Apoptose
Os inibidores da apoptose são compostos que previnem ou retardam o processo de morte celular programada, conhecido como apoptose. Esses inibidores são vitais no estudo dos mecanismos de sobrevivência celular e são usados para investigar doenças onde a apoptose é desregulada, como câncer, distúrbios neurodegenerativos e doenças autoimunes. Ao modular a apoptose, esses inibidores podem ajudar no desenvolvimento de terapias destinadas a controlar a morte celular. Na CymitQuimica, oferecemos uma ampla seleção de inibidores da apoptose de alta qualidade para apoiar sua pesquisa em biologia celular, oncologia e áreas relacionadas.
Subcategorias de "Apoptose"
- ASK(6 produtos)
- BCL(11 produtos)
- Caspase(127 produtos)
- FOXO1(3 produtos)
- IAP(65 produtos)
- Mdm2(12 produtos)
- PD-1/PD-L1(126 produtos)
- PDK(9 produtos)
- PERK(24 produtos)
- Serina/treonina quinase(15 produtos)
- Survivina(13 produtos)
- TNF(91 produtos)
- c-RET(51 produtos)
- p53(62 produtos)
Exibir 6 mais subcategorias
Foram encontrados 5622 produtos de "Apoptose"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
AP23464
CAS:<p>AP23464 inhibits Src/Abl kinases, effective on imatinib-resistant CML cells (IC50=14nM), blocks cell cycle, induces apoptosis, not against T315I mutant.</p>Fórmula:C26H30N5O2PCor e Forma:SolidPeso molecular:475.52CZS-241
<p>CZS-241: Oral PLK4 inhibitor (IC50=2.6 nM), less potent TRKA blocker (IC50=2.74 μM), triggers apoptosis and S/G2 arrest, anti-leukemia, safe for normal cells.</p>Fórmula:C26H24ClF2N9OCor e Forma:SolidPeso molecular:551.98SMBA1
CAS:<p>SMBA1 is a Bax agonist with antitumor activity that can induce cell cycle arrest and apoptosis in malignant glioma cells.</p>Fórmula:C20H13NO3Pureza:99.2%Cor e Forma:SolidPeso molecular:315.32RET-IN-12
CAS:<p>RET-IN-12 is a RET inhibitor capable of acting on RET(WT) (IC50: 0.3 nM) and RET(V804M) (IC50: 1 nM).</p>Fórmula:C30H30F3N5O4Cor e Forma:SolidPeso molecular:581.59TJ08
CAS:<p>TJ08 has anticancer properties and can effectively induce G1/S phase blockade while promoting apoptosis in a variety of cancer cells.</p>Fórmula:C22H16FN3O4Pureza:99.89%Cor e Forma:SolidPeso molecular:405.38PDE5/HDAC-IN-1
CAS:<p>PDE5/HDAC-IN-1 is a potent inhibitor of phosphodiesterase 5 (PDE5) and HDAC, with IC50 values of 46.3 nM and 14.5 nM, respectively.</p>Fórmula:C27H29BrN4O4Cor e Forma:SolidPeso molecular:553.45Cinnabarinic acid
CAS:<p>mGlu4 receptor agonist</p>Fórmula:C14H8N2O6Pureza:98%Cor e Forma:SolidPeso molecular:300.22Berubicin HCl
CAS:<p>Berubicin hydrochloride, a brain-penetrating anthracycline, disrupts DNA replication and repair by inhibiting topoisomerase II.</p>Fórmula:C34H36ClNO11Cor e Forma:SolidPeso molecular:670.1EP12
CAS:<p>EP12, a c-Myc inhibitor and G4 stabilizer, induces apoptosis and DNA damage in multiple myeloma cells while obstructing P65/P50 nuclear translocation by</p>Fórmula:C26H22FN3O2Pureza:98%Cor e Forma:SolidPeso molecular:427.47NSC260594
CAS:<p>NSC260594 is a chemical compound that promotes apoptosis by binding to the shallow groove of the Mcl-1 protein and suppressing its expression through down-</p>Fórmula:C29H24N6O3Cor e Forma:SolidPeso molecular:504.54HIOC
CAS:<p>TrkB agonist; shields neurons & retinas; crosses blood-brain & retinal barriers.</p>Fórmula:C16H19N3O3Cor e Forma:SolidPeso molecular:301.34L6H21
CAS:<p>L6H21 is an MD-2 inhibitor that can be used to study cognitive impairment and brain damage.</p>Fórmula:C18H18O4Pureza:99.26%Cor e Forma:SolidPeso molecular:298.33APPA
CAS:<p>APPA, an aldose reductase inhibitor, demonstrates efficacy in preventing apoptosis and symptoms of Streptozotocin-induced diabetes in rats through inhibition of</p>Fórmula:C14H13NO3Pureza:98%Cor e Forma:SolidPeso molecular:243.26Anticancer agent 164
CAS:<p>CML-IN-1, also known as compound 7 and compound 4, is a potent anticancer agent that demonstrates a strong induced-apoptosis effect in the human chronic myeloid</p>Fórmula:C21H23F3N8O2S2Pureza:98%Cor e Forma:SolidPeso molecular:540.58Telomerase-IN-4
CAS:<p>Telomerase-IN-4 is a potent inhibitor of telomerase with antiproliferative properties and induces apoptosis [1].</p>Fórmula:C21H18N4OS2Pureza:98%Cor e Forma:SolidPeso molecular:406.52NVS-CECR2-1
CAS:<p>NVS-CECR2-1 is a CECR2 inhibitor with anti-tumor activity that inhibits chromatin binding of the CECR2 BRD.</p>Fórmula:C27H37N5O2SPureza:98.68%Cor e Forma:SolidPeso molecular:495.68Luxeptinib
CAS:<p>Luxeptinib (CG-806) is an oral, non-covalent pan-FLT3/BTK inhibitor for acute myeloid leukemia.</p>Fórmula:C25H17F4N5O2Cor e Forma:SolidPeso molecular:495.43AG311
CAS:<p>AG311 inhibits complex I; destabilizes HIF-1α; triggers necrosis in cancer cells, mitochondrial depolarization, superoxide, and calcium increase.</p>Fórmula:C17H15N5SCor e Forma:SolidPeso molecular:321.4Ac-IETD-CHO
CAS:<p>Ac-IETD-CHO is a potent, reversible inhibitor of granzyme B and caspase 8, which also impedes Fas-mediated apoptosis, hemorrhagic conditions, and liver failure.</p>Fórmula:C21H34N4O10Pureza:98%Cor e Forma:SolidPeso molecular:502.52Anticancer agent 147
CAS:<p>Compound 6j (Anticancer agent 147), a sophoridine derivative and ferroptosis inducer, promotes intracellular accumulation of Fe2+, reactive oxygen species (ROS</p>Fórmula:C32H40BrN3O2Pureza:98%Cor e Forma:SolidPeso molecular:578.58NBI-42902
CAS:<p>NBI-42902 is a potent GnRH receptor antagonist (Ki=0.56 nm, Kd=0.19 nm), suppressing serum LH in macaques without causing histamine release.</p>Fórmula:C27H24F3N3O3Cor e Forma:SolidPeso molecular:495.49IM-54
CAS:<p>IM-54 is a cell-permeable, effective, and selective necrosis inhibitor.</p>Fórmula:C19H23N3O2Pureza:99.24%Cor e Forma:SolidPeso molecular:325.4MRS 2693 trisodium salt
CAS:<p>MRS 2693 trisodium salt is a P2Y6 agonist.</p>Fórmula:C9H22IN5O12P2Pureza:98%Cor e Forma:SolidPeso molecular:581.15AQX-016A
CAS:<p>AQX-016A, a potent SHIP1 agonist, is an oral analog of pelorol, 3x stronger, inhibits PI3K, TNFa, for inflammation research.</p>Fórmula:C22H32O2Cor e Forma:SolidPeso molecular:328.49STAT3-IN-11
CAS:STAT3-IN-11 is a STAT3 inhibitor.STAT3-IN-11 promotes apoptosis in cancer cells and is a candidate compound for the treatment of cancer.Fórmula:C20H17NO4Pureza:98.3%Cor e Forma:SolidPeso molecular:335.35HDAC1/6-IN-1
CAS:<p>HDAC1/6-IN-1, a dual HDAC1 (89 nM) and HDAC6 (13 nM) inhibitor, blocks cancer cell cycle, triggers apoptosis, and halts metastasis.</p>Fórmula:C32H45N7O4Cor e Forma:SolidPeso molecular:591.74Antiproliferative agent-32
CAS:<p>Antiproliferative agent-32 (Compound 1c) impedes phosphorylation within the PI3K/Akt/mTOR signaling pathway, restrains proliferation of Huh7 and SK-Hep-1 cells</p>Fórmula:C19H15NO2Pureza:98%Cor e Forma:SolidPeso molecular:289.33Antitumor agent-115
CAS:<p>Antitumor agent-115 (SS-12) is a potent anti-tumor compound, exhibiting an IC50 range of 0.34 μM-24.14 μM against the 4T1 mouse breast cancer cell line.</p>Fórmula:C19H38ClNO2Pureza:98%Cor e Forma:SolidPeso molecular:347.96Propiomazine
CAS:<p>Propiomazine is an orally active antihistamine compound with sedative properties, useful for controlling insomnia in neurological disorders.</p>Fórmula:C20H24N2OSPureza:98.5%Cor e Forma:SolidPeso molecular:340.48Telomerase-IN-5
CAS:<p>Telomerase-IN-5 is a potent inhibitor of telomerase with antiproliferative properties, and it induces apoptosis [1].</p>Fórmula:C22H20N4OS2Pureza:98%Cor e Forma:SolidPeso molecular:420.55SZM-1209
CAS:<p>SZM-1209 is a potent and specific RIPK1 inhibitor with oral activity, displaying a dissociation constant (Kd) of 85 nM.</p>Fórmula:C31H29F5N4O5S2Pureza:98%Cor e Forma:SolidPeso molecular:696.71(R)-STU104
CAS:(R)-STU104 is a TAK1-MKK3 protein-protein interaction (PPI) inhibitor. (R)-STU104 is a candidate compound for the treatment of ulcerative colitis.Fórmula:C18H18O4Pureza:98.91% - 99.42%Cor e Forma:SolidPeso molecular:298.33Metallo-β-lactamase-IN-5
CAS:<p>Metallo-β-lactamase-IN-5 (compound 5c) is a powerful inhibitor of metallo-β-lactamases (MBLs).</p>Fórmula:C19H16N4O3Cor e Forma:SolidPeso molecular:348.36Caspase-3/7 activator 2
<p>Caspase-3/7 activator 2 triggers apoptosis with tumor selectivity and anti-proliferative properties.</p>Fórmula:C32H34N2O7Cor e Forma:SolidPeso molecular:558.62PI3Kδ/γ-IN-3
CAS:<p>PI3Kδ/γ-IN-3 (Compound 58) is an orally active dual inhibitor of PI3Kδ (IC50: 1 nM) and PI3Kγ (IC50: 16 nM).</p>Fórmula:C23H20ClN9OCor e Forma:SolidPeso molecular:473.92Justicidin B
CAS:<p>Justicidin B: anticancer, proapoptotic, inhibits bone resorption & platelets, antiviral, fungicidal, antiprotozoal.</p>Fórmula:C21H16O6Cor e Forma:SolidPeso molecular:364.35Tezacitabine
CAS:<p>Tezacitabine, a nucleoside analogue, inhibits ribonucleotide reductase, disrupts DNA replication, and induces apoptosis in tumor cells.</p>Fórmula:C10H12FN3O4Cor e Forma:SolidPeso molecular:257.22Isodispar B
CAS:<p>Isodispar B: an anticancer drug, halts many cancer types' growth, triggers cell death.</p>Fórmula:C20H18O5Cor e Forma:SolidPeso molecular:338.35Anticancer agent 99
CAS:<p>Anticancer agent 99 targets HepG2 cells, IC50 at 35.9 μM, induces apoptosis and hinders cell growth.</p>Fórmula:C19H20F3N3O2Cor e Forma:SolidPeso molecular:379.38EGFR-IN-57
CAS:<p>EGFR-IN-57: potent EGFR-TK blocker, IC50 0.054 μM, oral. Halts VEGFR-2, CK2α, topo IIβ, tubulin. Causes G2/M, pre-G1 arrest, cancer cell death.</p>Fórmula:C22H15N3O2SCor e Forma:SolidPeso molecular:385.44Thioxodihydroquinazolinone-19
CAS:<p>Thioxodihydroquinazolinone-19 triggers apoptosis in A2780cis ovarian cancer cells and enhances cisplatin efficacy.</p>Fórmula:C16H14N2OSPureza:98%Cor e Forma:SolidPeso molecular:282.36IDH1 Inhibitor 9
CAS:<p>IDH1 Inhibitor 9 (compound 11S) (2, 4, 8, 10 µM) induces apoptosis and causes cell cycle arrest in the S phase in a dose-dependent manner.</p>Fórmula:C26H30N4O3Cor e Forma:SolidPeso molecular:446.54RET-IN-15
CAS:<p>RET-IN-15 is an inhibitor of rearrangement kinase (RET) during transfection and can be used in cancer research.</p>Fórmula:C27H28N8O2Cor e Forma:SolidPeso molecular:496.56Anticancer agent 71
CAS:<p>Compound 4b, a potent anticancer, halts G2/M cell cycle, triggers apoptosis, alters Bax, Ikb-α, PARP, and Bcl-2 levels.</p>Fórmula:C18H13ClF3N5OCor e Forma:SolidPeso molecular:407.78Antiproliferative agent-11
<p>Antiproliferative agent-11, a Ruthenium(II) complex, targets multiple cancers with IC50s of 6-10 μM.</p>Fórmula:C31H34Cl2N6O3P2RuCor e Forma:SolidPeso molecular:772.56CGP 65015
CAS:<p>CGP 65015 is an oral iron chelator and can mobilize iron deposits.</p>Fórmula:C14H15NO4Pureza:98%Cor e Forma:SolidPeso molecular:261.27PHM16
CAS:<p>PHM16 is an ATP competitive FAK and FGFR2 inhibitor.</p>Fórmula:C20H22N6O4Pureza:98%Cor e Forma:SolidPeso molecular:410.43MI-389
CAS:MI-389 is a PROTAC degrader that induces the degradation of receptor tyrosine kinases (RTKs), useful for leukemia research.Fórmula:C35H35FN6O6Pureza:98.12%Cor e Forma:SolidPeso molecular:654.69ARN 14494
CAS:<p>ARN 14494, a potent SPT inhibitor (IC50=27.3 nM), reduces ceramide synthesis and neuroinflammation, and protects against β-amyloid toxicity.</p>Fórmula:C24H32N4O3Cor e Forma:SolidPeso molecular:424.54BIM-46174
CAS:<p>BIM-46174 has anticancer activity, inhibits the growth of a large number of human cancer cell lines, and induces caspase-3-dependent cancer cell apoptosis.</p>Fórmula:C22H30N4OSCor e Forma:SolidPeso molecular:398.57
