Apoptose
Os inibidores da apoptose são compostos que previnem ou retardam o processo de morte celular programada, conhecido como apoptose. Esses inibidores são vitais no estudo dos mecanismos de sobrevivência celular e são usados para investigar doenças onde a apoptose é desregulada, como câncer, distúrbios neurodegenerativos e doenças autoimunes. Ao modular a apoptose, esses inibidores podem ajudar no desenvolvimento de terapias destinadas a controlar a morte celular. Na CymitQuimica, oferecemos uma ampla seleção de inibidores da apoptose de alta qualidade para apoiar sua pesquisa em biologia celular, oncologia e áreas relacionadas.
Subcategorias de "Apoptose"
- ASK(6 produtos)
- BCL(11 produtos)
- Caspase(127 produtos)
- FOXO1(3 produtos)
- IAP(65 produtos)
- Mdm2(12 produtos)
- PD-1/PD-L1(126 produtos)
- PDK(9 produtos)
- PERK(24 produtos)
- Serina/treonina quinase(15 produtos)
- Survivina(13 produtos)
- TNF(91 produtos)
- c-RET(51 produtos)
- p53(62 produtos)
Exibir 6 mais subcategorias
Foram encontrados 5622 produtos de "Apoptose"
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PD-1/PD-L1-IN 6
CAS:<p>Compound A13 inhibits PD-1/PD-L1, enhances interferon-γ, lacks toxicity, and boosts immune response in co-culture models. IC50=132.8 nM.</p>Fórmula:C25H26N2O3Cor e Forma:SolidPeso molecular:402.49Nampt-IN-8
CAS:<p>Nampt-IN-8 is a NAMPT inhibitor (IC50: 0.183 μM) and a good substrate for NQO1. Nampt-IN-8 induces reactive oxygen species (ROS) production and apoptosis.</p>Fórmula:C36H35N3O4Cor e Forma:SolidPeso molecular:573.68Thienopyridone
CAS:<p>Thienopyridone: potent, selective PRL phosphatase inhibitor, IC50s: 173/277/128 nM for PRL-1/2/3, induces apoptosis, anticancer.</p>Fórmula:C13H10N2OSPureza:98%Cor e Forma:SolidPeso molecular:242.3NVX-207
CAS:<p>NVX-207 is a derivative of betulinic acid. It has anti-cancer activity.</p>Fórmula:C36H59NO6Pureza:98%Cor e Forma:SolidPeso molecular:601.86Anti-inflammatory agent 54
CAS:<p>Anti-inflammatory agent 54 (compound 9c), a Coixol derivative, exhibits anti-inflammatory properties by inhibiting the NF-κB pathway and reducing the expression</p>Fórmula:C17H16N2O5Cor e Forma:SolidPeso molecular:328.32Arylquin 1
CAS:<p>Arylquin 1: a Par-4 secretagogue targeting vimentin; causes non-apoptotic cancer cell death via LMP.</p>Fórmula:C17H16FN3Cor e Forma:SolidPeso molecular:281.33ARN5187
CAS:<p>ARN5187, a lysosomal REV-ERB β ligand, inhibits transcription and autophagy, shows efficacy, cytotoxicity, and induces apoptosis.</p>Fórmula:C24H32FN3OCor e Forma:SolidPeso molecular:397.53Ludartin
CAS:<p>Ludartin activates TRPA1, induces DNA damage, and lowers mitochondrial potential, yielding anticancer effects.</p>Fórmula:C15H18O3Cor e Forma:SolidPeso molecular:246.3Ozarelix
CAS:<p>Ozarelix: a GnRH antagonist that induces apoptosis in advanced prostate cancer, modulates death receptors, and reduces sex hormones.</p>Fórmula:C72H96ClN17O14Cor e Forma:SolidPeso molecular:1459.09Tubulin polymerization-IN-17
CAS:<p>Compound 23g, a potent inhibitor of tubulin aggregation, induces apoptosis, and inhibits cell migration; promising for cancer research.</p>Fórmula:C26H23NO5Cor e Forma:SolidPeso molecular:429.46ATAD2-IN-1
CAS:<p>ATAD2-IN-1 (compound 19f) serves as a potent ATAD2 inhibitor (IC 50: 0.27 μM), capable of inducing apoptosis. Additionally, it suppresses c-Myc activation and impedes the migration of BT-549 cells [1].</p>Fórmula:C22H26N6O5Cor e Forma:SolidPeso molecular:454.48PERK-IN-5
CAS:<p>PERK-IN-5: oral PERK inhibitor, IC50 of 2 nM; blocks p-eIF2α at 9 nM; hinders tumor growth in renal cancer model.</p>Fórmula:C25H26F2N4O3Cor e Forma:SolidPeso molecular:468.5Topoisomerase II inhibitor 11
CAS:<p>Topoisomerase II inhibitor 11 (compound 3d) is a potent inhibitor of Topoisomerase II (IC50: 2.89 μM).</p>Fórmula:C27H21BrCl2N2O2SCor e Forma:SolidPeso molecular:588.34Mammea A/BA
CAS:<p>Mammea A/BA combats T. cruzi by causing mitochondrial damage, ROS, DNA fragmentation, and vacuolization, leading to cell death. Useful for Chagas research.</p>Fórmula:C25H26O5Cor e Forma:SolidPeso molecular:406.47Aurora A inhibitor 2
CAS:<p>Aurora A inhibitor 2 (Compound 16h) is a potent inhibitor of Aurora A kinase (IC50: 21.94 nM).</p>Fórmula:C24H26N6O3Cor e Forma:SolidPeso molecular:446.5Antitumor agent-56
CAS:<p>Antitumor-56: Oral triptolide derivative; inhibits melanoma; anti-tumor, anti-inflammatory, NO-releasing properties.</p>Fórmula:C28H28N2O10SCor e Forma:SolidPeso molecular:584.59PARP1/BRD4-IN-1
CAS:<p>PARP1/BRD4-IN-1 selectively inhibits PARP1 (49 nM IC50) and BRD4 (202 nM IC50), hindering pancreatic cancer cell growth.</p>Fórmula:C29H26N6O3Cor e Forma:SolidPeso molecular:506.56MPT0B002
CAS:MPT0B002 is a microtubule inhibitor that acts by downregulating T315I mutant Bcr-Abl and inducing apoptosis of imatinib-resistant chronic myeloid leukemia cellsFórmula:C19H19NO4Pureza:98%Cor e Forma:SolidPeso molecular:325.36Clidanac
CAS:Clidanac is a potent anti-inflammatory drug and is found to uncouple the oxidative phosphorylation.Fórmula:C16H19ClO2Pureza:98%Cor e Forma:SolidPeso molecular:278.77PDE4-IN-10
CAS:<p>PDE4-IN-10 (7a), potent PDE4B inhibitor, IC50 7.01μM; selective, stable, TNF-α blocking, non-toxic in vitro.</p>Fórmula:C18H13NCor e Forma:SolidPeso molecular:243.3IZTZ-1
CAS:<p>IZTZ-1: c-MYC G4 stabilizer, reduces expression, blocks cell cycle, induces apoptosis, inhibits B16 melanoma growth.</p>Fórmula:C32H35N7SCor e Forma:SolidPeso molecular:549.73MBM-17S
CAS:<p>MBM-17S, a potent NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 3 nM, effectively inhibits cancer cell proliferation by inducing cell cycle arrest and</p>Fórmula:C36H40N6O10Pureza:98%Cor e Forma:SolidPeso molecular:716.74Apogossypolone (ApoG2)
CAS:<p>Apogossypolone (ApoG2) is a semi-synthesized derivative of gossypol which is a nonpeptidic small molecule inhibitor targeting Bcl-2 family proteins with K i</p>Fórmula:C28H26O8Cor e Forma:SolidPeso molecular:490.5Quinate
CAS:<p>Quinate: oral antiarrhythmic, inhibits P450db, blocks K+ channels (IC50 19.9 μM), used in malaria research.</p>Fórmula:C26H36N2O9Cor e Forma:SolidPeso molecular:520.579IDH1 Inhibitor 9
CAS:<p>IDH1 Inhibitor 9 (compound 11S) (2, 4, 8, 10 µM) induces apoptosis and causes cell cycle arrest in the S phase in a dose-dependent manner.</p>Fórmula:C26H30N4O3Cor e Forma:SolidPeso molecular:446.54CFM-5
CAS:<p>CFM-5 has anticonvulsant activity and is used in epilepsy research.</p>Fórmula:C23H18BrN3OSPureza:98%Cor e Forma:SolidPeso molecular:464.38MK-886 sodium salt
CAS:<p>MK-886 sodium salt inhibits leukotriene biosynthesis in leukocytes.</p>Fórmula:C27H33ClNNaO2SCor e Forma:SolidPeso molecular:494.06AMC-01
CAS:<p>AMC-01 has potential antiviral activity and induces dose- and time-dependent inactivation of eIF2-α via phosphorylation of serine residue 51.</p>Fórmula:C27H27BrN2O6Pureza:99.95%Cor e Forma:SolidPeso molecular:555.42673-A
CAS:<p>673-A inhibits ALDH1A, depletes ovarian CSCs, induces necroptosis, and reverses chemo resistance.</p>Fórmula:C15H13NOCor e Forma:SolidPeso molecular:223.27CX-5011
CAS:<p>CX-5011, a CK2 inhibitor, induces Rac1 activation and promotes apoptosis, effectively causing cancer cell death [1] [2].</p>Fórmula:C20H12N4O2Pureza:98%Cor e Forma:SolidPeso molecular:340.33Anticancer agent 59
Anticancer agent 59 suppresses various cancers, notably A549 at IC50 of 0.2 μM, induces apoptosis and disrupts mitochondria in mice.Fórmula:C42H59NO6Cor e Forma:SolidPeso molecular:673.92OT-82
CAS:OT-82 is a NAMPT inhibitor with anticancer activity and cytotoxicity and is used in the study of leukemias.Fórmula:C26H21FN4OPureza:98.91% - 99.315%Cor e Forma:SolidPeso molecular:424.47MPT0B392
CAS:<p>MPT0B392 is an orally active quinoline derivative, induces c-Jun N-terminal kinase (JNK) activation.</p>Fórmula:C19H20N2O6SCor e Forma:SolidPeso molecular:404.44Fenoldopam hydrochloride
CAS:<p>Fenoldopam HCl: D1 dopamine receptor agonist, vasodilator, doesn't cross blood-brain barrier, α2-adrenoceptor antagonist.</p>Fórmula:C16H17Cl2NO3Cor e Forma:SolidPeso molecular:342.222,5-Dihydroxybiphenyl
CAS:<p>2,5-Dihydroxybiphenyl: a small molecule that induces trichothiodystrophy A protein dimerization, modulating TFIIH activity.</p>Fórmula:C12H10O2Pureza:99.66%Cor e Forma:White To Grey-Brownish PowderPeso molecular:186.21Atopaxar Hydrobromide
CAS:Atopaxar, a reversible PAR-1 thrombin receptor antagonist, interferes with platelet signaling.Fórmula:C29H39BrFN3O5Pureza:98%Cor e Forma:SolidPeso molecular:608.54RIPK1-IN-11
CAS:<p>RIPK1-IN-11, an oral RIPK1 blocker, Kd 9.2 nM, IC50 67 nM, prevents necrosis and inflammation in cells.</p>Fórmula:C23H24N4O4SCor e Forma:SolidPeso molecular:452.53Ormeloxifene
CAS:estrogen receptor modulatorFórmula:C30H35NO3Pureza:98%Cor e Forma:SolidPeso molecular:457.6FW1256
CAS:FW1256: phenyl analog, slow H2S donor, inhibits NF-κB, induces apoptosis, anti-inflammatory, potential cancer/cardio treatment.Fórmula:C12H10NOPSCor e Forma:SolidPeso molecular:247.257DG
CAS:<p>7DG is a selective inhibitor of protein kinase R (PKR).</p>Fórmula:C26H30O5Cor e Forma:SolidPeso molecular:422.51ENMD-1068 HCl
CAS:<p>ENMD-1068 HCl (ENMD 1068) is a PAR-2 antagonist. ENMD-1068 HCl inhibits the development of endometriosis in a mouse model.</p>Fórmula:C15H29N3O2Pureza:99.91%Cor e Forma:SolidPeso molecular:283.41Tolbutamide Sodium
CAS:potassium channel blockerFórmula:C12H18N2NaO3SPureza:98%Cor e Forma:SolidPeso molecular:293.34Anticancer agent 76
CAS:<p>Compound CT2-3 is an anticancer agent that hinders growth, induces arrest, ROS, and apoptosis in NSCLC cells.</p>Fórmula:C32H33NO5SCor e Forma:SolidPeso molecular:543.67α-NETA
CAS:<p>α-NETA is a ChA inhibitor and an ALDH1A1 and CMKLR1 antagonist with anticancer activity and inhibits cholinesterase and acetylcholinesterase (AChE).</p>Fórmula:C16H20INOPureza:99.54%Cor e Forma:SolidPeso molecular:369.24SS28
CAS:<p>SS28 inhibits tubulin polymerization to cause cell cycle arrest at G2/M phase.</p>Fórmula:C18H20O3Pureza:98%Cor e Forma:SolidPeso molecular:284.35CCT373566
CAS:<p>CCT373566: potent BCL6 degrader, oral, IC50 2.2 nM; hinders cell growth in vitro & shrinks tumors in vivo.</p>Fórmula:C26H29ClF2N6O3Cor e Forma:SolidPeso molecular:547NSC10010 hydrochloride
CAS:<p>NSC10010 inhibits gammaherpesvirus B-lymphomas by activating NF-κB and c-Myc pathways.</p>Fórmula:C31H42Cl2N4O2Pureza:98%Cor e Forma:SolidPeso molecular:573.60PD-1-IN-18
CAS:<p>PD-1-IN-18 is a PD1 inhibitor of signaling pathway, and acts as an immunomodulator.</p>Fórmula:C11H17N5O8Pureza:98%Cor e Forma:SolidPeso molecular:347.28Caspase-3-IN-1
CAS:<p>Caspase-3-IN-1 is a potent inhibitor of Caspase-3 (IC50: 14.5 nM).</p>Fórmula:C26H25N3O6SCor e Forma:SolidPeso molecular:507.56UCB-6876
CAS:<p>UCB-6876 inhibits TNF signaling, stabilizes trimer asymmetry, shows concentration response, and is selective for TNFR1.</p>Fórmula:C17H18N2OCor e Forma:SolidPeso molecular:266.34
