Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase(115 produtos)
- CDK(546 produtos)
- Ciclo celular/Parada(5 produtos)
- Chk(48 produtos)
- DYRK(47 produtos)
- Dinamina(27 produtos)
- Ferroptose(227 produtos)
- HSP(180 produtos)
- Integrinas(269 produtos)
- Cinesina(87 produtos)
- LIM Quinase(20 produtos)
- Microtúbulo associado(274 produtos)
- PKC(126 produtos)
- PLK(25 produtos)
- ROCK(62 produtos)
- Rho(6 produtos)
- Wee1(14 produtos)
- c-Myc(76 produtos)
Exibir 10 mais subcategorias
Foram encontrados 3906 produtos de "Ciclo celular/Ponto de verificação"
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2'-Deoxy-2'-fluoro-l-uridine
CAS:2'-Deoxy-2'-fluoro-1-uridine: an L-nucleoside, inhibits RNA viruses by blocking viral RNA polymerase.Fórmula:C9H11FN2O5Cor e Forma:SolidPeso molecular:246.19CDK4/6-IN-5
CAS:CDK4/6-IN-5 inhibits CDK4/6; Ki: 0.2 nM (CDK4/D1) & 4.4 nM (CDK6/D3). (WO2019207463A1, A93)Fórmula:C22H28ClFN6O4SCor e Forma:SolidPeso molecular:527.01Ac-dA Phosphoramidite
CAS:Ac-dA Phosphoramidite is a phosphinamide monomer utilized for oligonucleotide synthesis.Fórmula:C42H50N7O7PCor e Forma:SolidPeso molecular:795.878Ripasudil free base
CAS:Ripasudil free base (K-115 (free base)) is a selective and potent ROCK inhibitor, is a novel and potent antiglaucoma agent.Fórmula:C15H18FN3O2SPureza:98%Cor e Forma:SolidPeso molecular:323.39Ref: TM-T7492
1mg75,00€5mg150,00€10mg238,00€25mg530,00€50mg873,00€100mg1.459,00€1mL*10mM (DMSO)166,00€N7-Methyl-2'-O-(2-methoxyethyl) guanosine
N7-Methyl-2’-O-(2-methoxyethyl) guanosine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies.Fórmula:C14H21N5O6Cor e Forma:SolidPeso molecular:355.35USP8-IN-3
CAS:USP8-IN-3 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with IC50 of 4.0 μM against USP8D.Fórmula:C18H18F3N5O2SPureza:99.79%Cor e Forma:SolidPeso molecular:425.43Ref: TM-T67873
1mg34,00€5mg60,00€10mg92,00€25mg195,00€50mg311,00€100mg449,00€500mg888,00€1mL*10mM (DMSO)79,00€6-Thioguanosine
CAS:6-Thioguanosine (6-Mercaptoguanosine) is an active nucleoside and low molecular weight gel.6-Thioguanosine has immunosuppressive properties.Fórmula:C10H13N5O4SPureza:97.05%Cor e Forma:Yellow-Green PowderPeso molecular:299.31c(phg-isoDGR-(NMe)k) TFA
C(phg-isoDGR-(NMe)k) TFA is a selective and potent ligand for α5β1-integrin, exhibiting an IC50 of 2.9 nM [1].Fórmula:C29H42F3N9O9Cor e Forma:SolidPeso molecular:717.69CPD-39
CAS:CPD-39 is an efficacious and orally active bifunctional PROTAC degrader targeting both CCND1 and CDK4. It exhibits antiproliferative effects.Fórmula:C46H57N15O4Cor e Forma:SolidPeso molecular:884.04OTUB2-IN-1
OTUB2-IN-1 is an OTUB2 inhibitor with antitumor activity and can be used to study skin cancer and non-small cell lung cancer (NSCLC).Fórmula:C19H18N2O6S2Pureza:98.19%Cor e Forma:SolidPeso molecular:434.49CDK6/9-IN-1
CAS:CDK6/9-IN-1, an oral dual inhibitor of CDK6/9, has IC50s of 40.5nM (CDK6) and 39.5nM (CDK9).Fórmula:C22H25ClN8OCor e Forma:SolidPeso molecular:452.95Leucettine L41
CAS:Leucettine L41 (LeucettineL41) is an inhibitor of DYRKs/CLKs, preferentially targeting DYRK1A, and inhibits DYRK2.Fórmula:C17H13N3O3Pureza:99.08%Cor e Forma:SolidPeso molecular:307.3Nocarnickelamides B
Nocarnickelamides B (Compound 2) is a linear peptide and an inhibitor of ROCK1/2. It exhibits dual inhibitory activity against ROCK1 and ROCK2, with IC50 values of 14.9 μM and 21.9 μM, respectively. This compound binds to the ATP binding site and inhibits ROCK-mediated cytoskeletal contraction markers, such as myosin light chain activation. Nocarnickelamides B can be utilized in glaucoma research.Fórmula:C29H42N6O9Cor e Forma:Odour SolidPeso molecular:618.68Psammaplin A
CAS:Psammaplin A: marine-derived, inhibits HDAC/DNA methyltransferases, strong DAC1 blocker (IC50=0.9nM), antimicrobial against Gram-positive bacteria, anticancer.Fórmula:C22H24Br2N4O6S2Cor e Forma:SolidPeso molecular:664.386-Amino-3-(furan-2-yl)-4-methoxy-1-(β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine
6-Amino-3-(furan-2-yl)-4-methoxy-1-(β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine, a purine nucleoside analogue, exhibits broad antitumor activity byFórmula:C15H17N5O6Cor e Forma:SolidPeso molecular:363.33IBU-DC Phosphoramidite
CAS:IBU-DC Phosphoramidite is used for synthesis of oligonucleotides.Fórmula:C43H54N5O8PCor e Forma:SolidPeso molecular:799.906GS-443902 trisodium
CAS:GS-443902 trisodium, a strong RdRp blocker, inhibits RSV/HCV with IC50 of 1.1/5 μM and is Remdesivir's active form.Fórmula:C12H16N5O13P3·xNaCor e Forma:SolidCDK7-IN-7
CAS:CDK7-IN-7: Selective CDK7 inhibitor, IC50 < 50 nM (Patent CN112661745A).Fórmula:C20H20BrF3N6O2Cor e Forma:SolidPeso molecular:513.319Cytidine 5'-diphosphate trisodium salt
CAS:CDP, a trisodium salt, helps synthesize DNA/RNA by aiding phosphoryl transfer from ATP to CMP via UMPK.Fórmula:C9H15N3Na3O11P2Pureza:99.55%Cor e Forma:White Crystalline PowderPeso molecular:472.158β,9α-Dihydroxylindan-4(5),7(11)-dien-8α,12-olide
CAS:8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide (compound 3), a sesquiterpene, exhibits anti-LIMK1 activity and inhibits cell motility [1].Fórmula:C15H18O4Cor e Forma:SolidPeso molecular:262.3UBD1031
UBD1031 exhibits strong affinity for the ubiquitin-binding domain (UBD) of USP16, with a dissociation constant (KD) of 48 nM. It inhibits the interaction between USP16 and ISG15, displaying an effective concentration (EC50) of 1.7 nM. UBD1031 can serve as a chemical probe for investigating USP16 UBD.Cor e Forma:Odour SolidChk1-IN-6
CAS:Chk1-IN-6 is a potent, selective, and orally bioavailable CHK1 inhibitor candidate.Fórmula:C16H18F3N7Cor e Forma:SolidPeso molecular:365.364Biotin-PEG7-C2-NH-Vidarabine-S-CH3
Biotin-PEG7-C2-NH-Vidarabine-S-CH3 is a PEG linker with Vidarabine, an anti-herpes/zoster antiviral.Fórmula:C37H62N8O12S2Cor e Forma:SolidPeso molecular:875.06N1-(2-Methyl)propyl pseudouridine
N1-(2-Methyl)propyl pseudouridine, a purine analog, targets lymphoid cancer by inhibiting DNA synthesis and inducing apoptosis.Fórmula:C13H20N2O6Cor e Forma:SolidPeso molecular:300.312'-O-(2-Methoxyethyl)guanosine 5'-triphosphate ammonium
2’-O-(2-Methoxyethyl)guanosine 5’-triphosphate (ammonium), a purine nucleoside analog, exhibits extensive antitumor properties, particularly against indolentFórmula:C13H34N9O15P3Cor e Forma:SolidPeso molecular:649.38α2β1 Integrin Ligand Peptide
CAS:The Asp-Gly-Glu-Ala (DGEA) amino acid domain of type I collagen interacts with the α2β1 integrin receptor on the cell membrane and mediates extracellularFórmula:C14H22N4O9Pureza:98%Cor e Forma:SolidPeso molecular:390.355'-O-DMT-N4-Bz-2'-F-dC
CAS:5’-O-DMT-N4-Bz-2’-F-dC is a nucleoside with protective and modification effects.Fórmula:C37H34FN3O7Cor e Forma:SolidPeso molecular:651.68LL-K12-18
LL-K12-18 is a dual-site molecular gel that enhances PPI between CDK12-DDB1 complexes thereby promoting the degradation of Cyclin K and anti-proliferation.Fórmula:C25H32Cl2N10OPureza:98.08% - 99.77%Cor e Forma:SoildPeso molecular:559.49LDV
CAS:α4β1 integrin (VLA-4) ligand (Kd ~ 12 nM). Non-fluorescent derivative of LDV FITC.Fórmula:C48H70N10O12Pureza:98%Cor e Forma:SolidPeso molecular:979.13GK13S
G13KS: UCHL1 ligand, deubiquitinase inhibitor; reduces monoubiquitin in glioblastoma cells.Fórmula:C21H22N6O2Cor e Forma:SolidPeso molecular:390.44UnyLinker 12 TEA
UnyLinker 12 TEA is a versatile linker used in the synthesis of oligoribonucleotides.Fórmula:C39H35NO10C6H15NCor e Forma:SolidPeso molecular:778.34655Carboxy-pyridostatin
CAS:Carboxy-pyridostatin, as a fluorescent probe, can target G-quadruplex structures and trap cytoplasmic RNA G-quadruplex structures in cells.
Fórmula:C35H34N10O7Cor e Forma:SolidPeso molecular:706.71LY2812223
CAS:LY2812223: selective mGlu2 agonist; binds mGlu2/mGlu3 (Ki=144/156 nM).Fórmula:C10H12N4O4SPureza:98%Cor e Forma:SolidPeso molecular:284.29WAY-230563
CAS:WAY-230563 is a serine/threonine kinase inhibitor that blocks CHK1/CHK2-mediated cell cycle checkpoints, leading to G2/M phase arrest in tumour cellsFórmula:C17H12N2O2SPureza:98.40%Cor e Forma:SolidPeso molecular:308.35Viquidacin
CAS:NXL-101, an oral/IV antibiotic for Gram-positive bacteria like MRSA, was discontinued by Novexel in 2008.Fórmula:C25H29FN2O4S2Cor e Forma:SolidPeso molecular:504.642'-Chloro-N6-(3-trifluoromethyl)benzyl adenosine
2’-Chloro-N6-(3-trifluoromethyl)benzyl adenosine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoidFórmula:C18H17ClF3N5O4Cor e Forma:SolidPeso molecular:459.81Adenosine-2-carboxy methyl amide
Adenosine-2-carboxy methyl amide: a purine analog with antitumor effects, inhibits DNA synthesis and induces apoptosis.Fórmula:C12H16N6O5Cor e Forma:SolidPeso molecular:324.29N1-Methyl-2'-β-C-methyl inosine
N1-Methyl-2’-beta-C-methyl inosine, a purine nucleoside analog, exhibits broad antitumor activity against indolent lymphoid malignancies through mechanisms thatFórmula:C12H16N4O5Cor e Forma:SolidPeso molecular:296.28GRGDSPK
CAS:GRGDSPK (EMD 56574) is an inhibitory peptide for RGD-mediated adhesion between integrin and extracellular matrix molecules.Fórmula:C28H49N11O11Pureza:98%Cor e Forma:SolidPeso molecular:715.76Surovatamig
Surovatamig is a bispecific antibody of the (H-γ4_L-κ)_VH-G4(h-CH2-CH3) type, targeting CD3D/CD3E/CD19.Cor e Forma:Odour Liquidc-Myc inhibitor 5
DA3: Fluorescent c-Myc inhibitor, targets c-MYC G-quadruplex (K D 16 μM), selective, suppresses c-MYC expression.Fórmula:C30H46N12Cor e Forma:SolidPeso molecular:574.778-Chloro-2'-O-methyl inosine
8-Chloro-2’-O-methyl inosine, a purine nucleoside analog, exhibits broad antitumor activity against indolent lymphoid malignancies.Fórmula:C11H13ClN4O5Cor e Forma:SolidPeso molecular:316.73'-Deoxy-N6-(m-methoxy benzyl)adenosine
3’-Deoxy-N6-(m-methoxy benzyl)adenosine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies.Fórmula:C18H21N5O4Cor e Forma:SolidPeso molecular:371.39Emicoron
CAS:Importazole is an inhibitor of the transport receptor importin-β. It specifically inhibits importin-β likely by altering its interaction with RanGTP.Fórmula:C52H58N6O4Pureza:98%Cor e Forma:SolidPeso molecular:831.05m7GpppGpG
CAS:m7GpppGpG, a trinucleotide cap, protects mRNA from 5′ exonucleases & aids splicing and translation.Fórmula:C31H41N15O25P4Cor e Forma:SolidPeso molecular:1147.6412R-LOX-IN-2
CAS:12R-LOX-IN-2 is a 12R-LOX inhibitor that inhibits the hyperproliferation of psoriatic cells and can be used in the study of psoriasis and other skin diseases.Fórmula:C19H13NOPureza:99.92%Cor e Forma:SolidPeso molecular:271.31Haspin-IN-4
Haspin-IN-4 (Compound 60) is a selective Haspin inhibitor with an IC50 of 0.01 nM and exhibits anticancer activity, making it suitable for cancer research.Cor e Forma:Odour SolidIV-361
CAS:IV-361, an orally active and selective CDK7 inhibitor with a Ki value of less than or equal to 50 nM, demonstrates potent anti-cancer activity (US20190256531A1Fórmula:C23H32FN5O2SiCor e Forma:SolidPeso molecular:457.62516,16-dimethyl Prostaglandin A1
CAS:16,16-dimethyl Prostaglandin A1 is a useful organic compound for research related to life sciences.Fórmula:C22H36O4Cor e Forma:SolidPeso molecular:364.5265-Azacytidine 5′-triphosphate sodium
5-Azacytidine 5'-triphosphate sodium, a cytidine analog, selectively inhibits the incorporation of [3 H]CTP into RNA by DNA-dependent RNA polymerase, withoutCor e Forma:Odour Solid
