Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase(96 produtos)
- CDK(505 produtos)
- Ciclo celular/Parada(4 produtos)
- Chk(42 produtos)
- DYRK(48 produtos)
- Dinamina(23 produtos)
- Ferroptose(215 produtos)
- HSP(170 produtos)
- Integrinas(227 produtos)
- Cinesina(68 produtos)
- LIM Quinase(19 produtos)
- Microtúbulo associado(261 produtos)
- PKC(102 produtos)
- PLK(28 produtos)
- ROCK(68 produtos)
- Rho(2 produtos)
- Wee1(15 produtos)
- c-Myc(68 produtos)
Exibir 10 mais subcategorias
Foram encontrados 3495 produtos de "Ciclo celular/Ponto de verificação"
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L-Threonolactone
CAS:<p>L-Threonolactone is a Carbohydrate Derivative.</p>Fórmula:C4H6O4Cor e Forma:SolidPeso molecular:118.09Mirvetuximab soravtansine
CAS:<p>Mirvetuximab soravtansine (IMGN853) is an antibody-drug coupling that targets FRα, inhibits cell growth, and can be used to study drug-resistant ovarian cancer</p>Pureza:6mg/ml - 6mg/mlCor e Forma:LiquidPeso molecular:150000 (average)XL413
CAS:<p>XL-413 is an oral CDC7 kinase inhibitor, potentially blocking DNA replication, mitosis, and cancer cell growth.</p>Fórmula:C14H12ClN3O2Pureza:98.40% - >99.99%Cor e Forma:SolidPeso molecular:289.72BAY1217389
CAS:<p>BAY 1217389 is an effective and selective inhibitor of the monopolar spindle 1 (MPS1) kinase (IC50<10 nM).</p>Fórmula:C27H24F5N5O3Pureza:98.14% - 99.42%Cor e Forma:SolidPeso molecular:561.5Tirofiban
CAS:<p>Tirofiban (L700462) (MK-383) is a selective palate GPIIb/IIIa antagonist which inhibits platelet aggregation with IC50 of 9 nM.</p>Fórmula:C22H36N2O5SPureza:99.83%Cor e Forma:SolidPeso molecular:440.63,4-Dihydroxybenzylamine hydrobromide
CAS:<p>3,4-Dihydroxybenzylamine hydrobromide inhibits DNA polymerase and melanoma growth, varying with tyrosinase activity.</p>Fórmula:C7H10BrNO2Pureza:98.49%Cor e Forma:Light Beige Crystalline PowderPeso molecular:220.06Mps1-IN-1
CAS:<p>Mps1-IN-1 is a potent, selective and ATP-competitive inhibitor of Mps1 kinase (IC50 : 367 nM )</p>Fórmula:C28H33N5O4SPureza:98.33%Cor e Forma:SolidPeso molecular:535.66JA2131
CAS:<p>JA2131: Small PARG inhibitor, IC50 0.4μM, induces DNA damage, stalls replication, kills cancer cells.</p>Fórmula:C13H19N5O2S2Cor e Forma:SolidPeso molecular:341.45Bofumustine
CAS:<p>Bofumustine is a chloroethyl nitrosourea with anti tumor properties.</p>Fórmula:C18H21ClN4O9Cor e Forma:SolidPeso molecular:472.83(S)-LY3177833 hydrate
CAS:<p>(S)-LY3177833 ((S)-Example 2) hydrate, an orally active CDC7 kinase inhibitor, exhibits extensive in vitro anticancer efficacy.</p>Fórmula:C16H14FN5O2Cor e Forma:SolidPeso molecular:327.31CDK2-IN-11
CAS:<p>CDK2-IN-11 inhibits CDK2 (IC50: 6.4 μM) and targets hCA II, IX, XII (Ki: 23.4-56.3 nM); suited for cancer research.</p>Fórmula:C18H14ClN7O2SCor e Forma:SolidPeso molecular:427.87BMVC
CAS:<p>BMVC is a potent G-quadruplex (G4) stabilizer and a selective telomerase inhibitor (IC50: ~0.2 μM) with anticancer activities.</p>Fórmula:C28H25I2N3Cor e Forma:SolidPeso molecular:657.33hDHODH-IN-3
CAS:<p>hDHODH-IN-3 is an inhibitor of human dihydroorotate dehydrogenase with a pMIC50 value of 8.6. hDHODH-IN-3 can inhibit measles virus replication.</p>Fórmula:C18H19BrN4O2Pureza:99.871%Cor e Forma:SolidPeso molecular:403.27(S)-CR8
CAS:<p>(S)-CR8 is an effective second-generation cyclin-dependent kinase inhibitor.</p>Fórmula:C24H29N7OCor e Forma:SolidPeso molecular:431.53RSK-IN-1
CAS:<p>RSK-IN-1 (compound 7d) shows anti-tumor activity. RSK-IN-1 is an inhibitor of RSK that inhibits the phosphorylation of YB-1 [1].</p>Fórmula:C22H17NO2Cor e Forma:SolidPeso molecular:327.38DHODH-IN-13
CAS:<p>DHODH-IN-13 is an inhibitor of DHODH with IC50 of 4.3 μM for rat liver. DHODH-IN-13 can be used in studies about rheumatoid arthritis.</p>Fórmula:C10H6F3N3O3Pureza:99.66%Cor e Forma:SolidPeso molecular:273.17hDHODH-IN-5
CAS:<p>hDHODH-IN-5 is an inhibitor of human dihydroorotate dehydrogenase (hDHODH, IC50 = 0.91 μM).</p>Fórmula:C21H21F3N2O2Pureza:99.55%Cor e Forma:SolidPeso molecular:390.4CCT068127
CAS:<p>CCT068127 is a potent CDK2 and CDK9 inhibitor.</p>Fórmula:C19H27N7OCor e Forma:SolidPeso molecular:369.46L-Fd4A
CAS:<p>L-Fd4A (compound 36) is an adenine derivative with anti-HIV (EC50=1.5μM) and anti-HBV (EC50=1.7μM) effects, low cytotoxicity.</p>Fórmula:C10H10FN5O2Cor e Forma:SolidPeso molecular:251.22Nucleoside-Analog-1
CAS:Nucleoside-Analog-1 is a 4′-Azidocytidine analogue, used to against Hepatitis C virus replication.Fórmula:C9H9N5O5Pureza:98%Cor e Forma:SolidPeso molecular:267.2XL-188
CAS:<p>XL-188: Potent, selective USP7 inhibitor, IC50 = 193 nM (domain), 90 nM (full). Boosts p53, p21; degrades HDM2. Unique among DUB inhibitors.</p>Fórmula:C32H42N6O4Cor e Forma:SolidPeso molecular:574.71Levofloxacin sodium
CAS:<p>Levofloxacin sodium: synthetic antibacterial, stops DNA replication by inhibiting bacterial DNA gyrase.</p>Fórmula:C18H20FN3NaO4Pureza:98%Cor e Forma:SolidPeso molecular:384.363CDK4/6-IN-12
CAS:<p>CDK4/6-IN-12 inhibits CDK4/6 with IC50s of 592.3 nM & 3090 nM, useful in cancer research.</p>Fórmula:C12H10N6Cor e Forma:SolidPeso molecular:238.25Kira8 Hydrochloride
CAS:<p>Kira8 Hydrochloride is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM.</p>Fórmula:C31H30Cl2N6O3SPureza:98%Cor e Forma:SolidPeso molecular:637.58SC-203885
CAS:<p>SC-203885 is a checkpoint kinase 2 inhibitor.</p>Fórmula:C15H13N5O2Pureza:98%Cor e Forma:SolidPeso molecular:295.3hDHODH-IN-4
CAS:hDHODH-IN-4, a potent DHODH inhibitor, has a pIC50 of 7.8 and blocks measles virus replication with a pMIC50 of 8.8.Fórmula:C21H24N4O2Pureza:99.87%Cor e Forma:SolidPeso molecular:364.44AnnH31
CAS:AnnH31 is a potent Dyrk1A inhibitor with an IC50 value of 81 nM.AnnH31 inhibits MAO-A with an IC50 of 3.2 μM.AnnH31 can be used as a probe to confirm theFórmula:C15H13N3OPureza:99.99%Cor e Forma:SolidPeso molecular:251.28SP-471P
CAS:<p>SP-471P inhibits DENV protease; EC50: DENV1-5.9 μM, DENV2-1.4 μM, DENV3-5.1 μM, DENV4-1.7 μM; CC50 >100 μM; lowers viral RNA synthesis.</p>Fórmula:C33H26BrN5O2Cor e Forma:SolidPeso molecular:604.5Crisnatol
CAS:<p>Crisnatol (BWA770U) is an oral anticancer DNA intercalator, toxic to breast cancer cells, not skin fibroblasts.</p>Fórmula:C23H23NO2Cor e Forma:SolidPeso molecular:345.43CDK8-IN-10
CAS:<p>CDK8-IN-10 is a selective and potent inhibitor of cell cycle protein-dependent kinase (CDK8) (IC50: 8.25 nM) that can be used to study cancer.</p>Fórmula:C25H15ClF3N5O3Cor e Forma:SolidPeso molecular:525.87A 65282
CAS:<p>A 65282: antibacterial isothiazoloquinolone, inhibits P4-unknotting, causes DNA breaks via topoisomerase II.</p>Fórmula:C17H16F2N4O2SPureza:98%Cor e Forma:SolidPeso molecular:378.4RP-106
CAS:<p>RP-106 is an ATP-competitive inhibitor of CDK5/p25, CDK1/cyclin B, and GSK-3.</p>Fórmula:C17H19N3OPureza:98%Cor e Forma:SolidPeso molecular:281.35PD 130883
CAS:<p>PD 130883 is a potent lipophilic quinazoline antifolate.</p>Fórmula:C18H15N5O3Pureza:98%Cor e Forma:SolidPeso molecular:349.34Cdc7-IN-17
CAS:<p>Cdc7-IN-17 is a potent inhibitor of CDC7 with an IC 50 of <10 μM that can be used in cancer research [1].</p>Fórmula:C13H15N5OSCor e Forma:SolidPeso molecular:289.36Apricitabine
CAS:<p>Apricitabine (SPD754) is a highly selective and orally active HIV-1 reverse transcriptase inhibitor (Ki=0.08 μM), the (-) enantiomer of 2′-deoxy-3′-oxy-4′-</p>Fórmula:C8H11N3O3SPureza:99.45%Cor e Forma:SolidPeso molecular:229.26ROCK-IN-D2
CAS:<p>ROCK-IN-D2 is an effective and selective inhibitor of ROCK.</p>Fórmula:C22H28N6OPureza:98%Cor e Forma:SolidPeso molecular:392.5RHI002-Me
CAS:<p>RHI002-Me is a methylated derivative of RHI002, a selective inhibitor of human RNaseH2.</p>Fórmula:C18H19N3O2S2Pureza:98%Cor e Forma:SolidPeso molecular:373.49MFH290
CAS:<p>MFH290 is a selective CDK12/13 inhibitor, covalently bonding with CDK12 Cys-1039, blocks Pol II CTD phosphorylation, and enhances olaparib's efficacy.</p>Fórmula:C26H31N5O3S2Cor e Forma:SolidPeso molecular:525.69A 65281
CAS:<p>A 65281: antibacterial isothiazoloquinolone, inhibits P4-unknotting, induces DNA breakage via topoisomerase II.</p>Fórmula:C17H16F2N4O2SPureza:98%Cor e Forma:SolidPeso molecular:378.4Capzimin
CAS:<p>Capzimin is a selective inhibitor of proteasome isopeptidase Rpn11.</p>Fórmula:C30H24N6O2S4Pureza:98.31% - 99.32%Cor e Forma:SolidPeso molecular:628.81(E/Z)-BIO-acetoxime
CAS:<p>(E/Z)-BIO-acetoxime: potent GSK-3 α/β inhibitor; IC50: GSK-3α/β 10nM, CDK5/p25 2.4μM, CDK2/A 4.3μM, CDK1/B 63μM.</p>Fórmula:C18H12BrN3O3Cor e Forma:SolidPeso molecular:398.21Zaurategrast ethyl ester
CAS:Zaurategrast ethyl ester, an α4β1/α4β7 integrin antagonist prodrug of CT7758, treats inflammatory/autoimmune conditions.Fórmula:C28H29BrN4O3Pureza:98%Cor e Forma:SolidPeso molecular:549.463'-Deoxyuridine-5'-triphosphate
CAS:<p>3'-dUTP, a nucleotide analogue, competitively inhibits RNA polymerases I & II, with a Ki of 2.0 µM.</p>Fórmula:C9H15N2O14P3Cor e Forma:SolidPeso molecular:468.14BRD9185
CAS:<p>BRD9185 is an inhibitor of Dihydroorotate dehydrogenase (DHODH) with an EC50 of 16 nM against multidrug-resistant blood-stage parasites in vitro.</p>Fórmula:C23H21F6N3O2Pureza:98%Cor e Forma:SolidPeso molecular:485.42CDK8-IN-7
CAS:<p>CDK8-IN-7 is a potent CDK8 inhibitor with a Kd of 3.5 nM, showing promise for AML research.</p>Fórmula:C30H40N2Cor e Forma:SolidPeso molecular:428.65DHODH-IN-1
CAS:<p>DHODH-IN-1 is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 25 nM. DHODH-IN-1 is an inhibitor of the pyrimidine biosynthetic pathway.</p>Fórmula:C21H20F3N3O2Pureza:99.76%Cor e Forma:SolidPeso molecular:403.4XVA143
CAS:<p>XVA143, an α/β I-like allosteric antagonist, blocks LFA-1 adhesion and combats P. gingivalis in mice, preventing bone loss.</p>Fórmula:C25H21Cl2N3O8Cor e Forma:SolidPeso molecular:562.36Aurora A/PKC-IN-1
CAS:<p>Aurora A/PKC-IN-1 inhibits AurA (IC50: 6.9 nM), PKCα (IC50: 16.9 nM), and hinders breast cancer cell growth and spread.</p>Fórmula:C16H14N6OSe2Cor e Forma:SolidPeso molecular:464.24NSC666715
CAS:<p>NSC666715 is the strand-displacement activity of DNA polymerase inhibitor.</p>Fórmula:C15H13Cl2N5O2S2Pureza:98%Cor e Forma:SolidPeso molecular:430.33HBV-IN-4
CAS:<p>HBV-IN-4, a phthalazinone, inhibits HBV DNA replication orally (IC50: 14 nM), encouraging genome-free capsids with strong anti-HBV effects.</p>Fórmula:C24H19ClFN5O3Cor e Forma:SolidPeso molecular:479.89
