Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase(94 produtos)
- CDK(500 produtos)
- Ciclo celular/Parada(4 produtos)
- Chk(42 produtos)
- DYRK(48 produtos)
- Dinamina(23 produtos)
- Ferroptose(215 produtos)
- HSP(169 produtos)
- Integrinas(224 produtos)
- Cinesina(66 produtos)
- LIM Quinase(19 produtos)
- Microtúbulo associado(261 produtos)
- PKC(102 produtos)
- PLK(28 produtos)
- ROCK(69 produtos)
- Rho(2 produtos)
- Wee1(15 produtos)
- c-Myc(69 produtos)
Exibir 10 mais subcategorias
Foram encontrados 3480 produtos de "Ciclo celular/Ponto de verificação"
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EMD534085
CAS:<p>EMD534085 is an effective and selective mitotic kinesin-5 inhibitor (IC50: 8 nM).</p>Fórmula:C25H31F3N4O2Pureza:98%Cor e Forma:SolidPeso molecular:476.53Cyclapolin 9
CAS:<p>Cyclapolin 9: Selective PLK1 inhibitor, IC50 500 nM, ATP-competitive, inactive against other kinases.</p>Fórmula:C9H4F3N3O4SPureza:99.5%Cor e Forma:SolidPeso molecular:307.21Trimetrexate glucuronate
CAS:<p>Trimetrexate glucuronate, a folic acid foe, blocks DNA/RNA synthesis by inhibiting purine and thymidylic acid production, may fight tumors.</p>Fórmula:C25H33N5O10Cor e Forma:SolidPeso molecular:563.564Chrysotobibenzyl
CAS:<p>Chrysotobibenzyl from Dendrobium pulchellum stems may trigger cell death in detached cells and hinder lung cancer growth.</p>Fórmula:C19H24O5Cor e Forma:SolidPeso molecular:332.39IRE1α kinase-IN-9
CAS:<p>IRE1α kinase-IN-9 (compound 2) is a potent inhibitor of IRE-1α, demonstrating an average IC50 value of less than 0.1 μM.</p>Fórmula:C24H24N2O6Pureza:98%Cor e Forma:SolidPeso molecular:436.46TC-Mps1-12
CAS:<p>TC-Mps1-12 is an effective and selective inhibitor of monopolar spindle 1 (IC50: 6.4 nM) .</p>Fórmula:C17H20N6OPureza:98%Cor e Forma:SolidPeso molecular:324.38CLK1-IN-1
CAS:<p>CLK1-IN-1 is a potent and selective inhibitor of the Cdc2-like kinase 1 (CLK1; IC50: 2 nM).</p>Fórmula:C24H16FN5OCor e Forma:SolidPeso molecular:409.42LY 207702
CAS:<p>LY 207702, a difluorinated purine nucleoside, exhibits antitumor activity in preclinical models.</p>Fórmula:C10H12F2N6O3Pureza:98%Cor e Forma:SolidPeso molecular:302.24CB 3717
CAS:<p>CB 3717 is an enzyme inhibitor, antineoplastic agent, folic acid antagonist.</p>Fórmula:C24H23N5O6Cor e Forma:SolidPeso molecular:477.47CP681301
CAS:<p>CP681301 is a potent CDK5 inhibitor with anti-tumor effects in Drosophila and reduces Glioma stem cells' growth and renewal.</p>Fórmula:C17H22N4OCor e Forma:SolidPeso molecular:298.38Synucleozid
CAS:<p>Synucleozid is a potent the SNCA mRNA inhibitor that encodes α-synuclein protein (IC50=1.5 μM), has the potential for the investigation of Parkinson’s disease.</p>Fórmula:C22H20N6Pureza:98%Cor e Forma:SolidPeso molecular:368.43Mps1-IN-4
CAS:<p>Mps1-IN-4 is a compound that selectively inhibits Monopolar spindle 1 (Mps1), exhibiting antiproliferative properties useful in cancer research.</p>Fórmula:C26H31F3N6O2Cor e Forma:SolidPeso molecular:516.56CDK4/6-IN-14
CAS:<p>CDK4/6-IN-14: potent CDK4/6 inhibitor, IC50s 10/16 nM, >60-fold selectivity over CDKs 1/2/7/9, selective across 205 kinases.</p>Fórmula:C24H27ClFN7OCor e Forma:SolidPeso molecular:483.97OM-137
CAS:<p>OM137 inhibits Aurora kinases, impedes cell growth at high doses, and enhances low-dose paclitaxel effects.</p>Fórmula:C13H14N4O3SCor e Forma:SolidPeso molecular:306.34CDK8-IN-6
CAS:<p>CDK8-IN-6 (compound 9) is a potent inhibitor of cyclin-dependent kinase 8 (CDK8) (Kd: 13 nM), CDK8-IN-6 showed potential research value in AML cancers.</p>Fórmula:C26H37ClN2Cor e Forma:SolidPeso molecular:413.04VRX-0466617
CAS:<p>VRX-0466617 is a novel selective Chk2 inhibitor.</p>Fórmula:C19H20BrN5O2SCor e Forma:SolidPeso molecular:462.36PF-4950834
CAS:<p>PF-4950834, a ATP-competitive, selective Rho kinase inhibitor, provides therapeutic benefits in chronic inflammatory diseases.</p>Fórmula:C21H19N3O2Pureza:98%Cor e Forma:SolidPeso molecular:345.39CI-898 HCl
CAS:<p>CI-898 HCl: lipophilic antifolate, DHFR inhibitor, effective on methotrexate-resistant cancers, synergizes with other drugs in advanced P338 leukemia.</p>Fórmula:C19H26Cl3N5O3Cor e Forma:SolidPeso molecular:478.8Pyrazofurin
CAS:<p>Pyrazofurin, a pyrimidine analogue, blocks cell growth and DNA synthesis by targeting UMP synthase & orotate-phosphoribosyltransferase (IC50: 0.06-0.37 μM).</p>Fórmula:C9H13N3O6Pureza:98%Cor e Forma:SolidPeso molecular:259.22CDK2-IN-12
CAS:<p>CDK2-IN-12 (10b), potent CDK2 inhibitor, IC50: 11.6 μM; inhibits hCA I/II/IX/XII, KI: 3534/638.4/44.3/48.8 nM; anti-cancer properties.</p>Fórmula:C20H17N9O2SCor e Forma:SolidPeso molecular:447.47DNA Gyrase-IN-2
CAS:<p>DNA Gyrase-IN-2 inhibits E. coli (IC50: 3.29-10.49 μM) and M. tuberculosis (IC50: 4.41-5.61 μM) COX, has antibacterial properties.</p>Fórmula:C24H24N8OS2Cor e Forma:SolidPeso molecular:504.63KH-CB19
CAS:<p>KH-CB19 is an effective and highly specific inhibitor of the CDC2-like kinase isoforms 1 and 4 (CLK1/CLK4).</p>Fórmula:C15H13Cl2N3O2Cor e Forma:SolidPeso molecular:338.19CDK5 inhibitor 20-223
CAS:<p>CDK5 inhibitor 20-223 is a potent CDK2/CDK5 inhibitor,anti-Colorectal Cancer (CRC), inhibiting cell migration and inducing cell cycle arrest.</p>Fórmula:C19H19N3OCor e Forma:SolidPeso molecular:305.372-Fluoroadenine
CAS:<p>2-Fluoroadenine (NSC-27364) has toxicity in nonproliferating and proliferating tumor cells. 2-Fluoroadenine can be used for anticancer studies.</p>Fórmula:C5H4FN5Pureza:98.84% - 99.62%Cor e Forma:White To Light Yellow Crystal PowderPeso molecular:153.12Dyrk1A-IN-3
CAS:<p>Dyrk1A-IN-3 is a selective DYRK1A inhibitor with an IC50 of 76 nM, useful for neurodegenerative disease research.</p>Fórmula:C18H16N6Cor e Forma:SolidPeso molecular:316.363,6-DMAD dihydrochloride
CAS:<p>3,6-DMAD dihydrochloride: Potent IRE1α-XBP1s inhibitor, affects IL-6 secretion and RNase activity, used in cancer research.</p>Fórmula:C22H33Cl2N5Cor e Forma:SolidPeso molecular:438.44Litronesib Racemate
CAS:<p>Litronesib is a selective, allosteric inhibitor of kinesin Eg5.Litronesib (Racemate) is the racemate of litronesib.</p>Fórmula:C23H37N5O4S2Cor e Forma:SolidPeso molecular:511.7PV-1115
CAS:<p>PV-1115 is an effective and highly selective inhibitor of the Chk2.</p>Fórmula:C20H19N7O3Pureza:98%Cor e Forma:SolidPeso molecular:405.41IPR-803
CAS:<p>IPR-803 is an effective inhibitor of the uPAR·uPA protein-protein interaction (PPI) with anti-tumor activity.</p>Fórmula:C27H23N3O4Pureza:95%Cor e Forma:SolidPeso molecular:453.49XIE18-6
CAS:<p>XIE18-6 is a novel INK4C inhibitor that blocks p18 activity and promotes ex vivo expansion of human and murine hematopoietic stem cells.</p>Fórmula:C18H15NO6SPureza:99.712%Cor e Forma:SolidPeso molecular:373.38HIV-1 inhibitor-43
CAS:<p>HIV-1 Inhibitor-43 suppresses HIV-1, with EC50: 21.3 nM (Y188L), 6.2 nM (K103N-Y181C), <0.7 nM (K103N/Y181C), and lowers HIV RNA/p24 protein.</p>Fórmula:C24H21ClN2O4SCor e Forma:SolidPeso molecular:468.95M443
CAS:<p>M443 is a potent small molecule inhibitor of MRK that inhibits radiation-induced activation of p38 and Chk2 and can be used in cancer research.</p>Fórmula:C31H30F3N7O2Pureza:98.95%Cor e Forma:SolidPeso molecular:589.61GP29
CAS:<p>GP29 is a Type II kinase inhibitor of the IRE1α endoribonuclease that acts by targeting the ATP-binding pocket of IRE1α.</p>Fórmula:C33H28F3N5O3Pureza:98%Cor e Forma:SolidPeso molecular:599.610-Deazaaminopterin
CAS:<p>10-Deazaaminopterin is a poly-gamma-glutamyl metabolite of the experimental anticancer drug, a folic acid antagonist, antineoplastic agent enzyme inhibitor.</p>Fórmula:C20H21N7O5Cor e Forma:SolidPeso molecular:439.42BA-1049
CAS:<p>BA-1049 is a selective ROCK2 inhibitor.</p>Fórmula:C16H21N3O2SCor e Forma:SolidPeso molecular:319.42ANI-7
CAS:<p>ANI-7, an AhR pathway activator, selectively impedes MCF-7 breast cancer cell growth (GI50: 0.56 μM).</p>Fórmula:C13H8Cl2N2Pureza:99.07%Cor e Forma:SolidPeso molecular:263.12WF-536 Hydrochloride
CAS:<p>WF-536 Hydrochloride, a novel inhibitor of ROCK, inhibits tumour metastasis in some animal models.</p>Fórmula:C14H16ClN3OCor e Forma:SolidPeso molecular:277.751-Methylcytosine
CAS:<p>1-Methylcytosine (4-amino-1-methylpyrimidin-2(1H)-one) is a methylated form of the cytosine and can be used as the nucleobase of hachimoji DNA paired with</p>Fórmula:C5H7N3OPureza:99.88%Cor e Forma:SolidPeso molecular:125.13IRE1α kinase-IN-7
CAS:<p>IRE1α kinase-IN-7 is a chemical compound functioning as an inhibitor of IRE1α kinase, primarily utilized in the research of diseases related to endoplasmic</p>Fórmula:C28H25F3N6OCor e Forma:SolidPeso molecular:518.53Lysine-methotrexate
CAS:<p>Lysine-methotrexate is an anticancer drug. It is an inhibitor of dihydrofolate reductase.</p>Fórmula:C21H27N9O3Pureza:98%Cor e Forma:SolidPeso molecular:453.5OXA-06 Dihydrochloride
CAS:<p>OXA-06 Dihydrochloride is a PANC-1 cell migration and MYPT1 phosphorylation inhibitor.</p>Fórmula:C21H18FN3Pureza:98%Cor e Forma:SolidPeso molecular:331.39Binucleine 2
CAS:<p>Binucleine 2: Drosophila Aurora B kinase inhibitor (Ki=0.36μM), dose-dependent, minimal effect on human/X. laevis kinases, disrupts mitosis in fly cells.</p>Fórmula:C13H11ClFN5Cor e Forma:SolidPeso molecular:291.71DNA Gyrase-IN-4
CAS:<p>DNA Gyrase-IN-4 inhibits DNA cyclooxygenase (IC50: 0.13 μM) and is effective against Salmonella and E. coli.</p>Fórmula:C22H15Cl2NO4SCor e Forma:SolidPeso molecular:460.33DHODH-IN-3
CAS:<p>DHODH-IN-3: Human DHODH inhibitor with IC50 of 261 nM, Kiapp 32 nM, potential anti-malaria drug.</p>Fórmula:C17H13ClN2O2Pureza:98%Cor e Forma:SolidPeso molecular:312.75BMVC2
CAS:<p>BMVC2 (o-BMVC), a carbazole derivative of BMVC, is a G-quadruplex (G4) stabilizer.</p>Fórmula:C28H25I2N3Cor e Forma:SolidPeso molecular:657.33(Rac)-Managlinat dialanetil
CAS:<p>Managlinat dialanetil, an orally available and potent inhibitor of fructose 1,6-bisphosphatase (FBPase) used in research 2 type diabetes.</p>Fórmula:C21H33N4O6PSPureza:98.52%Cor e Forma:SolidPeso molecular:500.55MtTMPK-IN-6
CAS:<p>MtTMPK-IN-6 inhibits M. tuberculosis thymidylate kinase with IC50 of 29 μM, promising for TB research.</p>Fórmula:C23H25N3O3Cor e Forma:SolidPeso molecular:391.46Datelliptium chloride
CAS:<p>Datelliptium chloride is a DNA-intercalating agent derived from ellipticine. Datelliptium chloride shows anti-tumor activities.</p>Fórmula:C23H28ClN3OPureza:98%Cor e Forma:SolidPeso molecular:397.94BMH-22
CAS:<p>BMH-22 is an RNA polymerase I inhibitor that acts by causing nucleolar stress and showing potent anticancer activity across many tumor types.</p>Fórmula:C16H17N3Cor e Forma:SolidPeso molecular:251.33JNJ-9676
CAS:<p>JNJ-9676 is an orally active inhibitor of the coronavirus membrane protein, thereby blocking viral assembly and release.coronavirus and SARS-CoV.</p>Fórmula:C28H21F2N5O2Pureza:99.83%Cor e Forma:SoildPeso molecular:497.5CDK12-IN-3
CAS:<p>CDK12-IN-3 is a CDK12 inhibitor with anti-tumor activity and can be used for the study of malignant tumors.</p>Fórmula:C23H28F2N8OPureza:99.85%Cor e Forma:SolidPeso molecular:470.52KIRA-7
CAS:<p>KIRA-7: imidazopyrazine, anti-fibrotic, inhibits IRE1α RNase (IC50: 110 nM) allosterically.</p>Fórmula:C27H23FN6OCor e Forma:SolidPeso molecular:466.51S-(N-PhenethylthiocarbaMoyl)-L-cysteine
CAS:<p>PEITC-Cys: anticarcinogenic, antileukemic, inhibits DNA synthesis in HL60, P450 inhibitor.</p>Fórmula:C12H16N2O2S2Cor e Forma:SolidPeso molecular:284.4CDK12-IN-E9
CAS:<p>CDK12-IN-E9 is a potent and selective covalent CDK12 inhibitor and non-covalent CDK9 inhibitor while avoiding ABC transporter-mediated efflux.</p>Fórmula:C24H30N6O2Cor e Forma:SolidPeso molecular:434.53L 888607 Racemate
CAS:<p>L 888607 Racemate blocks DP1 and TP receptors with 132 nM and 17 nM affinity.</p>Fórmula:C19H15ClFNO2SCor e Forma:SolidPeso molecular:375.84Aurora A/PKC-IN-1
CAS:<p>Aurora A/PKC-IN-1 inhibits AurA (IC50: 6.9 nM), PKCα (IC50: 16.9 nM), and hinders breast cancer cell growth and spread.</p>Fórmula:C16H14N6OSe2Cor e Forma:SolidPeso molecular:464.24DHODH-IN-1
CAS:<p>DHODH-IN-1 is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 25 nM. DHODH-IN-1 is an inhibitor of the pyrimidine biosynthetic pathway.</p>Fórmula:C21H20F3N3O2Pureza:99.76%Cor e Forma:SolidPeso molecular:403.4CDK7-IN-20
<p>CDK7-IN-20: potent, irreversible CDK7 inhibitor, IC50 of 4nM, 206x selectivity vs. other CDKs, potential for ADPKD study.</p>Fórmula:C30H26N6O3Cor e Forma:SolidPeso molecular:518.57HBV-IN-16
CAS:<p>HBV-IN-16, a quinoline derivative, inhibits HBV cccDNA, key for viral replication (from patent WO2019121357A1).</p>Fórmula:C22H20ClNO4Cor e Forma:SolidPeso molecular:397.85TH470
CAS:<p>TH470, a potent and highly selective inhibitor of LIM kinase 1/2 (LIMK1/2), demonstrates specificity with IC50 values of 9.8 nM for LIMK1 and 13 nM for LIMK2,</p>Fórmula:C30H31N5O5S2Cor e Forma:SolidPeso molecular:605.73ERCC1-XPF-IN-1
CAS:<p>ERCC1-XPF-IN-1: potent ERCC1-XPF inhibitor (IC50: 0.49 μM), hampers CPD removal, boosts UV toxicity, hinders DNA repair.</p>Fórmula:C28H32ClN5O2Cor e Forma:SolidPeso molecular:506.04CDK4/6-IN-9
CAS:<p>CDK4/6-IN-9 selectively inhibits CDK4/6 (IC50: 905 nM); potential for MM research.</p>Fórmula:C22H23FN8Cor e Forma:SolidPeso molecular:418.47DAP-81
CAS:<p>DAP-81, a diaminopyrimidine, inhibits Plk1 (IC50: 0.9 nM), disrupts microtubules, causes monopolar spindles; in preclinical studies.</p>Fórmula:C25H20N6O4Cor e Forma:SolidPeso molecular:468.46BAY-958
CAS:<p>BAY-958 is a potent and selective inhibitor of PTEFb/CDK9.</p>Fórmula:C17H16FN5O3SPureza:98%Cor e Forma:SolidPeso molecular:389.4DHFR-IN-2
CAS:<p>DHFR-IN-2 (4e) is a potent MtDHFR uncompetitive inhibitor with a 7 μM IC50, promising for TB research.</p>Fórmula:C14H13NO2Cor e Forma:SolidPeso molecular:227.26BRD9185
CAS:<p>BRD9185 is an inhibitor of Dihydroorotate dehydrogenase (DHODH) with an EC50 of 16 nM against multidrug-resistant blood-stage parasites in vitro.</p>Fórmula:C23H21F6N3O2Pureza:98%Cor e Forma:SolidPeso molecular:485.42CID 5951923
CAS:<p>CID 5951923 is an inhibitor of KLF5 transcription factor with an IC50 of 603 nM.</p>Fórmula:C16H18N2O7SPureza:99.95%Cor e Forma:SolidPeso molecular:382.39Integrin modulator 1
CAS:<p>Integrin modulator 1 is a selective α4β1 integrin agonist (IC50 9.8 nM) that enhances adhesion with EC50 12.9 nM, aiding integrin-dependent studies.</p>Fórmula:C13H14N2O4Pureza:99.61%Cor e Forma:SolidPeso molecular:262.26Cdc7-IN-9
CAS:<p>Cdc7-IN-9 can be used for the research of cancer which is a potent inhibitor of Cdc7 [1].</p>Fórmula:C15H17N5OSCor e Forma:SolidPeso molecular:315.39Zaurategrast ethyl ester
CAS:<p>Zaurategrast ethyl ester, an α4β1/α4β7 integrin antagonist prodrug of CT7758, treats inflammatory/autoimmune conditions.</p>Fórmula:C28H29BrN4O3Pureza:98%Cor e Forma:SolidPeso molecular:549.46MTH1-IN-2
CAS:<p>MTH1-IN-2 is an inhibitor of MutT homolog 1 (MTH1), with anti-tumor activity.</p>Fórmula:C24H27N3O5SPureza:98%Cor e Forma:SolidPeso molecular:469.55αvβ1 integrin-IN-1 TFA (1689540-62-2 free base)
<p>αvβ1 integrin-IN-1 TFA is an effective and selective αvβ1 integrin inhibitor (IC50: 0.63 nM).</p>Fórmula:C28H35F3N6O8SPureza:98%Cor e Forma:SolidPeso molecular:672.678-Deazahomofolic acid
CAS:<p>8-Deazahomofolic acid is a potential thymidylate synthase (TS) inhibitor and other folate related enzymes inhibitor.</p>Fórmula:C21H22N6O6Pureza:98%Cor e Forma:SolidPeso molecular:454.44(E/Z)-BIO-acetoxime
CAS:<p>(E/Z)-BIO-acetoxime: potent GSK-3 α/β inhibitor; IC50: GSK-3α/β 10nM, CDK5/p25 2.4μM, CDK2/A 4.3μM, CDK1/B 63μM.</p>Fórmula:C18H12BrN3O3Cor e Forma:SolidPeso molecular:398.21Capzimin
CAS:<p>Capzimin is a selective inhibitor of proteasome isopeptidase Rpn11.</p>Fórmula:C30H24N6O2S4Pureza:98.31% - 99.32%Cor e Forma:SolidPeso molecular:628.81Tetrahydrouridine
CAS:<p>Tetrahydrouridine (NSC-112907; THU) is a multidrug resistance modulator.</p>Fórmula:C9H16N2O6Pureza:98%Cor e Forma:SolidPeso molecular:248.23Direct Black 38 free acid
CAS:<p>Ferristatin II (Direct Black 38 free acid) is a polysulphonated dye and promotes the degradation of transferrin receptor-1 in vitro and in vivo.</p>Fórmula:C34H27N9O7S2Pureza:98%Cor e Forma:SolidPeso molecular:737.77A 65281
CAS:<p>A 65281: antibacterial isothiazoloquinolone, inhibits P4-unknotting, induces DNA breakage via topoisomerase II.</p>Fórmula:C17H16F2N4O2SPureza:98%Cor e Forma:SolidPeso molecular:378.4MFH290
CAS:<p>MFH290 is a selective CDK12/13 inhibitor, covalently bonding with CDK12 Cys-1039, blocks Pol II CTD phosphorylation, and enhances olaparib's efficacy.</p>Fórmula:C26H31N5O3S2Cor e Forma:SolidPeso molecular:525.69ARN22089
CAS:<p>ARN22089 is an oral active CDC42 GTPase interaction inhibitor that blocks tumour growth in BRAF mutant mouse melanoma models and PDXs in vivo.</p>Fórmula:C23H27N5Pureza:98.37%Cor e Forma:SolidPeso molecular:373.49CDK2-IN-13
CAS:<p>CDK2-IN-13: Potent CDK2 inhibitor, arrests cell cycle, induces apoptosis, IC50=12 µM, used in cancer research.</p>Fórmula:C13H12ClN5Cor e Forma:SoildPeso molecular:273.72RHI002-Me
CAS:<p>RHI002-Me is a methylated derivative of RHI002, a selective inhibitor of human RNaseH2.</p>Fórmula:C18H19N3O2S2Pureza:98%Cor e Forma:SolidPeso molecular:373.49CCG-257081
CAS:<p>CCG-257081 blocks Rho/MRTF/SRF pathway; prevents fibrosis in mice; useful in cancer and fibrosis research.</p>Fórmula:C24H19ClF3N3O2Pureza:99.76% - 99.94%Cor e Forma:SolidPeso molecular:473.87Atuveciclib S-Enantiomer
CAS:<p>Atuveciclib S-Enantiomer is a (S)-form of BAY-1143572; a potent, selective CDK9 inhibitor with an IC50 of 16 nM.</p>Fórmula:C18H18FN5O2SPureza:98%Cor e Forma:SolidPeso molecular:387.43DHODH-IN-19
CAS:<p>DHODH-IN-19, a strong DHODH blocker, may help treat cancer and inflammation. (Patent WO2021238881A1)</p>Fórmula:C22H18ClF6N3O3Cor e Forma:SolidPeso molecular:521.84SPC-839
CAS:<p>SPC-839 is an IKK-2 Inhibitor with oral activity.</p>Fórmula:C18H14N4O3SCor e Forma:SolidPeso molecular:366.39RET-IN-19
CAS:<p>RET-IN-19, a potent RET inhibitor, anticancer: IC50 6.8 nM (RET-wt), 13.51 nM (RET V804M); for NSCLC research.</p>Fórmula:C28H28N6O4SCor e Forma:SolidPeso molecular:544.62ROCK-IN-D2
CAS:<p>ROCK-IN-D2 is an effective and selective inhibitor of ROCK.</p>Fórmula:C22H28N6OPureza:98%Cor e Forma:SolidPeso molecular:392.5KIF18A-IN-3
CAS:<p>KIF18A-IN-3 is a KIF18A inhibitor (IC50=61 nM) that causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues.</p>Fórmula:C28H38N4O5S2Pureza:98.45%Cor e Forma:SolidPeso molecular:574.76VE-465
CAS:<p>VE-465 is an inhibitor of Aurora kinase, which involves in multiple mitotic events.</p>Fórmula:C22H28N8OSCor e Forma:SolidPeso molecular:452.58(R)-Filanesib
CAS:<p>(R)-Filanesib is the R-enantiomer of ARRY-520. (R)-Filanesib is a synthetic kinesin spindle protein (KSP) inhibitor (IC50: 6 nM).</p>Fórmula:C20H22F2N4O2SCor e Forma:SolidPeso molecular:420.48CAY10760
CAS:<p>CAY10760 inhibits RAD51-BRCA2 interaction (EC50=19 μM), reduces homologous recombination by 54%, and hinders BxPC-3/Capan-1 cancer cell proliferation.</p>Fórmula:C28H24ClN3O3Cor e Forma:SolidPeso molecular:485.96Antitumor agent-85
<p>Antitumor agent-85 stabilizes G4-DNA with potent anti-tumor effects.</p>Fórmula:C24H33N7Cor e Forma:SolidPeso molecular:419.57Apricitabine
CAS:<p>Apricitabine (SPD754) is a highly selective and orally active HIV-1 reverse transcriptase inhibitor (Ki=0.08 μM), the (-) enantiomer of 2′-deoxy-3′-oxy-4′-</p>Fórmula:C8H11N3O3SPureza:99.45%Cor e Forma:SolidPeso molecular:229.26PD 130883
CAS:<p>PD 130883 is a potent lipophilic quinazoline antifolate.</p>Fórmula:C18H15N5O3Pureza:98%Cor e Forma:SolidPeso molecular:349.34GW8510
CAS:<p>GW8510 is a CDK2 and RRM2 inhibitor that affects DNA synthesis and antiproliferation in tumor cells. In mammalian aging models, GW851 prolongs lifespan.</p>Fórmula:C21H15N5O3S2Pureza:99.32%Cor e Forma:SolidPeso molecular:449.51RP-106
CAS:<p>RP-106 is an ATP-competitive inhibitor of CDK5/p25, CDK1/cyclin B, and GSK-3.</p>Fórmula:C17H19N3OPureza:98%Cor e Forma:SolidPeso molecular:281.35CDK4/6-IN-8
CAS:<p>CDK4/6-IN-8 (Compound 7p) is a selective inhibitor of CDK4 (IC50=5.01 nM) and CDK6 (IC50=3.97 nM).</p>Fórmula:C18H18N6O5Cor e Forma:SolidPeso molecular:398.37A 65282
CAS:<p>A 65282: antibacterial isothiazoloquinolone, inhibits P4-unknotting, causes DNA breaks via topoisomerase II.</p>Fórmula:C17H16F2N4O2SPureza:98%Cor e Forma:SolidPeso molecular:378.4CDK8-IN-10
CAS:<p>CDK8-IN-10 is a selective and potent inhibitor of cell cycle protein-dependent kinase (CDK8) (IC50: 8.25 nM) that can be used to study cancer.</p>Fórmula:C25H15ClF3N5O3Cor e Forma:SolidPeso molecular:525.87
