Apoptose
Os inibidores da apoptose são compostos que previnem ou retardam o processo de morte celular programada, conhecido como apoptose. Esses inibidores são vitais no estudo dos mecanismos de sobrevivência celular e são usados para investigar doenças onde a apoptose é desregulada, como câncer, distúrbios neurodegenerativos e doenças autoimunes. Ao modular a apoptose, esses inibidores podem ajudar no desenvolvimento de terapias destinadas a controlar a morte celular. Na CymitQuimica, oferecemos uma ampla seleção de inibidores da apoptose de alta qualidade para apoiar sua pesquisa em biologia celular, oncologia e áreas relacionadas.
Subcategorias de "Apoptose"
- ASK(6 produtos)
- BCL(11 produtos)
- Caspase(125 produtos)
- FOXO1(3 produtos)
- IAP(66 produtos)
- Mdm2(12 produtos)
- PD-1/PD-L1(125 produtos)
- PDK(9 produtos)
- PERK(25 produtos)
- Serina/treonina quinase(15 produtos)
- Survivina(13 produtos)
- TNF(92 produtos)
- c-RET(51 produtos)
- p53(62 produtos)
Exibir 6 mais subcategorias
Foram encontrados 5600 produtos de "Apoptose"
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eIF4A3-IN-17
CAS:<p>eIF4A3-IN-17, a silvestrol analogue, disrupts eIF4F assembly; EC50: 0.9-15 nM. Used in cancer pathogenesis research.</p>Fórmula:C28H25NO7Cor e Forma:SolidPeso molecular:487.5Z-LLY-FMK
CAS:<p>Z-LLY-FMK (Calpain Inhibitor IV) serves as an inhibitor of calpain, a family of proteases implicated in the apoptosis of various cell systems.</p>Fórmula:C30H40FN3O6Pureza:98%Cor e Forma:SolidPeso molecular:557.65Agerafenib hydrochloride
CAS:<p>Agerafenib hydrochloride is a highly potent inhibitor of BRAFV600E (Kd: 14 nM).</p>Fórmula:C24H23ClF3N5O5Pureza:98%Cor e Forma:SolidPeso molecular:553.92TL02-59
CAS:<p>TL02-59: Fgr inhibitor (IC50=0.03nM), also targets Lyn (0.1nM), Hck (160nM), halts acute myelogenous leukemia growth.</p>Fórmula:C32H34F3N5O4Pureza:98.77%Cor e Forma:SolidPeso molecular:609.64Eeyarestatin I
CAS:<p>Eeyarestatin I blocks ER protein degradation, hinders p97/atx3 processes, and induces anticancer proteins.</p>Fórmula:C27H25Cl2N7O7Pureza:98% - 98.99%Cor e Forma:SolidPeso molecular:630.44Nedometinib
CAS:<p>Nedometinib (NFX-179) is a MEK1 inhibitor with anticancer and antitumor activities, which can be used to study malignant tumors.</p>Fórmula:C17H16FIN4O3Pureza:99.18%Cor e Forma:SolidPeso molecular:470.24HDAC-IN-46
CAS:<p>HDAC-IN-46 inhibits HDAC1 & HDAC6, affects p-p38, Bcl-xL & cyclin D1, blocks G2 phase & induces apoptosis in TNBC research.</p>Fórmula:C22H30N8O2Cor e Forma:SolidPeso molecular:438.53RUNX-IN-2
CAS:<p>RUNX-IN-2 (Compound Conjugate 3) covalently attaches to RUNX-binding sequences, preventing RUNX proteins from associating with their targets, thereby inhibiting</p>Fórmula:C71H88Cl2N24O11Pureza:98%Cor e Forma:SolidPeso molecular:1524.52HDAC-IN-60
CAS:<p>HDAC-IN-60 (compound 21a), a potent histone deacetylase (HDAC) inhibitor, promotes intracellular reactive oxygen species (ROS) production, induces DNA damage,</p>Fórmula:C20H26N2O6Pureza:98%Cor e Forma:SolidPeso molecular:390.43IK-862
CAS:<p>IK-862 is a selective TACE inhibitor with potential anti-inflammatory and anticancer activity for the study of neuritis.</p>Fórmula:C25H27N3O4Pureza:97.75% - 98.29%Cor e Forma:SolidPeso molecular:433.5MY-673
CAS:<p>MY-673, a colchicine binding site inhibitor (CBSI), impedes tubulin polymerization and disrupts the ERK signaling pathway, consequently modulating SMAD4 protein</p>Fórmula:C18H14N2O4Cor e Forma:SolidPeso molecular:322.31MP7
CAS:<p>MP7 (PDK1 inhibitor) is a inhibitor of phosphoinositide-dependent kinase-1 (PDK1).</p>Fórmula:C28H22F2N4O4Pureza:99.84% - 99.89%Cor e Forma:SolidPeso molecular:516.5BCL6-IN-4
CAS:<p>BCL6-IN-4, a potent inhibitor of B-cell lymphoma 6 (BCL6), exhibits anti-tumor activities with an inhibitory concentration 50 (IC50) value of 97 nM[1].</p>Fórmula:C25H35ClN6O3Cor e Forma:SolidPeso molecular:503.04Immunosuppressant-1
CAS:<p>Immunosuppressant-1 (Compound 31) suppresses T-cell proliferation triggered by anti-CD3/anti-CD28 co-stimulation and demonstrates immunosuppressive effects,</p>Fórmula:C14H12BrNO3Pureza:98%Cor e Forma:SolidPeso molecular:322.15DLC-50
CAS:<p>DLC-50 is a dual inhibitor of PARP-1 and HDAC-1, exhibiting IC50 values of 1.2 nM and 31 nM respectively. It hinders the proliferation of cancer cells such as MDA-MB-436, MDA-MB-231, and MCF-7 with IC50 values of 0.3 μM, 2.7 μM, and 2.41 μM respectively. Additionally, DLC-50 induces apoptosis in MDA-MB-231 cells and causes cell cycle arrest at the G2 phase.</p>Fórmula:C28H32FN5O4S2Cor e Forma:SolidPeso molecular:585.71ZINC00784494
CAS:<p>ZINC00784494 is a selective inhibitor of LCN2 (lipocalin-2), which inhibits cancer cell proliferation and reduces p-AKT , and promotes apoptosis. IBC.</p>Fórmula:C20H14N2O3SPureza:98.90%Cor e Forma:SolidPeso molecular:362.4BRD4 Inhibitor-18
CAS:<p>BRD4 Inhibitor-18: potent (IC50: 110 nM), impairs MV-4-11 cell growth, disrupts G0/G1 phase, and induces apoptosis.</p>Fórmula:C26H26ClN3O3SCor e Forma:SolidPeso molecular:496.02HDAC-IN-50
CAS:<p>HDAC-IN-50, a potent FGFR/HDAC inhibitor (IC50: 0.18-13 nM), induces apoptosis, cell cycle arrest, and shows anti-tumor activity.</p>Fórmula:C31H41N7O4Cor e Forma:SolidPeso molecular:575.7FHND5071
CAS:<p>FHND5071, a potent and selective RET kinase inhibitor, exerts antitumor effects through the inhibition of RET autophosphorylation and may be utilized for tumor</p>Fórmula:C30H30D3N9OCor e Forma:SolidPeso molecular:538.66ST1074
CAS:<p>ST1074, a dual inhibitor of CerS2 and CerS4, promotes apoptosis and is applicable in cancer research [1].</p>Fórmula:C20H36ClNO3Pureza:98%Cor e Forma:SolidPeso molecular:373.96BAX-IN-1
CAS:<p>BAX-IN-1 is a potential selective inhibitor of Bcl-2-associated X protein (BAX).</p>Fórmula:C16H14N6OCor e Forma:SolidPeso molecular:306.32Ginsenoside Rk1
CAS:<p>Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures.</p>Fórmula:C42H70O12Pureza:98.46% - 99.13%Cor e Forma:SolidPeso molecular:767SAFit1
CAS:<p>SAFit1 is an inhibitor of FK506 binding protein 51 (FKBP51)-specific (Ki: 4±0.3 nM).</p>Fórmula:C42H53NO11Pureza:98%Cor e Forma:SolidPeso molecular:747.87BHD
CAS:<p>BHD, a reversible male contraceptive agent, effectively induces spermatogenic cell apoptosis and causes abnormalities in seminiferous tubules in vivo at doses</p>Fórmula:C21H16Cl2N4OCor e Forma:SolidPeso molecular:411.28RIP2 kinase inhibitor 1
CAS:<p>Potent RIP2 kinase inhibitor with 0.03 μM IC50, selective for autoimmune disease treatment.</p>Fórmula:C17H17N5O2SPureza:98%Cor e Forma:SolidPeso molecular:355.41PARP1-IN-14
CAS:<p>PARP1-IN-14 (compound 19k) is a potent PARP1 inhibitor demonstrating an inhibition concentration (IC50) of 0.6 ± 0.1 nM.</p>Fórmula:C28H24FN7O3Pureza:98%Cor e Forma:SolidPeso molecular:525.53Sirt1/2-IN-2
CAS:<p>Sirt1/2-IN-2 (compound hsa55) serves as a dual inhibitor for SIRT1 with an IC50 of 1.8 μM and SIRT2 with an IC50 of 2.4 μM, respectively.</p>Fórmula:C18H14N4O3S2Pureza:98%Cor e Forma:SolidPeso molecular:398.46BQZ-485
CAS:<p>BQZ-485, a potent GDI2 inhibitor, interacts with Tyr245 to disrupt the native GDI2-Rab1A interaction.</p>Fórmula:C32H39NO3Pureza:98%Cor e Forma:SolidPeso molecular:485.66Q-VD(OMe)-OPh
CAS:<p>Q-VD-OPh: broad-spectrum, non-toxic caspase inhibitor; cost-effective, specific for apoptotic inhibition.</p>Fórmula:C27H27F2N3O6Pureza:98%Cor e Forma:SolidPeso molecular:527.52CUR61414
CAS:<p>CUR61414 is a cell-permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM) and selectively binds to smoothened (Ki = 44 nM).</p>Fórmula:C31H42N4O5Pureza:97.34% - 98%Cor e Forma:SolidPeso molecular:550.69WYE-132
CAS:<p>WYE-125132: potent mTOR inhibitor, IC50 0.19 nM, selective over PI3Ks/hSMG1/ATR.</p>Fórmula:C27H33N7O4Pureza:99.16%Cor e Forma:SolidPeso molecular:519.6HDAC-IN-59
CAS:<p>HDAC-IN-59 (compound 13a), a potent histone deacetylase (HDAC) inhibitor, enhances intracellular reactive oxygen species (ROS) production, induces DNA damage,</p>Fórmula:C20H25NO7Pureza:98%Cor e Forma:SolidPeso molecular:391.42Cu(II)-Elesclomol
CAS:<p>Cu(II)-Elesclomol is a complex formed by the anticancer agent Elesclomol and Cu(II), which has anticancer activity and can be used in the study of leukemia.</p>Fórmula:C19H18CuN4O2S2Pureza:99.99%Cor e Forma:SolidPeso molecular:462.05MRT199665
CAS:<p>MRT199665, a selective MARK/SIK/AMPK inhibitor, blocks SIK CRTC3 S370 phosphorylation and triggers apoptosis in AML cells.</p>Fórmula:C28H31N5O2Cor e Forma:SolidPeso molecular:469.58c-Met/MEK1/Flt-3-IN-1
<p>Antiproliferative Against-3 (comp 33) demonstrates significant activity against Hela (IC 50 = 0.21 µM), A549 (IC 50 = 0.39 µM), and MCF-7 (IC 50 = 0.33 µM) cell</p>Fórmula:C39H37FN6O5Cor e Forma:SolidPeso molecular:688.75CPT-Se3
CAS:<p>CPT-Se3, a camptothecin derivative, boosts anticancer activity, triggers apoptosis in Hep G2, and is cytotoxic to various cells with IC50 of 2.19-4.7 μM.</p>Fórmula:C24H20N2O6Se2Pureza:98%Cor e Forma:SolidPeso molecular:590.35AGN194204
CAS:<p>AGN194204 (IRX4204), an oral RXR agonist, inactive against RAR, has Kd 0.4-3.8 nM & EC50 0.08-0.8 nM, with anti-inflammatory and anticarcinogenic properties.</p>Fórmula:C24H32O2Pureza:98%Cor e Forma:SolidPeso molecular:352.51Immuno modulator-1
CAS:<p>Immuno modulator-1 (compound 22) effectively suppresses the secretion of TNFα and IL-2 in human peripheral blood mononuclear cells (hPBMC) with IC50 values of 4</p>Fórmula:C32H31FN6O4Cor e Forma:SolidPeso molecular:582.62AGN 192870
CAS:<p>AGN 192870 is a potent retinoic acid receptor (RAR) antagonist.AGN 192870 can be used to study cell growth arrest, differentiation and apoptosis.</p>Fórmula:C27H22O2Pureza:99.22%Cor e Forma:SolidPeso molecular:378.46BI-0252
CAS:<p>BI-0252 is an inhibitor of MDM2-p53 (IC50:4 nM).</p>Fórmula:C30H26Cl2FN3O3Pureza:98%Cor e Forma:SolidPeso molecular:566.45C 87
CAS:C 87: Small-molecule TNF-α inhibitor, binds TNFα, inhibits cytotoxicity with IC50 of 8.73 μM, blocks signaling.Fórmula:C24H15ClN6O3SPureza:≥98%Cor e Forma:SolidPeso molecular:502.93Ponicidin
CAS:<p>Ponicidin, a diterpenoid from Rabdosia rubescens, has immunoregulatory, anti-inflammatory, anti-viral, and anti-cancer properties.</p>Fórmula:C20H26O6Pureza:98.98% - 99.92%Cor e Forma:SolidPeso molecular:362.42Pelcitoclax
CAS:<p>Pelcitoclax (APG-1252) is a powerful inhibitor of the Bcl-2 and Bcl-xl proteins, displaying significant antineoplastic and pro-apoptotic properties[1].</p>Fórmula:C57H66ClF4N6O11PS4Cor e Forma:SolidPeso molecular:1281.84INI-43
CAS:<p>INI-43 targets Kpnβ1, disrupting nuclear transport in cervical/esophageal cancers, affecting NFAT, NFκB, AP-1, NF localization.</p>Fórmula:C22H23N7Pureza:99.83%Cor e Forma:SolidPeso molecular:385.46USP7-IN-3
CAS:<p>USP7-IN-3 is a potent and selective allosteric inhibitor of ubiquitin-specific protease 7 (USP7).</p>Fórmula:C29H31F3N6O3Pureza:98%Cor e Forma:SolidPeso molecular:568.59EGFR kinase inhibitor 1
CAS:<p>Potent EGFR blocker; acts on WT, L858R/T790M (IC50: 1.7 nM), less on T790M/C797S; stalls cell cycle, induces apoptosis, deters metastasis.</p>Fórmula:C30H31N7O2Cor e Forma:SolidPeso molecular:521.61AT-9283 L-lactate
CAS:<p>AT-9283 L-lactate is an inhibitor of aurora kinase.</p>Fórmula:C22H29N7O5Pureza:98%Cor e Forma:SolidPeso molecular:471.52RET-IN-13
CAS:<p>RET-IN-13: potent quinoline RET inhibitor; IC50 = 0.5 nM (WT), 0.9 nM (V804M); potential for RET-related tumor/intestinal disease research.</p>Fórmula:C32H33F4N5O3Cor e Forma:SolidPeso molecular:611.63p-Tolylmaleimide
CAS:<p>p-Tolylmaleimide (p Tolylmaleimide) is an inhibitor of the water channel and binds to Aquaporin Z.</p>Fórmula:C11H9NO2Pureza:99.94%Cor e Forma:SolidPeso molecular:187.19c-Met-IN-10
CAS:<p>c-Met-IN-10: potent kinase inhibitor (IC50=16 nM), halts cancer cell activity/movement, induces apoptosis, for anticancer research.</p>Fórmula:C26H21FN6O5Cor e Forma:SolidPeso molecular:516.48
