Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase(115 produtos)
- CDK(547 produtos)
- Ciclo celular/Parada(5 produtos)
- Chk(48 produtos)
- DYRK(46 produtos)
- Dinamina(27 produtos)
- Ferroptose(227 produtos)
- HSP(180 produtos)
- Integrinas(275 produtos)
- Cinesina(87 produtos)
- LIM Quinase(21 produtos)
- Microtúbulo associado(273 produtos)
- PKC(127 produtos)
- PLK(25 produtos)
- ROCK(61 produtos)
- Rho(6 produtos)
- Wee1(14 produtos)
- c-Myc(77 produtos)
Exibir 10 mais subcategorias
Foram encontrados 3920 produtos de "Ciclo celular/Ponto de verificação"
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TC113
TC113, a c(RGDyK)-linked Gemcitabine, targets αvβ3 integrin, entering A549 cells, and inhibits WM266.4 and A549 cell growth.Fórmula:C37H50F2N12O13Cor e Forma:SolidPeso molecular:908.86UnyLinker 12 TEA
UnyLinker 12 TEA is a versatile linker used in the synthesis of oligoribonucleotides.Fórmula:C39H35NO10C6H15NCor e Forma:SolidPeso molecular:778.34655Carboxy-pyridostatin
CAS:Carboxy-pyridostatin, as a fluorescent probe, can target G-quadruplex structures and trap cytoplasmic RNA G-quadruplex structures in cells.
Fórmula:C35H34N10O7Cor e Forma:SolidPeso molecular:706.71LX-7101 hydrochloride
CAS:LX-7101 hydrochloride is a potent LIMK and ROCK2 inhibitor with antihypertensive activity, inhibits LIMK1/2, ROCK, PKA, and can be used to study glaucoma.Fórmula:C23H29N7O3xHClPureza:98.96%Cor e Forma:SolidPeso molecular:487.99USP8-IN-2
CAS:USP8-IN-2 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with an IC50 of 4.0 μM against USP8D.Fórmula:C19H20ClF3N4OSPureza:99.92%Cor e Forma:SolidPeso molecular:444.9Ref: TM-T67876
1mg94,00€5mg200,00€1mL*10mM (DMSO)233,00€10mg313,00€25mg520,00€50mg740,00€100mg982,00€12R-LOX-IN-2
CAS:12R-LOX-IN-2 is a 12R-LOX inhibitor that inhibits the hyperproliferation of psoriatic cells and can be used in the study of psoriasis and other skin diseases.Fórmula:C19H13NOPureza:99.92%Cor e Forma:SolidPeso molecular:271.31CDK2/PIM1-IN-1
CDK2/PIM1-IN-1 is an inhibitor of the kinases CDK2 (IC50: 0.27 μM) and PIM1 (IC50: 0.67 μM). It can induce apoptosis (cell death) and reduce the expression of TNF-α, which promotes tumors. CDK2/PIM1-IN-1 exhibits antitumor activity.Cor e Forma:Odour Solid(+)-Glaucarubinone
(+)-Glaucarubinone is a natural product that can be used as a reference standard.Fórmula:C25H34O10Cor e Forma:SolidPeso molecular:494.537Eciruciclib
CAS:Eciruciclib is an inhibitor of CDK with antitumor properties.Fórmula:C27H33FN8Pureza:99.73%Cor e Forma:SolidPeso molecular:488.6AM5992
CAS:AM5992 (example 195) is a potent CDK4 and CDK6 inhibitor (CDK4, IC50= 0.013 μM). AM5992 can be used for the research of CDK4-mediated disorders.Fórmula:C27H33FN8OPureza:98%Cor e Forma:SoildPeso molecular:504.6PROTAC CDK9 degrader-5
CAS:PROTAC CDK9 degrader-5 selectively degrades CDK9 isoforms 42, 55 with DC50 of 0.10μM, 0.14μM via proteasome.Fórmula:C42H48Cl2N8O9Pureza:98%Cor e Forma:SolidPeso molecular:879.78Sangivamycin
CAS:Sangivamycin (NSC-65346) inhibits PKC (Ki=10μM) and hinders growth in various human cancers.
Fórmula:C12H15N5O5Pureza:99.85%Cor e Forma:SolidPeso molecular:309.28α-Methyl-DL-aspartic acid
CAS:α-Methyl-DL-aspartic acid specifically inhibits argininosuccinate synthase (ASS), the rate-limiting enzyme in 1-citrulline-to-1-arginine recycling.Fórmula:C5H9NO4Pureza:99.91%Cor e Forma:SolidPeso molecular:147.13AV-153
CAS:AV-153, a 1,4-dihydropyridine, reduces DNA damage, stimulates repair, and has anti-cancer properties.Fórmula:C14H19NNaO6Cor e Forma:SolidPeso molecular:320.297Rev 2'-O-MOE-C(Bz)-5'-amidite
'Rev 2’-O-MOE-C(Bz)-5’-amidite, a purine nucleoside analog, exhibits broad antitumor activity against indolent lymphoid malignancies.Fórmula:C49H58N5O10PCor e Forma:SolidPeso molecular:907.992'-Deoxy-2'-fluoro-l-uridine
CAS:2'-Deoxy-2'-fluoro-1-uridine: an L-nucleoside, inhibits RNA viruses by blocking viral RNA polymerase.Fórmula:C9H11FN2O5Cor e Forma:SolidPeso molecular:246.19DENV-IN-2
CAS:DENV-IN-2 inhibits dengue virus replication (EC50: 0.016 nM), affects all serotypes (EC50: 0.013-0.029 nM). Derived from WO2018215315A1 6AB.Fórmula:C29H26ClF3N2O6Cor e Forma:SolidPeso molecular:590.983'-β-C-ethynyl-N6-iso-pentenyl adenosine
3’-Beta-C-ethynyl-N6-iso-pentenyl adenosine is an adenosine analog.Fórmula:C17H21N5O4Cor e Forma:SolidPeso molecular:359.38PF07104091
CAS:PF07104091 inhibits CDK2, which may lead to cell cycle arrest, induce apoptosis and inhibit tumor cell proliferation. Cost-effective and quality-assured.Fórmula:C19H28N6O4Pureza:99.49% - 99.59%Cor e Forma:SolidPeso molecular:404.46Ref: TM-T9712
1mg334,00€2mg492,00€5mg780,00€1mL*10mM (DMSO)867,00€10mg1.144,00€25mg1.701,00€50mg2.295,00€100mg3.087,00€GS-443902
CAS:Remdesivir triphosphate (GS-443902) inhibits RSV/HCV RdRp with IC50s: 1.1/5 µM.Fórmula:C12H16N5O13P3Pureza:98%Cor e Forma:SolidPeso molecular:531.2PROTAC CDK9 degrader-11
CAS:PROTAC CDK9 degrader-11 (Compound C3) is an orally active PROTAC CDK9 degrader with a DC50 of 1.09 nM. This compound exhibits cytotoxicity in small cell lung cancer (SCLC) cells, with IC50 values in the nanomolar range. It induces cell cycle arrest at the G0/G1 phase and inhibits cell invasion in DMS114 and DMS53 cells. In addition, PROTAC CDK9 degrader-11 shows antitumor activity in an NCI-H446 xenograft mouse model. (Pink: ligand for target protein CDK9 ligand 3; Black: linker; Blue: ligand for E3 ligase Cereblon E3 ligase Ligand 56)Fórmula:C39H48Cl2N10O5Cor e Forma:SolidPeso molecular:807.768m7GpppCpG
CAS:m7GpppCpG, a trinucleotide cap analogue, is used for synthesizing RNA with cap 0 or cap 1 structures.Fórmula:C30H41N13O25P4Cor e Forma:SolidPeso molecular:1107.617-TFA-ap-7-Deaza-ddG
CAS:Compound 19d, a nucleotide derivative, is used to make thiotriphosphate dye terminators for DNA sequencing.Fórmula:C16H16F3N5O4Cor e Forma:SolidPeso molecular:399.33bio-THZ1
CAS:bio-THZ1 is a biotinylated version of THZ1. THZ1 is a selective and irreversibly covalent CDK7 inhibitor (IC50: 3.2 nM).Fórmula:C52H65ClN12O8SPureza:98%Cor e Forma:SolidPeso molecular:1053.67N4-Benzoyl-2'-deoxy-2'-fluoro-β-D-arabinocytidine
N4-Benzoyl-2’-deoxy-2’-fluoro-β-D-arabinocytidine, a purine nucleoside analog, exhibits widespread antitumor activity, particularly against indolent lymphoidFórmula:C16H16FN3O5Cor e Forma:SolidPeso molecular:349.31ART812
CAS:ART812 is an orally active inhibitor of DNA polymerase Polθ, possessing an IC50 value of 7.6 nM.Fórmula:C19H16ClF4N3O4Pureza:99.07%Cor e Forma:SolidPeso molecular:461.79Ref: TM-T40236
1mg110,00€1mL*10mM (DMSO)265,00€5mg268,00€10mg427,00€25mg707,00€50mg1.044,00€100mg1.459,00€CHK1-IN-12
CHK1-IN-12 (Compound example 1-5) is a highly selective and orally active checkpoint kinase 1 (CHK1) inhibitor, demonstrating an in vitro enzyme IC50 of ≤10 nM and a cellular IC50 of ≤50 nM. This compound suppresses the phosphorylation activity of CHK1 kinase, disrupts DNA damage response pathways, and induces tumor cell cycle arrest and apoptosis. CHK1-IN-12 shows promise for cancer research applications.Fórmula:C19H19N7O2Cor e Forma:SolidPeso molecular:377.160025'-O-DMT-rU
CAS:5’-O-DMT-rU is a modified nucleoside and can be used to synthesize RNA.Fórmula:C30H30N2O8Cor e Forma:SolidPeso molecular:546.57Olsutamig
CAS:Olsutamig is a bivalent humanized IgG4κ monoclonal antibody inhibitor targeting FOLH1/PSMA and CD3E. It is capable of binding simultaneously to PSMA on tumor cell surfaces and CD3E on T cell surfaces, leading to significant activation of T cells and the specific destruction of prostate cancer cells.Cor e Forma:LiquidN1-Methyl-2'-deoxy-2'-fluoroarabinoguanosine
Nucleoside Derivatives - Fluoro-modified nucleosides; N-Methylated alkylated nucleosidesCor e Forma:SoildRef: TM-TNU0546
5mgA consultar10mgA consultar25mgA consultar50mgA consultar100mgA consultar500mgA consultarms2i6A
CAS:ms2i6A is a mitochondrial tRNA-specific modification, which regulates efficient mitochondrial translation and energy metabolism in mammals.Fórmula:C16H23N5O4SCor e Forma:SolidPeso molecular:381.452',3',5'-Tri-O-benzoyl-5-iodouridine
CAS:Nucleoside Derivatives - Halo-Nucleosides, 5-Modified pyrimidine nucleosidesFórmula:C30H23IN2O9Cor e Forma:SolidPeso molecular:682.42Ref: TM-TNU0905
5mgA consultar10mgA consultar25mgA consultar50mgA consultar100mgA consultar500mgA consultar2,6-Bis(4-morpholinyl)-9-b-D-ribofuranosyl-9H-purine
Nucleoside Derivatives –6-Subtituted nucleosides；2-Substituted nucleosidesCor e Forma:SoildRef: TM-TNU1411
5mgA consultar10mgA consultar25mgA consultar50mgA consultar100mgA consultar500mgA consultar5-Iodo-2'-O-methylcytidine
CAS:5-Iodo-2'-O-methylcytidine is a Halo-nucleoside; 2'-O-Methyl nucleoside.Fórmula:C10H14IN3O5Cor e Forma:SolidPeso molecular:383.14Ref: TM-TNU0018
5mgA consultar10mgA consultar25mgA consultar50mgA consultar100mgA consultar500mgA consultar2-Amino-6-methythio-9-(β-D-ribofuranosyl)-9H-purine
CAS:2-Amino-6-methythio-9-(beta-D-ribofuranosyl)-9H-purine is a Nucleoside Derivative - 6-Modified purine nucleoside; Thio-nucleoside.Fórmula:C11H15N5O4SCor e Forma:SolidPeso molecular:313.33Ref: TM-TNU0491
5mgA consultar10mgA consultar25mgA consultar50mgA consultar100mgA consultar500mgA consultar5-Phenylcytidine
CAS:5-Phenylcytidine is a Nucleoside Derivative - 5-Modified pyrimidine nucleoside.Fórmula:C15H17N3O5Cor e Forma:SolidPeso molecular:319.31Ref: TM-TNU0150
5mgA consultar10mgA consultar25mgA consultar50mgA consultar100mgA consultar500mgA consultar2-Chloro-6-methoxypurine -9-β-D-(2'-deoxy-2'-fluoro)-arabinoriboside
CAS:Fluoro-modified nucleoside; Halo-nucleoside; 2/6/8-Modified purine nucleoside; Arabino-nucleoside;Fórmula:C11H12ClFN4O4Cor e Forma:SolidPeso molecular:318.69Ref: TM-TNU0104
5mgA consultar10mgA consultar25mgA consultar50mgA consultar100mgA consultar500mgA consultar8-Benzyloxy-2'-deoxyguanosine
CAS:8-Benzyloxy-2'-deoxyguanosine is a Nucleoside Derivative - 8-Modified purine nucleoside.Fórmula:C17H19N5O5Cor e Forma:SolidPeso molecular:373.36Ref: TM-TNU0931
5mgA consultar10mgA consultar25mgA consultar50mgA consultar100mgA consultar500mgA consultar9-(3-Deoxy-3-fluoro-β-D-ribofuranosyl)-6-[5-(propyn-1-yl)pyridin-3-yl]purine
CAS:9-(3-Deoxy-3-fluoro-β-D-ribofuranosyl)-6-[5-(propyn-1-yl)pyridin-3-yl]purine is a Nucleoside Derivative - Fluoro-modified nucleoside, 6-Modified purineFórmula:C18H16FN5O3Cor e Forma:SolidPeso molecular:369.35Ref: TM-TNU0735
5mgA consultar10mgA consultar25mgA consultar50mgA consultar100mgA consultar500mgA consultar5-Methyl-2-thio-xylo-uridine
CAS:Nucleoside Derivatives - Xylo-nucleosides; Thio-nucleosidesFórmula:C10H14N2O5SCor e Forma:SolidPeso molecular:274.29Ref: TM-TNU0433
5mgA consultar10mgA consultar25mgA consultar50mgA consultar100mgA consultar500mgA consultar2'-Deoxy-N4,N4-dimethylcytidine
CAS:2'-Deoxy-N4,N4-dimethylcytidine is a Nucleoside Derivative - N-Methylated nucleoside.Fórmula:C11H17N3O4Cor e Forma:SolidPeso molecular:255.27Ref: TM-TNU1206
5mgA consultar10mgA consultar25mgA consultar50mgA consultar100mgA consultar500mgA consultar2-Chloro-2'-C-methyl-6-N,N-dimethyladenosine
CAS:2’-C-Methyl nucleoside; Halo-nucleoside; 2/6/8-Modified purine nucleosideFórmula:C13H18ClN5O4Cor e Forma:SolidPeso molecular:343.77Ref: TM-TNU0111
5mgA consultar10mgA consultar25mgA consultar50mgA consultar100mgA consultar500mgA consultar5'-O-DMT-dT
CAS:5'-O-DMT-dT (5'-O-(4,4'-Dimethoxytrityl)thymidine) is a nucleoside derivative that finds utility in oligonucleotide synthesis.Fórmula:C31H32N2O7Cor e Forma:White PowderPeso molecular:544.595'-O-Acetyl-2',3'-dideoxy-2',3'-didehydro-uridine
CAS:Nucleoside Derivatives - Didehydro-nucleosidesFórmula:C11H12N2O5Cor e Forma:SolidPeso molecular:252.22Ref: TM-TNU0993
5mgA consultar10mgA consultar25mgA consultar50mgA consultar100mgA consultar500mgA consultar5'-O-(4,4'-Dimethoxytrityl)-5-methoxyuridine
CAS:Nucleoside Derivatives - 5-Modified pyrimidine nucleosideFórmula:C31H32N2O9Cor e Forma:SolidPeso molecular:576.59Ref: TM-TNU0852
5mgA consultar10mgA consultar25mgA consultar50mgA consultar100mgA consultar500mgA consultar8-Chloro-2'-β-C-methyl inosine
CAS:Nucleoside Derivatives - 2’-Modified nucleosides; 8-Modified purine nucleosides; Halo-nucleosidesFórmula:C11H13ClN4O5Cor e Forma:SolidPeso molecular:316.7Ref: TM-TNU0553
5mgA consultar10mgA consultar25mgA consultar50mgA consultar100mgA consultar500mgA consultar7-Cyclopropylmethyl-7,8-dihydro-8-oxo-9-(b-D-xylofuranosyl) guanine
CAS:Nucleoside Derivatives - Xylo-nucleosides; 8-Modified purine nucleosides; N-Methylated alkylated nucleosidesFórmula:C14H19N5O6Cor e Forma:SolidPeso molecular:353.33Ref: TM-TNU0388
5mgA consultar10mgA consultar25mgA consultar50mgA consultar100mgA consultar500mgA consultar2-Amino-2'-deoxyadenosine
CAS:2-Amino-2'-deoxyadenosine is a deoxyribonucleoside used for the oligonucleotide synthesis.Fórmula:C10H14N6O3Cor e Forma:SolidPeso molecular:266.265-Hydroxymethyl xylo-uridine
CAS:Nucleoside Derivatives - Xylo-nucleosides; 5-Modified pyrimidine nucleosidesFórmula:C10H14N2O7Cor e Forma:SolidPeso molecular:274.23Ref: TM-TNU0484
5mgA consultar10mgA consultar25mgA consultar50mgA consultar100mgA consultar500mgA consultar5-(2-Hyroxyethyl)-2'-deoxyuridine
CAS:5-(2-Hyroxyethyl)-2'-deoxyuridine is a Nucleoside Derivative - 5-Modified pyrimidine nucleoside.Fórmula:C11H16N2O6Cor e Forma:SolidPeso molecular:272.25Ref: TM-TNU1280
5mgA consultar10mgA consultar25mgA consultar50mgA consultar100mgA consultar500mgA consultar
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