Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase(116 produtos)
- CDK(548 produtos)
- Ciclo celular/Parada(5 produtos)
- Chk(48 produtos)
- DYRK(46 produtos)
- Dinamina(27 produtos)
- Ferroptose(233 produtos)
- HSP(180 produtos)
- Integrinas(276 produtos)
- Cinesina(87 produtos)
- LIM Quinase(21 produtos)
- Microtúbulo associado(273 produtos)
- PKC(128 produtos)
- PLK(25 produtos)
- ROCK(61 produtos)
- Rho(6 produtos)
- Wee1(14 produtos)
- c-Myc(77 produtos)
Exibir 10 mais subcategorias
Foram encontrados 3936 produtos de "Ciclo celular/Ponto de verificação"
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Deoxythymidine triphosphate
CAS:Deoxythymidine triphosphate (dTTP) is one of the four nucleoside triphosphates that are used in the in vivo synthesis of DNA.Fórmula:C10H17N2O14P3·XNaPureza:99.78%Cor e Forma:White Amorphous PowderPeso molecular:482.17（free base）STAMBP-IN-1
CAS:STAMBP-IN-1 is a novel selective antagonist of deubiquitinase STAM-binding protein (STAMBP), decreasing NALP7 protein levels and suppressing IL-1β release afterFórmula:C27H28N4O4SPureza:99.64%Cor e Forma:SolidPeso molecular:504.6Ref: TM-T8706
1mg67,00€5mg152,00€1mL*10mM (DMSO)192,00€10mg236,00€25mg507,00€50mg730,00€100mg1.018,00€NVP-LCQ195
CAS:NVP-LCQ195 (LCQ-195) (AT9311) is a potent inhibitor of CDK1, CDK2, CDK3 and CDK5 (IC50: 1-42 nM).Fórmula:C17H19Cl2N5O4SPureza:99.56% - 99.85%Cor e Forma:SolidPeso molecular:460.33Ref: TM-TQ0068
1mg46,00€5mg92,00€1mL*10mM (DMSO)94,00€10mg138,00€25mg255,00€50mg374,00€100mg533,00€200mg705,00€Risdiplam
CAS:Risdiplam (RG7916) is a centrally and peripherally distributed and orally administrable small molecule SMN2 pre-mRNA splicing modifier.Cost-effective and quality-assured.Fórmula:C22H23N7OPureza:98.68% - 99.64%Cor e Forma:SolidPeso molecular:401.46RKI-1447
CAS:RKI-1447 is a potent inhibitor of ROCK1 and ROCK2. It has anti-invasive and antitumor activities.Fórmula:C16H14N4O2SPureza:98% - 99.73%Cor e Forma:SolidPeso molecular:326.37Ref: TM-T1898
5mg49,00€1mL*10mM (DMSO)54,00€10mg93,00€25mg177,00€50mg295,00€100mg391,00€200mg494,00€500mg797,00€Indisulam
CAS:Indisulam (E 7070) is a dual-action anticancer drug, blocking G1/S cell cycle transition by degrading cyclin E and activating p53/p21.Fórmula:C14H12ClN3O4S2Pureza:98.68% - 99.77%Cor e Forma:SolidPeso molecular:385.85Ref: TM-T4321
1mg34,00€2mg43,00€5mg63,00€1mL*10mM (DMSO)69,00€10mg88,00€25mg130,00€50mg198,00€100mg298,00€P 22077
CAS:P 22077 (P22077) is an inhibitor of ubiquitin-specific protease USP7 with EC50 of 8.6 μM. It also inhibits the closely related USP47.Fórmula:C12H7F2NO3S2Pureza:97.9% - 99.64%Cor e Forma:SolidPeso molecular:315.32DUB-IN-3
CAS:DUB-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor and the IC50 for USP8 is 0.56 μM.Fórmula:C16H9N5OPureza:99.34%Cor e Forma:SolidPeso molecular:287.28Ref: TM-T11112
1mg130,00€2mg178,00€5mg309,00€1mL*10mM (DMSO)324,00€10mg442,00€25mg705,00€50mg982,00€100mg1.333,00€500mg2.655,00€THAL-SNS-032
CAS:THAL-SNS-032 is a selective CDK9 degrader PROTAC.Fórmula:C40H52N8O10S2Pureza:99.68%Cor e Forma:SolidPeso molecular:869.02Ref: TM-T17069
1mg110,00€5mg259,00€10mg389,00€1mL*10mM (DMSO)389,00€25mg622,00€50mg884,00€100mg1.198,00€CK7
CAS:CK7, a Cdk2/9 inhibitor, is instrumental in the synthesis of Nek1 inhibitors BSc5231 and BSc5367.Fórmula:C14H12N6O2SPureza:99.54%Cor e Forma:SolidPeso molecular:328.35Ref: TM-T9615
1mg50,00€5mg114,00€1mL*10mM (DMSO)126,00€10mg177,00€25mg356,00€50mg557,00€100mg858,00€200mg1.153,00€GRGDSP acetate(91037-75-1 free base)
GRGDSP acetate(91037-75-1 free base) is a synthetic linear RGD peptide and is an integrin inhibitor.Fórmula:C24H41N9O12Pureza:99.77%Cor e Forma:SolidPeso molecular:647.64Gly-Arg-Gly-Asp-Ser acetate(96426-21-0 free base)
Gly-Arg-Gly-Asp-Ser (GRGDS) acetate is a cell binding protein domain derived from the cell-binding region of fibronectin.Fórmula:C19H34N8O11Pureza:99.81%Cor e Forma:SolidPeso molecular:550.52Adavosertib
CAS:Adavosertib (MK-1775) is a small molecule inhibitor of the checkpoint kinase WEE1 (IC50: 5.2 nM). It hinders the G2 DNA damage checkpoint.Fórmula:C27H32N8O2Pureza:98.65% - 99.86%Cor e Forma:SolidPeso molecular:500.6Ref: TM-T2077
5mg46,00€1mL*10mM (DMSO)49,00€10mg66,00€25mg81,00€50mg96,00€100mg110,00€200mg161,00€500mg260,00€AZ3146
CAS:AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM.Fórmula:C24H32N6O3Pureza:97.84% - >99.99%Cor e Forma:SolidPeso molecular:452.55VLX1570
CAS:VLX1570 is a competitive inhibitor of proteasome DUB activity with IC50 ranging from 4.2 uM to 8.6 uM. It has potent inhibition for USP14.Fórmula:C23H17F2N3O6Pureza:98.53% - 99.91%Cor e Forma:SolidPeso molecular:469.39Ref: TM-T4067
1mg90,00€2mg146,00€5mg245,00€1mL*10mM (DMSO)251,00€10mg385,00€25mg645,00€50mg888,00€100mg1.234,00€Thiazovivin
CAS:Thiazovivin, a ROCK inhibitor (IC50: 0.5 μM), increases the survival rate of hESC.Fórmula:C15H13N5OSPureza:98.00%Cor e Forma:SolidPeso molecular:311.36Ref: TM-T2155
1mg34,00€2mg46,00€5mg64,00€1mL*10mM (DMSO)70,00€10mg98,00€25mg180,00€50mg304,00€100mg444,00€N-Cyclohexyl-4-[1-(1-piperazinyl)-2,6-naphthyridin-3-yl]-2-pyridinamine
CAS:Novel 2,6-naphthyridine inhibits PKC/PKD, identified by HTS.Fórmula:C23H28N6Pureza:98.35%Cor e Forma:SolidPeso molecular:388.512-Aminofluorene
CAS:2-Aminofluorene (2-Fluorenamine) is a biochemical.Fórmula:C13H11NPureza:99.9%Cor e Forma:Light Yellow CrystallinePeso molecular:181.23Indirubin-3′-oxime
CAS:Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.Fórmula:C16H11N3O2Pureza:98.34%Cor e Forma:SolidPeso molecular:277.28Ref: TM-T9138
1mg44,00€1mL*10mM (DMSO)92,00€5mg93,00€10mg120,00€25mg236,00€50mg356,00€100mg532,00€200mg772,00€LY3177833
CAS:LY3177833 is an Cdc7 kinase inhibitor (IC50 : 3.3 nM)Fórmula:C16H12FN5OPureza:99.87%Cor e Forma:SolidPeso molecular:309.3Ref: TM-T7810
1mg38,00€5mg80,00€1mL*10mM (DMSO)87,00€10mg109,00€25mg212,00€50mg318,00€100mg477,00€200mg677,00€CW-069
CAS:CW-069 (IC50=75 μM）, an allosteric selective inhibitor of microtubule motor protein HSET, exhibits remarkable specificity over KSP.Fórmula:C23H21IN2O3Pureza:97.52% - 99.52%Cor e Forma:SolidPeso molecular:500.33Ref: TM-T6209
1mg40,00€5mg86,00€1mL*10mM (DMSO)94,00€10mg118,00€25mg205,00€50mg290,00€100mg409,00€500mg888,00€Phthalazinone pyrazole
CAS:Phthalazinone pyrazole: a potent, selective oral Aurora-A kinase inhibitor, overexpressed in tumors with oncogenic activity.Fórmula:C18H15N5OPureza:97.03%Cor e Forma:SolidPeso molecular:317.34Pyridostatin
CAS:Pyridostatin (RR82) is a synthetic small-molecule stabilizer of G-quadruplexes, a secondary structure of DNA that usually exists in the end of the chromosome orFórmula:C31H32N8O5Pureza:98%Cor e Forma:SolidPeso molecular:596.64iRGD peptide
CAS:iRGD peptide: 9-amino acid cyclic compound (CRGDKGPDC), found through phage display in mice with tumors.Fórmula:C35H57N13O14S2Pureza:98.77%Cor e Forma:SolidPeso molecular:948.04PHA-767491
CAS:PHA-767491 (CAY10572) is a potent ATP-competitive dual Cdc7/CDK9 inhibitor with IC50 of 10 nM and 34 nM, respectively.Fórmula:C12H11N3OPureza:99.49% - >99.99%Cor e Forma:SolidPeso molecular:213.24Ref: TM-T6206
2mg34,00€5mg49,00€1mL*10mM (DMSO)50,00€10mg64,00€25mg92,00€50mg138,00€100mg197,00€200mg295,00€TMPyP4 tosylate
CAS:TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand and is a telomerase inhibitor with antitumor effects in osteosarcoma cell lines.Fórmula:C72H66N8O12S4Pureza:98.61% - 99.85%Cor e Forma:SolidPeso molecular:1363.6CCG-222740
CAS:CCG-222740 is an inhibitor of Rho/MRTF pathwayFórmula:C23H19ClF2N2O3Pureza:98.76%Cor e Forma:SolidPeso molecular:444.86Ref: TM-T7764
2mg39,00€5mg62,00€1mL*10mM (DMSO)66,00€10mg94,00€25mg172,00€50mg260,00€100mg371,00€200mg530,00€RI-1
CAS:RI-1 (RAD51 inhibitor 1) is a RAD51 inhibitor (IC50: 5-30 μM).Fórmula:C14H11Cl3N2O3Pureza:99.3% - 99.62%Cor e Forma:SolidPeso molecular:361.61CCG-203971
CAS:CCG-203971 is an inhibitor of SRE activation in the prostate cancer cell line PC-3 (IC50: 6.4 μM), with 87% inhibition of SRE activation achieved at 100 μM.Fórmula:C23H21ClN2O3Pureza:98.82% - 99.50%Cor e Forma:SolidPeso molecular:408.88Activated Protein C (390-404), human acetate
Activated Protein C (390-404), human acetate (Activated Protein C ) inhibits APC anticoagulant activity.Fórmula:C93H134N22O25Pureza:99.92%Cor e Forma:SolidPeso molecular:1960.19Metoprine
CAS:Metoprine is a potent inhibitor of histamine N-methyltransferase (HMT), with potential antineoplastic activity.Fórmula:C11H10Cl2N4Pureza:98.42%Cor e Forma:SolidPeso molecular:269.13Irigenin
CAS:Irigenin mediates its antimetastatic effect by specifically and selectively blocking the α9β1 and α4β1 integrin binding sites on the C-C loop of the ExtraFórmula:C18H16O8Pureza:99.50% - 99.85%Cor e Forma:SolidPeso molecular:360.31AT-130
CAS:AT-130: Strong HBV inhibitor (IC50 0.13 μM), low toxicity in HepAD38, hinders RNA packaging.Fórmula:C22H22BrN3O5Pureza:97.81%Cor e Forma:SolidPeso molecular:488.33Ref: TM-T26674
1mg39,00€5mg86,00€1mL*10mM (DMSO)93,00€10mg124,00€25mg215,00€50mg320,00€100mg482,00€200mg662,00€EHop-016
CAS:EHop-016 is a specific Rac GTPase inhibitor with IC50 of 1.1 μM for Rac1 in MDA-MB-231 and MDA-MB-435 cells, equally effective inhibition for Rac3.Fórmula:C25H30N6OPureza:98.99% - >99.99%Cor e Forma:SolidPeso molecular:430.55Ref: TM-T2427
5mg46,00€1mL*10mM (DMSO)49,00€10mg70,00€25mg120,00€50mg202,00€100mg316,00€200mg467,00€500mg747,00€kb NB 142-70
CAS:kb NB 142-70 is a selective protein kinase D (PKD) inhibitor (IC50 values are 28.3, 58.7 and 53.2 nM for PKD1, 2 and 3 respectively).Fórmula:C11H9NO2S2Pureza:98.15% - ≥95%Cor e Forma:SolidPeso molecular:251.32TH5427
CAS:TH5427 is a lead NUDT5 inhibitor(MG assay IC50 = 29 nM).Fórmula:C20H20Cl2N8O3Pureza:99.54%Cor e Forma:SolidPeso molecular:491.33Ref: TM-T39785L
1mg92,00€2mg130,00€5mg200,00€10mg290,00€25mg495,00€50mg623,00€100mg842,00€200mg1.134,00€RKI1313
CAS:RKI1313 (RKI-1313) was a selective inhibitor for ROCK-dependent signaling, cytoskeletal changes, anchorage-independent colony formation, migration, and invasionFórmula:C17H16N4O2SPureza:99.53% - ≥95%Cor e Forma:SolidPeso molecular:340.4Ref: TM-T2011
500µg50,00€1mg66,00€5mg135,00€1mL*10mM (DMSO)152,00€10mg197,00€25mg349,00€50mg512,00€100mg730,00€6-Thioinosine
CAS:6-Thioinosine (6TI) is a purine antimetabolite, acts as an anti-adipogenesis agent.Fórmula:C10H12N4O4SPureza:97.74%Cor e Forma:SolidPeso molecular:284.2910074-A4
CAS:10074-A4 is a c-Myc binding compound that associates with c-Myc370–409 and behaves like a “ligand cloud” around a “protein cloud”, with distinct features fromFórmula:C18H14Cl2N2O3SPureza:99.06%Cor e Forma:SolidPeso molecular:409.29Ref: TM-T9628
1mg56,00€2mg80,00€1mL*10mM (DMSO)101,00€5mg114,00€10mg177,00€25mg318,00€50mg454,00€100mg627,00€200mg845,00€THZ1 Hydrochloride
THZ1 Hydrochloride: selective covalent CDK7 inhibitor, IC50 of 3.2 nM; affects CDK12/13 & lowers MYC expression.Fórmula:C31H29Cl2N7O2Cor e Forma:SolidPeso molecular:602.51Chroman 1 dihydrochloride
Chroman 1 dihydrochloride: potent ROCK2 inhibitor (IC50: 1 pM), also affects ROCK1 (52 pM) and MRCK (150 nM).Fórmula:C24H30Cl2N4O4Cor e Forma:SolidPeso molecular:509.43Pyridostatin Trihydrochloride
CAS:Pyridostatin Trihydrochloride (RR-82 Trihydrochloride) is a G-quadruplexe stabilizer, with a Kd of 490 nM.Fórmula:C31H35Cl3N8O5Pureza:99.69%Cor e Forma:SolidPeso molecular:706.02Isoindigotin
CAS:Isoindigotin is used in the therapy of Y.
Fórmula:C16H10N2O2Pureza:98.14% - ≥95%Cor e Forma:SolidPeso molecular:262.26GSK180736A
CAS:GSK180736A: GRK2 inhibitor (IC50 0.77µM), >100x selectivity vs GRKs, weak at PKA (IC50 30µM), strong vs ROCK1 (IC50 100nM).Fórmula:C19H16FN5O2Pureza:98.38% - 98.98%Cor e Forma:SolidPeso molecular:365.36Ref: TM-T3513
1mg39,00€2mg50,00€1mL*10mM (DMSO)62,00€5mg70,00€10mg94,00€25mg161,00€50mg290,00€100mg538,00€500mg1.161,00€4μ8C
CAS:4μ8C (IRE1 Inhibitor III)(IC50=76 nM) is an effective and specific IRE1 Rnase inhibitor.Fórmula:C11H8O4Pureza:97.48% - 98.45%Cor e Forma:SolidPeso molecular:204.18K858 (Racemic)
CAS:K858 Racemic (K858) is a selective mitotic kinesin Eg5 inhibitor which acts in an ATP-noncompetitive manner.Fórmula:C13H15N3O2SPureza:>99.99%Cor e Forma:SolidPeso molecular:277.34IU1-248
CAS:IU1-248 is a derivative of IU1. IU1-248 is a potent and selective USP14 inhibitor with an IC50 of 0.83 μM[1].Fórmula:C20H23N3O2Pureza:99.3%Cor e Forma:SolidPeso molecular:337.42Ref: TM-T9375
1mg48,00€5mg92,00€1mL*10mM (DMSO)102,00€10mg152,00€25mg301,00€50mg424,00€100mg605,00€200mg845,00€Empesertib
CAS:Empesertib (BAY 1161909) is an orally bioavailable and selective inhibitor Mps1(IC50 < 1 nM), with potential antineoplastic activity.Fórmula:C29H26FN5O4SPureza:97.45% - 99.4%Cor e Forma:SolidPeso molecular:559.61GSK269962A
CAS:GSK269962A (GSK269962A HCl) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.Fórmula:C29H30N8O5Pureza:99.14% - 99.71%Cor e Forma:SolidPeso molecular:570.66-Bromo-2-hydroxy-3-methoxybenzaldehyde
CAS:6-Bromo-2-hydroxy-3-methoxybenzaldehyde (NSC-95682) is an inhibitor of IRE-1α (IC50 : 0.08 μM).Fórmula:C8H7BrO3Pureza:99.82%Cor e Forma:SolidPeso molecular:231.045-ETHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE
CAS:5-ETHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE targets PLK1.Fórmula:C8H13N3SPureza:99.03%Cor e Forma:SolidPeso molecular:183.27Belumosudil
CAS:Belumosudil (Rezurock) is an orally available, and specific ROCK2 inhibitor (IC50/Ki: 60/41 nM).Fórmula:C26H24N6O2Pureza:97.64% - 98.59%Cor e Forma:SolidPeso molecular:452.51Ref: TM-T6867
2mg46,00€5mg70,00€1mL*10mM (DMSO)74,00€10mg95,00€25mg158,00€50mg236,00€100mg356,00€500mg848,00€ML167
CAS:ML167 (CID44968231) is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor.Fórmula:C19H17N3O3Pureza:99.82% - >99.99%Cor e Forma:SolidPeso molecular:335.36Ref: TM-T2670
2mg33,00€5mg47,00€1mL*10mM (DMSO)50,00€10mg71,00€25mg135,00€50mg222,00€100mg331,00€200mg470,00€JNJ-7706621
CAS:JNJ-7706621 is a potent aurora kinase inhibitor, and also inhibits CDK1 and CDK2.Fórmula:C15H12F2N6O3SPureza:99.1% - 99.85%Cor e Forma:SolidPeso molecular:394.36Ref: TM-T6126
1mg48,00€1mL*10mM (DMSO)94,00€5mg100,00€10mg155,00€25mg268,00€50mg432,00€100mg595,00€200mg833,00€Natalizumab
CAS:Natalizumab used for the treatment of relapsing remitting multiple sclerosis and Crohn's disease.Pureza:97.15% (SDS-PAGE); 97.2% (SEC-HPLC) - 98.00%Cor e Forma:LiquidPeso molecular:146.19 kDaNSC 617145
CAS:NSC 617145 (NSC617145) is an inhibitor of WRN helicase that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependentFórmula:C13H10Cl4N2O4Pureza:99.78%Cor e Forma:SolidPeso molecular:400.04Ref: TM-T9168
1mg34,00€2mg49,00€5mg73,00€1mL*10mM (DMSO)80,00€10mg90,00€25mg164,00€50mg227,00€100mg358,00€500mg842,00€SC-514
CAS:SC-514 (GK 01140) is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression.Fórmula:C9H8N2OS2Pureza:99.88% - >99.99%Cor e Forma:SolidPeso molecular:224.3Triazavirin
CAS:Triazavirin is a nucleoside analogue of nucleic acid and an antiviral agent.Fórmula:C5H7N6NaO5SPureza:99.55%Cor e Forma:SolidPeso molecular:286.2BS-181 hydrochloride
CAS:BS-181 hydrochloride (BS-181 HCl) is a highly selective CDK7 inhibitor with IC50 of 21 nM.Fórmula:C22H32N6·HClPureza:99.21%Cor e Forma:SolidPeso molecular:416.99Ref: TM-T6162
200mgA consultar1mg37,00€2mg52,00€5mg79,00€1mL*10mM (DMSO)87,00€10mg116,00€25mg250,00€50mg416,00€100mg645,00€NSC23005 Sodium
CAS:NSC23005 sodium is a novel and effective p18 inhibitor (ED50=5.21 nM) in promoting Hematopoietic stem cells (HSCs) expansion in both murine and human models.Fórmula:C13H16NNaO4SPureza:99.64%Cor e Forma:SolidPeso molecular:305.32NY2267
CAS:NY2267 (Acetic acid, 2-[[6-[2-(cyclohexylamino)-1-[[(4-methoxyphenyl)methyl](2-pyridinylcarbonyl)amino]-2-oxoethyl]-2-naphthalenyl]oxy]-, 1,1-dimethylethylFórmula:C38H43N3O6Pureza:99.16% - 99.27%Cor e Forma:SolidPeso molecular:637.76Abemaciclib
CAS:Abemaciclib (LY2835219) is a dual inhibitor of CDK4/6 (IC50=2/10 nM) with selectivity and specificity.Fórmula:C27H32F2N8Pureza:99.43% - 99.87%Cor e Forma:SolidPeso molecular:506.59CCG-100602
CAS:CCG-100602 inhibits RhoA/C-mediated, SRF-driven luciferase expression in PC-3 prostate cancer cells (IC50 :9.8 μM).Fórmula:C21H17ClF6N2O2Pureza:99.58%Cor e Forma:SolidPeso molecular:478.82Ref: TM-T22062
5mg35,00€1mL*10mM (DMSO)40,00€10mg54,00€25mg108,00€50mg178,00€100mg286,00€200mg425,00€Dalpiciclib hydrochloride
Dalpiciclib (SHR-6390) HCl is an oral CDK4/6 inhibitor with IC50s of 12.4/9.9 nM, an antitumor for breast and esophageal cancers.Fórmula:C25H31ClN6O2Cor e Forma:SolidPeso molecular:483.01GSK2850163 hydrochloride
CAS:GSK2850163 hydrochloride is a novel IRE1α inhibitor with IC50 of 20 nM for kinase and 200 nM for RNA enzyme.Fórmula:C24H30Cl3N3OCor e Forma:SolidPeso molecular:482.87AZD-7762
CAS:AZD-7762, an effective and specific inhibitor of Chk1（IC50=5 nM）, is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck.Fórmula:C17H19FN4O2SPureza:98.96% - 99.19%Cor e Forma:SolidPeso molecular:362.42Ref: TM-T6093
1mg35,00€2mg50,00€5mg77,00€1mL*10mM (DMSO)84,00€10mg90,00€25mg167,00€50mg265,00€100mg424,00€Levomefolate calcium
CAS:Levomefolate calcium is an artificial form of folate. It is a coenzymated form of folic acid and a more bioavailable alternative in dietary supplements.Fórmula:C20H23CaN7O6Pureza:97.35%Cor e Forma:Off-White To Pale Yellow SolidPeso molecular:497.52Carotegrast methyl
CAS:Carotegrast methyl (AJM300), an orally-active small molecule, can antagonize the α4 integrin receptor. It is a specific and dual α4β1/α4β7 integrin antagonist.Fórmula:C28H26Cl2N4O5Pureza:99.26% - 99.72%Cor e Forma:SolidPeso molecular:569.44Abemaciclib methanesulfonate
CAS:Abemaciclib methanesulfonate (LY2835219) is a specific and effective inhibitor of CDK4(IC50=2 nM) and CDK6(IC50=10 nM).
Fórmula:C27H32F2N8·CH4O3SPureza:98.69% - 99.44%Cor e Forma:SolidPeso molecular:602.7Afuresertib hydrochloride
CAS:Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)Fórmula:C18H18Cl3FN4OSPureza:99.96%Cor e Forma:SolidPeso molecular:463.8Ref: TM-T7885
2mg49,00€5mg71,00€1mL*10mM (DMSO)81,00€10mg89,00€25mg155,00€50mg240,00€100mg414,00€200mg538,00€KB-0742 dihydrochloride
CAS:KB-0742 dihydrochloride is a potent, selective and orally inhibitor of CDK9.Fórmula:C16H27Cl2N5Pureza:99.79%Cor e Forma:SolidPeso molecular:360.33Ref: TM-T9446
1mg90,00€2mg136,00€5mg222,00€1mL*10mM (DMSO)235,00€10mg358,00€25mg597,00€50mg850,00€100mg1.153,00€LIMK-IN-22j
CAS:LIMK-IN-22j (LIMK inhibitor 22j) is an effective and selective inhibitor of LIMK.Fórmula:C20H21BrN8Pureza:99.165%Cor e Forma:SolidPeso molecular:453.34BMS-265246
CAS:BMS-265246 is a potent and selective CDK1/2 inhibitor.Fórmula:C18H17F2N3O2Pureza:99.25% - 99.57%Cor e Forma:SolidPeso molecular:345.34Ref: TM-T2679
1mg34,00€5mg71,00€1mL*10mM (DMSO)78,00€10mg110,00€25mg210,00€50mg318,00€100mg455,00€200mg617,00€Alisertib
CAS:Alisertib (MLN 8237) is a specific Aurora A inhibitor (IC50: 1.2 nM). The selectivity of Alisertib(MLN 8237) is >200-fold higher for Aurora A than Aurora B.Fórmula:C27H20ClFN4O4Pureza:98.31% - >99.99%Cor e Forma:SolidPeso molecular:518.92Ref: TM-T2241
5mg52,00€1mL*10mM (DMSO)59,00€10mg92,00€25mg146,00€50mg215,00€100mg334,00€200mg430,00€500mg705,00€SBC-115076
CAS:SBC-115076 is a potent extracellular proprotein convertase subtilisin kexin type 9 (PCSK9) antagonist.Fórmula:C31H33N3O5Pureza:97.07% - 99.89%Cor e Forma:SolidPeso molecular:527.61Ref: TM-T2626
1mg38,00€2mg50,00€5mg80,00€1mL*10mM (DMSO)87,00€10mg94,00€25mg172,00€50mg309,00€100mg477,00€500mg1.063,00€BRD32048
CAS:BRD32048 is a top candidate ETV1 perturbagen. BRD32048 inhibits p300-dependent acetylation of ETV1, thereby promoting its degradation.Fórmula:C16H22N6OPureza:99.87%Cor e Forma:SolidPeso molecular:314.39Ref: TM-T23820
1mL*10mM (DMSO)44,00€2mg50,00€5mg105,00€10mg172,00€25mg304,00€50mg485,00€100mg782,00€200mg1.054,00€IXA4
CAS:IXA4 is a highly selective, nontoxic activator of IRE1/XBP1s and reduces APP secretion by activating IRE1.Fórmula:C24H28N4O4Pureza:99.8% - 99.85%Cor e Forma:SolidPeso molecular:436.5STF-083010
CAS:STF-083010 is a selective inhibitor of the IRE1α endonuclease.Fórmula:C15H11NO3S2Pureza:98.09% - 99.45%Cor e Forma:SolidPeso molecular:317.38Ref: TM-T6681
5mg49,00€1mL*10mM (DMSO)55,00€10mg75,00€25mg114,00€50mg193,00€100mg349,00€200mg527,00€500mg767,00€Cyclo(RADfK)
CAS:Cyclo(RADfK) is a selective α(v)β(3) integrin ligand used in neoangiogenesis research, therapy, and diagnostics; it's a control for RGD peptides.Fórmula:C28H43N9O7Pureza:>99.99%Cor e Forma:SolidPeso molecular:617.7E7820
CAS:E7820 (ER68203-00) is an angiogenesis inhibitor by suppressing integrin a2 (a cell adhesion molecule expressed on endothelial cells).Fórmula:C17H12N4O2SPureza:98.31% - 99.11%Cor e Forma:SolidPeso molecular:336.37Ref: TM-T4435
1mg34,00€2mg49,00€5mg65,00€1mL*10mM (DMSO)80,00€10mg84,00€25mg137,00€50mg200,00€100mg321,00€200mg477,00€EN4
CAS:EN4 (EN4 MYC inhibitor) MYC inhibitor is a covalent ligand that targets cysteine 171 (C171) of MYC.Fórmula:C25H24N2O4Pureza:98.51%Cor e Forma:SolidPeso molecular:416.472'-Fluoro-2'-Deoxyadenosine
CAS:2'-Fluoro-2'-Deoxyadenosine is efficiently cleaved to the toxic 2-fluoroadenine (FAde) by Escherichia coli purine nucleoside phosphorylase (PNP).Fórmula:C10H12FN5O3Pureza:99.95%Cor e Forma:SolidPeso molecular:269.23NG 52
CAS:NG 52 (NG-52) is a cell-permeable, reversible, and ATP-compatible inhibitor of the cell cycle-regulating kinase Cdc28p and the related Pho85p kinase.Fórmula:C16H19ClN6OPureza:98% - 99.34%Cor e Forma:SolidPeso molecular:346.81Tiazofurin
CAS:Tiazofurin, a synthetic nucleoside, has anti-cancer effects and inhibits IMPDH as TAD after metabolism.Fórmula:C9H12N2O5SPureza:99.91%Cor e Forma:SolidPeso molecular:260.27dGTP
CAS:dGTP (2'-Deoxyguanosine-5'-triphosphate) is one of the guanosine nucleotides which is highly susceptible to oxidative damage to 8-O-GDP, 8-O-dGTP, 8-O-GTP, andFórmula:C10H16N5O13P3Pureza:99.64%Cor e Forma:SolidPeso molecular:507.18Trimethoprim sulfate
CAS:Trimethoprim sulfate, a dihydrofolate reductase inhibitor, treats bacterial infections and sometimes malaria; may depress hematopoiesis.Fórmula:C28H38N8O10SCor e Forma:SolidPeso molecular:678.72THZ1
CAS:THZ1 (CDK7 inhibitor) is a selective inhibitor of CDK7, binding to the Cys residue located at the outer end of the classical kinase domain. Cost-effective and quality-assured.Fórmula:C31H28ClN7O2Pureza:97.42% - 99.27%Cor e Forma:SolidPeso molecular:566.05MLN8054
CAS:MLN8054 is a potent and selective Aurora A kinase inhibitor with an IC50 of 4 nM.Fórmula:C25H15ClF2N4O2Pureza:98.07% - 98.26%Cor e Forma:SolidPeso molecular:476.86Ref: TM-T6315
1mg50,00€2mg67,00€5mg84,00€1mL*10mM (DMSO)88,00€10mg120,00€25mg220,00€50mg356,00€100mg537,00€CCT245737
CAS:CCT245737 is an orally active, selective Chk1 inhibitor, and is >1,000-fold selective over CHK2 and CDK1.Cost-effective and quality-assured.Fórmula:C16H16F3N7OPureza:98.28% - 99.93%Cor e Forma:SolidPeso molecular:379.34Ref: TM-T7080
1mg37,00€2mg49,00€5mg79,00€1mL*10mM (DMSO)87,00€10mg113,00€25mg213,00€50mg350,00€100mg523,00€Cucurbitacin B
CAS:Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells.Fórmula:C32H46O8Pureza:97.1% - 99.93%Cor e Forma:SolidPeso molecular:558.70Y16
CAS:Y16 is a G protein-coupled Rho GEFs inhibitor and also a specific inhibitor of LARG with a Kd of 76 nM.Cost-effective and quality-assured.Fórmula:C24H20N2O3Pureza:98.26% - 99.85%Cor e Forma:SolidPeso molecular:384.43Ref: TM-T3553
1mg34,00€2mg48,00€5mg70,00€1mL*10mM (DMSO)77,00€10mg109,00€25mg177,00€50mg263,00€100mg389,00€CX-5461 dihydrochloride
CX-5461 dihydrochloride: Oral Pol I inhibitor, HCT-116 (IC50: 142 nM), A375 (IC50: 113 nM), MIA PaCa-2 (IC50: 54 nM), weak on Pol II (IC50 ≥ 25 μM).Fórmula:C27H29Cl2N7O2SCor e Forma:SolidPeso molecular:586.546-Mercaptopurine hydrate
CAS:6-Mercaptopurine hydrate is a leukemia treatment; it blocks purine metabolism, affecting DNA synthesis.Fórmula:C5H6N4OSPureza:97.54% - 99.14%Cor e Forma:Light Yellow Crystalline PowderPeso molecular:170.19AT7519 TFA
CAS:AT7519 inhibits CDK1-6 kinases; IC50 ranges 0.018-0.66 μM.Fórmula:C18H18Cl2F3N5O4Cor e Forma:SolidPeso molecular:496.27Arg-Gly-Asp-Ser
CAS:Arg-Gly-Asp-Ser (RGDS peptide) is a conserved tetrapeptide sequence found in fibronectin, and the von Willebrand factor.Fórmula:C15H27N7O8Pureza:98.29%Cor e Forma:SolidPeso molecular:433.42LSN2839567
CAS:LSN2839567 (Abemaciclib metabolite M2) is a CDK4 and CDK6 inhibitor with anticancer activity, inhibits CDK9, and can be used in breast cancer research.Fórmula:C25H28F2N8Pureza:99.14%Cor e Forma:SolidPeso molecular:478.545-Bromouridine
CAS:5-Bromouridine is a antitumor uracil derivative that induces apoptosis in cancer cells by inhibiting DNA synthesis and is also a marker for DNA and RNA.Fórmula:C9H11BrN2O6Pureza:99.89%Cor e Forma:White PowderPeso molecular:323.1Tenidap
CAS:Tenidap (CP-66248) is a selective COX-1 and SLC26A3 inhibitor with anti-inflammatory, analgesic, and anti-rheumatic activities.Fórmula:C14H9ClN2O3SPureza:98.56% - 99.42%Cor e Forma:SolidPeso molecular:320.75CDK12-IN-5
CAS:CDK12-IN-5 is a potent CDK12 inhibitor with potential anticancer and antitumor activity, and can be used orally in the study of breast and ovarian cancer.Fórmula:C18H15F5N8OPureza:99.37%Cor e Forma:SolidPeso molecular:454.36Ref: TM-T40290
1mg157,00€5mg378,00€1mL*10mM (DMSO)416,00€10mg612,00€25mg1.251,00€50mg1.972,00€100mg2.673,00€Z62954982
CAS:Z62954982 (ZINC08010136) is a Rac1 inhibitor that inhibits Rac1 activation and reduces proliferation, p38 phosphorylation, and IL-6 levels in pulmonary arteriesFórmula:C20H21N3O5SPureza:98.28%Cor e Forma:SolidPeso molecular:415.46Ref: TM-T37113
1mg35,00€5mg75,00€1mL*10mM (DMSO)87,00€10mg105,00€25mg173,00€50mg255,00€100mg371,00€200mg530,00€
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