Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase(115 produtos)
- CDK(546 produtos)
- Ciclo celular/Parada(5 produtos)
- Chk(48 produtos)
- DYRK(47 produtos)
- Dinamina(27 produtos)
- Ferroptose(227 produtos)
- HSP(180 produtos)
- Integrinas(268 produtos)
- Cinesina(87 produtos)
- LIM Quinase(20 produtos)
- Microtúbulo associado(274 produtos)
- PKC(126 produtos)
- PLK(25 produtos)
- ROCK(62 produtos)
- Rho(6 produtos)
- Wee1(14 produtos)
- c-Myc(76 produtos)
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Foram encontrados 3904 produtos de "Ciclo celular/Ponto de verificação"
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6-Amino-4-methoxy-1-(2-deoxy-β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine
CAS:6-Amino-4-methoxy-1-(2-deoxy-β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine, a pyrimidine nucleoside analog, exhibits a broad spectrum of biochemical andFórmula:C11H15N5O4Cor e Forma:SolidPeso molecular:281.276-Thioguanosine
CAS:6-Thioguanosine (6-Mercaptoguanosine) is an active nucleoside and low molecular weight gel.6-Thioguanosine has immunosuppressive properties.Fórmula:C10H13N5O4SPureza:97.05%Cor e Forma:Yellow-Green PowderPeso molecular:299.31Endo-1,4-β-xylanase
CAS:Endo-1,4-β-xylanase (CtXyn11A) is a type of xylan hydrolase that hydrolyzes the β-1,4-glycosidic bond of the xylan molecule.Cor e Forma:SolidMethylcarbamyl PAF C-8
Methylcarbamyl PAF C-8 is resistant to degradation by PAF-AH and has a half-life of over 100 minutes in platelet-poor plasma, exhibiting platelet aggregation activity. In NRK-49 cells overexpressing PAF receptor, it induces the expression of c-myc, c-fos, and activates mitogen-activated protein kinase (MAPK). Furthermore, Methylcarbamyl PAF C-8 can induce G1 phase cell cycle arrest. This compound shows potential for research in cardiovascular and anti-cancer applications.Cor e Forma:Odour SolidCBR-2092
CAS:CBR-2092 is a DNA-directed RNA polymerase and DNA topoisomerase inhibitor.Fórmula:C65H81FN6O15Cor e Forma:SolidPeso molecular:1205.388m7GpppUmpG
CAS:m7GpppUmpG, a trinucleotide cap analogue, enables RNA synthesis with cap 0 or 1 structures.Fórmula:C31H42N12O26P4Cor e Forma:SolidPeso molecular:1122.63CDK6/9-IN-1
CAS:CDK6/9-IN-1, an oral dual inhibitor of CDK6/9, has IC50s of 40.5nM (CDK6) and 39.5nM (CDK9).Fórmula:C22H25ClN8OCor e Forma:SolidPeso molecular:452.95CB 3705
CAS:CB 3705 is a bio-active chemical.Fórmula:C21H21N5O6Cor e Forma:SolidPeso molecular:439.42Ribonuclease T1
CAS:Rnase T1, an endonuclease, degrades single-stranded RNA to yield 3'-GMP oligonucleotides.
Cor e Forma:SolidAntibacterial agent 271
Antibacterialagent 271 is an antimicrobial compound that significantly inhibits Escherichia coli, with a minimum inhibitory concentration (MIC) of 2.2 μM. It disrupts bacterial membrane integrity, reducing metabolic activity. By binding to DNA grooves, it inhibits replication and induces reactive oxygen species (ROS) accumulation, leading to bacterial death. Antibacterialagent 271 shows considerable potential in combating bacterial infections.Cor e Forma:Odour SolidNocarnickelamides B
Nocarnickelamides B (Compound 2) is a linear peptide and an inhibitor of ROCK1/2. It exhibits dual inhibitory activity against ROCK1 and ROCK2, with IC50 values of 14.9 μM and 21.9 μM, respectively. This compound binds to the ATP binding site and inhibits ROCK-mediated cytoskeletal contraction markers, such as myosin light chain activation. Nocarnickelamides B can be utilized in glaucoma research.Fórmula:C29H42N6O9Cor e Forma:Odour SolidPeso molecular:618.68Garenoxacin
CAS:Garenoxacin (BMS284756) is a novel oral des-fluoro(6) quinolone for the treatment of Gram-positive and Gram-negative bacterial infections.Fórmula:C23H20F2N2O4Pureza:98%Cor e Forma:SolidPeso molecular:426.41JA397
JA397 is an effective and selective inhibitor of the TAIRE family, showing cellular activity with IC50 values ranging from 21 nM to 307 nM.Fórmula:C24H31N7O4Peso molecular:481.243753,6-DMAD hydrochloride
3,6-DMAD hydrochloride functions as an inhibitor for the IRE1α-XBP1 pathway within the unfolded protein response mechanism.Fórmula:C22H31N5xHClPureza:98%Cor e Forma:SolidPeso molecular:365.52CDK9 ligand 3
CAS:CDK9ligand 3 is a ligand for CDK9 and can be utilized in the synthesis of PROTAC degraders, specifically PROTAC CDK9degrader-11.Fórmula:C18H18BrCl2N5O3Cor e Forma:SolidPeso molecular:503.1773'-β-C-Methyl-N6-isopentenyl adenosine
3’-Beta-C-Methyl-N6-isopentenyl adenosine is an adenosine analog.Fórmula:C16H23N5O4Cor e Forma:SolidPeso molecular:349.38LDV
CAS:α4β1 integrin (VLA-4) ligand (Kd ~ 12 nM). Non-fluorescent derivative of LDV FITC.Fórmula:C48H70N10O12Pureza:98%Cor e Forma:SolidPeso molecular:979.13SNM1A-IN-1
SNM1A-IN-1 (compound 11a) serves as an inhibitor of the DNA damage repair enzyme SNM1A, exhibiting cytotoxic properties [1].Cor e Forma:Odour SolidCDK1-IN-2
CAS:CDK1-IN-2 (cdk1 inhibitor 2) is a CDK1 inhibitor with IC50 of 5.8 μM.Fórmula:C17H11ClN2OPureza:98.53%Cor e Forma:SoildPeso molecular:294.73Ref: TM-T64373
1mg50,00€5mg107,00€10mg170,00€25mg354,00€50mg567,00€100mg810,00€500mg1.644,00€1mL*10mM (DMSO)103,00€(E/Z)-THZ1 2HCl
CAS:THZ1 2HCl: selective CDK7 allosteric inhibitor, IC50 3.2 nM, hinders cancer cell growth.
Fórmula:C31H30Cl3N7O2Pureza:99.51%Cor e Forma:SolidPeso molecular:638.98N1-Methyl-2'-β-C-methyl inosine
N1-Methyl-2’-beta-C-methyl inosine, a purine nucleoside analog, exhibits broad antitumor activity against indolent lymphoid malignancies through mechanisms thatFórmula:C12H16N4O5Cor e Forma:SolidPeso molecular:296.28m7GpppCmpG
CAS:m7GpppCmpG, a trinucleotide cap analogue, enables RNA manufacturing with cap 0 or cap 1 structures.Fórmula:C31H43N13O25P4Cor e Forma:SolidPeso molecular:1121.64PROTAC CDK9 degrader-8
PROTAC CDK9 Degrader-8 (Compound 21) is a potent degrader of CDK9 with an IC50 of 0.01 μM, utilized in cancer research [1].Fórmula:C44H52Cl2N10O7Pureza:98%Cor e Forma:SolidPeso molecular:903.85TMX-2039
CAS:TMX-2039 is a pan-CDK inhibitor that targets cell cycle CDKs (CDK1, CDK2, CDK4, CDK5, and CDK6) and transcription CDKs (CDK7 and CDK9), with IC50 values of 2.6, 1.0, 52.1, 0.5, 35.0, 32.5, and 25 nM, respectively. It serves as a ligand for the target protein in PROTAC applications.Fórmula:C17H20BrFN6O3SCor e Forma:SolidPeso molecular:487.347CTP Synthetase-IN-1 Ammonium salt
CTP Synthetase-IN-1 Ammonium salt is a CTPS inhibitor with potential antibacterial, anti-inflammatory, and antitumor activity for the study of SARS-CoV-2 viral infectionsFórmula:C20H22F3N7O3S2Pureza:99.97%Cor e Forma:SolidPeso molecular:529.56PDI-IN-4
PDI-IN-4 (Compound 14d) is a protein disulfide isomerase inhibitor with an IC50 value of 0.48 μM. It prevents platelet aggregation and thrombosis by reducing the activation of GPIIb/IIIa, without causing significant cytotoxicity. PDI-IN-4 is applicable in thrombosis research.Fórmula:C17H12F3NO2Cor e Forma:SolidPeso molecular:319.278PKMYT1-IN-8
PKMYT1-IN-8 (Compound 137) is an inhibitor of PKMYT1, with an IC50 value of 9 nM. It also inhibits EPHB3, EPHA1, KIT, EPHB1, EPHA2, EPHA3, and EPHB2, exhibiting IC50 values of 1.79, 3.17, 4.29, 6.32, 6.83, 8.10, and 10.9 μM, respectively. Additionally, PKMYT1-IN-8 suppresses the proliferation of cancer cells OVCAR3 with a GI50 of 2.02 μM.
Fórmula:C17H16F3N5O2Cor e Forma:SolidPeso molecular:379.336DNA Gyrase-IN-15
DNA Gyrase-IN-15 (Compound 11) is an antibacterial agent that inhibits both DHPS and DNA gyrase, with IC50 values of 1.73 and 0.07 µM, respectively. It shows antimicrobial activity against Enterococcus faecium (MIC of 15.62 µg/mL), Acinetobacter baumannii, Enterobacter (MIC of 7.81 µg/mL), Pseudomonas aeruginosa, Klebsiella pneumoniae, and Staphylococcus aureus. Additionally, DNA Gyrase-IN-15 exhibits antibiofilm activity against Enterococcus faecium.Fórmula:C31H26N4O4S2Cor e Forma:SolidPeso molecular:582.693CDK12-IN-6
CAS:CDK12-IN-6, a pyrazolotriazine, strongly inhibits CDK12 (IC50 1.19 μM at 2 mM ATP), but not CDK2/Cyclin E or CDK9/Cyclin T1 (both IC50 >20 μM).Fórmula:C20H21F2N9Cor e Forma:SolidPeso molecular:425.448MU1920
MU1920 is an ATP-competitive, selective inhibitor of haspin with an IC50 of 6 nM. In mouse plasma and microsomes, it demonstrates favorable pharmacokinetic properties and metabolic stability. Although it lacks significant anticancer activity, MU1920 is suitable for developing chemical probes.
Fórmula:C17H15N5SCor e Forma:SolidPeso molecular:321.4αvβ5 integrin-IN-1
CAS:αvβ5 integrin-IN-1, a potent and selective αvβ5 integrin inhibitor, exhibits a high inhibitory potency with a pIC50 value of 8.2.Fórmula:C25H28F3N3O3Cor e Forma:SolidPeso molecular:475.512Uridine-5-oxo-acetyl-(9-fluorenylmethyl) ester
Uridine analogue with antitumor effects; inhibits DNA synthesis, induces apoptosis in lymphoid cancers.Fórmula:C24H24N2O9Cor e Forma:SolidPeso molecular:484.46Ascochlorin A
CAS:Ascochlorin A, a compound with a dissociation constant (K D) of 3.29 μM, serves as a novel and potent human dihydroorotate dehydrogenase (hDHODH) inhibitorFórmula:C23H31ClO4Cor e Forma:SolidPeso molecular:406.95KIF18A-IN-11
KIF18A-IN-11 (Compound 13) is an effective inhibitor of KIF18A, exhibiting IC50 values below 100 nM in OVCAR3 and MDA-MB-157 cells. It is applicable for cancer research.Fórmula:C28H38F2N6O4SPeso molecular:592.26433DENV-IN-2
CAS:DENV-IN-2 inhibits dengue virus replication (EC50: 0.016 nM), affects all serotypes (EC50: 0.013-0.029 nM). Derived from WO2018215315A1 6AB.Fórmula:C29H26ClF3N2O6Cor e Forma:SolidPeso molecular:590.98TLK1-IN-1
TLK1-IN-1 (Compound 5n) is a TLK1 inhibitor with an IC50 of 7.2 μM for TLK1B and a GI50 of 2.7 μM for LNCaP cells. It induces DNA damage and apoptosis (Apoptosis) in cancer cells and is applicable in prostate cancer research.Fórmula:C24H23BrClN5O3Cor e Forma:SoildPeso molecular:544.83Fibronectin Active Fragment Control
CAS:Fibronectin: a ~440kDa glycoprotein, binds integrins, collagen, fibrin, and heparan sulfate in the extracellular matrix.Fórmula:C18H32N8O9Pureza:98%Cor e Forma:SolidPeso molecular:504.49α2β1 Integrin Ligand Peptide
CAS:The Asp-Gly-Glu-Ala (DGEA) amino acid domain of type I collagen interacts with the α2β1 integrin receptor on the cell membrane and mediates extracellularFórmula:C14H22N4O9Pureza:98%Cor e Forma:SolidPeso molecular:390.355'-O-DMT-N4-Bz-2'-F-dC
CAS:5’-O-DMT-N4-Bz-2’-F-dC is a nucleoside with protective and modification effects.Fórmula:C37H34FN3O7Cor e Forma:SolidPeso molecular:651.68GSK299423
CAS:GSK299423: Antibiotic possibly effective against bacteria with New Delhi metal-β-lactamase, targeting topoisomerases.Fórmula:C25H27N5O2SPureza:97.34%Cor e Forma:SolidPeso molecular:461.581,8-Diazanaphthalene
CAS:1,8-Diazanaphthalene inhibits Protein Kinase B with a binding constant Ka=407 μM.Fórmula:C8H6N2Peso molecular:130.15Aurora kinase-IN-7
Aurora kinase-IN-7 (compound 4b) is an orally active inhibitor selectively targeting AURKB. It is utilized in the study of aggressive cancers.Fórmula:C26H21FN6OPeso molecular:452.48BSJ-03-204
CAS:BSJ-03-204 is a selective Cdk4/6 degrader.Fórmula:C43H48N10O8Cor e Forma:SolidPeso molecular:832.9Eg5-IN-3
Eg5-IN-3 (5) is an Eg5 inhibitor targeting a novel allosteric site (α4/α6/L11). It disrupts tubulin assembly, leading to abnormal and irregular formations, which subsequently causes typical mitotic arrest, akin to the effects of Monastrol.Fórmula:C23H23N7O2Peso molecular:429.19132N1-Methylpseudouridine-5′-triphosphate tetralithium
N1-Methylpseudouridine-5′-triphosphate tetralithium, also known as 1-Methylpseudouridine-5′-triphosphate tetralithium, is a nucleobase-modified nucleotide.Fórmula:C10H13Li4N2O15P3Cor e Forma:SolidPeso molecular:521.9GK13S
G13KS: UCHL1 ligand, deubiquitinase inhibitor; reduces monoubiquitin in glioblastoma cells.Fórmula:C21H22N6O2Cor e Forma:SolidPeso molecular:390.44TAS-119
CAS:TAS-119 (TAS-2104) is an orally available, selective and potent inhibitor of Aurora A with an IC50 of 1.0 nM.TAS-119 also inhibits Aurora B with an IC50 of 95Fórmula:C23H22Cl2FN5O3Pureza:99.65%Cor e Forma:SolidPeso molecular:506.36Ref: TM-T34787
1mg97,00€5mg235,00€10mg378,00€25mg748,00€50mg1.169,00€100mg1.644,00€1mL*10mM (DMSO)261,00€3'-Deoxy-GTP trisodium
3'-Deoxy-GTP (3′-Deoxyguanosine 5′-triphosphate) trisodium, an analog of GTP, functions as an RNA chain terminator, thereby inhibiting RNA synthesis. It is capable of suppressing dengue virus DENV NS5 RdRp with an IC50 value of 0.02 μM.
Cor e Forma:Odour Solid2'-Fluoro-2'-deoxy-arabinoadenosine 5'-triphosphate triethylamine
2’-Fluoro-2’-deoxy-arabinoadenosine 5’-triphosphate (triethylamine) is a purine nucleoside analog with significant antitumor properties, particularly effectiveFórmula:C34H75FN9O12P3Cor e Forma:SolidPeso molecular:913.93UnyLinker 12 TEA
UnyLinker 12 TEA is a versatile linker used in the synthesis of oligoribonucleotides.Fórmula:C39H35NO10C6H15NCor e Forma:SolidPeso molecular:778.34655
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