Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase(100 produtos)
- CDK(520 produtos)
- Ciclo celular/Parada(4 produtos)
- Chk(43 produtos)
- DYRK(48 produtos)
- Dinamina(25 produtos)
- Ferroptose(218 produtos)
- HSP(173 produtos)
- Integrinas(248 produtos)
- Cinesina(75 produtos)
- LIM Quinase(19 produtos)
- Microtúbulo associado(279 produtos)
- PKC(107 produtos)
- PLK(26 produtos)
- ROCK(68 produtos)
- Rho(2 produtos)
- Wee1(15 produtos)
- c-Myc(73 produtos)
Exibir 10 mais subcategorias
Foram encontrados 3655 produtos de "Ciclo celular/Ponto de verificação"
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GS-441524 HCl
CAS:GS-441524: Inhibits FIP virus, EC50 at 0.78 μM, precursor to active triphosphate, non-toxic up to 100 μM, works at ≥1 μM, metabolite of Remdesivir.Fórmula:C12H14ClN5O4Cor e Forma:SolidPeso molecular:327.72Quarfloxin
CAS:<p>Quarfloxin (CX-3543), a fluoroquinolone, inhibits neuroblastoma with nanomolar IC50, disrupting nucleolin and G-quadruplex DNA.</p>Fórmula:C35H33FN6O3Pureza:99.77%Cor e Forma:SolidPeso molecular:604.6710074-G5
CAS:<p>10074-G5 is an inhibitor of c-Myc-Max dimerization.</p>Fórmula:C18H12N4O3Pureza:99.51% - 99.67%Cor e Forma:SolidPeso molecular:332.31RCM-1
CAS:<p>RCM-1 is an inhibitor of FOXM1.</p>Fórmula:C20H12N2OS4Pureza:98.08%Cor e Forma:SolidPeso molecular:424.582'-Fluoro-2'-Deoxyadenosine
CAS:<p>2'-Fluoro-2'-Deoxyadenosine is efficiently cleaved to the toxic 2-fluoroadenine (FAde) by Escherichia coli purine nucleoside phosphorylase (PNP).</p>Fórmula:C10H12FN5O3Pureza:99.95%Cor e Forma:SolidPeso molecular:269.23ML216
CAS:ML216 (CID-49852229) inhibits BLM helicase (IC50: 1.8 μM), 28-fold selective over RECQ1, RECQ5, and UvrD (IC50s > 50 μM).Fórmula:C15H9F4N5OSPureza:98.12%Cor e Forma:SolidPeso molecular:383.32Palmatine chloride
CAS:Palmatine chloride an isoquinoline alkaloid, is an important medicinal herbal extract with diverse pharmacological and biological properties.Fórmula:C21H22ClNO4Pureza:97.9% - 99.47%Cor e Forma:SolidPeso molecular:387.867BIO
CAS:<p>7BIO triggers nonapoptotic death, blocks FLT3, DYRK1A/2, Aurora B/C kinases.</p>Fórmula:C16H10BrN3O2Pureza:99.67%Cor e Forma:SolidPeso molecular:356.17AS2863619
CAS:<p>AS2863619 is an oral inhibitor of cyclin-dependent kinase(CDK8) and CDK19. Inhibition of CDK8/19 enhances STAT5 activation.Cost-effective and quality-assured.</p>Fórmula:C16H14Cl2N8OPureza:>99.99%Cor e Forma:SolidPeso molecular:405.24Hu7691
CAS:<p>Hu7691 is an Akt inhibitor that inhibits Akt1, Akt2, and Akt3, suppresses neuroblastoma cell proliferation, and induces differentiation of neuroblastoma cells.</p>Fórmula:C22H22ClF3N4OPureza:99.81%Cor e Forma:SolidPeso molecular:450.88TH-263
CAS:TH-263 is inactive toward both LIMK1 and LIMK2 and thus can be used as negative control for TH-257, and is a diaryl sulfonamide derivative.Fórmula:C21H20N2O3SPureza:99.54%Cor e Forma:SolidPeso molecular:380.46BRD9876
CAS:<p>BRD9876 is a selective inhibitor of MM1S growth.</p>Fórmula:C16H14N2Pureza:97.81%Cor e Forma:SolidPeso molecular:234.3AT-9283 HCl
CAS:AT-9283, a multi-targeted kinase inhibitor, is used potentially for the treatment of multiple myeloma.Fórmula:C19H24ClN7O2Cor e Forma:SolidPeso molecular:417.89Leukadherin-1
CAS:<p>Leukadherin-1 boosts CD11b/CD18 adhesion, lowers leukocyte movement, cuts inflammation.</p>Fórmula:C22H15NO4S2Pureza:98.49% - 98.93%Cor e Forma:SolidPeso molecular:421.49Ro5-3335
CAS:<p>Ro5-3335 (CBFβ-Runx1 inhibitor II) is core binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins.</p>Fórmula:C13H10ClN3OPureza:99.42% - 99.87%Cor e Forma:SolidPeso molecular:259.69Bohemine
CAS:Bohemine is a cyclin-dependent kinase inhibitor.Fórmula:C18H24N6OPureza:99.09% - 99.53%Cor e Forma:SolidPeso molecular:340.425-Chloro-2'-deoxyuridine
CAS:<p>5-Chloro-2'-deoxyuridine (5-Chlorodeoxyuridine) is a thymine analog.</p>Fórmula:C9H11ClN2O5Pureza:99.54%Cor e Forma:SolidPeso molecular:262.65EG1
CAS:<p>EG1, a novel specific inhibitor of Pax2 transcription activation, targets the DNA binding domain and inhibits embryonic kidney development.</p>Fórmula:C22H18N2O5Pureza:97.48%Cor e Forma:SolidPeso molecular:390.39Ganciclovir hydrate
CAS:Ganciclovir hydrate: oral anti-cytomegalovirus; inhibits HSV 1/2, CMV, adenoviruses, FHV-1; brain-penetrating.Fórmula:C9H15N5O5Cor e Forma:SolidPeso molecular:273.249Trimethoprim sulfate
CAS:<p>Trimethoprim sulfate, a dihydrofolate reductase inhibitor, treats bacterial infections and sometimes malaria; may depress hematopoiesis.</p>Fórmula:C28H38N8O10SCor e Forma:SolidPeso molecular:678.72STAMBP-IN-1
CAS:STAMBP-IN-1 is a novel selective antagonist of deubiquitinase STAM-binding protein (STAMBP), decreasing NALP7 protein levels and suppressing IL-1β release afterFórmula:C27H28N4O4SPureza:99.64%Cor e Forma:SolidPeso molecular:504.6Nemorubicin HCL
CAS:Nemorubicin HCL, a PNU152243A salt, acts on resistant tumors via topoisomerase I inhibition and targets NER pathway upregulated cells.Fórmula:C32H38ClNO13Cor e Forma:SolidPeso molecular:680.12-Aminofluorene
CAS:<p>2-Aminofluorene (2-Fluorenamine) is a biochemical.</p>Fórmula:C13H11NPureza:99.9%Cor e Forma:Light Yellow CrystallinePeso molecular:181.23XL228
CAS:XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively).Fórmula:C22H31N9OPureza:99.07%Cor e Forma:SolidPeso molecular:437.54RNase L-IN-2
CAS:<p>RNase L-IN-2 activates RNase L at 22 uM, has antiviral effects on various RNA viruses, non-toxic at effective levels.</p>Fórmula:C16H14N2O2SPureza:98.81%Cor e Forma:SolidPeso molecular:298.36RK33
CAS:"RK33 is a DDX3 inhibitor causing G1 arrest, apoptosis, and radiation sensitization in DDX3-overexpressing cells."Fórmula:C23H20N6O3Pureza:99.04% - 99.72%Cor e Forma:SolidPeso molecular:428.44Tozasertib
CAS:Tozasertib (MK-0457) is a pan-Aurora kinase inhibitor (Kis: 0.6/18/4.6 nM for Aurora A/Aurora B/Aurora C).Fórmula:C23H28N8OSPureza:99.99%Cor e Forma:SolidPeso molecular:464.59SAR-020106
CAS:SAR-020106 is a potent, ATP-competitive, and selective CHK1 inhibitor with an IC50 of 13.3 nmol/L on the isolated human enzyme.Fórmula:C19H19ClN6OPureza:97.78%Cor e Forma:SolidPeso molecular:382.85Camostat mesylate
CAS:Camostat mesylate (FOY-S980) is a trypsin-like protease inhibitor and inhibits airway epithelial sodium channel (ENaC) function.Fórmula:C21H26N4O8SPureza:99.31% - 99.85%Cor e Forma:Crystalline SolidPeso molecular:494.52ML-7 hydrochloride
CAS:ML-7 hydrochloride (ML-7 HCl) is a cell-permeable, reversible, effective, ATP-competitive, and specific inhibitor of myosin light chain kinase (Ki: 300 nM);Fórmula:C15H18ClIN2O2SPureza:99% - 99.26%Cor e Forma:White PowderPeso molecular:452.74TH5427 hydrochloride
CAS:TH5427 HCl inhibits NUDT5 with 29 nM IC50; 690x more selective over MTH1; blocks ATP in breast cancer cells, hindering growth.Fórmula:C20H21Cl3N8O3Cor e Forma:SolidPeso molecular:527.79TAK-960 hydrochloride
CAS:TAK-960 hydrochloride is an oral, potent PLK1 inhibitor with IC50 of 0.8 nM, effective against various tumor cells and xenografts.Fórmula:C27H35ClF3N7O3Cor e Forma:SolidPeso molecular:598.06Tipiracil hydrochloride
CAS:<p>Tipiracil hydrochloride (MA-1 hydrochloride) is a thymidine phosphorylase inhibitor (TPI).</p>Fórmula:C9H12Cl2N4O2Pureza:98.13% - ≥95%Cor e Forma:SolidPeso molecular:279.12BAY-1816032
CAS:<p>BAY-1816032 is a benzimidazole budding inhibition relieved homolog protein 1 kinase (BUB1) inhibitor.Cost-effective and quality-assured.</p>Fórmula:C27H24F2N6O4Pureza:98.02% - 99.81%Cor e Forma:SolidPeso molecular:534.51SPHINX
CAS:<p>SPHINX is a new generation inhibitor of SPRK1</p>Fórmula:C17H17F3N2O3Pureza:99.29%Cor e Forma:SolidPeso molecular:354.32Longdaysin
CAS:Longdaysin is an inhibitor of CK1α and CK1δ (IC50s: 5.6/8.8 μM). It also can inhibit ERK2 (IC50: 52 μM).Fórmula:C16H16F3N5Pureza:99.97%Cor e Forma:SolidPeso molecular:335.33Abemaciclib
CAS:Abemaciclib (LY2835219) is a dual inhibitor of CDK4/6 (IC50=2/10 nM) with selectivity and specificity.Fórmula:C27H32F2N8Pureza:99.43% - 99.87%Cor e Forma:SolidPeso molecular:506.59T-5224
CAS:T-5224 is a transcription factor c-Fos/AP-1 inhibitor, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcriptionFórmula:C29H27NO8Pureza:97.88% - 99.29%Cor e Forma:SolidPeso molecular:517.535-Fluorocytidine
CAS:5-Fluorocytidine with antiviral activityFórmula:C9H12FN3O5Pureza:99.23%Cor e Forma:White PowderPeso molecular:261.21Phthalazinone pyrazole
CAS:<p>Phthalazinone pyrazole: a potent, selective oral Aurora-A kinase inhibitor, overexpressed in tumors with oncogenic activity.</p>Fórmula:C18H15N5OPureza:97.03%Cor e Forma:SolidPeso molecular:317.34THZ2
CAS:THZ2 (CDK7-IN-1), an analog of THZ1, is a potent and selective CDK7 inhibitor(IC50:13.9 nM),with the potential to treat Triple-negative breast cancer (TNBC).Fórmula:C31H28ClN7O2Pureza:98.28%Cor e Forma:SolidPeso molecular:566.05Pyridostatin TFA
CAS:<p>Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes including c-</p>Fórmula:C37H35F9N8O11Pureza:97.09% - 99.84%Cor e Forma:SolidPeso molecular:938.71FOY 251
CAS:<p>FOY 251 is a proteinase inhibitor, and is an anti-proteolytic active metabolite camostate.</p>Fórmula:C17H19N3O7SPureza:97.11% - 99.33%Cor e Forma:SolidPeso molecular:409.41Adefovir dipivoxil
CAS:<p>Adefovir dipivoxil (GS 0840) is a dipivoxil formulation of adefovir, a nucleoside reverse transcriptase inhibitor analog of adenosine with activity against</p>Fórmula:C20H32N5O8PPureza:98% - 99.80%Cor e Forma:It Has Broad-Spectrum Antiviral ActivityPeso molecular:501.47Palmatine
CAS:<p>Palmatine, also known as Burasaine, inhibits dopamine production and may treat flavivirus, jaundice, dysentery, hypertension, and liver issues.</p>Fórmula:C21H22NO4Pureza:96.28% - 99.49%Cor e Forma:SolidPeso molecular:352.4Fadraciclib
CAS:<p>Fadraciclib (CYC065) is an orally available, second-generation ATP-competitive inhibitor of CDK2/CDK9 kinases (IC50s: 5/26 nM).</p>Fórmula:C21H31N7OPureza:99.75%Cor e Forma:SolidPeso molecular:397.52SBC-110736
CAS:SBC-110736 is a proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitorFórmula:C26H27N3O2Pureza:99.44%Cor e Forma:SolidPeso molecular:413.51BTB-1
CAS:BTB-1 (NSC156750) is a novel small molecule inhibitor of the mitotic motor protein Kif18A.Fórmula:C12H8ClNO4SPureza:99.71%Cor e Forma:SolidPeso molecular:297.71CCG-222740
CAS:CCG-222740 is an inhibitor of Rho/MRTF pathwayFórmula:C23H19ClF2N2O3Pureza:98.76%Cor e Forma:SolidPeso molecular:444.86Ganciclovir sodium
CAS:Ganciclovir sodium, a sodium salt with anti-CMV and HSV-1 antiviral properties.Fórmula:C9H13N5NaO4Pureza:99.93%Cor e Forma:SolidPeso molecular:278.22
