Apoptose
Os inibidores da apoptose são compostos que previnem ou retardam o processo de morte celular programada, conhecido como apoptose. Esses inibidores são vitais no estudo dos mecanismos de sobrevivência celular e são usados para investigar doenças onde a apoptose é desregulada, como câncer, distúrbios neurodegenerativos e doenças autoimunes. Ao modular a apoptose, esses inibidores podem ajudar no desenvolvimento de terapias destinadas a controlar a morte celular. Na CymitQuimica, oferecemos uma ampla seleção de inibidores da apoptose de alta qualidade para apoiar sua pesquisa em biologia celular, oncologia e áreas relacionadas.
Subcategorias de "Apoptose"
- ASK(9 produtos)
- BCL(11 produtos)
- Caspase(141 produtos)
- FOXO1(3 produtos)
- IAP(66 produtos)
- Mdm2(12 produtos)
- PD-1/PD-L1(138 produtos)
- PDK(9 produtos)
- PERK(25 produtos)
- Serina/treonina quinase(14 produtos)
- Survivina(14 produtos)
- TNF(92 produtos)
- c-RET(55 produtos)
- p53(63 produtos)
Exibir 6 mais subcategorias
Foram encontrados 5865 produtos de "Apoptose"
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PD-1/PD-L1-IN 6
CAS:Compound A13 inhibits PD-1/PD-L1, enhances interferon-γ, lacks toxicity, and boosts immune response in co-culture models. IC50=132.8 nM.Fórmula:C25H26N2O3Cor e Forma:SolidPeso molecular:402.49Thienopyridone
CAS:Thienopyridone: potent, selective PRL phosphatase inhibitor, IC50s: 173/277/128 nM for PRL-1/2/3, induces apoptosis, anticancer.Fórmula:C13H10N2OSPureza:98%Cor e Forma:SolidPeso molecular:242.3Anti-inflammatory agent 54
CAS:<p>Anti-inflammatory agent 54 (compound 9c), a Coixol derivative, exhibits anti-inflammatory properties by inhibiting the NF-κB pathway and reducing the expression</p>Fórmula:C17H16N2O5Cor e Forma:SolidPeso molecular:328.32IZTZ-1
CAS:IZTZ-1: c-MYC G4 stabilizer, reduces expression, blocks cell cycle, induces apoptosis, inhibits B16 melanoma growth.Fórmula:C32H35N7SCor e Forma:SolidPeso molecular:549.73Tolbutamide Sodium
CAS:potassium channel blockerFórmula:C12H18N2NaO3SPureza:98%Cor e Forma:SolidPeso molecular:293.34NSC10010 hydrochloride
CAS:NSC10010 inhibits gammaherpesvirus B-lymphomas by activating NF-κB and c-Myc pathways.Fórmula:C31H42Cl2N4O2Pureza:98%Cor e Forma:SolidPeso molecular:573.60BMH-7
CAS:BMH-7 (Histamine H4 receptor antagonist-2) is a p53 activator, demonstrating anti-cancer activity by activating the p53 pathway.Fórmula:C20H21N5OPureza:99.71%Cor e Forma:SolidPeso molecular:347.41EGFR-IN-51
CAS:<p>EGFR-IN-51 effectively inhibits EGFR and mutations with IC50s of 0.493-461.63 μM; it induces apoptosis in cancer cells.</p>Fórmula:C21H15N3O2SCor e Forma:SolidPeso molecular:373.43Tubulin polymerization-IN-26
CAS:<p>Tubulin-IN-26 blocks microtubule formation at colchicine site; IC50 4.64μM; may help in lung cancer study.</p>Fórmula:C25H23N3O2Cor e Forma:SolidPeso molecular:397.47Tubulin polymerization-IN-31
CAS:<p>Compound 4c, inhibits tubulin polymerization, IC50 3.64 μM, and induces cancer cell apoptosis.</p>Fórmula:C18H13ClFN3Cor e Forma:SolidPeso molecular:325.77GLUT4-IN-2
CAS:GLUT4-IN-2, selective GLUT4 blocker; IC50: 6.8μM (GLUT4), 11.4μM (GLUT1). Induces apoptosis, G0/G1 arrest, has antitumor effects.Fórmula:C17H11N3O4S2Pureza:99.90%Cor e Forma:SolidPeso molecular:385.423-(3-Phenoxybenzyl)amino-β-carboline
CAS:3-(3-Phenoxybenzyl)amino-β-carboline is a highly effective tubulin inhibitor, selectively degrading αβ-tubulin heterodimers.Fórmula:C24H19N3OCor e Forma:SolidPeso molecular:365.43Sibiriline
CAS:<p>Sibiriline is a Receptor-Interacting Protein Kinase 1 inhibitor that acts by preventing immune-dependent hepatitis.</p>Fórmula:C13H10N2OPureza:98%Cor e Forma:SolidPeso molecular:210.23RS6212
CAS:<p>RS6212 is a specific lactate dehydrogenase (LDH) inhibitor (IC50=12.03 μ M）。 RS6212 shows strong anticancer activity in a variety of cancer cell lines.</p>Fórmula:C20H22N4O3SCor e Forma:SolidPeso molecular:398.48RIP1 kinase inhibitor 7
CAS:RIP1 Kinase Inhibitor 7 (Compound 41) serves as a potent inhibitory agent for receptor interacting protein 1 kinase (RIP1) with an IC50 of under 100 nM.Fórmula:C20H20FN3OPureza:98%Cor e Forma:SolidPeso molecular:337.39CK2/ERK8-IN-1
CAS:<p>TMCB inhibits CK2 (Ki: 0.25 µM), ERK8 (IC50: 0.50 µM), PIM1, DYRK1A, HIPK2 (Ki: 8.65-15.25 µM), and induces apoptosis.</p>Fórmula:C11H9Br4N3O2Pureza:98.22%Cor e Forma:SolidPeso molecular:534.82Darinaparsin
CAS:<p>Darinaparsin, a dimethylated arsenic-glutathione compound, is cytotoxic to various cancer cells with diverse IC50 values and inhibits tumor growth in mice.</p>Fórmula:C12H22AsN3O6SCor e Forma:SolidPeso molecular:411.31CMLD012612
CAS:CMLD012612 is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. It inhibits cell translation and is cytotoxic to NIH/3T3 cells (IC50: 2 nM).Fórmula:C31H33N3O7Pureza:98%Cor e Forma:SolidPeso molecular:559.61STAT3-IN-3
CAS:STAT3-IN-3 is a potent and selective signal transducer inhibitor and transcription 3 (STAT3) activator.Fórmula:C27H26BrN3O6SPureza:98%Cor e Forma:SolidPeso molecular:600.48PCAF-IN-2
CAS:<p>PCAF-IN-2 inhibits PCAF (IC50 = 5.31 µM), induces apoptosis, and halts G2/M cell cycle, showing anti-tumor properties.</p>Fórmula:C10H7F3N6Cor e Forma:SolidPeso molecular:268.2Ki23057
CAS:<p>Ki23057, a FGFR2 inhibitor, boosts chemo effects in resistant gastric cancer, may work with SN38/PTX/VP16, enhancing apoptosis via ERCC1/p53 synergy.</p>Fórmula:C30H35N3O4Cor e Forma:SolidPeso molecular:501.62LG190178
CAS:<p>LG190178, a vitamin D receptor (VDR) ligand, is a therapeutic agent used for the treatment of psoriasis, osteoporosis, and secondary hyperparathyroidism.</p>Fórmula:C28H42O5Cor e Forma:SolidPeso molecular:458.63Apoptotic agent-1
CAS:Compound 8a is an apoptotic agent that boosts Fas receptor and Cyto C genes to fight cancer with low toxicity.Fórmula:C12H6ClN5O2SCor e Forma:SolidPeso molecular:319.73VEGFR-2/BRAF-IN-1
<p>VEGFR-2/BRAF-IN-1 inhibits VEGFR-2, BRAF V600E & BRAF WT with IC50 of 49, 63 and 5 nM, triggers apoptosis, and halts G1/S cell cycle.</p>Fórmula:C26H20Cl2F3N5O3S2Cor e Forma:SolidPeso molecular:642.5Xanthine oxidase-IN-6
<p>Xanthine oxidase-IN-6: potent oral mixed-type XOD inhibitor, IC50 1.37 µM, anti-hyperuricemia, renal protection.</p>Fórmula:C29H34N2O15Cor e Forma:SolidPeso molecular:650.58GZD856
CAS:GZD856 is an orally bioavailable PDGFRα/β inhibitor (IC50s: 68.6 and 136.6 nM) with anti-lung cancer activities.Fórmula:C29H27F3N6OPureza:98%Cor e Forma:SolidPeso molecular:532.56ASK1-IN-3
CAS:ASK1-IN-3, selective ASK1 inhibitor with 33.8 nM IC50; inhibits cell cycle kinases; induces apoptosis in HepG2 cells.Fórmula:C18H18N8O2Cor e Forma:SolidPeso molecular:378.39MDM2-IN-1
CAS:MDM2-IN-1 is a synthetic MDM2-p53 interaction (MDM2) inhibitor and contains the trans (D-)configuration.Fórmula:C23H21Cl2FN2O3Cor e Forma:SolidPeso molecular:463.33YH-306
CAS:<p>YH-306 (TRV055 acetate ) is a modulator of the FAK signaling pathway that acts by suppressing colorectal tumor growth and metastasis.</p>Fórmula:C19H18N2O2Pureza:98.06%Cor e Forma:SolidPeso molecular:306.36HMBPP triammonium
CAS:HMBPP triammonium is a stimulator of gamma delta T cells.Fórmula:C5H15NO8P2Cor e Forma:SolidPeso molecular:279.122MCL-1/BCL-2-IN-3
CAS:MCL-1/BCL-2-IN-3 is a selective and potent Mcl-1 and Bcl-2 dual inhibitor with IC50s of 5.95 and 4.78 μM, respectiely.Fórmula:C27H25BrN2O5SCor e Forma:SolidPeso molecular:569.47PI3Kα-IN-7
CAS:<p>PI3Kα-IN-7 (Compound A12) is a potent PI3Kα inhibitor, and also inhibits PI3Kβ.</p>Fórmula:C17H22N8O2SCor e Forma:SolidPeso molecular:402.47B-Raf IN 9
CAS:B-Raf IN 9 is a potent B-Raf inhibitor (IC50=24.79 nM), induces G2/M arrest and apoptosis, and inhibits PC-3 prostate cancer cells (IC50=7.83 μM).Fórmula:C23H20N4OSCor e Forma:SolidPeso molecular:400.5c-Met-IN-9
CAS:<p>c-Met-IN-9 is a 4-phenoxypyridine derivative and a c-Met kinase inhibitor (IC50: 12 nM). c-Met-IN-9 induces apoptosis and shows antitumour effects.</p>Fórmula:C25H19F2N5O3Cor e Forma:SolidPeso molecular:475.45Apoptosis inducer 6
CAS:Apoptosis inducer 6 is an anticancer agent with broad-spectrum anticancer activity that induces apoptosis, which triggers cell death.Fórmula:C27H26N4O3SCor e Forma:SolidPeso molecular:486.59TL02-59 dihydrochloride
CAS:<p>TL02-59 dihydrochloride is an orally active inhibitor of Src-family kinase Fgr (IC50: 0.03 nM).</p>Fórmula:C32H36Cl2F3N5O4Pureza:98%Cor e Forma:SolidPeso molecular:682.56MIR96-IN-1
CAS:MIR96-IN-1 selectively inhibits biogenesis of microRNA-96, upregulating a protein target (FOXO1) and inducing apoptosis in cancer cells.Fórmula:C33H48N8O2Cor e Forma:SolidPeso molecular:588.79(1S,2S)-Bortezomib
CAS:(1S,2S)-Bortezomib (Bortezomib) is an enantiomer of Bortezomib.Fórmula:C19H25BN4O4Pureza:99.6%Cor e Forma:SolidPeso molecular:384.24TRAF-STOP inhibitor 6877002
CAS:<p>TRAF-STOP 6877002 inhibits CD40-TRAF6, curbing leukocyte recruitment and macrophage activation/proliferation in plaques.</p>Fórmula:C17H17NOPureza:99.76%Cor e Forma:SolidPeso molecular:251.32Ramentaceone
CAS:Ramentaceone is an antineoplastic.Fórmula:C11H8O3Pureza:98%Cor e Forma:SolidPeso molecular:188.18Anti-osteoporosis agent-1
CAS:<p>Anti-osteoporosis agent-1 (comp 4aa) is an effective RPA (replication protein A) inhibitor, demonstrating potency with an IC50 value of 18 μM [1].</p>Fórmula:C20H19ClN2O2Cor e Forma:SolidPeso molecular:354.83UCD38B HCl
CAS:<p>UCD38B HCl, a cell-permeable uPA inhibitor, induces programmed necrosis in high-grade glioma cells.</p>Fórmula:C15H17Cl2N7O3Pureza:98%Cor e Forma:SolidPeso molecular:414.25Anti-melanoma agent 1
CAS:<p>Anti-melanoma agent 1 (Compound 5m) is an anti-melanoma agent that induces apoptosis.</p>Fórmula:C28H28N2O2Cor e Forma:SolidPeso molecular:424.53ZINC69391
CAS:<p>ZINC69391 inhibits Rac1, reduces cancer cell growth and metastasis, and induces apoptosis.</p>Fórmula:C14H14F3N5Pureza:99.61%Cor e Forma:SolidPeso molecular:309.29PARP-2-IN-3
CAS:<p>PARP-2-IN-3 is used in the study of breast cancer as a PARP-2 inhibitor with antitumor activity that induces apoptosis (apoptosis) and necrosis in cancer cells.</p>Fórmula:C20H20ClN3O3Pureza:99.33%Cor e Forma:SolidPeso molecular:385.84HBV-IN-23
CAS:HBV-IN-23: HBV replication inhibitor, IC50 0.58μM, affects resistant strains, induces HepG2 apoptosis, anti-HCC.Fórmula:C25H27N3O3SCor e Forma:SolidPeso molecular:449.57Nec-3a
CAS:Nec-3a, an analogue of Necrostatin-3, acts as a RIP1 inhibitor with an inhibition concentration (IC50) of 0.44 μM.Fórmula:C21H18F4N2O4Cor e Forma:SolidPeso molecular:438.37DAT-230
CAS:DAT-230 is a microtubule inhibitor effective against cancer cells, causing cell cycle arrest and apoptosis via caspase activation.Fórmula:C20H21NO2SCor e Forma:SolidPeso molecular:339.45Tubulin polymerization-IN-13
CAS:Compound 4f inhibits tubulin polymerization (IC50: 0.37 μM), induces apoptosis, and has notable anti-cancer properties.Fórmula:C20H21NO6Cor e Forma:SolidPeso molecular:371.38
