Apoptose
Os inibidores da apoptose são compostos que previnem ou retardam o processo de morte celular programada, conhecido como apoptose. Esses inibidores são vitais no estudo dos mecanismos de sobrevivência celular e são usados para investigar doenças onde a apoptose é desregulada, como câncer, distúrbios neurodegenerativos e doenças autoimunes. Ao modular a apoptose, esses inibidores podem ajudar no desenvolvimento de terapias destinadas a controlar a morte celular. Na CymitQuimica, oferecemos uma ampla seleção de inibidores da apoptose de alta qualidade para apoiar sua pesquisa em biologia celular, oncologia e áreas relacionadas.
Subcategorias de "Apoptose"
- ASK(9 produtos)
- BCL(11 produtos)
- Caspase(142 produtos)
- FOXO1(3 produtos)
- IAP(67 produtos)
- Mdm2(12 produtos)
- PD-1/PD-L1(138 produtos)
- PDK(9 produtos)
- PERK(25 produtos)
- Serina/treonina quinase(14 produtos)
- Survivina(14 produtos)
- TNF(89 produtos)
- c-RET(56 produtos)
- p53(63 produtos)
Exibir 6 mais subcategorias
Foram encontrados 5903 produtos de "Apoptose"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
RET-IN-20
RET-IN-20: potent RET inhibitor (IC50 = 13.7 nM), reduces p-Ret/p-Shc, induces apoptosis, anti-tumor effects.Fórmula:C32H33FN6O4Cor e Forma:SolidPeso molecular:584.64Setafrastat
CAS:Setafrastat is a vascular endothelial growth factor (VEGF) promotor and rotamase inhibitor.Fórmula:C25H33F2N3O4Cor e Forma:SolidPeso molecular:477.54DAT-230
CAS:DAT-230 is a microtubule inhibitor effective against cancer cells, causing cell cycle arrest and apoptosis via caspase activation.Fórmula:C20H21NO2SCor e Forma:SolidPeso molecular:339.45Misetionamide
CAS:Misetionamide: Oral oxathiazin-like, GAPDH inhibitor with anticancer properties for research use.Fórmula:C3H7NO3SCor e Forma:SolidPeso molecular:137.16DB2313 HCl
CAS:DB2313: first-in-class, potent inhibitor of PU.1, disrupts gene interactions, down-regulates PU.1 targets.Fórmula:C42H45Cl4FN8O2Cor e Forma:SolidPeso molecular:854.67Topoisomerase I inhibitor 3
CAS:Topoisomerase I (Compound ZML-14) inhibitor 3 induces HepG2 cell apoptosis and arrests cell cycle at G2/M phase.Fórmula:C18H14FNO3Cor e Forma:SolidPeso molecular:311.31R-547 mesylate
CAS:R547 Mesylate is a potent ATP-competitive inhibitor of CDK1, CDK2, CDK4 with Ki value of 2 nM, 3 nM, 1 nM respectively.Fórmula:C19H25F2N5O7S2Cor e Forma:SolidPeso molecular:537.56A-802715
CAS:<p>A-802715 is a novel methylxanthine derivative that decreases the endogenous formation and blood levels of pro-inflammatory substances and increases the</p>Fórmula:C16H26N4O3Pureza:96.29%Cor e Forma:SolidPeso molecular:322.4GKK1032B
CAS:GKK1032B: antiproliferative, antibacterial, halts HeLa S3, MCF-7, Vero cells, B. subtilis, M. tuberculosis.Fórmula:C32H39NO4Cor e Forma:SolidPeso molecular:501.66CT-1
CAS:<p>CT-1 is a DNA minor groove ligand and causes p53-dependent breast cancer cell apoptosis.</p>Fórmula:C29H23F3N4OPureza:99.79%Cor e Forma:SolidPeso molecular:500.51Quinidine Monosulfate
CAS:<p>Quinidine Monosulfate: an oral antiarrhythmic, CYP450db inhibitor, K+ blocker (IC50 19.9 μM), used in malaria research.</p>Fórmula:C40H50N4O8SCor e Forma:SolidPeso molecular:746.92Anticancer agent 67
CAS:<p>Anticancer agent 67 is a ciprofloxacin analogue, an anticancer agent that induces apoptosis and increases sub-G1 cell populations in MCF-7 cells.</p>Fórmula:C26H24F2N6O2S2Cor e Forma:SolidPeso molecular:554.63CMLD012073
CAS:CMLD012073: Potent eIF4A inhibitor, halts eukaryotic translation; IC50 10 nM in NIH/3T3 cells.Fórmula:C30H30N2O7Pureza:98%Cor e Forma:SolidPeso molecular:530.57AG-024322
CAS:AG-024322 is a pan-CDK inhibitor with antitumor activity, induces apoptosis, and can be used in the study of metabolic diseases.Fórmula:C23H20F2N6Pureza:98.53%Cor e Forma:SolidPeso molecular:418.44OXPHOS-IN-1
CAS:OXPHOS-IN-1 inhibits oxidative phosphorylation; halts MIA PaCa-2 (IC50: 2.34 μM) and BxPC-3 cells growth (IC50: 13.82 μM).Fórmula:C19H29N3O6S2Cor e Forma:SolidPeso molecular:459.58EGFR-IN-52
CAS:EGFR-IN-52, a potent EGFR inhibitor, has IC50s: 0.358 μM (wild-type), 86.02 μM (L858R-TK), 432.67 μM (T790M-TK); induces cancer cell apoptosis.Fórmula:C19H18N4O3SCor e Forma:SolidPeso molecular:382.44Antitumor agent-44
CAS:<p>Antitumor agent-44 (Compound 5n) elicits potent antitumor effects by inducing disruption of mitochondrial homeostasis, cell cycle arrest, and apoptosis in human</p>Fórmula:C24H15N3O3Cor e Forma:SolidPeso molecular:393.39SPRC
CAS:"SPRC, a synthetic antioxidant, boosts H2S production, activates STAT3, and guards against doxorubicin heart damage."Fórmula:C6H9NO2SPureza:98%Cor e Forma:SolidPeso molecular:159.21Topoisomerase I inhibitor 5
CAS:<p>Topoisomerase I inhibitor 5 halts DNA replication, induces MCF-7 cell apoptosis, and overcomes drug resistance. IC50 value is noted.</p>Fórmula:C24H24N2O2Cor e Forma:SolidPeso molecular:372.46Autophagy-IN-2
CAS:Autophagy-IN-2 (7h) blocks autophagic flux, triggers cancer cell death, aids in triple-negative breast cancer study.Fórmula:C17H19N5OCor e Forma:SolidPeso molecular:309.37Vin-C01
CAS:<p>Vin-C01, a potent protector of pancreatic β-cells (EC50=0.22μM), aids in type 2 diabetes research by preventing STZ-induced β-cell apoptosis.</p>Fórmula:C20H24N2OCor e Forma:SolidPeso molecular:308.42BMS-1166 hydrochloride
CAS:"Motixafortide blocks CXCR4 with 1 nM potency. BMS-1166 hinders PD-1/PD-L1, boosting T cell activation, IC50: 1.4 nM."Fórmula:C36H34Cl2N2O7Pureza:98%Cor e Forma:SolidPeso molecular:677.57Esuberaprost Sodium
CAS:<p>Famitinib (SHR1020), an oral drug, inhibits c-kit, VEGFR-2, and PDGFRβ (IC50: 2.3/4.7/6.6 nM) and triggers apoptosis in gastric cancer.</p>Fórmula:C23H27FN4O2Cor e Forma:SolidPeso molecular:410.48CAY10789
CAS:CAY10789: potent CysLT1R antagonist (IC50 2.8 µM), GPBAR1 agonist (EC50 3 µM), reduces U937 cell adhesion, TNF-α, stable with promising pharmacokinetics.Fórmula:C17H15NO2Cor e Forma:SolidPeso molecular:265.31YLT-11
<p>YLT-11: Oral PLK4 inhibitor, Kd 5.2 nM; less effective on PLK1/2/3; inhibits cancer cell growth and induces G2/M arrest and apoptosis.</p>Fórmula:C24H24N6OCor e Forma:SolidPeso molecular:412.49Caspase-3/7 activator 3
Caspase-3/7 activator 3 triggers apoptosis with tumor selectivity and anti-proliferative effects.Fórmula:C24H27NO5Cor e Forma:SolidPeso molecular:409.47CRA-026440
CAS:CRA-026440(PCI-34051) is a highly potent HDAC inhibitor with inhibitory effects on HDAC1, HDAC2, HDAC3, HDAC6, HDAC8 and HDAC10 with Ki values of 4,14,11,15,7Fórmula:C23H24N4O4Pureza:96.42%Cor e Forma:SolidPeso molecular:420.46Anticancer agent 63
CAS:<p>Compound 3h fights various cancers; most effective on MCF-7 (IC50 3.4 μM). Triggers apoptosis; alters Bcl-2, IL-2, Caspase-3 levels, has antioxidant effects.</p>Fórmula:C17H24F3NOSeCor e Forma:SolidPeso molecular:394.33SAR125844
CAS:SAR125844, a potent and highly selective inhibitor of the MET receptor tyrosine kinase (RTK), for intravenous administration. (IC50 value of 4.2 nmol/L)Fórmula:C25H23FN8O2S2Pureza:98.73%Cor e Forma:SolidPeso molecular:550.63Nutlin-1
CAS:Nutlin-1 is a p53-MDM2 binding inhibitor, p-Glycoprotein (p-gp) transport substrate, and antitumor agent.Fórmula:C32H34Cl2N4O4Cor e Forma:SolidPeso molecular:609.54Cyclamidomycin
CAS:Cyclamidomycin is an antibiotic. It also functions as an inhibitor of nucleoside diphosphokinase of Escherichia coli.Fórmula:C7H10N2OCor e Forma:SolidPeso molecular:138.17Hetrombopag
CAS:Hetrombopag: potent thrombopoietin receptor agonist, well tolerated, safe, promising for immune thrombocytopenia research.Fórmula:C25H22N4O5Cor e Forma:SolidPeso molecular:458.47BR102375
CAS:BR102375 is a non-TZD PPAR γ full agonist (EC50: 0.28 μM) for the treatment of type 2 diabetes.Fórmula:C31H34N6O4Pureza:98%Cor e Forma:SolidPeso molecular:554.64Topoisomerase IIα-IN-3
CAS:<p>Topoisomerase IIα-IN-3 is a DNA-inserting topoisomerase-Iiα inhibitor that blocks the cell cycle in G0/G1 phase and induces apoptosis.</p>Fórmula:C29H20N6O2SCor e Forma:SolidPeso molecular:516.57VU 0364739 hydrochloride
CAS:VU 0364739 hydrochloride (VU 0364739 HCl) is a phospholipase D2 (PLD2) inhibitor that induces apoptosis and can be used in cancer research.Fórmula:C26H28ClFN4O2Pureza:99.36%Cor e Forma:SolidPeso molecular:482.98VS 8
CAS:VS 8: potent oral VEGFR-2 inhibitor, anti-angiogenic, induces cancer cell apoptosis & migration, acts on CSCs.Fórmula:C26H20F3N3O3Cor e Forma:SolidPeso molecular:479.45Mutant p53 modulator-1
CAS:Mutant p53 modulator-1 inhibits cancer with p53 mutations; see patent WO2021231474A1, compound 231B.Fórmula:C27H32F4N8O2Cor e Forma:SolidPeso molecular:576.59VEGFR-2-IN-28
CAS:VEGFR-2-IN-28 is a potent inhibitor of VEGFR-2 (IC50: 0.83 μM). VEGFR-2-IN-28 induces apoptosis and exhibits antitumor effects.Fórmula:C26H17N7O7Cor e Forma:SolidPeso molecular:539.46(5Z,2E)-CU-3
CAS:<p>(5Z,2E)-CU-3 is a potent and selective inhibitor of DGKα isozyme with an IC50 value of 0.6 μM and inhibition of DGKα by competing ATP with a Km value of 0.48 mM</p>Fórmula:C16H12N2O4S3Pureza:99.02%Cor e Forma:SolidPeso molecular:392.47PSB 0474
CAS:P2Y6 receptor agonistFórmula:C17H20N2O13P2Pureza:98%Cor e Forma:SolidPeso molecular:522.29HL271
CAS:HL271, a derivative of metformin, is a potent AMPK activator that increases AMPK phosphorylation. HL271 attenuates aging-associated cognitive impairment.Fórmula:C13H17ClF3N5OPureza:98%Cor e Forma:SolidPeso molecular:351.76PK9327
CAS:PK9327 is a small-molecule stabilizer that targets cavity-creating p53 cancer mutations.Fórmula:C21H22N2SCor e Forma:SolidPeso molecular:334.48Antitumor agent-81
CAS:Antitumor agent-81, a P62-RNF168 agonist, reduces H2A ubiquitination, hinders DNA repair, and inhibits tumor growth.Fórmula:C19H19N7O3Cor e Forma:SolidPeso molecular:393.4MMP-9-IN-5
CAS:MMP-9-IN-5: MMP-9 and AKT inhibitor (IC50: 4.49 nM and 1.34 nM), induces apoptosis for cancer research.Fórmula:C27H20IN3O4Cor e Forma:SolidPeso molecular:577.37BMS-200
CAS:BMS-200 is a potent PD-1/PD-L1 interaction inhibitor with IC50 of 80 nM.Fórmula:C27H27F2NO6Cor e Forma:SolidPeso molecular:499.5MSN-50
CAS:MSN-50, an inhibitor of Bax and Bak oligomerization, inhibits liposome permeabilization, prevents genotoxic cell death and promotes neuroprotection.Fórmula:C36H38BrN3O6Cor e Forma:SolidPeso molecular:688.61FKGK 18
CAS:FKGK 18: GVIA iPLA2 inhibitor, 99.9% at 0.091 fraction, selective, IC50 ~50 nM–3 μM, reduces blood glucose and diabetes in NOD mice.Fórmula:C16H15F3OCor e Forma:SolidPeso molecular:280.28Bax activator-1
CAS:Bax activator-1 (compound 106) is a Bax activator. It induces Bax-dependent tumor cell apoptosis[1].Fórmula:C29H36N4O3Cor e Forma:SolidPeso molecular:488.62KY1022
CAS:<p>KY1022 is a ras destabilizer. KY1022 targets the Wnt/ß-catenin pathway and inhibits development of metastatic colorectal cancer.</p>Fórmula:C17H19N3OSCor e Forma:SolidPeso molecular:313.42CMLD010509
CAS:CMLD010509 (SDS-1-021) inhibits oncogenic proteins MDM2, CCND1, MYC, MAF, MCL-1 in multiple myeloma.Fórmula:C27H26BrNO7Pureza:98%Cor e Forma:SolidPeso molecular:556.4
