitor(IC50s: 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3,

(S)-JQ-35 (TEN-010) is a BET bromodomain inhibitor with anti-tumor activity, particularly in breast cancer research.

<p>Tirabrutinib, an oral Btk inhibitor (IC50=6.8 nM), crosses the BBB and halts B cell signaling for autoimmune and hematologic studies.</p>

<p>Applications 20(R)-Ginsenoside Rg3 causes an inhibition of phosphatidylinositol 3-kinase/Akt activation that, in turn, results in modulations in Bcl-2 family proteins in such a way that the apoptosis of U87 cells are regulated. Elicits a significant inhibition of in vitro cell adhesion and invasion of U87 cells. in vitro stereoselective inhibition of ginsenosides toward UDP-glucuronosyltransferase isoforms and in vivo inhibition of tumor angiogenesis of lung cancer.<br>References Liu, Y., et al.: Chengdu Yixueyuan Xuebao, 9, 4 (2014); Liu, Y., et al.: Linchuang Junyi Zazhi, 42, 1138 (2014), Kim, D., et al.: Toxicol. Lett., 259, 1 92016); Geng, L., et al.: Zhonghua Zhongyiyao Zazhi, 29, 601 (2014)<br></p>

<p>Applications Solasodine Hydrochloride enhances the effect of As2O3 in inducing apoptosis in HeLa cell, which is related to its inhibiting telomerase activity in HeLa cells.<br>References Ai, J., et al.: Chin. J. Endemiol., 30, 279 (2011)<br></p>

<p>Stability Hygroscopic<br>Applications Esculentoside A is a saponin isolated from the root of Phytolacca esculenta. Modulates the immune response. and effects cell proliferation and apoptosis in cells. Anti-inflammatory. 500<br>References Ma, H. et al.: Arch. Med. Sci., 9, 354 (2013); Zhong, W. et al.: J. Surg, Res., 185, 364 (2013);<br></p>

<p>5'-Amino-5'-deoxyadenosine (NH2dAdo) is an adenosine kinase inhibitor targeting malignant tumors of the inert lymphatic system with antitumor and anticancer</p>

<p>L-Glutamic acid monosodium salt monohydrate (MSG monohydrate) is an important food additive with gastrointestinal protective effects.</p>

<p>Applications Avasimibe is a selective inhibitor of Cholesterol Acyltransferase 1 and CYP2C9. Avasimibe is known to induce apoptosis of glioma cell lines as a model of glioblastoma.<br>References Bemlih, S., et al.: Cancer. BIol. Therap., 9, 1025 (2010); Fahmi, O.A., et al.: Drug. Meta. Disp. 38, 1605 (2010);<br></p>

<p>Sodium oleate (cis-9-Octadecenoic acid sodium salt) (Oleic acid sodium) is an abundant monounsaturated fatty acid sodium.</p>

<p>Anticancer agent 43 is a potent anticancer agent that induces apoptosis through caspase 3, PARP1, and Bax protein-dependent pathways.Anticancer agent 43 induces</p>

"(S)-(−)-Perillyl alcohol, a lavender monoterpene, inhibits Ras farnesylation, promotes apoptosis, and has anti-cancer effects."

Ac-YVAD-CHO (L 709049) is an ICE and caspase-1-like protease inhibitor with anti-inflammatory activity that inhibits the production of mature IL-lβ.

PIT-1 is a selective PIP3 antagonist that inhibits cancer cell survival and induces apoptosis by inhibiting PIP3-dependent PI3K/Akt signalling.

Tapotoclax (AMG-176) is an orally active MCL1 inhibitor for the study of myeloid leukemia.

L-Cystine dihydrochloride, a sulfur-based glutathione precursor, maintains GSH balance, used in cell culture.

<p>Applications L-Selenocystine is a diselenide-bridged amino acid which show chemopreventive activity against tobacco-derived nitrosamine (NNK) induced lung tumors. It causes apoptosis in A375, HepG2 and MCF7 cancer cells by inducing intracellular reactive oxygen species.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Li, L., et al.: J. Biochem. Mol. Toxic., 19, 396 (2005); Chen, T., et al.: Biomed. Pharmacother., 63, 105 (2009);<br></p>

Vamifeport (VIT-2763), an inhibitor targeting iron transport proteins, improves anemia and erythropoiesis and can be studied β-thalassemia

<p>Applications An Amadori compound having the potential to alter cellular adhesion, inhibit cancer metastasis and induce apoptosis.<br>References Horiuchi, T., et al.: Agric. Biol. Chem., 55, 333 (1991), Sosnovsky, G., et al.: J. Pharm. Sci., 82, 649 (1993), Glinsky, G., et al.: Cancer Res., 56, 5319 (1996),<br></p>

<p>Applications Deoxycholyltaurine rescues human colon cancer cells from apoptosis by activating EGFR-dependent PI3K/Akt signaling.<br>References Cheng, K., et al.: Biochem. J., 330, 353 (1998), Cheng, K., et al.: Cancer Res., 63, 6744 (2003), Bellacosa, A., et al.: Adv. Cancer Res., 94, 29 (2005), Cheng, K., et al.: Biochem. Pharmacol., 70, 1035 (2005), Fang, D., et al.: J. Biol. Chem., 282, 11221 (2007),<br></p>

<p>p53 Activator 7 is a highly potent and cell-permeable activator of the p53 mutation Y220C (MDM-2/p53), which induces apoptosis.</p>

PPA-904 is a specific phenothiazine photosensitizer,and used in photodynamic therapy.

<p>AOH1996: Oral PCNA ligand, disrupts TRC, triggers DNA stress, apoptosis, and enhances DNA damage agent effects.</p>

S3QEL-2 is a site-specific inhibitor of complex III superoxide production with neuroprotective effects.

<p>Sabutoclax (BI-97C1)(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM,</p>

GSK1904529A (GSK 4529) is a specific inhibitor of IGF-1R (IC50=27 nM) and IR(IC50=25 nM) .

<p>4-Vinylphenol, a metabolite from lactic acid bacteria in wine, induces apoptosis. Found in Hedyotis diffusa Willd.</p>

BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride is a resorcinol di-Ph ether scaffold-based programmed cell death-1 (PD-1)/programmed cell death ligand 1 (

<p>4-tert-Octylphenol, an endocrine disruptor, hinders neuronal growth and alters behavior in mice.</p>

RAPTA-C 可通过线粒体和 p53-JNK 途径诱导 EAC 细胞周期停滞和凋亡，可用于研究乳腺癌和卵巢癌。

<p>Cholesteryl Hemisuccinate (Cholesterol hydrogen succinate) is a highly soluble cholesterol analogue often used in polar solutions for its hepatoprotective,</p>

TAS1553, an oral PPI inhibitor with 0.0396 μM IC50, blocks DNA replication, reduces dATP levels, and induces apoptosis in cancer research.

CPUY192018 is an inhibitor of Keap1-Nrf2 protein-protein interactions, and can be used to study mitochondrial autophagy.

<p>Adebrelimab (SHR-1316) is a humanized monoclonal antibody targeting PD-L1 with antitumor activity for the study of solid tumors.</p>