Apoptose
Os inibidores da apoptose são compostos que previnem ou retardam o processo de morte celular programada, conhecido como apoptose. Esses inibidores são vitais no estudo dos mecanismos de sobrevivência celular e são usados para investigar doenças onde a apoptose é desregulada, como câncer, distúrbios neurodegenerativos e doenças autoimunes. Ao modular a apoptose, esses inibidores podem ajudar no desenvolvimento de terapias destinadas a controlar a morte celular. Na CymitQuimica, oferecemos uma ampla seleção de inibidores da apoptose de alta qualidade para apoiar sua pesquisa em biologia celular, oncologia e áreas relacionadas.
Subcategorias de "Apoptose"
- ASK(9 produtos)
- BCL(11 produtos)
- Caspase(142 produtos)
- FOXO1(3 produtos)
- IAP(67 produtos)
- Mdm2(12 produtos)
- PD-1/PD-L1(138 produtos)
- PDK(9 produtos)
- PERK(25 produtos)
- Serina/treonina quinase(14 produtos)
- Survivina(14 produtos)
- TNF(89 produtos)
- c-RET(56 produtos)
- p53(63 produtos)
Exibir 6 mais subcategorias
Foram encontrados 5903 produtos de "Apoptose"
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PD-1-IN-18
CAS:PD-1-IN-18 is a PD1 inhibitor of signaling pathway, and acts as an immunomodulator.Fórmula:C11H17N5O8Pureza:98%Cor e Forma:SolidPeso molecular:347.28Anticancer agent 76
CAS:Compound CT2-3 is an anticancer agent that hinders growth, induces arrest, ROS, and apoptosis in NSCLC cells.Fórmula:C32H33NO5SCor e Forma:SolidPeso molecular:543.67PERK-IN-5
CAS:PERK-IN-5: oral PERK inhibitor, IC50 of 2 nM; blocks p-eIF2α at 9 nM; hinders tumor growth in renal cancer model.Fórmula:C25H26F2N4O3Cor e Forma:SolidPeso molecular:468.5ARN 14494
CAS:<p>ARN 14494, a potent SPT inhibitor (IC50=27.3 nM), reduces ceramide synthesis and neuroinflammation, and protects against β-amyloid toxicity.</p>Fórmula:C24H32N4O3Cor e Forma:SolidPeso molecular:424.54PHM16
CAS:PHM16 is an ATP competitive FAK and FGFR2 inhibitor.Fórmula:C20H22N6O4Pureza:98%Cor e Forma:SolidPeso molecular:410.43CGP 65015
CAS:CGP 65015 is an oral iron chelator and can mobilize iron deposits.Fórmula:C14H15NO4Pureza:98%Cor e Forma:SolidPeso molecular:261.27Antiproliferative agent-11
Antiproliferative agent-11, a Ruthenium(II) complex, targets multiple cancers with IC50s of 6-10 μM.Fórmula:C31H34Cl2N6O3P2RuCor e Forma:SolidPeso molecular:772.56AQX-016A
CAS:AQX-016A, a potent SHIP1 agonist, is an oral analog of pelorol, 3x stronger, inhibits PI3K, TNFa, for inflammation research.Fórmula:C22H32O2Cor e Forma:SolidPeso molecular:328.49CZS-241
CZS-241: Oral PLK4 inhibitor (IC50=2.6 nM), less potent TRKA blocker (IC50=2.74 μM), triggers apoptosis and S/G2 arrest, anti-leukemia, safe for normal cells.Fórmula:C26H24ClF2N9OCor e Forma:SolidPeso molecular:551.98AP23464
CAS:AP23464 inhibits Src/Abl kinases, effective on imatinib-resistant CML cells (IC50=14nM), blocks cell cycle, induces apoptosis, not against T315I mutant.Fórmula:C26H30N5O2PCor e Forma:SolidPeso molecular:475.52Antitumor agent-57
CAS:Antitumor agent-57 (Compound 3o) is a potent NQO1-directed antitumor compound.Fórmula:C20H15NO5Cor e Forma:SolidPeso molecular:349.34CMC2.24
CAS:CMC2.24 inhibits Ras and ERK1/2, fights pancreatic tumors in mice, blocks MMPs (IC50: 2-69 µM), and reduces osteoarthritis by stabilizing cartilage.Fórmula:C26H21NO5Cor e Forma:SolidPeso molecular:427.45VO-OHPic
CAS:VO-OHPic, a selective PTEN inhibitor (IC50 = 46 nM), reduces apoptosis and inflammation in doxorubicin-induced cardiomyopathy.Fórmula:C12H10N2O8VCor e Forma:SolidPeso molecular:361.16Anti-inflammatory agent 22
CAS:<p>Compound 14a is an oral anti-inflammatory with an IC50 of 14.6 μM for TNF-α, preventing adipogenesis and reducing mouse limb lymphedema.</p>Fórmula:C22H16O6Cor e Forma:SolidPeso molecular:376.36IM-93
CAS:IM-93 inhibits ferroptosis and NETosis with an IC< sub>50 of 0.45 μM for cell death inhibition [1].Fórmula:C21H28N4O2Cor e Forma:SolidPeso molecular:368.47Mcl1-IN-3
CAS:Mcl1-IN-3 is an Mcl1 inhibitor. It has an IC50 and Ki of 0.67 and 0.13 μM, respectively.Fórmula:C27H22ClN3O4Pureza:98%Cor e Forma:SolidPeso molecular:487.93p-nitro-Pifithrin-α
CAS:p-nitro-Pifithrin-α is a cell-permeable analog of pifithrin-α, a potent p53 inhibitor.Fórmula:C15H16BrN3O3SCor e Forma:SolidPeso molecular:398.27TRK-IN-23
CAS:TRK-IN-23 (compound 24b) is a potent, orally active inhibitor of TRK with IC50s of 0.5 nM for TRKA, 9 nM for TRKC, 14 nM for TRKA G595R, 4.4 nM for TRKA F589L,Fórmula:C20H17FN4O2Pureza:98%Cor e Forma:SolidPeso molecular:364.37Topoisomerase II inhibitor 10
CAS:Topoisomerase II inhibitor 10 is a potent inhibitor of topoisomerase II (IC50: 7.45 μM).Fórmula:C27H20N6O7SCor e Forma:SolidPeso molecular:572.55Alteminostat
CAS:Alteminostat is used as a histone deacetylase inhibitor and is an antineoplastic drug candidate.Fórmula:C27H36N6O3Cor e Forma:SolidPeso molecular:492.61HLI98C
CAS:HLI98C is a HDM2 ubiquitin ligase inhibitor with anti-tumor activity.Fórmula:C17H9ClN4O4Cor e Forma:SolidPeso molecular:368.73Cl-amidine
CAS:Cl-amidine, an oral PAD inhibitor (IC50: 0.8-6.2 μM for PAD1/3/4), induces apoptosis in cancer cells.Fórmula:C14H19ClN4O2Pureza:98%Cor e Forma:SolidPeso molecular:310.78ZC0101
CAS:ZC0101: potent oral IDO1/TrxR inhibitor. IC50: 0.084/7.98 μM. Induces apoptosis, ROS in cancer cells.Fórmula:C17H15N3O2Cor e Forma:SolidPeso molecular:293.32TH-Z835
CAS:TH-Z835 is a selective inhibitor for the KRAS (G12D) mutation, demonstrating an inhibitory concentration (IC50) of 1.6 μM.Fórmula:C30H38N6OPureza:98%Cor e Forma:SolidPeso molecular:498.66RO2468
CAS:RO2468 is a potent and orally active inhibitor of the p53-MDM2.Fórmula:C30H30Cl2FN5O4Pureza:98%Cor e Forma:SolidPeso molecular:614.49Cadein1
Cadein1, an isoquinolinium derivative, induces G2/M phase delay and caspase-dependent apoptosis in cancer cells lacking functional p53.Fórmula:C33H48F2INO2Cor e Forma:SolidPeso molecular:655.64BMS-37
CAS:BMS-37 is a novel inhibitor of PD-1/PD-L1 immune checkpoint.Fórmula:C27H32N2O4Cor e Forma:SolidPeso molecular:448.55GEM144
CAS:GEM144: oral POLA1/HDAC11 inhibitor; boosts p53, p21; halts G1/S cycle; triggers cell death.Fórmula:C28H31NO5Cor e Forma:SolidPeso molecular:461.55ATSP-7041
CAS:ATSP-7041 is a novel potent and selective dual inhibitor of mdm2 (ki = 0.9 nm) and mdmx (ki = 7 nm)Fórmula:C87H125N17O21Cor e Forma:SolidPeso molecular:1745.02Se-Methylselenocysteine hydrochloride
CAS:<p>Se-Methylselenocysteine hydrochloride, a precursor to Methylselenol, exhibits significant cancer chemopreventive and antioxidant activities.</p>Fórmula:C4H10ClNO2SePureza:98%Cor e Forma:SolidPeso molecular:218.54(S)-PERK-IN-5
CAS:(S)-PERK-IN-5 is the S-enantiomer of PERK-IN-5. (S)-PERK-IN-5 is a PERK inhibitor (IC50: 0.101-0.250 μM).Fórmula:C25H26F2N4O3Cor e Forma:SolidPeso molecular:468.5ATX inhibitor 13
CAS:ATX inhibitor 13: orally active, IC50 3.4 nM, halts RAW264.7 cells at G2, curbs growth/migration, prompts apoptosis, suppresses tumors.Fórmula:C31H35Cl2N5O3Cor e Forma:SolidPeso molecular:596.55Topoisomerase II inhibitor 7
CAS:Topoisomerase II inhibitor 7 halts cell division and induces apoptosis, targeting topoisomerase II alpha with a 3.19 μM IC50.Fórmula:C32H28BrN5O5SCor e Forma:SolidPeso molecular:674.56QTX125
CAS:QTX125: potent, selective HDAC6 inhibitor with strong antitumor effects.Fórmula:C23H19N3O5Cor e Forma:SolidPeso molecular:417.41MR2938
CAS:MR2938: AChE inhibitor (IC50=5.04μM), reduces NO (IC50=3.29μM), blocks MAPK/JNK, NF-κB; for AD research.Fórmula:C21H24N4O3Cor e Forma:SolidPeso molecular:380.44YLT205
CAS:YLT205 is an inducer of apoptosis in human colorectal cells that acts by inhibiting tumor growth.Fórmula:C16H12BrClN4O2S2Pureza:98%Cor e Forma:SolidPeso molecular:471.78MDM2-p53-IN-16
CAS:MDM2-p53-IN-16 inhibits p53/MDM2 complex (IC 50 = 4.3 nM), triggers p53, causes GBM cell apoptosis, useful in cancer research.Fórmula:C32H33N3O5Cor e Forma:SolidPeso molecular:539.62Tubulin polymerization-IN-22
CAS:<p>Tubulin polymerization-IN-22 inhibits tubulin (IC50=8.1μM), blocks G2/M phase, and triggers apoptosis.</p>Fórmula:C19H16O4Cor e Forma:SolidPeso molecular:308.33NF-κB-IN-5
CAS:NF-κB-IN-5 (compound 4d) is an orally active NF-κB inhibitor.Fórmula:C23H27N3O4Cor e Forma:SolidPeso molecular:409.48LG308
CAS:<p>LG308, a synthetic compound, has anti-tumor properties, inducing apoptosis and mitotic arrest, thereby suppressing prostate cancer growth.</p>Fórmula:C19H17FN2OCor e Forma:SolidPeso molecular:308.35PHA-680626
CAS:PHA-680626 is a PLK inhibitor, effective on resistant leukemia cells, with IC50: Plk1 (0.53 μM), Plk2 (0.07 μM), Plk3 (1.61 μM).Fórmula:C23H26N6O2SCor e Forma:SolidPeso molecular:450.56Anti-inflammatory agent 47
CAS:Flo8, an anti-inflammatory and antioxidant agent, effectively suppresses the release of reactive oxygen species (ROS) and nitric oxide (NO) while inhibitingFórmula:C25H18N2O3Pureza:98%Cor e Forma:SolidPeso molecular:394.42GW837016X
CAS:GW837016X, also known as NEU-391, is a potent inhibitor of protozoan parasite proliferation.Fórmula:C25H20ClFN4OSCor e Forma:SolidPeso molecular:478.97Obatoclax
CAS:Obatoclax (GX15-070), a pan-BCL-2 inhibitor (Ki 220 nM) induces autophagy, degrades cyclin D1, and has anti-cancer/antiparasitic properties.Fórmula:C20H19N3OPureza:99.44%Cor e Forma:SolidPeso molecular:317.38LWG-301
LWG-301, a GLS1 allosteric inhibitor, IC50 7 nM, impedes glutamine metabolism and prompts apoptosis; shows antitumor effects.Fórmula:C28H38N8O3SCor e Forma:SolidPeso molecular:566.72ARN5187 trihydrochloride
CAS:ARN5187 trihydrochloride: a REV-ERBβ inhibitor that blocks transcription, autophagy, and induces apoptosis with lysosomal cytotoxicity.Fórmula:C24H35Cl3FN3OCor e Forma:SolidPeso molecular:506.912PD-1/PD-L1-IN-20
CAS:<p>PD-1/PD-L1-IN-20 is a small molecule inhibitor of PD-1/PD-L1 protein-protein interaction.</p>Fórmula:C30H26BrClN2O3Cor e Forma:SolidPeso molecular:577.9Undecylprodigiosin
CAS:Undecylprodigiosin is a classical cytotoxic immunosuppressant, suppressing immune functions. It also inhibits DNA synthesis.Fórmula:C25H35N3OCor e Forma:SolidPeso molecular:393.56CAY10773
CAS:CAY10773, a sorafenib derivative, inhibits cancer cells over non-cancerous ones and induces apoptosis or ferroptosis in T24 cells.Fórmula:C22H17Cl2N5OCor e Forma:SolidPeso molecular:438.31FD223
CAS:FD223, a PI3Kδ inhibitor, is highly potent (IC50=1 nM) and selective, limiting AML cell growth by causing G1 arrest.Fórmula:C17H12ClN5O2SCor e Forma:SolidPeso molecular:385.83
