Apoptose

Stability Light Sensitive
Applications Pyropheophorbide A Methyl Ester is a chlorophyll (C379815) analog for studies of photosynthesis. Methyl pyropheophorbide a (Pyropheophorbide-a methyl ester), a chlorophyll-a derivative, and is a potent photosensitizer that can be used in photodynamic therapy (PDT) of cancer. Methyl pyropheophorbide a has photodynamic activity and can induce apoptosis and inhibit tumor growth.
References Bensasson, R., et al.: Nature, 290, 329 (1981); Moore, A., et al.: Science, 216, 982 (1982)

Applications Bisabolene is a sesquiterpene and can be extracted from oregano and other aromatic plants. It may be a potential anticancer agent that can induce apoptosis in A549 cancer cell line.
References Grosso, N. R., et al.: Argent., Pat. Appl. AR 90961 A1 20141217 (2014); Yfanti, P., et al.: Am J Plant Sci. 6, 2092 (2015)

Applications L-Selenocystine is a diselenide-bridged amino acid which show chemopreventive activity against tobacco-derived nitrosamine (NNK) induced lung tumors. It causes apoptosis in A375, HepG2 and MCF7 cancer cells by inducing intracellular reactive oxygen species.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Li, L., et al.: J. Biochem. Mol. Toxic., 19, 396 (2005); Chen, T., et al.: Biomed. Pharmacother., 63, 105 (2009);

Applications β-Lapachone is a naturally occurring quinone obtained from the bark of the lapacho tree (Tabebuia avellanedae) with cancer chemopreventive properties. Induces apoptosis in HL-60 and human prostate cancer cells.
References Renslo, A., et al.: Nat. Chem. Biol., 2, 701 (2006), Hopkins, A., et al.: Nat. Chem. Biol., 4, 682 (2008), Stuart, K., et al.: J. Clin. Invest., 118, 1301 (2008), Martin, R., et al.: Science, 25, 1680 (2009),

Applications GDC 0152 is a peptidomimetic small molecule antagonist of inhibitor of apoptosis (IAP) proteins with antitumor activity.
References Yue, Q., et. al.: Drug Metab. Dispos., 41, 508 (2013)

Impurity Phenylbutyrate USP Related Compound B
Applications α-Tetralone (Phenylbutyrate USP Related Compound B) is a reagent used in the synthesis of amino-pyrazolopyridines with anti-NF-κB and pro-apoptotic potential.
References Orlikova, B., et al.: Eur. J. Med. Chem., 85, 450 (2014);

Applications 4-Benzyloxy-3-methoxybenzoic Acid is used in the synthesis of Hsp90 inhibitors as EGCG analogues. Also used in the preparation of vanillates exhibiting cytostatic properties towards cancel cells resistant to pro-apoptotic stimuli.
References Khandelwal, A. et al.: J. Org. Chem., 78, 7859 (2013); Lamoral-Theys, D. et al.: Bioorg. Med. Chem., 18, 3823 (2010);

Applications Santamarine is a sesquiterpene lactone shows anticancer properties by inhibiting proliferation and inducing apoptosis.
References Mehmood, T., et al.: J. Cancer, 8, 1-11 (2017)